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CTNNA1


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Symbol:CTNNA1
Name(s):catenin (cadherin-associated protein), alpha 1, 102kDa
Type:protein-coding
Organism:Homo sapiens
Synonyms:CAP102, FLJ36832
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18078809 These results suggest induction of SRF-mediated transcription by alpha(E)-catenin either downstream of RhoA or via a parallel pathway.
17760743 prognostic and chemosensitivity marker for invasive bladder cancer
17576040 we explored the implication of three proteins (E-cadherin, a- and b-catenins) that form the cadherin-catenin complex, a receptorial structure strictly involved in tumoral vascular invasion and embolization in this biologic event
17668349 The previously reported characteristics of this mutation, E-cadherin (V832M) do not apply to human epithelial cells expressing this mutant protein.
15541354 Our results suggest that alpha-catenin links CCR5 and CXCR4 to the cytoskeleton and is involved in the organization of these receptors at the membrane, thereby possibly affecting HIV-1 infection.
15695815 ubiquitin-independent degradation of alpha-catenin regulates beta-catenin signaling and maintenance of the differentiated phenotype of articular chondrocytes
16273278 These results indicate that the interaction of alpha-catenin and actin functions in the assembly of desmosomes in epithelial cells.
16798615 Direct attachment of alpha-catenin to F-actin is required to promote cadherin-mediated contact formation and strong cell-cell adhesive states.
12532469 Abnormal E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma tissues. Abnormal E-cadherin and alpha-catenin with differentiation, lymph node and liver metastases. Aberrant beta-catenin with lymph node and liver metastases.
14599963 Pancreatic cancer likely occurs in case of the inactivation of E-cadherin and alpha-catenin genes and abnormal expression of proteins

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActinin alpha 1catenin, alpha 1--Pubmed
HPRDactinin, alpha 1Catenin, alpha 1--Pubmed
HPRDCadherin 5catenin, alpha 1--Pubmed
HPRDcadherin 5, type 2 preproproteinCatenin, alpha 1--Pubmed
HPRDCatenin, alpha 1catenin, beta 1, 88kDa--Pubmed
HPRDCatenin, alpha 1spectrin, alpha, non-erythrocytic 1--Pubmed
HPRDCatenin, alpha 1tight junction protein 2 isoform 1--Pubmed
HPRDCatenin alpha 1tight junction protein 2 isoform 1--Pubmed
HPRDCatenin, alpha 1myeloid/lymphoid or mixed-lineage leukemia--Pubmed
HPRDCatenin, alpha 1vinculin isoform meta-VCL--Pubmed

Recent Publications on CTNNA1:

Pubmed Logo
Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies.
Complete loss or deletion of the long arm of chromosome 5 is frequent in...
15th October, 2009
Department of Medicine, Johns Hopkins University School of Medicine, Cancer Res. 2009 Nov 1;69(21):8482-90. Epub 2009 Oct 13.
DOI Direct Link
Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis.
Pancreatic cancer with liver metastases has a poor prognosis and the...
19th August, 2009
Department of Oncology, Shanghai Medical College, Fudan University, Cancer Lett. 2009 Sep 28;283(1):84-91. Epub 2009 Apr 17.
DOI Direct Link
Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.
To better understand the molecular basis of radiation-induced osteosarcoma...
23rd July, 2009
Laboratoire de Cancerologie Experimentale, iRCM, DSV, CEA, Int J Cancer. 2009 Aug 1;125(3):612-20.
DOI Direct Link
Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.
BACKGROUND: Toluene diisocyanate (TDI) is the most important cause of...
31st March, 2009
Department of Allergy and Rheumatology, Ajou University School of Clin Exp Allergy. 2009 Feb;39(2):203-12.
DOI Direct Link
Gene expression profiling in skeletal muscle of Holstein-Friesian bulls with single-nucleotide polymorphism in the myostatin gene 5'-flanking region.
Myostatin (GDF-8) is a key protein responsible for skeletal muscle growth...
24th October, 2008
Department of Physiological Sciences, Faculty of Veterinary Medicine, J Appl Genet. 2008;49(3):237-50.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6962904 Elastin peptide analogs and uses thereof
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles

View more patents.

CTNNA1 results (if any) from reagent suppliers

Google CSE Logo
C2081 Anti-α-Catenin antibody produced in rabbit whole antiserum
microarray: suitable. Gene Information, human ... CTNNA1(1495). rat ... Ctnna1( 307505). mouse ... Ctnna1(12385). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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p-α E-catenin (Ser 641) Antibody sc-101824
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CTNNA1, 1495, 5q31.2, NM_001903 ...
http://www.scbt.com/datasheet-101824-p-alpha-e-catenin-ser-6...

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Kaiso antibody [6F / 6F8] - ChIP Grade (ab12723) | Abcam
Immunoprecipitation analysis showed that Kaiso interacts with Ctnnd1 but not with Ctnnb1, Ctnna1 or Cdh1. Immunofluorescence analysis demonstrated a diffuse
...
http://www.abcam.com/Kaiso-antibody-6F-6F8-ChIP-Grade-ab1272...

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PhosphoSignature™
CTNNA1. Catenin alpha-1 (Cadherin-associated protein). P35221. 100. 177. NAGNEQDLGIQyK. 4. 282. 1.6. 1.5-1.8. CTNND1. Catenin delta-1 (Cadherin-
associated ...
http://www.cellsignal.com/technologies/phosphoscan/pdfs/PSig...

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Quantitative cancer stem cell phosphoprotein profiling
CTNNA1. DNAJA1. YWHAE. CKAP4. HSPA5. YWHAQ. PTK2. HSPB1. HSPD1. (includes EG: 3329). (includes EG:1097). HNRPK. HSP90AA1. HSP90B1 ...
http://www.piercenet.com/previews/Vol13Iss1/1601749_Previews...

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