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CTNNB1
| Symbol: | CTNNB1 | | Name(s): | catenin (cadherin-associated protein), beta 1, 88kDa | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CTNNB, DKFZp686D02253, FLJ25606, FLJ37923 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17724465 |
Deregulated beta-catenin signaling may occur in high-risk neuroblastomas without MYCN amplification resulting in transactivation of MYC and other target genes to induce an aggressive phenotype. |
| 18048388 |
Wnt/beta-catenin pathyway is activated by epigenetic inactivation of Dkk3, thereby promoting the growth of lung cancer cells |
| 18165946 |
FGF9 mutant tumors showed normal membranous beta-catenin expression and the absence of mutation in the beta-catenin gene |
| 18199649 |
data indicate that beta-catenin signaling is an intrinsic molecular pathway restricting HIV replication in PBMCs |
| 17950943 |
The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression. |
| 18218837 |
Over-expression of beta-catenin was sufficient to suppress the differentiation and mineralization of DPSCs. |
| 18206728 |
the importance of beta-catenin in the immortalization process of HPCs, from its dispensable role in their maintenance. |
| 17875931 |
Data indicate that Sox4 and 17 can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts. |
| 18086858 |
beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation. |
| 15520370 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | acid phosphatase 1 isoform c | Catenin beta | - | - | Pubmed |
| HPRD | adenomatosis polyposis coli | catenin, beta 1, 88kDa | - | - | Pubmed |
| BIND | adenomatous polyposis coli | catenin, beta 1, 88kDa | Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc. | - | Pubmed |
| BIND | adenomatous polyposis coli | catenin, beta 1, 88kDa | APC interacts with Beta-catenin. | - | Pubmed |
| BIND | Homo sapiens chromosome 19, reference assembly. | catenin, beta 1, 88kDa | CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter. | - | Pubmed |
| BIND | Homo sapiens chromosome 10 | catenin, beta 1, 88kDa | CTNNB1 (beta-catenin) interacts with the FAS promoter. | - | Pubmed |
| HPRD | androgen receptor isoform 1 | catenin, beta 1, 88kDa | - | - | Pubmed |
| HPRD | androgen receptor isoform 1 | catenin, beta 1, 88kDa | - | - | Pubmed |
| BIND | Homo sapiens chromosome 11, reference assembly. | catenin, beta 1, 88kDa | CTNNB1 (beta-catenin) interacts with the CCND1 promoter. | - | Pubmed |
| HPRD | cyclin D1 | catenin, beta 1, 88kDa | - | - | Pubmed |
Recent Publications on CTNNB1: |  |
MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.
The radial glial cells serve as neural progenitors and as a migratory... | 3rd November, 2009
| UNC Neuroscience Center and the Department of Cell and Molecular
| Development. 2009 Sep;136(17):2965-75.
DOI Direct Link |
WNT signaling in ovarian follicle biology and tumorigenesis.
The WNTS are an expansive family of glycoprotein signaling molecules known... | 31st October, 2009
| Centre de Recherche en Reproduction Animale, Faculte de Medecine
| Trends Endocrinol Metab. 2009 Oct 27.
DOI Direct Link |
Cushing's syndrome in an infant secondary to malignant adrenocortical tumors with somatic mutation of beta-catenin.
Abstract A role of beta-catenin (CTNNB1) in the molecular pathogenesis of... | 30th October, 2009
| 1 Faculty of Science, Prince of Songkla University.
| Pediatr Dev Pathol. 2009 Oct 19.
DOI Direct Link |
Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas.
Aberrant activation of wingless (Wnt) signaling is involved in the... | 23rd October, 2009
| Department of Structural Biology, Max Planck Institute of Molecular
| Int J Cancer. 2009 Oct 21.
DOI Direct Link |
A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans.
BACKGROUND: Very recently a gene marker panel that allows the mutational... | 21st October, 2009
| Institute of Nutritional Science, University of Potsdam, Nuthetal,
| Cancer Epidemiol. 2009 Aug;33(2):123-9. Epub 2009 Jun 10.
DOI Direct Link |
→View more research publications. |
Press Releases on CTNNB1:
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| Cequent Names F. Stephen Laroux, Ph.D., Director, Immunology and Inflammatory Diseases |
2nd June, 2009 |
Cequent Pharmaceuticals, Inc. |
CAMBRIDGE, Mass., June 2 /PRNewswire/ -- Cequent Pharmaceuticals, a pioneer in the development of novel products to deliver RNAi-based treatments to prevent and treat human disease, announced that
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| Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research |
15th April, 2009 |
Cequent Pharmaceuticals, Inc. |
Monday poster honored with special recognition awarded to top-rated abstracts
CAMBRIDGE, Mass., April 15 /PRNewswire/ -- Cequent Pharmaceuticals, a pioneer in the development of
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| Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference |
6th January, 2009 |
Cequent Pharmaceuticals |
CAMBRIDGE, Mass., Jan. 6 /PRNewswire/ -- Cequent Pharmaceuticals, a pioneer in the development of novel products to deliver RNAi-based treatments to prevent and treat human disease, announced that
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CTNNB1 results (if any) from reagent suppliers | 
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Ctnnb1 antibody, Beta-catenin Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit Ctnnb1 antibody (interacts with human mouse rat xenopus), anti-Ctnnb1, Beta-catenin antibody, rabbit polyclonal antibody, Beta-catenin ...
http://www.genwaybio.com/product_info.php?products_id=20068...
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CTNNB1 Antibody
Specific antibody for the gene product of CTNNB1, the protein Catenin beta 1. Validated for specificity by gene-silencing with siRNA followed by Western ...
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b-Catenin (CTNNB1) Dephospho antibody, b-Catenin (CTNNB1 ...
Buy quality sheep b-Catenin (CTNNB1) Dephospho antibody (interacts with human mouse), anti-b-Catenin (CTNNB1) Dephospho, b-Catenin (CTNNB1) Dephospho ...
http://www.genwaybio.com/product_info.php?products_id=222018...
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Antibodies to Wnt Signaling
human ... CTNNB1(1499), canine, human, chicken, bovine, ARR, IF (i), WB, pricing ... human ... CTNNB1(1499), bovine, canine, chicken, human, IF (d), pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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CTNNB1 peptide, beta-Catenin (Ab-41/45) Antibody Blocking Peptide ...
Buy quality CTNNB1 peptide (n/a), CTNNB1, beta-Catenin (Ab-41/45) Antibody Blocking Peptide peptide, (n/an/a). Beta-catenin; Catenin beta-1, ...
http://www.genwaybio.com/product_info.php?products_id=213310...
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C4231 Monoclonal Anti-phospho-β-Catenin (pSer33/pSer37) antibody ...
isotype, IgG2b. Gene Information, human ... CTNNB1(1499). rat ... Ctnnb1(84353). mouse ... Ctnnb1(12387). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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beta Catenin antibody, beta Catenin [15B8] Antibody, Mouse ...
Mouse monoclonal [15B8] to beta Catenin; 1499; CTNNB1; 114550; P35222; CTNNB; 395964; CTNNB1; CHBCAT;; Catenin beta-1, CTNB1_HUMAN.
http://www.genwaybio.com/product_info.php?products_id=192649...
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