Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17724465 |
Deregulated beta-catenin signaling may occur in high-risk neuroblastomas without MYCN amplification resulting in transactivation of MYC and other target genes to induce an aggressive phenotype. |
| 18048388 |
Wnt/beta-catenin pathyway is activated by epigenetic inactivation of Dkk3, thereby promoting the growth of lung cancer cells |
| 18165946 |
FGF9 mutant tumors showed normal membranous beta-catenin expression and the absence of mutation in the beta-catenin gene |
| 18199649 |
data indicate that beta-catenin signaling is an intrinsic molecular pathway restricting HIV replication in PBMCs |
| 17950943 |
The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression. |
| 18218837 |
Over-expression of beta-catenin was sufficient to suppress the differentiation and mineralization of DPSCs. |
| 18206728 |
the importance of beta-catenin in the immortalization process of HPCs, from its dispensable role in their maintenance. |
| 17875931 |
Data indicate that Sox4 and 17 can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts. |
| 18086858 |
beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation. |
| 15520370 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15523694 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16356174 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16843107 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17160944 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17903198 |
immunohistochemistry for b-catenin may be a powerful tool for detecting those adenomas with an increased risk for malinancy. |
| 17854061 |
REVIEW of studies pointing to molecular mechanisms that govern the integration between cell-cell adhesion and gene expression, as reflected in the switches between these two functions of beta-catenin in colon cancer cells |
| 18008331 |
membranous overexpression of E-cadherin and beta-catenin are associated with the metastatic prostate cancer cells in bone and the high frequency of expression suggests their involvement in the intercellular adhesion of the metastatic cells in bone |
| 17621269 |
Ajuba promoted GSK-3beta-mediated phosphorylation of beta-catenin by reinforcing the association between beta-catenin and GSK-3beta. |
| 17992121 |
These data show activation of the Wnt/beta-catenin-signalling pathway in uveal melanoma and suggest that components of this pathway might be useful prognostic markers as well as attractive therapeutic targets to treat this disease. |
| 18077326 |
These observations assign to the tumor suppressor Fhit an unexpected role in the regulation of beta-catenin-mediated gene transcription. |
| 17914096 |
HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells. |
| 17637758 |
These observations unravel the interplay between beta-catenin and Rac1 that is initiated by T-Ag and results in stabilization of beta-catenin and its presence in cell membrane ruffles. |
| 17982235 |
analysis of Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas |
| 17852416 |
Beta-Catenin was co-immunoprecipitated with ERalpha, indicating that these two proteins form a new signaling complex and transcription factor. |
| 18044981 |
an internally truncated LRP5 receptor is strongly implicated in deregulated activation of the WNT/beta-catenin signaling pathway in hyperparathyroid tumors |
| 17673525 |
Beta-catenin transgene signaling plays a role in the proliferation of neural progenitor cells in the subventricular zone of adult mouse brain. |
| 17851558 |
FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization. |
| 17905526 |
This paper focuses on changes in E-cadherin (CDH1), adenomatous polyposis coli (APC), and beta-catenin (CTNNB1) in 50 tumors of the central nervous system |
| 17172473 |
CTNNB1 mutation is a later event in Wilms tumourigenesis. CTNNB1 mutations might be associated with rhabdomyogenesis |
| 17507638 |
Characterization of endogenous CDHE-CTNNB complexes with ELISA represents a dramatic improvement over other assays. |
| 18006828 |
EpCAM is a Wnt-beta-catenin signaling target gene |
| 18006853 |
KCC3 down-regulates E-cadherin/beta-catenin complex formation by inhibiting transcription of E-cadherin gene and accelerating proteosome-dependent degradation of beta-catenin protein |
| 17641414 |
Elevated expression of cell-cycle regulators p16(INK4A), p21(CIP1), and cytoplasmic/nuclear beta-catenin correlated with increased colorectal cancers risk, as did elevated expression of survivin and human telomerase reverse transcriptase. |
| 17785436 |
Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells. |
| 17393422 |
Interaction of MUCI with CTNNB modulates cyclin D1 in H. pylori-induced stomach neoplasms. |
| 17663505 |
E-cadherin and beta-catenin have roles in progression of Epstein-Barr virus-associated gastric carcinoma |
| 17595165 |
Blockade of Wnt3a stimulation of IP(5) generation blocks beta-catenin accumulation |
| 17764657 |
MUC1 may affect cancer cell migration by increasing E-cadherin/beta-catenin complex formation and restoring E-cadherin membrane localization |
| 17952864 |
Sporadic desmoids are usually associated with somatic mutations in codons 41 or 45 of exon 3 of beta-catenin (CTNNB1). |
| 17429067 |
Data show that E-cadherin/beta-catenin-based adherens junctions are dispensable for tight junction formation and apical lumen biogenesis but not for apical lumen remodeling. |
| 17558858 |
there are somatic mutations of APC & beta-catenin genes in desmoid-type fibromatosis & abnormalities in Wnt signal pathway; these abnormalities may result in aberrant cell proliferation & apoptosis, which may be important in tumorigenesis & progression |
| 17576040 |
we explored the implication of three proteins (E-cadherin, a- and b-catenins) that form the cadherin-catenin complex, a receptorial structure strictly involved in tumoral vascular invasion and embolization in this biologic event |
| 17721184 |
Mutation-specific restriction enzyme digestion was used to detect CTNNB1 mutations in desmoid-type fibromatosis. |
| 17710160 |
Cytoplasmic beta-catenin is associated with COX-2 overexpression, supporting the role of cytoplasmic beta-catenin in stabilizing PTGS2 (COX-2) mRNA. |
| 16688229 |
variations in beta-catenin protein levels were dependent on post-transcriptional mechanisms involving the Wnt/beta-catenin pathway only in leukemic cells |
| 17592150 |
Specification of enteroendocrine but not Paneth cells occurs independently of Wnt signals by conditional deletion of beta-catenin transgene in immature cells expressing the transcription factor, neurogenin 3. |
| 17526942 |
methylation may play important role in progression and metastasis of small bowel carcinoid tumors |
| 17679465 |
Beta-catenin may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin. |
| 17454753 |
racial factor may not be related to the occurrence of mismatch repair defects and CTNNB1 mutations in our multi-racial patient cohort. |
| 17522055 |
3,3'-diindolylmethane -induced cell growth inhibition and apoptosis induction are partly mediated through the regulation of Akt/FOXO3a/GSK-3beta/beta-catenin/AR signaling |
| 17601559 |
TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts and non-tumoral fibroblasts, despite the oncogenic mutations already present in this gene in tumoral fibroblasts of desmoid tumors. |
| 17284619 |
No evidence of mutations in parathyroid adenomas. |
| 17513457 |
OxPAPC promoted novel interactions between focal adhesion and adherens junction complexes via paxillin and beta-catenin association, which was critically dependent on Rac and Cdc42 activities. |
| 12124804 |
Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. |
| 12587534 |
matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis |
| 15696778 |
All 61 meningothelial meningiomas, 10 of 12 invasive meningiomas, and 3 of 5 anaplastic meningiomas were positive for both ECAD and beta-catenin, while these were both negative in all of the fibrous meningiomas. |
| 15806138 |
TCF4 expression mediated by beta-catenin/p300 may be important for initial steps during trans-differentiation of endometrial carcinoma cells. |
| 12972427 |
interaction with the co-activator, p300, underlies the trans-repression of beta-catenin signaling by nuclear receptors and their ligands |
| 15670774 |
Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins. |
| 16084063 |
results suggest that the Wnt/beta-catenin signaling pathway plays dual functions in head and neck squamous cell carcinoma (HNSCC) development: promoting both cell survival and invasive growth of HNSCC cells. |
| 17121828 |
Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism |
| 17383052 |
CTNNB1 was expressed strongly on the cuboidal cell membranes and cytoplasm in both tumor types, but to a lesser extent in the polygonal cells, localizing mainly in the cytoplasm. |
| 11819825 |
Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China. |
| 12209999 |
Role of Wnt pathway in medulloblastoma oncogenesis: accumulation of beta-catenin in tumor cells was immunohistochemically proven in 5 cases; 2 cases showed positive immunoreactivity for Wnt-1 and another 2 showed mutation of either CTNNB1 or AXIN1 |
| 12969793 |
Overexpression of beta-catenin is associated with hepatocellular carcinoma |
| 15082903 |
Wnt signaling pathway associated with beta-catenin regulation in breast cancer tissue |
| 12820959 |
CTNNB is ubiquinated at specific lysines by the F-box protein beta-TrCP1. |
| 15695815 |
ubiquitin-independent degradation of alpha-catenin regulates beta-catenin signaling and maintenance of the differentiated phenotype of articular chondrocytes |
| 16378715 |
beta-catenin mutation and its nuclear localization are frequent causes of Wnt signaling pathway activation suggesting that beta-catenin activation mutations contribute to tumorigenesis of pilomatricomas |
| 16378739 |
colon cancer cells retain significant amounts of LEF-1 induced nuclear beta-catenin compared to LEF-1 transfected normal epithelial cells; beta-Catenin binds directly to CRM1 & overexpression of CRM1 reduces nuclear beta-catenin-mediated transactivation |
| 15500294 |
The beta-catenin, the main system of adherens junction, present in the tight junctions in HepG2 cells. |
| 16501564 |
Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas. |
| 11939410 |
results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway |
| 16476742 |
analysis of a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein |
| 17090604 |
Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells. |
| 15138556 |
Translocalization of beta-catenin is associated with invasion in gastric cancer |
| 12183361 |
Nr-CAM is the gene most extensively induced by beta catenin |
| 15737630 |
In conclusion, prolonged CPB time entails neutrophil-mediated decrease in MVEC beta-catenin expression, and thus may be an important trigger for BBB disruption. |
| 16124054 |
Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin. |
| 16239965 |
Data suggest a beta-catenin-dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma. |
| 11790773 |
aardvark gene product |
| 16786128 |
beta-catenin might be involved in the Hh signaling pathway via enhancement of the transcriptional activity of GLI |
| 11953860 |
nuclear beta-catenin expression significantly related to ulcerative growth of colorectal cancer |
| 12729800 |
Data show that beta-catenin and poly(ADP-ribose) polymerase are cleaved during rhodostomin-induced apoptosis, indicating that cell detachment is a prerequisite for apoptosis. |
| 17219201 |
mutations in the CTNNB1 gene most frequently coexisted with mutations in the PTEN gene (7/9, 77.8%). |
| 17551084 |
Bilateral Wilms tumours showed loss of the wild type WT1 allele (loss of heterozygosity (LOH)) and a tumour specific mutation in catenin beta1 (CTNNB1). |
| 12532436 |
Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis. |
| 12532469 |
Abnormal E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma tissues. Abnormal E-cadherin and alpha-catenin with differentiation, lymph node and liver metastases. Aberrant beta-catenin with lymph node and liver metastases. |
| 14563838 |
the beta-catenin pathway is activated by histamine |
| 15987741 |
Transendothelial migration is compromised in melanoma cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process. |
| 16133456 |
The expression of beta-catenin, p63 and CD34 in the course of androgenetic alopecia is reported. |
| 12692418 |
These results indicate that the altered expression of beta-catenin, but not cyclin D1, in hepatocellular carcinoma may play an important role in tumor progression by stimulating tumor cell proliferation. |
| 17241872 |
GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation in colon cancer |
| 15381903 |
negative immunoreactivity of beta-catenin in serous carcinomas and the presence of residual tumor seem to be useful markers in selecting patients likely to have an unfavorable course |
| 12592400 |
Data show that beta-catenin is overexpressed in Kaposi sarcoma and primary effusion lymphoma, and that this overexpression is regulated by the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen LANA. |
| 15289833 |
abnormal immunhistochemical E-cadherin and beta-catenin expression is associated with changes in pit pattern in invasive colorectal neoplasms |
| 12297840 |
beta-catenin, which participates in the Wnt signaling pathway, might play a more important role in the formation of hepatic adenoma than in that of focal nodular hyperplasia. |
| 16204248 |
TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes |
| 16760136 |
beta-catenin level depends on the way and level of Wnt pathway activation |
| 12130512 |
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. |
| 16830381 |
Comparative analysis of nuclear and membrane/cytoplasmic beta-catenin can predict local tumor infiltration. |
| 11967263 |
Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45) |
| 12482967 |
These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. |
| 12606944 |
Pulse-labeled beta-catenin replaces the beta-catenin bound to the cell surface prebiotinylated E-cadherin immediately after synthesis or arrives at the plasma membrane in a complex with the E-cadherin precursor. |
| 12618757 |
The MUC1/beta-catenin interaction occurs in primary tumors, & is dramatically increased in metastatic lesions. |
| 15572674 |
The interaction and functional cooperation between FHL2, CITED4, and CTNNB were studied. |
| 15790758 |
crosstalk between the beta-catenin and NF-kappaB signaling pathways is an important regulator of intestinal inflammation |
| 15888491 |
Tumor sections frmo colorectal cancer patients showed elevated expression levels of AKT1, correlating with enhanced cytoplasmic/nuclear expression of beta-catenin. |
| 15896469 |
Wnt/beta-catenin signalling pathway is activated in most of gastric cancers, which may play pivotal roles either in gastric cancer formation or in tumour invasion and dissemination |
| 11950845 |
ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas |
| 16132582 |
Altered beta-catenin distribution in gastric cancer may result from the imbalance of E-cadherin production and Wnt expression, which confers on gastric cancer cells more aggressive behaviors. |
| 16254206 |
Beta-catenin may be an important modulator of angiogenesis and myocyte regeneration |
| 16328013 |
Results showed that inhibition of PI-3 kinase with wortmannin was accompanied by a considerably reduced expression of beta-catenin. |
| 16407829 |
In esophageal adenocarcinomas, nuclear translocation of beta-catenin was observed regardless of the expression of APC. |
| 12060769 |
targeted inactivation reveals effects of beta-catenin mutation |
| 14520463 |
Increased expression of beta-catenin is associated with ovarian epithelial cell transformation and in tumour progression |
| 15972952 |
The presence of activated beta-catenin and c-myc in the epidermis of chronic wounds may serve as a molecular marker of impaired healing |
| 12111402 |
Mutation in exon 3 of the beta-catenin gene was found in 2 of the 20 endometrial cancer samples; however, it was not found in the 25 endometrial hyperplasias or the 20 associated hyperplasias. |
| 11921277 |
CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers. |
| 15279902 |
beta-catenin is downregulated by H2O2 which negatively modulates the Wnt signal pathway |
| 12556519 |
CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin |
| 14985333 |
beta-catenin phosphorylation/degradation is regulated by CDK2 |
| 15694380 |
Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling |
| 11920497 |
mutations rare in ulcerative colitis-related colorectal carcinomas |
| 15668893 |
Alterations in beta-catenin and PTEN genes, as well as MSI, are frequent in low-stage ovarian carcinomas of endometrioid type that have a favorable prognosis. |
| 15905404 |
results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress |
| 15958533 |
ADAM10 has a role in E-cadherin shedding and epithelial cell-cell adhesion, migration, and beta-catenin translocation |
| 16199882 |
PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated. |
| 12235125 |
Beta catenin induced human melanoma growth requires the downstream target Microphthalmia-associated transcription factor. |
| 12810642 |
When colon cancer cells with high beta-catenin levels were treated with beta-catenin antisense ODNs, VEGF-A expression was reduced by more than 50%. There is a close link between beta-catenin signaling & VEGF-A expression regulation in colon cancer. |
| 15111320 |
Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during tumor cell differentiation |
| 12478897 |
The aberrant expression of beta-catenin protein was statistically correlated to the lymph node metastasis in esophageal cancer. |
| 15781969 |
Findings suggest that phospho-beta-catenin accumulation in Alzheimer's disease might result from impaired proteasome function. |
| 16126725 |
cadherins mediate both the association of PS1 and beta-catenin and the effects of PS1 on the cellular levels of beta-catenin |
| 16474376 |
Phospho-beta-catenin may have a different involvement in invasive breast carcinomas, according to its subcellular distribution. |
| 16621789 |
BMP-2 antagonizes Wnt-3a signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation |
| 16644723 |
GR can bind beta-catenin in vitro, suggesting that GC and Wnt signaling pathways are linked directly through their effectors |
| 16772034 |
Splice forms of crucial genes of the Wnt-pathway, beta-Catenin, LRP5, GSK3beta, Axin-1 and CtBP1 are expressed in human colorectal tissue. |
| 16798748 |
APC regulates beta-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms |
| 16865250 |
Reduced membranous expression of beta-catenin was associated with metastasis in salivary adenoid cystic carcinoma |
| 17030184 |
Exposure of colon cancer cells to nitric oxide unraveled a so-far-unidentified mechanism of beta-catenin regulation. |
| 17143299 |
Wnt/beta-catenin signaling has a role in neurodevelopment as well as in neurodegenerative diseases [review] |
| 17240357 |
Up-regulates prolactin expression using the distal promoter. |
| 17466258 |
inhibition of beta-catenin and in effect c-myc expression through activation of PPARgamma may help prostate cancer cells to restore several characteristics of normal prostate cells phenotype |
| 17638895 |
Fascin is a novel target of beta-catenin-TCF signaling and is expressed at the invasive front of human colon cancer |
| 11957146 |
beta-catenin plays a role in endometrial carcinogenesis, particularly in endometrioid carcinomas |
| 12209953 |
data support the notion that upregulation of cyclin D1 and Fra-1 in human colorectal adenocarcinomas is driven by abnormally expressed beta-catenin; however, the regulation of c-myc expression in colorectal tumors appears to be more complex |
| 12927518 |
IpaC interacts with beta-catenin and destabilizes the cadherin-mediated cell adhesion complex. |
| 14993280 |
alpha-catenin and alpha-catulin have distinct activities that downregulate, respectively, beta-catenin and Ras signals converging on the cyclin D1 promoter |
| 11940574 |
Activation of AXIN2 expression by beta-catenin-T cell factor |
| 12219004 |
Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis. |
| 12824925 |
types of mutations in sinonasal NK/T cell lymphoma in northeast district of China |
| 15194432 |
E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin. |
| 15665104 |
Induction of the Wnt/beta-catenin pathway by LiCl also elevated PPARgamma levels and induced PPARgamma-dependent reporter and endogenous target genes. |
| 15853773 |
The regulation of GLCE expression by 2 cis-acting elements of the beta-catenin-TCF4 complex located in the enhancer region of the promoter are reported. |
| 16082250 |
nuclear beta-catenin is a rare phenomenon in colorectal SRCC, but the involvement of it may indicate a worse prognosis with shorter survival than colorectal SRCC without nuclear beta-catenin expression |
| 16356174 |
APC and K-ras, but not CTNNB1 mutations have roles in regulation of expression of hMLH1 in sporadic colorectal carcinomas |
| 16382042 |
sulindac sulfone can modulate the APC/beta-catenin pathway in vitro but its efficacy is dependent upon the mutational status of APC and beta-catenin |
| 16428447 |
High Pin1 expression in primary prostate cancer markedly inhibits the beta-catenin interaction with androgen receptor. |
| 16513652 |
active CKIepsilon generation may induce a negative feedback loop by phosphorylation of sites on LRP5/6 that modulate axin binding and hence beta-catenin degradation |
| 16565090 |
the MED12 interface within Mediator is a new component in the Wnt/beta-catenin pathway |
| 16717102 |
histone deacetylase inhibitor sodium butyrate induces G1/S phase arrest in E1A + Ras-transformed cells through down-regulation of E2F1 activity and stabilization of beta-catenin |
| 16730693 |
When beta-catenin is activated in transgenic En1 expressing cells, it induces Dermo1 expression in all cells of the En1 domain and disrupts muscle gene expression. |
| 16952352 |
Data suggest that intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated Met-beta-catenin dissociation, beta-catenin translocation, activation and mitogenesis. |
| 14660579 |
beta-catenin interferes with transforming growth factor-beta-mediated growth arrest by inducing the expression of BAMBI |
| 12398896 |
beta-catenin plays an important role in oncogenesis through the crossregulation of NF-kappa B in breast and colonic neoplasms |
| 12937339 |
provides support that E-cadherin induction by WNT/beta-catenin signaling is an evolutionarily conserved pathway operative in lung cancer cells and that loss of expression may be important in lung cancer development or progression |
| 15126105 |
High nuclear expression of beta-catenin is correlated with locally advanced colorectal cancer |
| 15215241 |
beta-catenin/TCF transcriptional activity is blocked by Cdx1 and Cdx2, which then inhibits colon cancer cell proliferation |
| 15492040 |
beta-catenin is targeted to adhesive or transcriptional complexes, depending on its molecular form |
| 15381698 |
terminal tail is responsible for discerning among binding of factors to the armadillo domain |
| 15591320 |
identify selective beta-catenin binding hot spots of Tcf4, E-cadherin, and APC |
| 15698401 |
Beta-catenin stabilization because of either beta-catenin or AXIN I mutation might be a late event for malignant progression rather than an early genetic event involving the initiation of HCC development. |
| 15837931 |
Lysophosphatidic acid induced colon cancer cell proliferation requires the beta-catenin signaling pathway. |
| 16291872 |
The positive inter-regulation between beta-cat/Tcf-4 signaling and ET-1 signaling potentiates proliferation and survival of prostate cancer (CaP) cells, thereby representing a novel mechanism that contributes to CaP progression. |
| 16344550 |
CoCoA uses different combinations of functional domains in its synergistic coactivator function with beta-catenin or GRIP1 |
| 16465411 |
Immunohistological examination of nuclear accumulation of beta-catenin may be useful for diagnosing malignant immunohistological examination of nuclear accumulation of beta-catenin may thus be useful for diagnosing malignant PLTs. |
| 12515622 |
beta-catenin, p53 and PCNA may play important roles in the carcinogenesis of colorectal adenoma. |
| 12917489 |
model of the interactions between beta-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors |
| 15514031 |
IGF-I modulates androgen signaling through beta-catenin |
| 15684397 |
Suppression of beta-catenin expression by small interfering RNA decreased the apoptotic response to TGF-beta. |
| 15728254 |
LEF-1 expression is regulated through PITX2, LEF-1 and beta-catenin direct physical interactions |
| 12857869 |
a role for beta-catenin in the control of cell cycle and apoptosis at G2/M |
| 14766232 |
beta-catenin binds to MUC1 and has a role in T cell receptor signaling |
| 12708483 |
There is a possible role of progesterone in regulation of beta-catenin expression in endometrial tumors. Nuclear beta-catenin accumulation, like gene abnormalities, is associated with the alteration of tumor morphology due to progesterone. |
| 11857309 |
increased expression predicts favorable prognosis in resected nonsmall cell lung carcinoma |
| 15660698 |
Loss of expression of E-cadherin and beta-catenin may play an important role in the progression of pulmonary adenocarcinoma. |
| 12389996 |
found a pattern of beta-catenin immunostaining in typical carcinoid tumors of the appendix that was different from the pattern seen in non-appendiceal carcinoid tumors |
| 12694354 |
Aberrant beta-catenin expression may play an important role in the histologic differentiation and tumor staging of mucoepidermoid carcinoma. |
| 15455387 |
Lower levels of nuclear beta-catenin is associated with prostate cancer progression |
| 15557107 |
beta-catenin accumulates in the nucleus of epithelial cells of juvenile polyps |
| 16496348 |
beta-catenin is activated by HBxAg, in part, through the upregulated expression of the HBxAg effector URG11; URG11 stimulates the beta-catenin promoter and hepatocellular growth and survival |
| 16724116 |
These data indicate that the intracellular amounts of HIC1 protein can modulate the level of the transcriptional stimulation of the genes regulated by canonical Wnt/beta-catenin signaling. |
| 16930546 |
in vivo modulation of PRA1 may be involved in TCF/beta-catenin signaling, as well as cellular proliferation and tumorigenesis |
| 16945989 |
These findings suggest that the participation of beta-catenin in adhesion and signaling may represent a novel mechanism through which gonadotropins may regulate the cellular fate of human ovarian surface epithelial cells. |
| 17128412 |
COX-2 and beta-Catenin may have roles in regulating intracellular Survivin levels in mouse and human colon cancer |
| 17504383 |
Loss of beta-catenin expression is a strong and independent predictor of an unfavorable outcome in patients with endometrial carcinoma. |
| 17510365 |
findings show that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 and APC; data provide a possible mechanistic explanation for the tumor suppressor activity of WTX |
| 17510384 |
hepatocellular carcinomas (HCC) with extensive methylation harbor frequent beta-catenin mutations; HCCs with high levels of chromosomal instability are associated with p53 mutations, suggesting presence of two independent pathways for pathogenesis of HCC |
| 17579030 |
Transgenic mice express stabilized beta-catenin, which augments IL-7 receptor signaling in thymocytes during positive selection and promotes development of single-positive CD8 antigen-expressing thymocytes. |
| 12679314 |
dysregulation of beta-catenin may contribute to pancreatic duct adenocarcinoma progression through distinct mechanisms |
| 14742711 |
FAM associates with E-cadherin and beta-catenin during trafficking to the plasma membrane |
| 11839663 |
Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival |
| 12127563 |
Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin. beta-Catenin plays a role in promoting Jurkat survival. |
| 12297048 |
Presenilin couples beta-catenin phosphorylation through two sequential kinase activities independent of the Wnt-regulated Axin/CK1alpha complex. |
| 11836555 |
Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas |
| 12575848 |
In human pilomatricoma, the frequency of beta-catenin gene mutations was remarkably low (30%),in Exon 3 of the beta-catenin gene . |
| 14633602 |
Beta-catenin gene mutations are a peculiar feature of skin tumors with matrical differentiation and correlate with a pattern of intense and diffuse beta-catenin nuclear expression. |
| 15654359 |
beta-catenin plays a central role in mesenchymal cells during the healing process, and is an appealing therapeutic target for disorders of wound healing. |
| 15817486 |
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin |
| 15899904 |
cyclooxygenase-2/PGE2 may exert pro-oncogenic actions through stimulating the beta-catenin/T cell factor-mediated transcription, which plays critical roles in colorectal carcinogenesis |
| 16442529 |
Expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/beta-catenin complex. Phosphorylation of Bcr by the tyrosine kinase pp60(src) can lead to dissociation of the transcriptionally inactive Bcr/Tcf1 complex |
| 16574648 |
PCP-2 may play an important role in the maintenance of epithelial integrity, and a loss of its regulatory function may be an alternative mechanism for activating beta-catenin signaling. |
| 16696969 |
Results suggest that alternative splicing and AU-rich elements can act together in regulating beta-catenin mRNA stability and thereby provide a step of controlling the cellular beta-catenin concentration. |
| 16707106 |
beta-catenin is regulated via epsilon-cleavage of N-cadherin |
| 17203186 |
accumulation of beta-catenin in colorectal cancer is related to chromosomal instability |
| 17229887 |
N-cadherin and beta-catenin play role in cell migration via PDGF-Rbeta-mediated signaling through the scaffolding molecule NHERF2 |
| 17341890 |
Decreased beta-catenin expression is associated with advanced gallbladder cancers |
| 11836379 |
No germline mutations of CTNNB1 have been identified nor linkage to chromosome 3p21 been demonstrated in 8 subjects with Birt-Hogg-Dube syndrome, suggesting that CTNNB1 should be excluded as a candidate gene for BHD. |
| 14977843 |
beta-catenin has a role in progression of colorectal neoplasms |
| 11834740 |
Proof for the regulated phosphorylation of the Ser/Thr residues of beta-catenin by Wnt signaling. |
| 12052822 |
wnt3a-beta catenin signaling regulates LEF-1 gene expression |
| 12907143 |
in breast and lung tumor cells, MDA-7 protein expression modulates cell-cell adhesion and intracellular signaling via coordinate regulation of the beta-catenin and PI3K pathways |
| 15102686 |
MUC1 and beta-catenin have a role in progression and invasiveness of colorectal carcinomas |
| 15254684 |
beta-catenin nuclear accumulation plays a role in Dukes' D human colorectal cancers |
| 15304487 |
there is cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha |
| 15791567 |
data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression |
| 12169098 |
oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism |
| 12606575 |
Data indicate that the rate of nuclear export of adenomatous polyposis coli protein (APC), rather than its nuclear import or steady-state levels, determines the transcriptional activity of beta-catenin. |
| 12737446 |
CTNNB1 mutations were found in 2/19 adenomas without APC mutation. |
| 16163548 |
The cytoplasmic accumulation of beta-catenin is a common characteristic of oral SCC, but is not closely associated with mutational alterations in the APC, beta-catenin and Axin1 genes. |
| 16371504 |
The data suggest a novel role for tyrosine phosphorylation of N-cadherin by Src family kinases in the regulation of beta-catenin association during transendothelial migration of melanoma cells. |
| 11831984 |
Beta-catenin might be related to the occurrence and development of kidney tumor. |
| 15149841 |
CTNNB strongly increased activity of the eN/Nt5 promoter and this increase depended on the presence of TCF-1; demonstrated a link between Wnt signaling and the regulation of eN and ADA, which control the metabolism of adenosine |
| 12771132 |
beta-catenin is degraded via a retinoid X receptor-mediated pathway |
| 12883680 |
Mutations of CTNNB1 may not be a factor in tumorigenesis of cervical cancer |
| 11856748 |
The minimal necessary components of the androgen receptor and beta-catenin required for binding nuclear accumulation of beta-catenin nuclear import appears to be the DNA/ligand binding regions and the Armadillo repeats of beta-catenin |
| 16012954 |
beta-Catenin transgenic mice show an in vivo hepatotrophic effect secondary to increased basal hepatocyte proliferation |
| 12970740 |
our data indicate that inactivation of beta-catenin by a 3p21.3 homozygous deletion might be a crucial event in the development of the mesothelioma NCI-H28 cells. |
| 15239100 |
LECT2, which encodes a protein with chemotactic properties for human neutrophils, is a direct target gene of Wnt/beta-catenin signaling in the liver. |
| 12045208 |
results indicate selection for APC genotypes that are likely to retain some activity in downregulating beta-catenin signaling |
| 15064706 |
p53-mediated reduction in beta-catenin involves enhanced phosphorylation of beta-catenin on key NH(2)-terminal serines. |
| 12603528 |
Mutations of beta-catenin, as well as overexpression of beta-catenin and the Tcf-4 gene, independently activate the Wnt pathway in HCC, with the target gene most likely to be C-myc. |
| 14637149 |
We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner. |
| 15077166 |
Cyr61 activated the beta-catenin/TCF4 complex, which promoted the expression of c-myc and the latter induced expression of p53 |
| 15832407 |
The beta-catenin expression in hepatocellular carcinoma cells was heterogeneous among types of hepatitis viral infection |
| 15927956 |
analysis of conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein |
| 16343437 |
These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion. |
| 16462762 |
These results unravel a novel pathway in the control of beta-catenin cellular transport and strongly suggest that SYT-SSX2 contributes to tumor development, in part through beta-catenin signaling |
| 16507986 |
the cross talk of KLF4 and beta-catenin plays a critical role in homeostasis of the normal intestine as well as in tumorigenesis of colorectal cancers. |
| 16628468 |
The results indicate that estrogen plus overexpressed ERalpha induce LoVo cell apoptosis might mediate through the increase of hTNF-alpha gene expression, which in turn activate caspase-8, -9 and caspase-3 and lead to the DNA fragmentation and apoptosis. |
| 16753179 |
the central region of APC is unstructured in the absence of beta-catenin and Axin; beta-catenin may interact with each of the APC 15aa and 20aa repeats independently |
| 17008323 |
vascular endothelial growth factor expression is induced through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells |
| 17018282 |
Data show that P68 RNA helicase mediates platelet-derived growth factor-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. |
| 17052462 |
crystallographic analysis of how beta-catenin, BCL9, BCL9-2 and Tcf4 interact |
| 17090192 |
Alterations in adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to pathogenesis of pleuropulmonary desmoid tumors and solitary fibrous tumors. |
| 17259169 |
PS/gamma-secretase-mediated cleavage of LAR controls LAR-beta-catenin interaction, suggesting an essential role for PS/gamma-secretase in the regulation of LAR signaling |
| 17242406 |
the recruitment of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, ultimately, keratinocyte differentiation |
| 11747475 |
Loss of beta-catenin may result in the disruption of the function of the cell-cell adhesion complex, which may cause weak cell-cell adhesion and confer invasive properties on a tumor. |
| 12452049 |
abnormal expression of beta-catenin in gastric carcinoma and survival |
| 12748295 |
Data show that both UBF1 and UBF2 activate RNA polymerase II-regulated, beta-catenin-responsive promoters. |
| 12952940 |
Results report a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of beta-catenin. |
| 16038041 |
Both cell surface reduction and intranuclear accumulation of beta-catenin were detected in intestinal metaplasia |
| 16114033 |
Splice variants of CTNNB1 ands downstream targets were used as markers for neoplastic progression of esophageal cancer. |
| 16712787 |
STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells |
| 16756720 |
Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors |
| 16815294 |
In conclusion, the canonical Wnt/beta-catenin pathway enhanced monocyte-endothelial cell adhesion without changing expression levels of adhesion molecules. |
| 16843107 |
These data indicate that somatic mutations affecting APC and CTNNB1 do not play a major role in the pathogenesis of sporadic ependymomas. |
| 16942611 |
These data indicate that changes in Wnt expression per se are unlikely to be the cause of the observed dysregulation of beta-catenin expression in DD. |
| 16953230 |
A functional crosstalk between hepatocyte growth factor receptor (MET) and beta-catenin signaling sustains and increases colorectal carcinoma cell invasive properties. |
| 17050667 |
These data reveal a potentially important role for transcriptionally active beta-catenin in the regulation of Rad6B gene expression, and link aberrant beta-catenin signaling with transcriptional deregulation of Rad6B and breast cancer development. |
| 17168211 |
beta-catenin may have a role in progression of colorectal neoplasms to metastatic liver lesions |
| 17289029 |
Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription. |
| 17505512 |
Nuclear beta-catenin expression was significantly greater in Multiple colorectal adenoma patients' tumours than in sporadic adenomas. |
| 15331612 |
In HT29 and HCT116 colorectal cancer cells, beta-catenin/TCF transcriptional activity is inhibited by AP-2alpha due to formation of AP-2alpha/APC/beta-catenin complex. |
| 12037680 |
Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B] |
| 11893906 |
findings indicate that alterations of beta-catenin are frequent in cancer of the uterine cervix and suggest that they may play an important role in the development of these tumors |
| 11930117 |
One out of 62 melanoma cell lines was found to carry a mutation in exon 3 of the beta-catenin gene indicating that aberration of the Wnt-1/wingless pathway through activation of beta-catenin is a rare event |
