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CTSB


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Gene DB Home
Symbol:CTSB
Name(s):cathepsin B
Type:protein-coding
Organism:Homo sapiens
Synonyms:APPS, CPSB
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17991740 Induction of cathepsin B is associated with the activation of protein p38 MAP kinase.
11513559 Observational study of genotype prevalence. (HuGE Navigator)
16492714 Observational study of gene-disease association. (HuGE Navigator)
17990360 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17724614 Cyclosporine down regulated Cathepsin B.
17990360 Polymorphisms in reg1alpha gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis.
17726009 glycosaminoglycans may play a physiological role in the activation of procathepsin B
16077201 Cathepsin B substrate, BID, serves as molecular switch between apotosis and autophagy in camptothecin treated breast cancer cells.
17507477 Data show that insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus.
17519890 level of active cathepsin B and L is increased in tumors

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursorcathepsin B preproprotein--Pubmed
HPRDalpha-2-macroglobulin precursorcathepsin B preproprotein--Pubmed
HPRDannexin A2 isoform 2cathepsin B preproprotein--Pubmed
HPRDannexin A2 isoform 2cathepsin B preproprotein--Pubmed
HPRDapolipoprotein E precursorcathepsin B preproprotein--Pubmed
HPRDapolipoprotein E precursorcathepsin B preproprotein--Pubmed
HPRDcystatin C precursorcathepsin B preproprotein--Pubmed
HPRDcystatin C precursorcathepsin B preproprotein--Pubmed
HPRDcystatin Acathepsin B preproprotein--Pubmed
HPRDcystatin Acathepsin B preproprotein--Pubmed

Recent Publications on CTSB:

Pubmed Logo
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm.
Anthrax lethal toxin (LeTx) is a virulence factor secreted by Bacillus...
28th October, 2009
Univeristy of Western Ontario, Canada; J Biol Chem. 2009 Oct 26.
DOI Direct Link
Differential LC-MS-based proteomics of surgical human cholangiocarcinoma tissues.
Cholangiocarcinoma is an intractable cancer for which there is no...
9th October, 2009
Department of Surgical Oncology, Hokkaido University Graduate School of J Proteome Res. 2009 Aug;8(8):4092-103.
DOI Direct Link
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.
The cathepsin family of endosomal proteases is required for proteolytic...
8th October, 2009
Department of Microbiology and Immunology, Vanderbilt University School of J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
DOI Direct Link
The role of cathepsins in involution and breast cancer.
Cysteine cathepsins are proteolytic enzymes that reside in endolysosomal...
17th September, 2009
Department of Pathology, University of Cambridge, Cambridge, MA, USA. J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):171-9. Epub 2009 May 13.
DOI Direct Link
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse.
We developed a panel of non-obese diabetic (NOD) mice deficient in major...
12th August, 2009
Department of Immunology and Howard Hughes Medical Institute, University J Autoimmun. 2009 Aug 5.
DOI Direct Link

View more research publications.

Press Releases on CTSB:

BioPortfolio Logo
URMC Breaks Ground for New Translational Research Institute 27th October, 2008 University of Rochester Medical Center

ROCHESTER, N.Y., Oct. 27 /PRNewswire-USNewswire/ -- The University of Rochester Medical Center (URMC) today broke ground on the

Clinical Trials:

Clinical Trials Logo
A Phase I/II Study of Radiation Therapy, Paclitaxel Poliglumex and Cetuximab in Advanced Head and Neck Cancer

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7183073 Method for detecting microorganisms
7081340 Gene expression profiling in biopsied tumor tissues
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6956273 Photoelectric conversion element and solid-state image sensing device, camera, and image input apparatus using the same

View more patents.

CTSB results (if any) from reagent suppliers

Google CSE Logo
cathepsin B (FL-339) Antibody sc-13985
Human, CTSB, 1508, 8p23.1, NM_001908, NM_147780, NM_147781, NM_147782, NM_147783 · P07858 · 116810. Mouse, Ctsb, 13030, 14 D1, P10605 ...
http://www.scbt.com/datasheet-13985-cathepsin-b-fl-339-antib...

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C6243 Monoclonal Anti-Cathepsin B antibody produced in mouse ~1.5 ...
indirect ELISA: suitable. isotype, IgG1. Gene Information, human ... CTSB(1508). rat ... CTSB(1508). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Antibodies to Cathepsins and Granzymes
rat ... CTSB(1508) human ... CTSB(1508), human, rat, ELISA (i), IHC, WB, pricing . C0715, Monoclonal Anti-Cathepsin D antibody produced in mouse, CTD-19 ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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cathepsin B (N-19) Antibody sc-6491
... Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CTSB, 1508, 8p23.1, NM_001908, NM_147780, NM_147781, NM_147782, NM_147783 · P07858 ...
http://www.scbt.com/ko/datasheet-6491-cathepsin-b-n-19-antib...

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CD-CY
HPA018156, Anti-CTSB antibody produced in rabbit, affinity isolated antibody, human ... CTSB(1508), human, IHC (p), PA, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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C0150 Cathepsin B from human placenta lyophilized powder, ≥5 ...
form, lyophilized powder. composition, Protein, ~50% Lowry. Gene Information, human ... CTSB(1508). storage temp. −20°C ...
https://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N...

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