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CYP2B6


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Symbol:CYP2B6
Name(s):cytochrome P450, family 2, subfamily B, polypeptide 6
Type:protein-coding
Organism:Homo sapiens
Synonyms:CPB6, CYP2B, CYPIIB6, IIB1, P450
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18223457 Observational study of genotype prevalence. (HuGE Navigator)
18281305 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
12207635 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
12242601 Observational study of genotype prevalence. (HuGE Navigator)
12439223 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
12629583 Observational study of gene-disease association. (HuGE Navigator)
14515060 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15178651 Observational study of genetic testing. (HuGE Navigator)
15194512 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15248218 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

View more information from publications.

Recent Publications on CYP2B6:

Pubmed Logo
Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.
Oltipraz, a synthetic derivative of the cruciferous vegetable product...
17th October, 2009
INSERM U620, Universite de Rennes 1, F-35043, France; IFR 140, Rennes, Toxicol In Vitro. 2009 Oct 12.
DOI Direct Link
Tamoxifen-induced adduct formation and cell stress in human endometrial glands.
The beneficial effects of tamoxifen in the prevention and treatment of...
9th October, 2009
1 Uppsala University; Drug Metab Dispos. 2009 Oct 7.
DOI Direct Link
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
The aim of the current study is to identify the human cytochrome P450...
9th October, 2009
1 Daiichi Sankyo Co., Ltd.; Drug Metab Dispos. 2009 Oct 19.
DOI Direct Link
Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women.
Objectives To investigate the association of single nucleotide...
9th October, 2009
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, J Antimicrob Chemother. 2009 Oct 6.
DOI Direct Link
Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: Cell-cycle dependent expression.
Hepatocyte growth factor (HGF), an antimitogenic factor for HepG2 cells,...
3rd October, 2009
1 School of Pharmaceutical Sciences, University of Shizuoka; Drug Metab Dispos. 2009 Oct 1.
DOI Direct Link

View more research publications.

Press Releases on CYP2B6:

BioPortfolio Logo
Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia 8th December, 2008 Novartis
TASIGNA prolongs the QT interval. Sudden deaths have been reported in patients receiving nilotinib. TASIGNA should not be used in patients with hypokalemia, hypomagnesemia, or long QT
OXFORD BIOMEDICA SIGNS LICENSE AGREEMENT WITH MASSACHUSETTS GENERAL 1st April, 2004 Oxford Biomedica

OXFORD BIOMEDICA ONCOLOGY UPDATE

1st December, 2003 Oxford Biomedica

OXFORD BIOMEDICA ONCOLOGY UPDATE

Oxford BioMedica receives approval from GTAC for MetXia(R) to enter 1st October, 2003 Oxford Biomedica

BioNews Results for CYP2B6

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BioPortfolio Logo
Methods for reducing the risk of an adverse drug interaction in a patient suffering from insomnia
PharmCast:  Nov 11 2009 4:49AM Matching: cyp2b6
Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects
Clinical Pharmacology & Therapeutics:  Oct 20 2009 7:11AM Matching: cyp2b6
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation o
Drug Metabolism And Disposition:  Oct 7 2009 10:25PM Matching: cyp2b6
Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cy
Drug Metabolism And Disposition:  Oct 6 2009 7:34AM Matching: cyp2b6

Clinical Trials:

Clinical Trials Logo
Effects of CYP2B6 Genetic Polymorphisms on Efavirenz Pharmacokinetics

Patents:

Patents logo
US Patent No.Title
5891696 Compositions for cytochrome P450 biotransformation reactions
6645745 Identification of a new member of the cytochrome P450 3A (CYP3A) gene family: CYP3AX
6727244 Mammalian metabolites of a tachykinin receptor antagonist
6756229 Human cell line showing stable expression of cytochromes P450
6815543 Process for catalyzing the oxidation of organic compounds

View more patents.

CYP2B6 results (if any) from reagent suppliers

Google CSE Logo
CYP Antibody / CYP Antibodies
CYP2B6 (C-15) Antibody, sc-55924, goat IgG, Internal (h), WB, IF, ELISA, human. CYP2B6 (H-110) Antibody, sc-67224, rabbit IgG, 186-295 (h), WB, IP, IF, ...
http://www.scbt.com/table-cyp.html...

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Cayman Chemical | Cytochrome P450 2B6 (human) Human Reductase ...
CYP2B6 HR. • See below for pricing and ordering. • See more Enzymes; Proteins; Recombinant Proteins; ... CYP2B6 HR. Stability, 2 years. Storage, -80°C ...
http://www.caymanchem.com/app/template/Product.vm/catalog/10...

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CYP2B6 (H-110) Antibody sc-67224
rabbit polyclonal IgG, 200µg/ml; epitope corresponding to amino acids 186-295 mapping within an internal region of CYP2B6 of human origin; recommended for ...
http://www.scbt.com/ko/datasheet-67224-cyp2b6-h-110-antibody...

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Product Data Sheet
Human CYP2B6 appears to be the primary enzyme involved in the N-demethylation of ... The antiserum detects human CYP2B6 in Western blotting (56 kDa), ...
http://www.biomol.com/SiteData/docs/productdata/cr3290.pdf...

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CYP2B6 (H-110) Antibody sc-67224
CYP2B6 (H-110) 抗体sc-67224 CYP2B6 (H-110) Antibody sc-67224.
http://www.scbt.com/zh/datasheet-67224-cyp2b6-h-110-antibody...

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Purified Anti-Cytochrome P450-2B6 Antibody - BioLegend
Other Names: CYP2B6. Structure: Cytochrome P450 superfamily. Splice variants, approximately 56 kD. Distribution: Membrane-bound, endoplasmic reticulum. ...
http://www.biolegend.com/purified-anti-cytochrome-p450-2b6-a...

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CYP2B6 (C-15) Antibody sc-55924
goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of CYP2B6 of human origin; recommended for detection of CYP2B6 of human origin by
...
http://www.scbt.com/ko/datasheet-55924-cyp2b6-c-15-antibody....

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