Thursday November 26 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

ADRBK1


Suggest Content
Advertise Here
Gene DB Home
Symbol:ADRBK1
Name(s):adrenergic, beta, receptor kinase 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BARK1, BETA-ARK1, FLJ16718, GRK2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17998459 Mechanical unloading leads to complete reversal in PI3Kgamma and betaARK1-associated PI3K activation. Furthermore, displacement of active PI3K from betaARK1 restores betaAR responsiveness in failing myocytes.
17544362 GRK2 interacts not only with epithelial Na(+) channels, but also with both Nedd4 and Nedd4-2.
12435819 a direct correlation between the expression of GRK2 and the desensitization of natively expressed H2 receptors in U-937 cells
12750365 GRK2 requires agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on the membrane in order to function
17000469 Overexpression of GRK2 in Alzheimer disease.
15618519 beta-Arrestin 2 and GRK2 are potential mediators of signaling by activated Smoothened
12456365 GRK2 plays a negative feedback regulatory role on protein kinase C(PKC)beta 1 activity in interaction between GRK2 and PKCbeta 1.
12679936 The pleckstsrin homology domain of this protein binds to PKC and affects the activity of PKC kinase.
15471870 analysis of the GRK2 binding site of Galphaq
15653687 GRK2 binding is critical not only for alpha2A-adrenergic receptor phosphorylation but also for full activity of the kinase.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDG protein dependent receptor kinase 2follicle stimulating hormone receptor isoform 1 precursor--Pubmed
HPRDG protein dependent receptor kinase 2rhodopsin--Pubmed
HPRDG protein dependent receptor kinase 2guanine nucleotide binding protein, q polypeptide--Pubmed
HPRDG protein dependent receptor kinase 2phosducin isoform a--Pubmed
HPRDG protein dependent receptor kinase 2arrestin beta 1 isoform A--Pubmed
HPRDG protein dependent receptor kinase 2phosducin-like--Pubmed
HPRDG protein dependent receptor kinase 2proto-oncogene tyrosine-protein kinase SRC--Pubmed
HPRDG protein dependent receptor kinase 2chemokine receptor 4--Pubmed
HPRDG protein dependent receptor kinase 2G protein-coupled receptor kinase-interactor 1--Pubmed
HPRDG protein dependent receptor kinase 2frequenin homolog--Pubmed

Recent Publications on ADRBK1:

Pubmed Logo
Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration.
Exposure to cocaine causes many neuroadaptations including alterations in...
27th October, 2009
Department of Pharmacology and the Center for Substance Abuse Research, Synapse. 2009 Oct;63(10):863-70.
DOI Direct Link
The mechanism of chemokine receptor 9 internalization triggered by interleukin 2 and interleukin 4.
In previous study, we found that the chemokine receptor 9 (CCR9) was...
29th September, 2009
Department of Immunology, College of Basic Medical Sciences, Wuhan Cell Mol Immunol. 2009 Jun;6(3):181-9.
G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans.
Hypertension occurs with higher prevalence and morbidity in black...
17th September, 2009
Center for Translational Medicine, Thomas Jefferson Hospital, Hypertension. 2009 Jul;54(1):71-6. Epub 2009 Jun 1.
DOI Direct Link
Hypertension: Are we beta-ARKing up the right tree?
Hypertension occurs with higher prevalence and morbidity in black...
17th September, 2009
Hypertension. 2009 Jul;54(1):27-8. Epub 2009 Jun 1.
DOI Direct Link
alpha-Tocopherol decreases the somatostatin receptor-effector system and increases the cyclic AMP/cyclic AMP response element binding protein pathway in the rat dentate gyrus.
Neuronal survival has been shown to be enhanced by alpha-tocopherol and...
26th August, 2009
Grupo de Neurobioquimica, Departamento de Bioquimica y Biologia Molecular, Neuroscience. 2009 Aug 4;162(1):106-17. Epub 2009 Apr 22.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Measuring G Protein-Coupled Receptor Kinase-2 (GRK2) in the Blood to Diagnose and Treat Patients With Heart Failure

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6936450 Variants of protein kinases
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

View more patents.

ADRBK1 results (if any) from reagent suppliers

Google CSE Logo
G Protein-coupled Receptor Kinase (GRK)
rat ... Adrbk1(25238), human, bovine, rat, ARR, IP, WB, pricing. G4540, Monoclonal Anti-GRK4-6 antibody produced in mouse, A16/17 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot
Cell Type, Tissue, Tumor, and Organ-Specific Markers - GeneTex Inc ...
ADRBK1 antibody (adrenergic, beta, receptor kinase 1), GTX101682, Rabbit PAb, WB , 100 μl, USD $269.00, -. ADRBK1 antibody (adrenergic, beta, receptor kinase ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

Thumbshot
GRK 2 (C-9) Antibody sc-13143
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADRBK1, 156, 11q13.1, NM_001619 ...
http://www.scbt.com/datasheet-13143-grk-2-c-9-antibody.html...

Thumbshot
Cytoskeleton/Cell Membrane/Cell Adhesion Research(1661) - GeneTex ...
ADRBK1 antibody (adrenergic, beta, receptor kinase 1), GTX101682, Rabbit PAb, WB , 100 μl, USD $269.00, -. | Page of 390. GeneTex, Inc. 2456 Alton Parkway, ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

Thumbshot
G0296 Anti-GRK2 antibody produced in rabbit affinity isolated ...
Synonym: Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti- BARK1, ... ADRBK1(156). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=G029...

Thumbshot
Abgent - Cell and Function Antibodies
AP7864aNEW, ADRBK1 Antibody (N-term), WB, E, H. AT1060a, ADRM1 monoclonal antibody (M01), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

Thumbshot
GRK Antibody / GRK Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. GRK 1 (C-20) Antibody, sc-561, rabbit IgG, C-terminus (cow), WB, IP, IF, ELISA ...
http://www.scbt.com/table-grk.html...

Thumbshot

Search Bioportfolio and other Life Science Sites for ADRBK1, or search for ADRBK1 on BioPortfolio's antibody search engine.
This page has been viewed 319 times
Recent Search Terms used to find this page:
beta adrenergic receptor kinase inhibition in drug discovery | ADRB-1 gene polymorphism and hypertension | ADRB-1 gene polymorphism and hypertension | adrbk1 serine threonine kinase | adrbk1 serine threonine kinase | Human B2-adrenoreceptor Ab ELISA Kit | Human B2-adrenoreceptor Ab ELISA Kit | beta receptor site proteins | beta adrenergic receptor kinase and G protein beta gamma EGFR | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.