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ADRBK2


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Gene DB Home
Symbol:ADRBK2
Name(s):adrenergic, beta, receptor kinase 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:BARK2, GRK3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17106420 Observational study of gene-disease association. (HuGE Navigator)
17621168 Observational study of gene-disease association. (HuGE Navigator)
18075471 Observational study of gene-disease association. (HuGE Navigator)
18075471 Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease.
17621168 No support for a major role for GRK3 gene promoter variants in cocaine addiction.
15728711 ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor.
15498832 the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase
12808434 dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBeta adrenergic receptor kinase 2chemokine receptor 4 isoform b--Pubmed
HPRDBeta adrenergic receptor kinase 2G protein-coupled receptor kinase-interactor 1--Pubmed
HPRDbeta adrenergic receptor kinase 2GIT1--Pubmed
HPRDbeta adrenergic receptor kinase 2CXCR4--Pubmed
HPRDbeta adrenergic receptor kinase 2chemokine receptor 4--Pubmed
HPRDbeta adrenergic receptor kinase 2chemokine receptor 4--Pubmed

Recent Publications on ADRBK2:

Pubmed Logo
The mechanism of chemokine receptor 9 internalization triggered by interleukin 2 and interleukin 4.
In previous study, we found that the chemokine receptor 9 (CCR9) was...
29th September, 2009
Department of Immunology, College of Basic Medical Sciences, Wuhan Cell Mol Immunol. 2009 Jun;6(3):181-9.
Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients.
G-protein coupled receptor kinase-3 (GRK3), translated from the gene,...
22nd September, 2009
Department of Psychiatry, University of California San Diego, La Jolla, J Psychiatr Res. 2009 Sep 17.
DOI Direct Link
Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.
Overactivation of G-protein-mediated functions and altered G-protein...
19th August, 2009
Brain Physiology and Metabolism Section, NIA, NIH, Bethesda, MD 20892, Int J Neuropsychopharmacol. 2009 Jul;12(6):851-60. Epub 2009 Apr 29.
DOI Direct Link
Correlation between beta-adrenoceptors and G-protein-coupled receptor kinases in pretransplantation heart failure.
INTRODUCTION: Prolonged catecholamine overstimulation of the myocardium in...
24th June, 2009
Heart Failure and Transplant Unit, Department of Cardiology, La Fe Transplant Proc. 2008 Nov;40(9):3014-6.
DOI Direct Link
Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization.
Although G protein-coupled receptor (GPCR) kinases (GRKs) have been shown...
10th October, 2008
Department of Internal Medicine and Center for Human Genomics, Wake Forest Biochemistry. 2008 Sep 2;47(35):9279-88. Epub 2008 Aug 9.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7553639 Alpha-synuclein kinase
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6673908 Tumor necrosis factor receptor 2

View more patents.

ADRBK2 results (if any) from reagent suppliers

Google CSE Logo
GRK 3 (C-14) Antibody sc-563
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADRBK2, 157, 22q11.23, NM_005160 ...
http://www.scbt.com/datasheet-563-grk-3-c-14-antibody.html...

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Panorama® Antibody Array - Kinase Protein
ADRBK2. adrenergic, beta, receptor kinase 2. 157 · AKT1. v-akt murine thymoma viral oncogene homolog 1. 207 · ALS2CR2. amyotrophic lateral sclerosis 2 ...
http://www.sigmaaldrich.com/life-science/cell-biology/protei...

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GRK Antibody / GRK Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. GRK 1 (C-20) Antibody, sc-561, rabbit IgG, C-terminus (cow), WB, IP, IF, ELISA ...
http://www.scbt.com/table-grk.html...

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Panorama® Antibody Array - Signal Transduction
ADRBK2. adrenergic, beta, receptor kinase 2. 157 · AKT1. v-akt murine thymoma viral oncogene homolog 1. 207 · AMD1. adenosylmethionine decarboxylase 1 ...
http://www.sigmaaldrich.com/life-science/cell-biology/protei...

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IS EASY
BARK2 (ADRBK2, GRK3). ULight-Topo IIa (22.9). ULight-Histone H3 (Thr3; 10.1). Carna Biosciences. 01-112. AKT1. ULight-rpS6 (20.5). ULight-PLK (19.1) ...
http://las.perkinelmer.com/content/Manuals/GDE_LANCEUltraSer...

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SelectScreen™ Kinase Profiling Target Panel
ADRBK2 (GRK3). AKT1 (PKB alpha). AKT2 (PKB beta). AKT3 (PKB gamma). ALK. AMPK a1 , b1, g1. AMPK a2, b1, g1. Aurora A. Aurora B. Aurora C ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf.Pa...

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Kinase Selector Tool
Select, 4EBP1, ABL, ABL [T315I] (ABL1), ACK, ADRBK2 (BARK2), AKT1/PKB&alpha, AKT1/PKBα, AKT2, AKT3, ALK, ALK3 (BMPR1A), AMPKα1, ARG, AUR A, AUR B, AUR C ...
http://las.perkinelmer.com/Catalog/KinaseSelector.htm...

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