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ADRBK2


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Symbol:ADRBK2
Name(s):adrenergic, beta, receptor kinase 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:BARK2, GRK3
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17106420 Observational study of gene-disease association. (HuGE Navigator)
17621168 Observational study of gene-disease association. (HuGE Navigator)
18075471 Observational study of gene-disease association. (HuGE Navigator)
18075471 Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease.
17621168 No support for a major role for GRK3 gene promoter variants in cocaine addiction.
15728711 ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor.
15498832 the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase
12808434 dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBeta adrenergic receptor kinase 2chemokine receptor 4 isoform b--Pubmed
HPRDBeta adrenergic receptor kinase 2G protein-coupled receptor kinase-interactor 1--Pubmed
HPRDbeta adrenergic receptor kinase 2GIT1--Pubmed
HPRDbeta adrenergic receptor kinase 2CXCR4--Pubmed
HPRDbeta adrenergic receptor kinase 2chemokine receptor 4--Pubmed
HPRDbeta adrenergic receptor kinase 2chemokine receptor 4--Pubmed

Recent Publications on ADRBK2:

Pubmed Logo
Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization.
Although G protein-coupled receptor (GPCR) kinases (GRKs) have been shown...
10th October, 2008
Department of Internal Medicine and Center for Human Genomics, Wake Forest Biochemistry. 2008 Sep 2;47(35):9279-88. Epub 2008 Aug 9.
DOI Direct Link
[The Arg16Glybeta2-adrenergic receptor polymorphism influences long term clinical responses to beta2-agonist]
BACKGROUND: The coding region variant Arg16Gly at the beta2-adrenoceptor...
18th September, 2008
Department of Respiratory Medicine, Hokkaido University School of Graduate Arerugi. 2008 Jun;57(6):713-21.
Clinically responsible genetic testing in neuropsychiatric patients: a bridge too far and too soon.
Although G protein-coupled receptor (GPCR) kinases (GRKs) have been shown...
5th September, 2008
University of California, San Diego, School of Medicine, Department of Am J Psychiatry. 2008 Aug;165(8):952-5.
DOI Direct Link
Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression.
BACKGROUND: We have previously reported a single nucleotide polymorphism...
16th August, 2008
Department of Psychiatry, University of California, San Diego, CA 92093, Biol Psychiatry. 2008 Jul 15;64(2):104-10. Epub 2008 Mar 21.
DOI Direct Link
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
G protein-coupled receptor kinase-2 and -3 (GRK2 and GRK3) in cardiac...
11th June, 2008
Institute for Surgical Research, University of Oslo and J Biol Chem. 2008 Apr 18;283(16):10601-10. Epub 2007 Dec 29.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6673908 Tumor necrosis factor receptor 2

ADRBK2 results (if any) from reagent suppliers

Google CSE Logo
A3607 Anti ADRBK2 592 605 antibody produced in rabbit IgG fraction ...
A3607 Anti-ADRBK2 (592-605) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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GRK3 Antibody (C-term)
Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid ... The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of
...
http://www.abgent.com/products/catalog_no/AP7005a/background...

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Life Science Antibody Products
A3482, Anti-ADRBK2 (122-135) antibody produced in rabbit New, IgG fraction of antiserum, human ... ADRBK2(157), human, WB. A3607, Anti-ADRBK2 (592-605) ...
http://www.sigmaaldrich.com/life-science/cell-biology/antibo...

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GRK 3 (C-14) Antibody sc-563
Number. Human, ADRBK2, 157, 22q11.23, NM_005160 · P35626 · 109636. Mouse, Adrbk2 , 320129, 5 F, Q3UYH7, N/A. Ordering Information ...
http://www.scbt.com/datasheet-563-grk-3-c-14-antibody.html...

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Adrbk2 adrenergic receptor kinase, beta 2
Adrbk2. Species. Rattus norvegicus. Entrez Gene ID. 25372. Alternate Symbol. Adrbk2; ADRBK2; GRK3. Refseq ID(s). NM_012897; XM_579356. Other Designations ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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GRK 3 (E-15) Antibody sc-9306
ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADRBK2, 157, 22q11.23, NM_005160 · P35626 ...
http://www.scbt.com/datasheet-9306-grk-3-e-15-antibody.html...

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G Proteins and Cyclic Nucleotides
A3482, Anti-ADRBK2 (122-135) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution New. A3607, Anti-ADRBK2 (592-605) antibody
...
http://www.sigmaaldrich.com/life-science/cell-biology/cell-b...

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GRK 2/3 (H-222) Antibody sc-8329
Mouse, Adrbk2, 320129, 5 F, Q3UYH7, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. GRK 2/3 (H-222), sc-8329, 200 µg/ml ...
http://www.scbt.com/datasheet-8329-grk-2-3-h-222-antibody.ht...

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Microsoft PowerPoint - HUPO talk for Paul.ppt
ADRBK2. 4. BCA E3 ligase. ZNF364. 6. Role in angiogenesis. EPHA2. 7. Ring finger domain. RNF126. 9. Proinflammatory cytokine. SCYE1. 14. Growth suppressor ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf.Pa...

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SelectScreen Kinase Profiling Target Panel
ADRBK2 (GRK3). AKT1 (PKB alpha). AKT2 (PKB beta). AKT3 (PKB gamma). ALK. AMPK a1 , b1, g1. AMPK a2, b1, g1. Aurora A. Aurora B. Aurora C ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf.Pa...

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