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CYP3A4
| Symbol: | CYP3A4 | | Name(s): | cytochrome P450, family 3, subfamily A, polypeptide 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CP33, CP34, CYP3A, CYP3A3, HLP, MGC126680, NF-25, P450C3, P450PCN1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18097620 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18223457 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18231117 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18240903 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18258609 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18294295 |
Observational study of gene-disease association, gene-gene interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18294936 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18309947 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17925385 |
PXR promoter and intron 1 SNPs associated with PXR target gene expression (CYP3A4) |
| 17952011 |
CYP3A4*1B variant is present in both the Tepehuano and Mestizo populations of northern Mexico at frequencies that are similar to that found in the white North American population, but different from that in African and Asian populations. | →View more information from publications. |
Recent Publications on CYP3A4: |  |
Evaluation of Induction Potency of New Drug Candidates on CYP1A2 and CYP3A4 using Real-Time One-Step RT-PCR in Primary Cultures of Cryopreserved Human Hepatocytes.
This study evaluates the induction potency of new drug candidates on mRNA... | 3rd November, 2009
| Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
| Drug Metab Pharmacokinet. 2009;24(5):446-50.
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Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.
Triptolide (TP), a major active and toxic component of Tripterygium... | 3rd November, 2009
| Institute of Materia Medica, College of Life Science and Technology,
| Toxicol Lett. 2009 Oct 29.
DOI Direct Link |
Generation of functional human hepatic endoderm from human induced pluripotent stem cells.
With the advent of induced pluripotent stem cell (iPSC) technology, it is... | 31st October, 2009
| Medical Research Council (MRC) Centre for Regenerative Medicine,
| Hepatology. 2009 Sep 29.
DOI Direct Link |
Human Liver Progenitor Cell Lines are Readily Established from Non-tumorous Tissue Adjacent to Hepatocellular Carcinoma.
Non-tumorous liver tissue removed during surgery to resect hepatocellular... | 31st October, 2009
| The First Affiliated Hospital, Zhejiang University School of Medicine,
| Stem Cells Dev. 2009 Oct 29.
DOI Direct Link |
[Interaction between four herb compounds and a western drug by CYP3A4 enzyme metabolism in vitro]
OBJECTIVE: To explore the interaction between herbal medicines and western... | 31st October, 2009
| Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences,
| Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(13):1705-11.
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→View more research publications. |
Press Releases on CYP3A4:
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| New Data Presented at ACR Meeting Demonstrates Colcrys(TM) (Colchicine, USP) Significantly Reduces Pain of Acute Gout Flare Within 24 Hours With Side Effects Comparable to Placebo |
19th October, 2009 |
URL Pharma, Inc. |
PHILADELPHIA, Oct. 19 /PRNewswire/ -- URL Pharma, Inc., today announced data from a pivotal Phase III study demonstrating that Colcrys(TM) (colchicine, USP), a low-dose colchicine,
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| Meda Launches Onsolis(TM) (Fentanyl Buccal Soluble Film) for the Treatment of Breakthrough Cancer Pain in Opioid Tolerant Patients |
13th October, 2009 |
Meda Pharmaceuticals Inc. |
-- Training prescribers, pharmacists, and patients about proper dosing and
administration.
Under the FOCUS Program, only prescribers, pharmacies, and patients
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| Pitavastatin Demonstrates no Significant Drug-to-Drug Interaction When Administered With CYP3A4 Inhibitors |
2nd September, 2009 |
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BARCELONA, Spain, September 2 /PRNewswire/ -- New data presented at the European Society of Cardiology congress (ESC)
demonstrated that the co-administration of the cytochrome inhibitor
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| Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily |
9th June, 2009 |
United Therapeutics Corporation |
Data Findings Published in June Issue of Circulation
SILVER SPRING, Md. and INDIANAPOLIS, June 9 /PRNewswire-FirstCall/ -- United Therapeutics Corporation (Nasdaq: UTHR) and
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| New Once-Daily RYZOLT(TM) (tramadol HCl extended-release tablets) Now Available in the U.S. |
7th May, 2009 |
Purdue Pharma L.P. |
STAMFORD, Conn., May 7 /PRNewswire/ -- RYZOLT(TM) (tramadol HCl extended-release tablets) is now available from Purdue Pharma L.P. for the management of moderate to moderately severe
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CYP3A4 results (if any) from reagent suppliers | 
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Anti-CYP3A4 Polyclonal Antibody
Polyclonal Antibody against CYP3A4 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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CYP3A4 Antibody (Center)
Western blot analysis of anti-CYP3A4 Antibody (Center) (RB15791) in NCI-H460 cell line lysates (35ug/lane). CYP3A4 (arrow) was detected using the purified
...
http://www.abgent.com/products/catalog_no/AP7788c_CYP3A4_Ant...
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Cytochrome P450 CYP3A4, human
Peptides , Cytochromes and Related Peptides , Cytochrome P450 CYP3A4, human; This 21-amino acid peptide corresponds to residues 253-273 of human cytochrome
...
http://www.anaspec.com/products/product.asp?id=32244...
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CYTOCHROME P450 3A4 antibody, CYTOCHROME P450 3A4 Antibody, Rabbit ...
Antiserum Preparation: Antisera to human CYP3A4 were raised by repeated ... Summary: This protein, CYP3A4, encodes a member of the cytochrome P450 ...
http://www.genwaybio.com/product_info.php?products_id=76478...
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CYP3A4 P450-Glo(tm) assays with Luciferin-IPA: The most sensitive ...
Luciferin-IPA shows high selectivity for CYP3A4 with minimal ... The Luciferin- IPA reaction with recombinant CYP3A4 was linear ...
http://www.promega.com/cnotes/cn023/CN023_17.pdf...
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CYP3A4 siRNA (h) sc-43711
Click here for details. suitable control antibody: CYP3A4 (C-17): sc-27639; sqRT -PCR Primer also available: CYP3A4 (h)-PR: sc-43711-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-43711-cyp3a4-sirna-h.html...
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Novel Bioluminescent Substrates to Measure CYP3A4 Activity in Cell ...
measuring the enzyme activity of CYP3A4, the principal drug- ... Assays of CYP3A4 from cultured cells use the substrates in a ...
http://www.promega.com/scientific_posters/ps002/ps002.pdf...
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