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DAG1


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Symbol:DAG1
Name(s):dystroglycan 1 (dystrophin-associated glycoprotein 1)
Type:protein-coding
Organism:Homo sapiens
Synonyms:156DAG, A3a, AGRNR, DAG
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17196572 Observational study of gene-disease association. (HuGE Navigator)
17516554 Data suggest that disturbances in the function of the dystroglycan complex might contribute to the definition of the malignant behavior of prostate cancer cells and suggest that androgens might regulate DG expression in these cells.
17640712 alpha dystroglycan glycosylation & laminin binding to alpha dystroglycan are altered in certain pediatric solid tumors and suggest that aberrant dystroglycan glycosylation may contribute to tumor cell biology in patients with RMS, medulloblastoma, & NBL.
16575202 DG may be involved in the progression of primary brain tumors
12920582 in human coxsackievirus B myocarditis a focal disruption of the DAG can principally occur and may contribute to the pathogenesis of human enterovirus-induced dilated cardiomyopathy
12386278 Glomeruli possess large amounts of a specifically composed complex; this complex may undergo changes in human glomerular disease; and flattening of foot processes is directly associated with dissociation of laminin-dystroglycan complexes.
12598319 Expression is frequently reduced in human breast and colon cancers and is associated with tumor progression.
15175275 mutation of certain residues prevents both ezrin binding and the induction of actin-rich surface protrusions
17005282 Fukutin seems to bind to both the hypoglycosylated and fully glycosylated form of alpha-dystroglycan, and seems bind to the core area rather than the sugar chain of alpha-dystroglycan
17012237 muscle-specific receptor tyrosine kinase activation and binding to dystroglycan are regulated by alternative mRNA splicing of agrin

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCaveolin 3dystroglycan 1 precursor--Pubmed
HPRDcaveolin 3Dystroglycan--Pubmed
HPRDDystroglycanlaminin alpha 2 subunit isoform a precursor--Pubmed
HPRDDystroglycangrowth factor receptor-bound protein 2 isoform 1--Pubmed
HPRDDystroglycandystrophin Dp427m isoform--Pubmed
HPRDDystroglycan43 kD receptor-associated protein of the synapse isoform 1--Pubmed
HPRDDystroglycanlaminin alpha 5--Pubmed
HPRDDystroglycanbreast cancer membrane protein 11--Pubmed
HPRDDystroglycanSHC transforming protein 1--Pubmed
HPRDdystroglycan 1 precursor43 kDa receptor associated protein of the synapse--Pubmed

Recent Publications on DAG1:

Pubmed Logo
The Dof protein DAG1 mediates PIL5 activity on seed germination by negatively regulating GA biosynthetic gene AtGA3ox1.
ABSTRACT We have previously shown that inactivation of the gene encoding...
31st October, 2009
Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Genetica e Plant J. 2009 Oct 26.
DOI Direct Link
Identification of Sp1 and GC-boxes as transcriptional regulators of mouse Dag1 gene promoter.
Dystroglycan is a widely expressed adhesion complex that anchors cells to...
7th August, 2009
Centro di Ricerche Oncologiche Giovanni XXIII, Universita Cattolica del Am J Physiol Cell Physiol. 2009 Nov;297(5):C1113-23. Epub 2009 Aug 5.
DOI Direct Link
Further evidence of Fukutin mutations as a cause of childhood onset limb-girdle muscular dystrophy without mental retardation.
The dystroglycanopathies comprise a clinically and genetically...
29th July, 2009
Children's Hospital of Orange County, Division of Metabolic Disorders, Neuromuscul Disord. 2009 May;19(5):352-6. Epub 2009 Apr 1.
DOI Direct Link
158th ENMC international workshop on congenital muscular dystrophy (Xth international CMD workshop) 8th-10th February 2008 Naarden, The Netherlands.
BACKGROUND: Congenital muscular dystrophies (CMD) with reduced...
29th July, 2009
Dubowitz Neuromuscular Centre, Institute of Child Health & Great Ormond Neuromuscul Disord. 2009 Mar;19(3):229-34. Epub 2008 Dec 18.
DOI Direct Link
Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study.
BACKGROUND: Congenital muscular dystrophies (CMD) with reduced...
26th June, 2009
Department of Child Neurology, Policlinico Gemelli, Largo Gemelli, 00168 Neurology. 2009 May 26;72(21):1802-9. Epub 2009 Mar 18.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Bowel Preparation Before Rectal Cancer Surgery

Patents:

Patents logo
US Patent No.Title
7588767 Microorganisms for therapy
6606684 Multi-tiered memory bank having different data buffer sizes with a programmable bank select
6446181 System having a configurable cache/SRAM memory
6420868 Read-out electronics for DC squid magnetic measurements
6335170 Gene expression in bladder tumors

View more patents.

DAG1 results (if any) from reagent suppliers

Google CSE Logo
β-dystroglycan (4F7) Antibody sc-33702
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, DAG1, 1605, 3p21.31, NM_004393 ...
http://www.scbt.com/datasheet-33702-beta-dystroglycan-4f7-an...

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PLCγ Antibody Sampler Kit #3860
... phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) (1). ...
http://www.cellsignal.com/products/3860.html...

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Neurobiology Antibodies :: Page 9
Dab1 [pY198] Ab, Rabbit poly Antibody, XBP-4083, H, M, R, C, WB, Dab1 [pY198] Ab , Rabbit poly. DAG1 Antibody, 48-780, H, WB, IHC, Dystroglycan ...
http://www.prosci-inc.com/shop/catalog1/Neurobiology-Antibod...

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MONOCLONAL ANTIBODY TO BOVINE BRAIN ALPHA-DYSTROGLYCAN (alpha-DG)
on alpha-dystroglycan expressed in all other tissues. Aliases. Dystrophin- associated glycoprotein 1 (DAG1). Species. Mouse IgG2b. Cross reactant.
Reactivity ...
http://www.hbt.nl/HM5010-0309.pdf...

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Abgent - Cell and Structure Antibodies - Cell_structure
AP7595b, DAAM2 Antibody (C-term), IHC, E, H. AP7595a, DAAM2 Antibody (N-term), IHC, E, H. AT1710a, DAG1 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...

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Rap1A/Rap1B (26B4) Rabbit mAb #2399
... proteins such as Crk, Epacs (or cAMP-GEFs) transmit signals from cAMP, and CD-GEFs (or CalDAG-GEFs) convey signals from either or both Ca2+ and DAG (1).
...
http://www.cellsignal.com/products/2399.html...

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Search Results
Stock# - 006835 Strain name - 129-Dag1/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/006835.html - 37Kb ...
http://www.jax.org/search/Main.jsp?sg=0&qt=genotypes&page=3...

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