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DAPK1


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Symbol:DAPK1
Name(s):death-associated protein kinase 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:DAPK, DKFZp781I035
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18336955 Observational study of gene-disease association. (HuGE Navigator)
16847012 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
17953697 Exposure to arsenic may induce DAPK promoter hypermethylation and inactivate the function of DAPK in urothelial carcinoma. ...a key molecular event ...in the malignant phenotype of tumour arising in patients from arsenic-contaminated environments
17895359 study reports that DAP kinase 1 promotes in vitro & in vivo phosphorylation of tropomyosin-1 on Ser283 & that this phosphorylation is essential for the H2O2-induced organization of the assembly of actin stress fibers in endothelial cells
17703233 these findings establish a major role for DAPk and its specific interaction with PKD in regulating the JNK signaling network under oxidative stress.
17690039 the DAPK gene epigenetically affected by methylation may be associated with the carcinogenesis of cholangiocarcinoma
16951219 The promoter hypermethylation of DAPK-1 is a marker of aggressive renal cell carcinoma and provides independent prognostic information on disease outcome.
17683884 Sodium arsenite caused DAPK promoter hypermethylation and gene silencing which may be involved in arsenic-induced carcinogenesis.
17592394 TIMP-3 promoter hypermethylation is elevated in HNSCC and is highly correlated with DAPK hypermethylation, implying a functional relationship between these genes.
17056602 the apoptosis regulatory activities mediated by DAPK are controlled both by phosphorylation status and protein stability

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDDeath associated protein kinase 1tumor necrosis factor receptor 1 precursor--Pubmed
HPRDDeath associated protein kinase 1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide--Pubmed
HPRDDeath associated protein kinase 1TNFRSF1A-associated via death domain--Pubmed
HPRDDeath associated protein kinase 1Fas-associated via death domain--Pubmed
HPRDDeath associated protein kinase 1mindbomb homolog 1--Pubmed
HPRDdeath-associated protein kinase 1DIP1--Pubmed
HPRDdeath-associated protein kinase 1Tumor necrosis factor receptor 1--Pubmed
HPRDdeath-associated protein kinase 114-3-3 Beta--Pubmed
HPRDdeath-associated protein kinase 1TRADD--Pubmed
HPRDdeath-associated protein kinase 1FADD--Pubmed

Recent Publications on DAPK1:

Pubmed Logo
Identification of Death-Associated Protein Kinases Inhibitors Using Structure-Based Virtual Screening.
Death-associated protein kinases (DAPKs) function in the early stages of...
3rd November, 2009
Drug Discovery Department, Research and Development Division, J Med Chem. 2009 Oct 30.
DOI Direct Link
Erratum to: RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
Death-associated protein kinases (DAPKs) function in the early stages of...
10th October, 2009
Department of General Thoracic Surgery, Shanghai Chest Hospital, Shanghai J Cancer Res Clin Oncol. 2009 Oct 9.
DOI Direct Link
RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
PURPOSE: To identify the DNA methylation biomarkers for the detection of...
9th October, 2009
Department of General Thoracic Surgery, Shanghai Chest Hospital, Shanghai J Cancer Res Clin Oncol. 2009 Dec;135(12):1675-84. Epub 2009 Jun 9.
DOI Direct Link
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.
Mouse models of intestinal tumors have advanced our understanding of the...
25th September, 2009
Fred Hutchinson Cancer Research Center, Clinical Research Division, Mol Carcinog. 2009 Sep 23.
DOI Direct Link
Intramedullary solitary fibrous tumor of dorsal spinal cord.
Solitary fibrous tumors (SFT) are rare neoplasms of mesenchymal origin...
16th September, 2009
Department of Neurological and Psychiatric Sciences, University of Bari Neuropathology. 2009 Sep 14.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608394 Methods and compositions for phenotype identification based on nucleic acid methylation
7171311 Methods of assigning treatment to breast cancer patients
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7354725 Kinase peptides and antibodies
7358048 Method for detection of promoter methylation status

View more patents.

DAPK1 results (if any) from reagent suppliers

Google CSE Logo
DAPK1 Antibody #3008
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide (KLH-coupled) corresponding to residues surrounding Gly905 of human
DAPK1. ...
http://www.cellsignal.com/products/3008.html...

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DAP Kinase 1 (DAPK1) Antibody (C-term)
DAP Kinase 1 (DAPK1) Antibody (C-term) Apoptosis, DAP Kinase 1 (DAPK1) Antibody (C-term) Cell Function, DAP Kinase 1 (DAPK1) Antibody (C-term) Protein ...
http://www.abgent.com/products/catalog_no/AP7217b...

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DAPK3/ZIPK Antibody #2928
Ectopic expression of wild-type DAPK1 induced cell death in HeLa cells. ... The catalytic domain of DAPK1 has very high sequence similarity to vertebrate ...
http://www.cellsignal.com/products/2928.html...

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DAP Kinase 1 antibody [DAPK-55] (ab10443) | Abcam
DAPK1 (Death-associated protein kinase 1) is a calmodulin dependent serine/ threonine serine kinase which functions as a positive mediator of gamma-int...
http://www.abcam.com/DAP-Kinase-1-antibody-DAPK-55-ab10443.h...

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DAPK3 Kinase #7441
Death-associated protein kinase (DAPK1) is a Ca2+/calmodulin-regulated serine/ threonine kinase that participates in a wide range of apoptotic signals ...
http://www.cellsignal.com/products/7441.html...

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Mib1/Mindbomb antibody - N-terminal (ab71749) | Abcam
It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote ...
http://www.abcam.com/mib1-mindbomb-antibody-n-terminal-ab717...

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DAPK3/ZIPK Antibody
DAPK1 Kinase #7647. DAPK3 Kinase #7441. Phospho-Stat3 (Ser727) (6E4) Mouse mAb # 9136. Phospho-Stat3 (Ser727) Antibody #9134. PAR-4 Antibody #2328 ...
http://www.cellsignal.com/pdf/2928.pdf...

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