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DCC


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Gene DB Home
Symbol:DCC
Name(s):deleted in colorectal carcinoma
Type:protein-coding
Organism:Homo sapiens
Synonyms:CRC18, CRCR1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14571268 Observational study of gene-disease association. (HuGE Navigator)
15523694 Observational study of gene-disease association. (HuGE Navigator)
15646429 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18054557 study provides evidence that most colorectal cancers have alterations in both UNC5C and DCC netrin receptors; while UNC5C expression is regulated primarily via epigenetic regulation, DCC defects are mediated through allelic deletions
17018594 DCC is a putative conditional tumor-suppressor gene that is epigenetically inactivated by promoter hypermethylation in a majority of head-and-neck squamous cell carcinomas.
15811950 DCC in both commissural neurons and immortalized cells, is partially associated with cholesterol- and sphingolipid-enriched membrane domains named lipid rafts.
16537496 the localization of DCC to lipid rafts is a prerequisite for its proapoptotic activity, both in immortalized cells and in primary neurons
11817894 The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.
12901278 Prognostic significance of the DCC gene protein expression in high-risk resected gastric carcinoma
12901294 Deletions in this gene are found in colorectal and gastric cancers

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDadenosine A2b receptorDCC--Pubmed
HPRDCaspase 3deleted in colorectal carcinoma--Pubmed
HPRDcaspase 3 preproproteinDCC--Pubmed
HPRDCaspase 9deleted in colorectal carcinoma--Pubmed
HPRDcaspase 9 isoform alpha preproproteinDCC--Pubmed
HPRDDCCnetrin 1--Pubmed
HPRDDCCNCK adaptor protein 1--Pubmed
HPRDdeleted in colorectal carcinomaNetrin 1--Pubmed
HPRDdeleted in colorectal carcinomaNCK1--Pubmed
BINDdeleted in colorectal carcinoma-DCC interacts with FAK.-Pubmed

Recent Publications on DCC:

Pubmed Logo
Does the dynamic cross cylinder test measure the accommodative response accurately?
BACKGROUND: The dynamic cross cylinder (DCC) test is a standard clinical...
29th October, 2009
State University of New York State College of Optometry, New York, New Optometry. 2009 Nov;80(11):630-4.
DOI Direct Link
The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality.
Proper axonal targeting is fundamental to the establishment of functional...
28th October, 2009
1 Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Brain. 2009 Oct 25.
DOI Direct Link
Streptococcus pneumoniae nasopharyngeal carriage in children attending day-care centers in the central region of Portugal, in the era of 7-valent pneumococcal conjugate vaccine.
The 7-valent pneumococcal conjugate vaccine became available in Portugal...
28th October, 2009
Infectious Diseases Unit, Pediatric Hospital of Coimbra, Coimbra, Microb Drug Resist. 2009 Dec;15(4):269-77.
DOI Direct Link
The C. elegans Dosage Compensation Complex Propagates Dynamically and Independently of X Chromosome Sequence.
BACKGROUND: The C. elegans dosage compensation complex (DCC) associates...
27th October, 2009
Department of Biology, Carolina Center for Genome Sciences and Lineberger Curr Biol. 2009 Oct 21.
DOI Direct Link
Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1.
Dosage compensation ensures similar levels of X-linked gene products in...
24th October, 2009
Department of Molecular, Cellular, and Developmental Biology, University PLoS Genet. 2009 Oct;5(10):e1000699. Epub 2009 Oct 23.
DOI Direct Link

View more research publications.

Press Releases on DCC:

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siFECTamineT is superior to in vitro market leader says new Biochemistry 1st December, 2001 Ic-Vec

siFECTamineT is superior to in

BioNews Results for DCC

: RSS Logo
BioPortfolio Logo
Cancer agency hires new director
The Dispatch:  Nov 9 2009 10:59AM Matching: dcc
DCGI to notify guidelines attached to Spurious Drugs Act to curb harassment of drug units
PharmaBiz:  Oct 22 2009 4:02AM Matching: dcc
Cancer Consortium earns top honor
Cape Gazette:  Oct 20 2009 7:00PM Matching: dcc
Weapon of prosecution to be used cautiously while enforcing Spurious Drugs Act: Experts
PharmaBiz:  Oct 10 2009 2:59AM Matching: dcc
Interfering with multimerization of netrin-1 receptors triggers tumor cell death
Nature:  Oct 9 2009 3:39PM Matching: dcc
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study Safety and Preliminary Efficacy of DCC-2036 in Patients With Leukemias

Patents:

Patents logo
US Patent No.Title
7605169 Antibacterial agents
7608118 Preconditioning fuel cell membrane electrode assemblies
7608253 Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
7608270 Dosage form
7608271 Modified human immunodeficiency virus anti-fusogenic GP41 peptides comprising a maleimide-containing group

View more patents.

DCC results (if any) from reagent suppliers

Google CSE Logo
DCC antibody (ab10525) | Abcam
Goat polyclonal to DCC. Deleted in colorectal cancer (DCC, chromosome 18q21) was originally identified as a putative tumor suppressor gene that is lost in ...
http://www.abcam.com/dcc-antibody-ab10525.html...

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DCC Antibody / DCC Antibodies
DCC Antibody / DCC Antibodies. ... DCC specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-dcc.html...

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DCC antibody [AF5] (ab16793) | Abcam
Mouse monoclonal [AF5] to DCC. Deleted in colorectal cancer (DCC, chromosome 18q21) was originally identified as a putative tumor suppressor gene that is ...
http://www.abcam.com/dcc-antibody-af5-ab16793.html...

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Anti-DCC Monoclonal Antibody
Monoclonal Antibody against DCC for use in Immunofluorescence, Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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DCC (H-205) Antibody sc-11437
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. Brain Res. Dev.
...
http://www.scbt.com/datasheet-11437-dcc-h-205-antibody.html...

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D3441 Anti-DCC antibody produced in goat lyophilized powder ...
D3441 Anti-DCC antibody produced in goat lyophilized powder, affinity isolated antibody.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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DCC (C-18) Antibody sc-6534
goat polyclonal IgG, 200 µg/ml; epitope mapping at the C-terminus of DCC of human origin; recommended for detection of DCC of m, r and h origin by WB, ...
http://www.scbt.com/datasheet-6534-dcc-c-18-antibody.html...

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