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CITED4


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Symbol:CITED4
Name(s):Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17311001 CITED4 is epigenetically silenced in the vast majority of oligodendroglial tumours with 1p and 19q deletions.
15572674 The interaction and functional cooperation between FHL2, CITED4, and CTNNB were studied.
15342390 Results show that breast cancer development is characterized by either nuclear loss or cytoplasmic translocation of CITED4, with consequent loss of hypoxia-inducible factor-1alpha transcriptional antagonist activity.
11744733 CITED4 functions as a transactivator when artificially targeted to a promoter element. CITED4 physically interacts with all TFAP2 isoforms in vitro and strongly co-activates all TFAP2 isoforms in Hep3B cells.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDE1A binding protein p300Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4--Pubmed
HPRDE1A binding protein p300Transcriptional coactivator 4--Pubmed
HPRDTranscription factor AP2-alphaCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4--Pubmed
HPRDtranscription factor AP-2 alpha isoform aTranscriptional coactivator 4--Pubmed
HPRDTranscription factor AP-2 betaCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4--Pubmed
HPRDtranscription factor AP-2 betaTranscriptional coactivator 4--Pubmed
HPRDAP2 gammaCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4--Pubmed
HPRDtranscription factor AP-2 gammaTranscriptional coactivator 4--Pubmed

Recent Publications on CITED4:

Pubmed Logo
Mutational analysis of the CITED4 gene in glioblastomas.
The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at...
13th September, 2008
Cancer Genet Cytogenet. 2008 Sep;185(2):114-6.
DOI Direct Link
Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q.
Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial...
7th September, 2007
Division of Molecular Genetics, Deutsches Krebsforschungszentrum, Oncogene. 2007 Jul 26;26(34):5010-6. Epub 2007 Feb 19.
DOI Direct Link
The viral protein A238L inhibits TNF-alpha expression through a CBP/p300 transcriptional coactivators pathway.
African swine fever virus (ASFV) is able to inhibit TNF-alpha-induced gene...
17th February, 2006
Centro de Biologia Molecular "Severo Ochoa" (Consejo Superior de J Immunol. 2006 Jan 1;176(1):451-62.
Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin.
Transcriptional activation of gene expression by Wnt signaling is driven...
31st December, 2004
Unite d'Oncogenese et Virologie Moleculaire, Institut Pasteur, 28 rue du Mol Cell Biol. 2004 Dec;24(24):10689-702.
DOI Direct Link
CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.
The interaction of hypoxia-inducible factor 1alpha and the CH1 domain of...
6th October, 2004
Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital Cancer Res. 2004 Sep 1;64(17):6075-81.
DOI Direct Link

View more research publications.

CITED4 results (if any) from reagent suppliers

Google CSE Logo
CITED4 antibody, CITED4 Antibody, Rabbit IgG Polyclonal Antibody
Buy quality rabbit CITED4 antibody (interacts with mouse rat), anti-CITED4, CITED4 antibody, rabbit igg polyclonal antibody, CITED4 Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=43983&...

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CITED4 antibody (ab48838) datasheet | Abcam
Rabbit polyclonal to CITED4. Cited4 is a member of the CITED family proteins that bind to CBP/p300 transcriptional integrators through their conserved ...
http://www.abcam.com/index.html?datasheet=48838...

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CITED Antibody / CITED Antibodies
CITED4 (C-17) Antibody, sc-49925, goat IgG, C-terminus (h), WB, IF, ELISA ... CITED4 shRNA Plasmid (h): sc-60387-SH, CITED4 shRNA Plasmid (m): sc-60388-SH.
...
http://www.scbt.com/table-cited.html...

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CITED4 antibodies | Abcam
CITED4 antibodies. ... CITED4 antibody [2D6.3]. IP, WB, ICC/IF, ELISA. Images · Customer Abreviews: 1 stars (out of 5) Customer Abreviews: 1 stars (out of ...
http://www.abcam.com/index.html?t=198576&pt=1&c=3580...

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CITED4 siRNA (h) sc-60387
CITED4 siRNA (h) sc-60387 CITED4 siRNA (h) sc-60387.
http://www.scbt.com/datasheet-60387-cited4-sirna-h.html...

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All Hypoxia-related proteins | Abcam
CITED4 antibody [2D6.3]. IP, WB, ICC/IF, ELISA. Images · Customer Abreviews: 1 stars (out of 5) Customer Abreviews: 1 stars (out of 5) Customer Abreviews: 1
...
http://www.abcam.com/index.html?c=4270...

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Mediators - Ab's - Protein and Antibody Solutions Provider - GenWay
CITED4; AU019445, AW742964, Mrg2 - MSG1-related protein 2; MRG-2; Cbp/p300- interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, ...
https://www.genwaybio.com/index.php?cPath=4111&fl=C...

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Abcam antibodies and reagents product map
... C3IP1 antibodies · C3IP1 proteins and peptides · CGBP antibodies · CITED4 antibodies · CTBP2 antibodies · CUTL1 antibodies · CoREST2 / RCOR2 antibodies
...
http://www.abcam.com/index.html?pageconfig=productmap&Cl=357...

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ABR–Affinity BioReagents, Quality Reagents. Quality Results.
A global supplier of monoclonal and polyclonal antibodies. Provides custom antibody production services.
http://www.bioreagents.com/index.cfm...

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