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AKR1C1
| Symbol: | AKR1C1 | | Name(s): | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DDH, DDH1, H-37, HAKRC, MBAB, MGC8954 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16543247 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17149600 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17945194 |
Overexpression of AKR1C1 counteracted the S-phase accumulation of cells and apoptosis caused by MTX treatment. This suggests a role of AKR1C1 in cell proliferation. |
| 17697149 |
Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), aldoketoreductase (AKR1C1) and prostaglandin F synthase (AKR1C3) were all expressed in hair follicles. |
| 17697149 |
Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), the aldoketoreductase AKR1C1 and the prostaglandin F synthase AKR1C3 were all expressed in hair follicles. |
| 17618725 |
Activity of AKR1C1 in overall oracin reduction was one order of magnitude higher compared to AKR1C2 and 1C4. |
| 15492289 |
Loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors. |
| 16338060 |
The expression of AKR1C1 and AKR1C3 in endometrial cancer will govern the ratio of P:E2. |
| 16361083 |
DDH may play important roles in tumor progression of squamous cell carcinoma via induction of apoptosis- and drug-resistance |
| 13678667 |
Glaucomatous optic nerve head astrocytes express a higher level of 3 alpha-HSD isoform AKR1C1 and its mRNA than normal astrocytes. | →View more information from publications. |
Recent Publications on AKR1C1: |  |
Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells.
We have shown previously that chronic low-dose arsenic exposure induces... | 27th October, 2009
| Graduate Institute of Life Sciences, National Defense Medical Center,
| Carcinogenesis. 2009 Oct;30(10):1813-20. Epub 2009 Aug 20.
DOI Direct Link |
Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.
Please cite this paper as: Aldo-keto reductase 1C subfamily genes in skin... | 24th October, 2009
| The Johnson & Johnson Skin Research Center, CPPW, a unit of Johnson &
| Exp Dermatol. 2009 Jul;18(7):611-8. Epub 2009 Mar 6.
DOI Direct Link |
Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.
The relevance of progesterone to breast carcinogenesis is highlighted by... | 23rd October, 2009
| Department of Epidemiology, School of Public Health, University of
| Am J Epidemiol. 2009 Nov 15;170(10):1241-9. Epub 2009 Oct 21.
DOI Direct Link |
Organophosphorus pesticides enhance the genotoxicity of benzo(a)pyrene by modulating its metabolism.
Organophosphorus compounds (OPs) are widely used as pesticides. They act... | 6th October, 2009
| Department of Genetic Toxicology and Cancer Biology, National Institute of
| Mutat Res. 2009 Dec 1;671(1-2):84-92. Epub 2009 Oct 2.
DOI Direct Link |
Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy.
Nrf2 is the key transcription factor for cytoprotective gene programs.... | 30th July, 2009
| Segal Cancer Centre, Sir Mortimer B Davis-Jewish General Hospital,
| Mol Cancer Ther. 2009 Aug;8(8):2432-40. Epub 2009 Jul 28.
DOI Direct Link |
→View more research publications. |
AKR1C1 results (if any) from reagent suppliers | 
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AKR1C1 antibodies: Developmental Biology > Reproduction > Hormones ...
AKR1C1 antibodies. ... AKR1C1 antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab72576 · AKR1C1 antibody ...
http://www.abcam.com/index.html?t=244220&pt=1&c=4593&ei=&mu=...
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DD (N-19) Antibody sc-20425
Human, AKR1C1, 1645, 10p15.1, NM_001353 · Q04828 · 600449. Human, AKR1C2, 1646, 10p15.1, NM_001354, NM_205845 · P52895 ...
http://www.scbt.com/ko/datasheet-20425-dd-n-19-antibody.html...
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AKR1C3 antibody [NP6.G6.A6] (ab49680) | Abcam
This antibody recognizes AKR1C3 and does not cross react with AKR1C1, AKR1C2, and AKR1C4. Tested applications (see key). ELISA, WB ...
http://www.abcam.com/AKR1C3-antibody-NP6-G6-A6-ab49680.html...
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DD1 (h): 293 Lysate sc-111203
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, AKR1C1, 1645, 10p15.1, Q04828 ...
http://www.scbt.com/product.php?datasheet=111203...
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Abcam antibodies and reagents product map
... ABCC13 antibodies (1) · ADH4 antibodies (2) · ADH7 antibodies (1) · AKR1B10 antibodies (4) · AKR1B10 proteins and peptides (1) · AKR1C1 antibodies (1) ...
http://www.abcam.com/index.html?c=2105...
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DD1 siRNA (h) sc-106791
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, AKR1C1, 1645, 10p15.1, NM_001353 ...
http://www.scbt.com/ko/datasheet-106791-dd1-sirna-h.html...
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Abcam antibodies and reagents product map
AKR1C1 antibodies (1) · Androgen Receptor antibodies (23) · Androgen Receptor proteins and peptides (5) · CGB5 antibodies (1) · CSHL1 antibodies (1) ...
http://www.abcam.com/index.html?cl=4588&pageconfig=productma...
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