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AKR1C2
| Symbol: | AKR1C2 | | Name(s): | aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18251165 |
The inhibition of activation of the beta-catenin/TCF-signaling pathway is believed to be one mechanism by which AKR1C2 siRNA exerts a gatekeeper function during hepatocarcinogenesis. |
| 12416991 |
The kinetics of 3-alpha-HSD type III indicates an ordered ternary complex mechanism characterized by allopregnanolone formation, with NAD cofactor binding before the steroid substrate and dissociating after release of the steroid product. |
| 15492289 |
Loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors. |
| 16478829 |
The regulation of AKR1C2 by antioxidant response element suggests that AKR1C2 detoxifies products of reactive oxidant injury. |
| 15383625 |
metabolizes tibolone |
| 15188492 |
Akr1c2 which is up-regulated in esophageal squamous cell carcinoma probably plays an important role in tumor development of esophagus and may be proposed as a potential molecular target treatments. |
| 13678667 |
Glaucomatous optic nerve head astrocytes express a higher level of 3alpha-HSD isoform AKR1C2 and its mRNA than normal astrocytes. |
| 16216911 |
Results suggest that 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 3 might play slightly different roles in zebrafish compared with human although testosterone itself is likely to have similar functions in both organisms. |
| 14671194 |
expression and activity of type 5 17beta-hydroxysteroid dehydrogenase and type 3 3alpha-hydroxysteroid dehydrogenase in female subcutaneous tissue and omental adipose tissue and in preadipocytes |
| 12810547 |
in prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-DHT and prevents activation of the androgen receptor. | →View more information from publications. |
Recent Publications on AKR1C2: |  |
Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells.
We have shown previously that chronic low-dose arsenic exposure induces... | 27th October, 2009
| Graduate Institute of Life Sciences, National Defense Medical Center,
| Carcinogenesis. 2009 Oct;30(10):1813-20. Epub 2009 Aug 20.
DOI Direct Link |
Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.
Please cite this paper as: Aldo-keto reductase 1C subfamily genes in skin... | 24th October, 2009
| The Johnson & Johnson Skin Research Center, CPPW, a unit of Johnson &
| Exp Dermatol. 2009 Jul;18(7):611-8. Epub 2009 Mar 6.
DOI Direct Link |
Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.
The relevance of progesterone to breast carcinogenesis is highlighted by... | 23rd October, 2009
| Department of Epidemiology, School of Public Health, University of
| Am J Epidemiol. 2009 Nov 15;170(10):1241-9. Epub 2009 Oct 21.
DOI Direct Link |
Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance.
OBJECTIVES: Recent studies suggest that tumor cells overexpressing... | 10th September, 2009
| Department of Biology, Laurentian University, Northern Ontario School of
| Pharmacogenet Genomics. 2009 Jun;19(6):477-88.
DOI Direct Link |
Comparison of the folding mechanism of highly homologous proteins in the lipid-binding protein family.
The folding mechanism of two closely related proteins in the intracellular... | 9th September, 2009
| Department of Biochemistry and Molecular Biology, Penn State University
| Proteins. 2009 Jun;75(4):799-806.
DOI Direct Link |
→View more research publications. |
AKR1C2 results (if any) from reagent suppliers | 
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AKR1C2 antibodies: Signal Transduction > Metabolism > Drug ...
AKR1C2 antibodies. ... AKR1C2 antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab54807 · AKR1C2 antibody ...
http://www.abcam.com/index.html?t=226044&pt=1&c=3613&ei=&mu=...
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Monoclonal Anti-AKR1C3 antibody produced in mouse (A6229) - Datasheet
and does not cross react with human AKR1C1, AKR1C2, and AKR1C4. The antibody may be used in ELISA, immunoblotting (~ 38 kDa), and immunohistochemistry.5 ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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AKR1C3 antibody [NP6.G6.A6] (ab49680) | Abcam
This antibody recognizes AKR1C3 and does not cross react with AKR1C1, AKR1C2, and AKR1C4. Tested applications (see key). ELISA, WB ...
http://www.abcam.com/AKR1C3-antibody-NP6-G6-A6-ab49680.html...
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Abgent - Cell and Function Antibodies
AT1092a, AKR1B10 monoclonal antibody (M03), ELISA,WB-Ce,WB-Re, H. AT1093a, AKR1C2 monoclonal antibody (M03), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...
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DD (N-19) Antibody sc-20425
Human, AKR1C2, 1646, 10p15.1, NM_001354, NM_205845 · P52895 · 600450. Human, AKR1C3, 8644, 10p15.1, NM_003739 · P42330 ...
http://www.scbt.com/datasheet-20425-dd-n-19-antibody.html...
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3C-3E
Monoclonal Anti-AKR1C2 antibody produced in mouse clone 3C11, purified immunoglobulin, buffered aqueous solution, 3C11 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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All Tumor biomarkers | Abcam
AKR1C2 antibody. WB. Images. Mouse monoclonal. Reacts with: RecFrag. Predicted: Hu. ab354 · Alkaline Phosphatase antibody. IP, WB, ELISA ...
http://www.abcam.com/index.html?c=4194...
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