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GADD45A
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18350249 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15642443 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17599061 |
Gadd45a-deficient human colon cancer cells exhibited slow base excision repair after treatment with methyl methanesulfonate, a pure base-damaging agent. |
| 17703175 |
UVB-induced Gadd45a overexpression protects melanoma cells from apoptosis, both by causing a G2 cell cycle arrest and by inhibiting the mitochondrial apoptotic pathway. |
| 16951143 |
p53 preferentially occupied the promoters of growth arrest genes p21 and GADD45 in senescent normal human diploid fibroblasts. |
| 17474084 |
Induction of GADD45A expression might play a role in mediating the apoptotic response of ovarian cancer cells to the synthetic retinoid CD437. |
| 17140287 |
In support of the idea that checkpoint activation and apoptosis induction are functionally linked, we show that Bax activation by Vpr was ablated when ATR or GADD45alpha was knocked down |
| 14586402 |
Histone deacetylase inhibitors can induce Gadd45 through its promoter without the need for functional p53, and both Oct-1 and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 promoter. |
| 14647444 |
Silencing of GADD45gamma, a negative regulator of cell growth, is most likely responsible for conferring a selective growth advantage during tumour evolution and outgrowth |
| 16157202 |
We conclude that the GADD45A gene is not involved in meningioma tumorigenesis. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| BIND | cyclin B1 | growth arrest and DNA-damage-inducible, alpha | Cyclin B1 interacts with Gadd45a. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45a from an unspecified species. | - | Pubmed |
| BIND | - | growth arrest and DNA-damage-inducible, alpha | Cdk1 interacts with Gadd45a. This interaction was modeled on a demonstrated interaction between human Cdk1 and Gadd45a from an unspecified species. | - | Pubmed |
| HPRD | cell division cycle 2 protein isoform 1 | growth arrest and DNA-damage-inducible, alpha | - | - | Pubmed |
| HPRD | cell division cycle 2 protein isoform 1 | growth arrest and DNA-damage-inducible, alpha | - | - | Pubmed |
| HPRD | Cyclin dependent kinase inhibitor 1A | growth arrest and DNA-damage-inducible, alpha | - | - | Pubmed |
| HPRD | cyclin-dependent kinase inhibitor 1A | GADD45 | - | - | Pubmed |
| HPRD | GADD45 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | - | - | Pubmed |
| BIND | Homo sapiens growth arrest and DNA-damage-inducible, alpha gene, complete cds. | early growth response 1 | Egr-1 interacts with Gadd45a promoter. | - | Pubmed |
| HPRD | growth arrest and DNA-damage-inducible, alpha | PRG6 | - | - | Pubmed |
| HPRD | growth arrest and DNA-damage-inducible, alpha | peroxisome proliferative activated receptor, alpha isoform 1 | - | - | Pubmed |
Recent Publications on GADD45A: |  |
Inhibitory effect of wild-type p53 gene on excessive replication of centrosomes in leukemia cell line K562.
BACKGROUND AND OBJECTIVE: Mutation and deletion of the p53 gene in tumor... | 23rd October, 2009
| Department of Clinical Hematology, Key Laboratory of Laboratory Medical
| Chin J Cancer. 2009 Feb;28(2):122-6. Epub 2009 Feb 23.
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Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression.
Proinflammatory cytokines induce nitric oxide-dependent DNA damage and... | 22nd October, 2009
| Edward A. Doisy Department of Biochemistry and Molecular Biology, St.
| J Biol Chem. 2009 Oct 2;284(40):27402-8. Epub 2009 Aug 2.
DOI Direct Link |
Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli.
The GADD45 family of proteins consists of three small proteins, GADD45A,... | 17th October, 2009
| Fels Institute for Cancer Research and Molecular Biology, Temple
| J Cell Biochem. 2009 Oct 15.
DOI Direct Link |
Transcriptional profiles during the differentiation and maturation of monocyte-derived dendritic cells, analyzed using focused microarrays.
Dendritic cells (DC) are professional antigen-presenting cells capable of... | 15th October, 2009
| Institute of Biotechnology and Clinical Immunology Research Laboratory of
| Cell Mol Biol Lett. 2009;14(4):587-608. Epub 2009 Jun 25.
DOI Direct Link |
Ligation or cross-linking of CD40 has different effects on AGS gastric cancer cells.
A gastric cancer (GC) cell line, AGS, has high-level expression of CD40, a... | 8th October, 2009
| Department of Oncology, the Affiliated Hospital of Nanjing Medical
| Cell Immunol. 2009;259(2):135-40. Epub 2009 Jun 21.
DOI Direct Link |
→View more research publications. |
GADD45A results (if any) from reagent suppliers | 
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GADD45A antibody (ab33173) | Abcam
Rabbit polyclonal to GADD45A. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions ...
http://www.abcam.com/GADD45A-antibody-ab33173.html...
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GADD45A Antibody (N-term)
Western blot analysis of anti-GADD45A Antibody (N-term) (Cat.#AP2785a) in Y79 cell line lysates (35ug/lane). GADD45A (arrow) was detected using the purified
...
http://www.abgent.com/products/catalog_no/AP2785a_GADD45A_An...
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GADD 45α (H-165) Antibody sc-797
Mouse, Gadd45a, 13197, 6 C1, P48316 ... UVB-induced G2 arrest of human melanocytes involves Cdc2 sequestration by Gadd45a in nuclear speckles. Cell
Cycle. ...
http://www.scbt.com/datasheet-797-gadd-45alpha-h-165-antibod...
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GADD45A proteins and peptides: Chromatin and Nuclear Signaling ...
GADD45A proteins and peptides. ... Applications (see key) & Reactivity (see key) . Image Abreview Publication. ab33369 · GADD45A peptide ...
http://www.abcam.com/index.html?t=150008&pt=2&c=876&ei=&mu=r...
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GADD 45α (C-20) Antibody sc-792
The Eukaryotic Initiation Factor-2 Kinase Pathway Facilitates Differential GADD45a Expression in Response to Environmental Stress. J. Biol. Chem. ...
http://www.scbt.com/datasheet-792-gadd-45alpha-c-20-antibody...
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Abgent - Stem Cell
AP2789bNEW, GABRB3 Antibody (C-term), WB, E, H. AP2789cNEW, GABRB3 Antibody ( Center), IHC, E, H. AP2785aNEW, GADD45A Antibody (N-term), WB, E, H, M ...
http://www.abgent.com/products/category/stem_cell...
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GADD 45α (C-4) Antibody sc-6850
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GADD45A, 1647, 1p31.3, NM_001924 ...
http://www.scbt.com/datasheet-6850-gadd-45alpha-c-4-antibody...
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