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AFP


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Gene DB Home
Symbol:AFP
Name(s):alpha-fetoprotein
Type:protein-coding
Organism:Homo sapiens
Synonyms:FETA, HPAFP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17433605 Observational study of gene-disease association. (HuGE Navigator)
17852813 Results show that measurements of AFP, CEA and CA125 are more readily affected by long-term frozen storage compared with frequent freezing-thawing.
16627685 The gene expression profile of hepatoblasts throughout life consists of high levels of expression of alpha-fetoprotein(AFP).
17433605 The novel polymorphisms identified in the promoter region of the AFP gene may be pathologically significant in HCC.
11788893 both the ratio of AFP-L3 (AFP-L3%) and the absolute value of AFP-L3 (AFP-L3-AV) were examined in 80 patients with HCC, and evaluated with respect to characteristics of HCC such as grade of differentiation, size of tumor and morphological findings
15028291 mouse and human alpha-fetoprotein enhancers are strikingly different
12176010 alpha-fetoprotein directly binds to CCR5 in primary macrophages
17237442 effects of a necrosis-inducing treatment (embolization) on anti-alpha-fetoprotein (AFP)-specific CD4(+) T cell responses in hepatocellular carcinoma (HCC) patients and controls using an array of AFP-derived peptides.
17465484 AFP increase in patients with liver cancer was positively correlated with the infection of HBV and HCV. The serum AFP elevation by the infection of HBV and HCV is one of mechanisms which lead to hepatocarcinogenesis
15305374 AFP elevation appears to contribute to vascular invasion and hepatocellular carcinoma progression

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-fetoprotein precursorchemokine receptor 5--Pubmed
HPRDalpha-fetoprotein precursorchemokine receptor 5--Pubmed

Recent Publications on AFP:

Pubmed Logo
Clinical practice : NTBC therapy for tyrosinemia type 1: how much is enough?
Four patients with tyrosinemia type 1 (ages 6-32 months) were treated with...
3rd November, 2009
Department of Pediatrics, Cairo University, 44 Mohei El-Deen Abu El-Ezz Eur J Pediatr. 2009 Oct 31.
DOI Direct Link
Characterisation of the activated liver progenitor cell niche, potential involvement of Wnt and Notch signalling.
BACKGROUND: Hepatic progenitor cells (HPCs) hold a great potential for...
3rd November, 2009
Belgium; Gut. 2009 Nov 1.
DOI Direct Link
[Etiopathological factors of hepatocellular carcinoma in Bangui, Central African Republic: Clinical, biological characteristics and virological aspects of patients.]
OBJECTIVES: To describe clinical, biological characteristics and...
31st October, 2009
Laboratoire des hepatites virales, institut Pasteur de Bangui, BP 923, Pathol Biol (Paris). 2009 Oct 27.
DOI Direct Link
[Differentiation of hepatic oval cell into mature hepatocyte induced by hepatic stellate cells.]
OBJECTIVE: To investigate the role of hepatic stellate cells in the...
31st October, 2009
Department of Hepatic Surgery, Tongji Hospital, Tongji Medical College, Zhonghua Gan Zang Bing Za Zhi. 2009 Oct;17(10):765-70.
AAFP News Now: AFP Edition.
OBJECTIVE: To investigate the role of hepatic stellate cells in the...
31st October, 2009
Am Fam Physician. 2009 Nov 1;80(9):913.

View more research publications.

Press Releases on AFP:

BioPortfolio Logo
Expert Panel of Pediatric Liver Specialists Publishes Recommendations for Monitoring and Referral of Children With Chronic Hepatitis B Infections 5th October, 2009 Hepatitis B Foundation

Improved monitoring for progression of disease in affected children is essential

DOYLESTOWN, Pa., Oct. 5 /PRNewswire-USNewswire/ -- An expert panel of

'Viewers Beware' Report by Watchdog Group Exposes Conservative Group Behind Anti-Healthcare Ads Running in Montana 1st June, 2009 Public Campaign Action Fund

Group led by conservative political operative with ties to convicted lobbyist Jack Abramoff

WASHINGTON, June 1 /PRNewswire-USNewswire/ -- Public Campaign Action Fund

"Viewers Beware" Report by Watchdog Group Exposes Conservative Group Behind Anti-Healthcare Ads Running in South Dakota 1st June, 2009 Public Campaign Action Fund

Group led by conservative political operative with ties to convicted lobbyist Jack Abramoff

WASHINGTON, June 1 /PRNewswire-USNewswire/ -- Public Campaign Action Fund issued

'Viewers Beware' Report by Watchdog Group Exposes Conservative Group Behind Anti-Healthcare Ads Running in Virginia 1st June, 2009 Public Campaign Action Fund

Group led by conservative political operative with ties to convicted lobbyist Jack Abramoff

WASHINGTON, June 1 /PRNewswire-USNewswire/ -- Public Campaign Action Fund issued

'Viewers Beware' Report By Watchdog Group Exposes Conservative Group Behind Anti-Healthcare Ads Running In Nebraska 1st June, 2009 Public Campaign Action Fund

Group led by conservative political operative with ties to convicted lobbyist Jack Abramoff

WASHINGTON, June 1 /PRNewswire-USNewswire/ -- Public Campaign Action Fund issued

BioNews Results for AFP

: RSS Logo
BioPortfolio Logo
AFP: Recorded AIDS deaths in Iran top 3,400: report
AEGIS:  Nov 14 2009 7:58PM Matching: afp
Australian bid to 'regrow' breasts after cancer surgery
Manila Bulletin:  Nov 14 2009 8:05PM Matching: afp
Global swine flu deaths slow as WHO toll passes 6,250 (AFP)
West Australian:  Nov 13 2009 11:03PM Matching: afp
Global swine flu deaths slow as WHO toll passes 6,250
West Australian:  Nov 13 2009 10:54PM Matching: afp
Global swine flu deaths slow as WHO toll passes 6,250 (AFP)
Yahoo! News Australia:  Nov 13 2009 10:41PM Matching: afp
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Immunization With AFP + GM CSF Plasmid Prime and AFP Adenoviral Vector Boost in Patients With Hepatocellular Carcinoma

Patents:

Patents logo
US Patent No.Title
7575919 Adenovirus vectors containing cell status-specific response elements and methods of use thereof
7585491 Immunoconjugates with an intracellularly-cleavable linkage
7585962 Multimerized enhancer domains for cell-specific expression
7587471 System and method for virtualizing network storages into a single file system view
7588767 Microorganisms for therapy

View more patents.

AFP results (if any) from reagent suppliers

Google CSE Logo
AFP Antibody #2137
AFP Antibody detects endogenous levels of total AFP protein in mouse and human cells. The antibody can only immunoprecipitate human AFP. ...
http://www.cellsignal.com/products/2137.html...

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alpha 1 Fetoprotein antibody [AFP-11] (ab3969) | Abcam
Mouse monoclonal [AFP-11] to alpha 1 Fetoprotein. Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life.
http://www.abcam.com/alpha-1-fetoprotein-antibody-afp-11-ab3...

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AFP Antibody / AFP Antibodies
Alpha fetoprotein (AFP) is expressed in fetal liver at varying levels throughout development and is present only in trace amounts in normal adult tissues. ...
http://www.scbt.com/table-afp.html...

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Immunohistochemistry : alpha-Fetoprotein/AFP - R&D Systems
Detection of alpha-fetoprotein (AFP) in paraffin-embedded human liver cancer tissue sections using 15 µg/mL of R&D Systems chicken anti-human AFP ...
http://www.rndsystems.com/ihc_molecule_images.aspx?m=1049...

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AFP Antibody a-1-fetoprotein
AFP antibody can be stored at 4C for short term (weeks) and -20C for long term.,
http://www.prosci-inc.com/shop/catalog1/AFP-Antibody-p-16602...

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AFP (3H8) Mouse mAb #3903
Confocal immunofluorescent analysis of HepG2 cells using AFP Mouse mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). ...
http://www.cellsignal.com/products/3903.html...

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AFP (39) Antibody sc-130302
mouse monoclonal IgG1, 200µg/ml; raised against recombinant AFP of human origin ... AFP (39): sc-130302. Western blot analysis of AFP expression in Hep G2 ...
http://www.scbt.com/datasheet-130302-afp-39-antibody.html...

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