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DLG2


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Symbol:DLG2
Name(s):discs, large homolog 2, chapsyn-110 (Drosophila)
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp781D1854, DKFZp781E0954, FLJ37266, MGC131811, PSD-93
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15304517 Coexpression of Kir2.1 and PSD-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 clustering and suppression of channel internalization.
17506987 postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy
16640776 identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDATP2B2chapsyn-110--Pubmed
HPRDplasma membrane calcium ATPase 2 isoform 1Channel associated protein of synapse 110--Pubmed
BINDATPase, Ca++ transporting, plasma membrane 2chapsyn-110PMCA2b interacts with SAP93. This interaction was modeled on a demonstrated interaction between human PMCA2b and SAP93 from rat and an unspecified source.-Pubmed
HPRDATP2B4chapsyn-110--Pubmed
HPRDATPase, Ca++ transporting, plasma membrane 4Channel associated protein of synapse 110--Pubmed
BINDplasma membrane calcium ATPase 4 isoform 4bchapsyn-110PMCA4b interacts with SAP93. This interaction was modeled on a demonstrated interaction between human PMCA4b and SAP93 from rat and an unspecified source.-Pubmed
HPRDSynapse associated protein 97chapsyn-110--Pubmed
HPRDdiscs, large homolog 1Channel associated protein of synapse 110--Pubmed
HPRDChannel associated protein of synapse 110nitric oxide synthase 1--Pubmed
HPRDChannel associated protein of synapse 110N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed

Recent Publications on DLG2:

Pubmed Logo
Tumor suppressor CADM1 is involved in epithelial cell structure.
The tumor suppressor, CADM1, is involved in cell adhesion and...
27th October, 2009
Division of Molecular Pathology, Institute of Medical Science, The Biochem Biophys Res Commun. 2009 Oct 23.
DOI Direct Link
All hazards training: incorporating a catastrophe preparedness mindset into the dental school curriculum and professional practice.
Catastrophic preparedness should be incorporated into the dental school...
19th December, 2007
Department of Cariology and Comprehensive Care, New York University Dent Clin North Am. 2007 Oct;51(4):805-18, vi.
DOI Direct Link
Non-random inactivation of large common fragile site genes in different cancers.
The common fragile sites are regions of profound genomic instability found...
6th December, 2007
Division of Experimental Pathology, Department of Laboratory Medicine and Cytogenet Genome Res. 2007;118(2-4):260-9.
DOI Direct Link
Upregulated expression of postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA in temporal lobe tissue of epilepsy.
OBJECTIVE: To investigate the expression of PSD-93 mRNA and NR2B mRNA in...
21st July, 2007
Department of Neurology, The First Affiliated Hospital, Chongqing Medical Biochem Biophys Res Commun. 2007 Jul 6;358(3):825-30. Epub 2007 May 11.
DOI Direct Link
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
PDZ domains are protein-protein interaction modules that generally bind to...
11th May, 2007
Structural Genomics Consortium, Oxford University, Botnar Research Centre, Protein Sci. 2007 Apr;16(4):683-94.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7595152 Detection of influenza virus
6993724 Information processing apparatus, information processing method, information processing program for performing output setup to device apparatus, and memory medium storing such program therein
6964868 Human genes and gene expression products II
6942981 Method of determining interactions with PDZ-domain polypeptides
6936417 Gene expression in bladder tumors

View more patents.

DLG2 results (if any) from reagent suppliers

Google CSE Logo
PSD-95 (N-18) Antibody sc-6926
goat polyclonal IgG, 200 µg/ml; epitope mapping at the N-terminus of PSD-95 of rat origin; recommended for detection of PSD-95 and DLG2 of m, r and h origin
...
http://www.scbt.com/datasheet-6926-psd-95-n-18-antibody.html...

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PSD95 antibody [7E3-1B8] (ab13552) | Abcam
PSD95 is a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same...
http://www.abcam.com/psd95-antibody-7e3-1b8-ab13552.html...

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PSD-93 (N-20) Antibody sc-12233
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, DLG2, 1740, 11q14.1, NM_001364 ...
http://www.scbt.com/datasheet-12233-psd-93-n-20-antibody.htm...

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ErbB4 antibody, ErbB4 Antibody, Rabbit Polyclonal Antibody
Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with CBFA2T3, MUC1 and WWOX. Subcellular Location: Membrane; Single-
pass ...
http://www.genwaybio.com/product_info.php?products_id=196265...

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Antibodies to Neural Proteins
Dlg2(64053), rat, WB CL, pricing. D3070, Anti-DCDC2 (C-terminal) antibody produced in rabbit New, (polyclonal), affinity isolated antibody ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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ABCA1 antibody, ABCA1 Antibody, Mouse Monoclonal Antibody
ABCA1 interacts with DLG2 (discs. large homolog 2. chapsyn-110 (Drosophila)), IgG (GenWay Catalog #: 20-271-80098). ABCA1 interacts with SYNTROPHIN ALPHA 1,
...
http://www.genwaybio.com/product_info.php?products_id=80098...

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Post-Synaptic Density Protein Antibody / Post-Synaptic Density ...
Post-Synaptic Density Protein Antibody / Post-Synaptic Density Protein Antibodies.
http://www.scbt.com/ko/table-post-synaptic_density_protein.h...

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