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ACAN


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Symbol:ACAN
Name(s):aggrecan
Type:protein-coding
Organism:Homo sapiens
Synonyms:AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18040638 mRNAs for type II collagen and aggrecan were expressed by MSCs treated with either TGFbeta1 or OP-1; however, substantial matrix production was not induced.
16402214 Observational study of gene-disease association. (HuGE Navigator)
16741449 Observational study of gene-disease association. (HuGE Navigator)
17632389 Observational study of gene-disease association. (HuGE Navigator)
17568421 Human cells cultured over 5 days increased expression of aggrecan and collagen II in both nucleus and annulus cells under increasing osmolarity.
17261541 Results show an aggrecan product with the COOH terminal neoepitope VPGVA is synthesized by intracellular processing in chondrocytes; M-calpain is the major candidate of the proteinase to generate this product during intracellular aggrecan processing.
17588949 COMP/TSP5 may function to support matrix interactions with aggrecan in cartilage extracellular matrix
17632389 The findings provide additional support for the role of the aggrecan gene VNTR polymorphism in intervertebral disc degeneration.
16080123 A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis.
14724283 the interaction between aggrecan and hyaluronan in cartilage is stabilized by Link protein

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAggrecan 1fibulin 2 precursor--Pubmed
HPRDAggrecan 1tenascin R--Pubmed
HPRDAggrecan 1fibulin 1 isoform D--Pubmed
HPRDaggrecan 1 isoform 2 precursorFibulin 1--Pubmed
HPRDaggrecan 1 isoform 2 precursorFibulin 2--Pubmed
HPRDaggrecan 1 isoform 2 precursorTenascin R--Pubmed
HPRDaggrecan 1 isoform 2 precursorhyaluronan and proteoglycan link protein 1--Pubmed
HPRDaggrecan 1 isoform 2 precursorhyaluronan and proteoglycan link protein 1--Pubmed
HPRDaggrecan 1 isoform 2 precursorlumican precursor--Pubmed
HPRDaggrecan 1 isoform 2 precursortumor necrosis factor, alpha-induced protein 6 precursor--Pubmed

Recent Publications on ACAN:

Pubmed Logo
The association between smoking and hypertension in a population-based sample of Vietnamese men.
OBJECTIVE: The association between tobacco smoking and blood pressure in...
16th October, 2009
aCan Tho University of Medicine and Pharmacy, Can Tho, Vietnam bMenzies J Hypertens. 2009 Oct 13.
DOI Direct Link
Stem cell related gene expression in clonal populations of mesenchymal stromal cells from bone marrow.
Decline in the frequency of potent mesenchymal stem cells (MSCs) has been...
24th September, 2009
Queensland University of Technology, Institrute of Health and Biomedical Tissue Eng Part A. 2009 Sep 22.
DOI Direct Link
Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa.
BACKGROUND: Brain-derived neurotrophic factor (BDNF) mutant mice show...
11th September, 2009
Department of Psychiatry and Psychotherapy, Charite - Universitatsmedizin J Psychiatry Neurosci. 2009 Jul;34(4):323-9.
BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture.
This study addresses synergistic effects of bone morphogenetic protein-2...
11th September, 2009
Department of Haematology and Bone Marrow Stem Cell Transplant Unit, St Tissue Eng Part A. 2009 Jun;15(6):1311-20.
DOI Direct Link
Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation.
ABSTRACT: INTRODUCTION: Autologous chondrocyte transplantation (ACT) is a...
3rd September, 2009
Tissue Engineering Laboratory and Berlin-Brandenburg Center for Arthritis Res Ther. 2009 Sep 2;11(5):R133.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
4064139 Substituted 9,10-dihydroanthracen-9,10-imines
4897263 Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids
4900819 Method in the production of crystalline explosives
4925308 Calibration of three-dimensional space
4946875 In situ cyclopolymerized vinyl anhydride in polyepoxide

View more patents.

ACAN results (if any) from reagent suppliers

Google CSE Logo
C8035 Monoclonal Anti-Chondroitin Sulfate antibody produced in ...
isotype, IgM. Gene Information, human ... ACAN(176). rat ... Acan(58968). mouse ... Acan(11595). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C803...

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aggrecan/brevican (C-20) Antibody sc-16493
Human, ACAN, 176, 15q26.1, NM_001135, NM_013227 · P16112 ... Mouse, Acan, 11595, 7 D3, Q61282, N/A. Mouse, Bcan, 12032, 3 F1, Q61361 ...
http://www.scbt.com/datasheet-16493-aggrecan-brevican-c-20-a...

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Antibodies to Extracellular Matrix Proteins
Acan(11595), chicken, rabbit, human, pig, rat, bovine, mouse, ARR, IF (i), pricing. C2456, Monoclonal Anti-Collagen, Type I antibody produced in mouse ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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aggrecan (H-300) Antibody sc-25674
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACAN, 176, 15q26.1, NM_001135, ...
http://www.scbt.com/datasheet-25674-aggrecan-h-300-antibody....

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Peptides, Peptide Products - GenWay Biotech Inc.
ACAN; AGC1; CSPG1; MSK16 - SYNTHETIC HUMAN AGGRECAN (aa4-17); Aggrecan core protein, Peptide ELISA, Source: N/A Reactivity: Human ...
http://www.genwaybio.com/all_peptides.php...

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Search Results
AGGRECAN; ACAN (1) · SPONDYLOEPIPHYSEAL DYSPLASIA, KIMBERLEY TYPE (1). GO Biological Process. protein binding (1) · extracellular region (1) ...
http://www.sigmaaldrich.com/catalog/Lookup.do?D7=0&D10=&N17=...

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Mitogen Activated Protein Kinase (MAPK)
Gene Symbol. ACAN · COL4A5 · HAPLN1 · TIMP1 · COL4A1 · COL4A6 · HSPG2 · TIMP2 · COL4A3 · FN1 · LAMC3 · TNC. Membrane Receptors and Proteins. Gene Symbol ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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