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DPP4
| Symbol: | DPP4 | | Name(s): | dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ADABP, ADCP2, CD26, DPPIV, TP103 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17944883 |
Since hepatic glycogen synthesis, a GLP-1 action, was impaired, the altered expressions of GLP-1 and DPPIV may be involved in the development of HCV-associated glucose intolerance. |
| 15490304 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17904681 |
DPP-IV enzyme activity appears to be depressed in response to poor glycaemic control in type 2 diabetes. |
| 17846797 |
DPPIV and SDF-1alpha/CXCR4 play crucial roles in regulating the migratory potential of HPMCs, which may be involved in the re-epithelialization of denuded basement membrane at the site of peritoneal injury. |
| 18007554 |
Serum DPPIV activity and staining intensity of CD26 in liver are correlated with histopathologic grade of NASH (Non-alcoholic steatohepatitis)and hepatosteatosis. DPPIV can be proposed as a candidate with several potential functions in NASH pathogenesis. |
| 17610364 |
role for CD26 in in vivo engraftment of hematopoietic stem cells from human umbilical cord blood into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice |
| 17525828 |
Plasma sCD26 was significantly elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface CD26 expression was up-regulated especially on CD4+ and iNKT lymphocytes (all P < 0.05) but not on other cell types. |
| 17786309 |
Increased Dipeptidyl-Peptidase IV activity is associated with astrocytic tumours |
| 12483204 |
The CD26 structure indicates how substrate specificity is achieved and reveals a new and unexpected opening to the active site. |
| 17244786 |
Levels in blood are suppresse after administration of vildagliptin to type 2 diabetics. | →View more information from publications. |
Recent Publications on DPP4: |  |
Efficacy and safety of incretin based therapies: clinical trial data.
OBJECTIVE: Provide a comprehensive overview of efficacy and safety data on... | 30th October, 2009
| Department of Pharmacotherapy, College of Pharmacy, Washington State
| J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S30-40.
DOI Direct Link |
Type 2 diabetes: epidemiology and treatment, pathophysiology, new therapeutics, and the evolving role of the pharmacist.
OBJECTIVE: Provide a comprehensive overview of efficacy and safety data on... | 30th October, 2009
| Washington State University, USA.
| J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S2.
DOI Direct Link |
Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors.
OBJECTIVE: To review the pharmacology (absorption, metabolism,... | 30th October, 2009
| Department of Pharmacotherapy, College of Pharmacy, Washington State
| J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S16-29.
DOI Direct Link |
Identifying Genes for Establishing a Multigenic Test for Hepatocellular Carcinoma Surveillance in Hepatitis C Virus-Positive Cirrhotic Patients.
In this study, we used the Affymetrix HG-U133A version 2.0 GeneChips to... | 29th October, 2009
| 1Department of Biostatistics, 2Massey Cancer Center, 3Division of
| Cancer Epidemiol Biomarkers Prev. 2009 Oct 27.
DOI Direct Link |
Sitagliptin treatment of patients with type 2 diabetes does not affect CD4+ T-cell activation.
Dipeptidyl peptidase IV (DPP4) inhibitors have recently become widely used... | 27th October, 2009
| Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX
| J Diabetes Complications. 2009 Oct 22.
DOI Direct Link |
→View more research publications. |
BioNews Results for DPP4:  |  |
| Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? |
MDLinx: Nov 6 2009 11:00AM Matching: dpp4
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| Zacks Analyst Blog Highlights: Bristol-Myers Squibb Co., AstraZeneca Plc, Merck & Co, GlaxoSmithKline and Eli |
NewsBlaze: Oct 8 2009 3:51AM Matching: dpp4
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| Zacks Analyst Blog Highlights: Bristol-Myers Squibb Co., AstraZeneca Plc, Merck & Co, GlaxoSmithKline and Eli Lilly |
SmartBrief: Oct 8 2009 12:04AM Matching: dpp4
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| Zacks Analyst Blog Highlights: Bristol-Myers Squibb Co., AstraZeneca Plc, Merck & Co, GlaxoSmithKline and Eli |
TradingMarkets: Oct 7 2009 9:49PM Matching: dpp4
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| Zacks Analyst Blog Highlights: Bristol-Myers Squibb Co., AstraZeneca Plc, Merck & Co, |
Forbes.com: Oct 7 2009 9:32PM Matching: dpp4
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| Promote your company here: BioNewsCast - Press Release Distribution | →View more news. |
DPP4 results (if any) from reagent suppliers | 
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WH0001803M3 Monoclonal Anti-DPP4 antibody produced in mouse clone ...
WH0001803M3 Monoclonal Anti-DPP4 antibody produced in mouse clone 1C5, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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DPP4 Antibody
Dipeptidylpeptidase 4 (DPP4) Rabbit anti-Human Polyclonal. Antibody. CONJUGATE: none ... APPLICATION DETAILS: DPP4 antibody can be used for ...
http://www.prosci-inc.com/shop/pdf/48-349.pdf...
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CD26 antibody - Spacer region (ab28340) | Abcam
Synthetic peptide based on the spacer region of human CD26 (DPP4) before the cysteine-rich region. Read Abcam's proprietary immunogen policy ...
http://www.abcam.com/CD26-antibody-Spacer-region-ab28340.htm...
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CD26 (H-270) Antibody sc-9153
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, DPP4, 1803, 2q24.2, NM_001935 ...
http://www.scbt.com/datasheet-9153-cd26-h-270-antibody.html...
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DPP8 antibody - Aminoterminal end (ab42075) | Abcam
DPP-8 has only 27% identity with DPP-4, but seems to have similar substrate specificity. Although DPP-4 and FAP-a form a surface-bound heterodimer in some
...
http://www.abcam.com/DPP8-antibody-Aminoterminal-end-ab42075...
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GLP-1 AND EXENDIN-4 IN FOCUS
tives, and the launch of the first dipeptidyl peptidase-4 (DPP-4) inhibitor for human use, ... pidly produced by the action of DPP-4, which is chief- ...
http://antibodyshop.com/content/download/332/22631/version/1...
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Fibroblast activation protein, alpha antibody (ab54651) | Abcam
FAPa is the alpha subunit and DPP4 (CD26) the beta subunit of a heterodimeric ... Some cells make only FAPa homodimers, some only DPP4 homodimers. ...
http://www.abcam.com/Fibroblast-activation-protein-alpha-ant...
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