Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17944883 |
Since hepatic glycogen synthesis, a GLP-1 action, was impaired, the altered expressions of GLP-1 and DPPIV may be involved in the development of HCV-associated glucose intolerance. |
| 15490304 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17904681 |
DPP-IV enzyme activity appears to be depressed in response to poor glycaemic control in type 2 diabetes. |
| 17846797 |
DPPIV and SDF-1alpha/CXCR4 play crucial roles in regulating the migratory potential of HPMCs, which may be involved in the re-epithelialization of denuded basement membrane at the site of peritoneal injury. |
| 18007554 |
Serum DPPIV activity and staining intensity of CD26 in liver are correlated with histopathologic grade of NASH (Non-alcoholic steatohepatitis)and hepatosteatosis. DPPIV can be proposed as a candidate with several potential functions in NASH pathogenesis. |
| 17610364 |
role for CD26 in in vivo engraftment of hematopoietic stem cells from human umbilical cord blood into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice |
| 17525828 |
Plasma sCD26 was significantly elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface CD26 expression was up-regulated especially on CD4+ and iNKT lymphocytes (all P < 0.05) but not on other cell types. |
| 17786309 |
Increased Dipeptidyl-Peptidase IV activity is associated with astrocytic tumours |
| 12483204 |
The CD26 structure indicates how substrate specificity is achieved and reveals a new and unexpected opening to the active site. |
| 17244786 |
Levels in blood are suppresse after administration of vildagliptin to type 2 diabetics. |
| 17549790 |
Both the glycosylated and unglycosylated forms of GPC3 interact with CD26 peptidase, resulting in inhibition of the enzyme. |
| 12437097 |
REVIEW: expression and effects on immune cells |
| 15695814 |
HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bind to the active site of dipeptidyl-peptidase IV |
| 17492130 |
analysis of human dipeptidyl peptidase IV in its apo and diprotin B-complexed forms |
| 12832764 |
structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine |
| 16621928 |
Results indicate that the adhesion mechanism by endometrial CD26 may be involved in human blastocyst implantation. |
| 16700520 |
Results describe dipeptidyl peptidase-IV activity in synovial fluid and plasma of patients with rheumatoid and psoriatic arthritis. |
| 16700525 |
overexpression in HEK293 cells reduced cell adhesion, migration and invasion on ECM components, increased proliferation and promoted apoptosis, independently of enzyme activity |
| 15027119 |
DPPIV functions as a tumor suppressor, and its downregulation may contribute to the loss of growth control in NSCLC cells |
| 12175726 |
CD26 interferes with transduction pathway(s) needed for the maturation of T cells and plays an important role in T lymphocyte homeostasis in peripheral blood. |
| 12023964 |
expression of the seprase-DPPIV complex is restricted to migratory cells involved in wound closure |
| 14718659 |
crystal structures of DPPIV in the free form and in complex with the first 10 residues of the physiological substrate, neuropeptide Y (residues 1-10; tNPY) |
| 15146553 |
CD26/DPPIV is likely to directly modulate various SDF-1alpha induced functions |
| 15375776 |
summarize key aspects of CD26/DPPIV involvement in tumor biology and its potential role in cancer development and behavior |
| 16700508 |
expression and function of dipeptidyl peptidase IV and related enzymes in cancer; upregulation is apparently accompanied by decreased proliferation or survival of glioma cells |
| 16778789 |
Our data provide first evidence for a functional role of DP IV and APN in the sebaceous gland apparatus and for their inhibitors, used alone or in combination, as completely new substances possibly affecting acne pathogenesis in a therapeutic manner. |
| 11901152 |
Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. |
| 12112826 |
galectin-3 and CD26/DPPIV as preoperative diagnostic markers for thyroid nodules |
| 15215186 |
Adenosine down-regulates the surface expression of DPP4 on HT29 cells. |
| 15292258 |
A mutant stromal cell derived factor-1 that does not interact with heparan sulsfate is readily cleaved by Dipepidtyl peptidase IV. |
| 15353589 |
results suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation. |
| 12239451 |
Increased expression in human mesothelial cells by malignant ascites from ovarian carcinoma patients |
| 15213224 |
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase |
| 12579300 |
Review. CD26 has an essential role in human T-cell activation, as well as its ability to regulate the biological effects of selected chemokines through its DPPIV activity. |
| 15866709 |
The DAP IV from Pseudomonas sp. WO24 is expressed as 82 and 84-kDa isoforms, having two Met, Met-1 and Met-12, in its N-terminal sequence. |
| 11773049 |
Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans |
| 12031601 |
Decrease of serum dipeptidylpeptidase activity in severe sepsis patients: relationship to procalcitonin. |
| 14691230 |
Glycosylation of DPPIV is not a prerequisite for catalysis, dimerization, or adenosine deaminase binding. |
| 15540901 |
adult T-cell leukemia cells down-regulate CD26 antigens by means of epigenetic machinery; faintly detected transcripts of the gene were aberrantly methylated at the CpG islands within the promoter region in parallel with the advancement of ATL |
| 14525771 |
strong physical linkage of CD26 with CD45RA outside lipid rafts may be responsible for the attenuation of T-cell activation signaling through CD26 |
| 15911629 |
PLG has the potential to simultaneously regulate calcium signaling pathways and regulate pHi via an association with NHE3 linked to DPP IV, necessary for tumor cell proliferation and invasiveness |
| 16781669 |
both wild HNF-1alpha and wild HNF-1beta have a stimulatory effect on DPP-IV gene expression, but that mutant hepatocyte nuclear factors (HNF)-1alpha and mutant HNF-1beta attenuate the stimulatory effect |
| 12675218 |
an examination of the substrate specificity of this enzyme (REVIEW) |
| 12675220 |
The active site of this enzyme is examined and compared with Porphyromonas gingivalis. |
| 12675229 |
The kinetics of this enzyme are examined, after cloning in Pichia pastoris. |
| 12675231 |
Protein-protein interactions dependent on this enzyme are investigated using surface plasmon resonance. |
| 12675232 |
This protein acts synergistically with APN to regulate T cell function. |
| 12675233 |
An increase in this enzyme is associated with graft rejection. Inhibition of this enzyme prevents kieney graft rejection. |
| 12675238 |
plays a role in the digestion of an immunodominant epitope in celiac disease |
| 12675243 |
This enzyme is expressed in cutaneous infiltrates from patients with cutaneous T-cell lymphoma. |
| 12675245 |
This enzyme is expressed in endometrial adenocarcinoma and is negatively correlated with tumor grade. |
| 12675246 |
Adhesion to mesothelial is increased by overexpression of dipeptidyl peptidase IV. |
| 12675247 |
This enzyme suppresses ovarian carcinoma in peritoneal dissemination in vitro and in vivo. |
| 12675248 |
This enzyme is active in prostatic secretions and prostate cancer. |
| 12675253 |
This enzyme is a marker of mood in anorexia nervosa and bulimia nervosa patients. |
| 12675254 |
Serum levels are decreased in patients with Crohn and inflammatory bowel disease who are clinically depressed. |
| 12595736 |
crystals of dipeptidylpeptidase IV belongs to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 118.04, b = 125.92, c = 136.84 A, and diffracts beyond 2.6 A resolution |
| 15864535 |
Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes |
| 15175333 |
the catalytic mechanism of dipeptidyl peptidase IV requires tyrosine 547 |
| 15323360 |
review of structure, function and tissue distribution of CD26 [review] |
| 15448155 |
identified the C-terminal loop as essential for dimer formation and optimal catalysis |
| 15681827 |
decreased circulating CD26 levels in arthritis may influence CD26-mediated regulation of the chemotactic SDF-1/CXCR4 axis |
| 15819895 |
comparison of the structure of X-PDAP from Lactococcus lactis (PepX) with its human counterpart DPP-IV |
| 17071493 |
CD26 and cell surface adenosine deaminase are selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma |
| 17287217 |
Ligation of CD26 by caveolin-1 recruits a complex, including CD26 and CARMA1, which functions in lymphocyte activation. |
| 12634639 |
Expressed in normal endometrial glandular cells, but expression in endometrial adenocarcinoma is down-regulated with increasing grade. Regulatory role in neoplastic transformation and progression of endometrial adenocarcinomas. |
| 12529175 |
catalytic properties and inhibition of this proline-specific enzyme |
| 15797249 |
analysis of substrate binding sites of human dipeptidyl peptidase-IV |
| 16611738 |
Report shows that adenosine downregulation of DPPIV from the surface of colon cancer cells occurs independently of the classic receptors, and is mediated by a novel cell-surface mechanism that induces an increase in protein tyrosine phosphatase activity. |
| 16704418 |
The dipeptidyl peptidase IV gene family contains the four peptidases dipeptidyl peptidase IV, fibroblast activation protein, dipeptidyl peptidase 8 and dipeptidyl peptidase 9. |
| 12095981 |
DPIV mediated transcellular proteolysis |
| 11739489 |
Soluble CD26 induces T cell proliferation in Antigen presenting cells |
| 12727530 |
elevated serum levels in chronic hepatitis C and other viral infections suggest that this activity originates not only from the liver, but also from other sources such as peripheral blood cells involved in the control of viral infections. |
| 12471135 |
The process of CXCL12/SDF-1 alpha cleavage by CD26/DPPIV on a subpopulation of cord blood CD34+ cells represents a novel regulatory mechanism in hemopoietic stem and progenitor cells for the migration, homing, and mobilization of these cells. |
| 12820316 |
This enzyme is a marker in thyroid tumors. |
| 12213886 |
Involvement in extravillous trophoblast invasion and differentiation |
| 11882590 |
DPPIV activity is depressed in individuals with hypertension during acute ACEI-associated angioedema. |
| 12047913 |
chromogranin B(586-602) peptide can serve as a substrate for the lymphocyte surface glycoprotein CD26, also known as dipeptidyl peptidase IV (DPP IV), generating a new peptide ER-15 (CgB(588-602)) |
| 12176563 |
examination of expression and enzymatic activity in recipients of kidney allografts |
| 12767062 |
Increased adhesion of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV. |
| 12646248 |
report the structure of human dipeptidyl peptidase IV especially focusing on a unique eight-bladed beta-propeller domain; discuss the way for the access of the substrate to this domain |
| 15016824 |
Adenosine deaminase binding is diminished by mutation of ADA residues known to interact with CD26. |
| 15002062 |
Plasma DPP-IV hyperactivity in the obese did not seem to be affected by the overweight degree. Selective DPP-IV inhibitors could represent an ideal approach to obesity management. |
| 16829852 |
The presence of dipeptidyl peptidase IV can be used to support diagnosis of deep penetrating nevi in doubtful cases. Loss of dipeptidyl peptidase IV may also be causally linked to the transition of invasive to metastatic phenotypes. |
| 17270095 |
Significantly higher serum DPP IV and aminopeptidase N activities (P<0.001) were found in tonsillar hypertrophy patients compared with those with recurrent tonsillitis |
