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JAG1
| Symbol: | JAG1 | | Name(s): | jagged 1 (Alagille syndrome) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AGS, AHD, AWS, CD339, HJ1, JAGL1, MGC104644 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12427653 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16934875 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17368936 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17661408 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18060036 |
IL-6 treatment triggered Notch-3-dependent upregulation of the Notch ligand Jagged-1 and promotion of MS and MCF-7-derived spheroid growth |
| 17720887 |
Mutations in JAGGED1 is associated with Notch signaling inhibition and Alagille syndrome |
| 17984306 |
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer |
| 17822320 |
Overexpression of jagged1 is associated with breast cancer |
| 14726396 |
Notch receptors 1&2 and their ligand Jagged1 are highly expressed in cultured and primary MM cells, suggesting Notch signaling is involved in the tight interactions between neoplastic plasma cells and their bone marrow microenvironment |
| 11964309 |
interaction with Notch1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Jagged 1 | notch1 preproprotein | - | - | Pubmed |
| HPRD | Jagged 1 | notch 2 preproprotein | - | - | Pubmed |
| BIND | Human DNA sequence from clone RP5-1099D15 on chromosome 20 Contains the 3' end of a novel gene, the JAG1 gene encoding Jagged 1, a pseudogene aimilar to DNAJ protein, a CpG island, ESTs, STSs and GSSs. | jun oncogene | c-Jun interacts with Jagged1 promoter. | - | Pubmed |
| BIND | Human DNA sequence from clone RP5-1099D15 on chromosome 20 Contains the 3' end of a novel gene, the JAG1 gene encoding Jagged 1, a pseudogene aimilar to DNAJ protein, a CpG island, ESTs, STSs and GSSs. | v-fos FBJ murine osteosarcoma viral oncogene homolog | c-Fos interacts with Jagged1 promoter. | - | Pubmed |
| HPRD | jagged 1 precursor | Notch2 | - | - | Pubmed |
| HPRD | jagged 1 precursor | Notch 1 | - | - | Pubmed |
| HPRD | jagged 1 precursor | Notch homolog 3 | - | - | Pubmed |
| HPRD | jagged 1 precursor | Notch homolog 3 | - | - | Pubmed |
| HPRD | jagged 1 precursor | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | - | - | Pubmed |
| HPRD | jagged 1 precursor | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | - | - | Pubmed |
Recent Publications on JAG1: |  |
The tetralogy of Fallot-associated G274D mutation impairs folding of the second epidermal growth factor repeat in Jagged-1.
Notch signaling controls spatial patterning and cell-fate decisions in all... | 29th October, 2009
| Protein Structure and Bioinformatics Group, International Centre for
| FEBS J. 2009 Nov;276(21):6247-57. Epub 2009 Sep 23.
DOI Direct Link |
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.
Increased expression of Notch signaling pathway components is observed in... | 10th October, 2009
| Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University
| PLoS Pathog. 2009 Oct;5(10):e1000616. Epub 2009 Oct 9.
DOI Direct Link |
The function of Notch1 signaling was increased in parallel with neurogenesis in rat hippocampus after chronic fluoxetine administration.
Chronic fluoxetine administration can increase neurogenesis in the adult... | 6th October, 2009
| School of Clinical Medicine, Southeast University, Nanjing, China.
| Biol Pharm Bull. 2009 Oct;32(10):1776-82.
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Novel human pathological mutations. Gene symbol: JAG1. Disease: Alagille syndrome.
Notch signaling controls spatial patterning and cell-fate decisions in all... | 9th September, 2009
| Lab. Genetica Molecolare, Ospedali Riuniti, Bergamo, Italy.
| Hum Genet. 2009 Aug;126(2):350-1.
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Novel human pathological mutations. Gene symbol: JAG1. Disease: Alagille syndrome.
Notch signaling controls spatial patterning and cell-fate decisions in all... | 9th September, 2009
| Lab. Genetica Molecolare, Ospedali Riuniti, Bergamo, Italy.
| Hum Genet. 2009 Aug;126(2):350.
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→View more research publications. |
JAG1 results (if any) from reagent suppliers | 
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Search Bioportfolio and other Life Science Sites for JAG1,
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