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DVL1


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Symbol:DVL1
Name(s):dishevelled, dsh homolog 1 (Drosophila)
Type:protein-coding
Organism:Homo sapiens
Synonyms:DVL, MGC54245
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11803455 Observational study of gene-disease association. (HuGE Navigator)
18162551 a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1
14684739 interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates
15262978 Ccd1 drastically inhibited JNK activation both by Axin and by Dvl.
12556519 CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin
16621789 BMP-2 antagonizes Wnt-3a signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation
12824876 Amplification and increased expression of the DVL-1 gene is associated with breast carcinogenesis
11803455 The DVL1 gene spans a region of approximately 13.8 kb with 15 exons and six rare sequence variations. None of these had any association with late onset AD.
16457155 DVL1 was overexpressed in prostate cancer and its overexpression might be related to prostate cancer progression through the Wnt/beta-catenin pathway.
12883684 amplification and increased expression of the DVL-1 gene may play some role in the development of a portion of human cervical squamous cell cancer through derangement of the Wnt signaling pathway

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDarrestin beta 1 isoform Adishevelled 1--Pubmed
HPRDarrestin beta 1 isoform Adishevelled 1--Pubmed
HPRDCasein kinase 1, deltadishevelled 1--Pubmed
HPRDcasein kinase 1, delta isoform 1Dishevelled 1--Pubmed
HPRDcasein kinase 1 epsilondishevelled 1--Pubmed
HPRDcasein kinase 1 epsilondishevelled 1--Pubmed
HPRDCK2, alpha 1dishevelled 1--Pubmed
HPRDCasein kinase II, alpha 1dishevelled 1--Pubmed
HPRDcasein kinase II alpha 1 subunit isoform aDishevelled 1--Pubmed
HPRDBeta catenindishevelled 1--Pubmed

Recent Publications on DVL1:

Pubmed Logo
Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells.
Murine Prickle1 and Prickle2 belong to the planar cell polarity genes....
1st October, 2009
Biomedical Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Neurosci Lett. 2009 Dec 18;467(1):6-10. Epub 2009 Sep 27.
DOI Direct Link
Identification of tripeptides recognized by the PDZ domain of Dishevelled.
The development of inhibitors of Dishevelled (Dvl) PDZ protein-protein...
17th September, 2009
Department of Structural Biology, St Jude Children's Research Hospital, Bioorg Med Chem. 2009 Feb 15;17(4):1701-8. Epub 2009 Jan 3.
DOI Direct Link
Duplications and expression of DIVARICATA-like genes in dipsacales.
The genetics underlying flower symmetry shifts between radial and...
1st September, 2009
Department of Biological Sciences, St. John's University, Queens, NY, USA. Mol Biol Evol. 2009 Jun;26(6):1245-58. Epub 2009 Mar 16.
DOI Direct Link
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.
Mutations in PARK8, encoding LRRK2, are the most common known cause of...
25th July, 2009
Department of Pharmacology, The School of Pharmacy, Brunswick Square, Hum Mol Genet. 2009 Oct 15;18(20):3955-68. Epub 2009 Jul 22.
DOI Direct Link
Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution.
Dishevelled (Dvl) proteins are key transducers of Wnt signaling encoded by...
21st July, 2009
Section of Molecular Cell and Developmental Biology, University of Texas, Dev Dyn. 2009 Aug;238(8):2044-57.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7595152 Detection of influenza virus
7312041 Methods of diagnosing cervical cancer
7304060 Indazolyl-substituted pyrroline compounds as kinase inhibitors
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof
6967862 Semiconductor memory device with magnetic disturbance reduced

View more patents.

DVL1 results (if any) from reagent suppliers

Google CSE Logo
Dishevelled / Dvl1 antibody (ab21062) | Abcam
Rabbit polyclonal to Dishevelled / Dvl1. Dishevelled proteins act as scaffolds essential for Wnt signaling, providing docking sites for protein kinases, ...
http://www.abcam.com/Dishevelled-Dvl1-antibody-ab21062.html...

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Dvl-1 (3F12) Antibody sc-8025
See how others have used Dvl-1 (3F12): sc-8025 antibody and or Dvl-1 (3F12) ... Western blot analysis of Dvl-1 expression in SK-N-SH (A) and KNRK (B) whole ...
http://www.scbt.com/datasheet-8025-dvl-1-3f12-antibody.html...

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D3320 Anti-DVL1 (C-terminal) antibody produced in rabbit ~1.5 mg ...
D3320 Anti-DVL1 (C-terminal) antibody produced in rabbit ~1.5mg/mL, affinity isolated antibody, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=D332...

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Dishevelled / Dvl1 antibodies: Stem Cells > Signaling Pathways ...
Dishevelled / Dvl1 antibodies. ... Dishevelled / Dvl1 antibody. Fast Track. Images · unrated. Rabbit polyclonal. Predicted: Hu. Terms and conditions · Legal
...
http://www.abcam.com/index.html?t=112887&pt=1&c=3457&ei=&mu=...

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Dvl-1 (3F12) Antibody sc-8025
Dvl-1 shRNA (h) Lentiviral Particles, sc-35228-V, 200 µl ... Dvl-1 (3F12): sc- 8025. Western blot analysis of Dvl-1 expression in SK-N-SH (A) and KNRK (B) ...
http://www.scbt.com/ko/datasheet-8025-dvl-1-3f12-antibody.ht...

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Neurobiology
D3570, Anti-DVL1 antibody produced in rabbit ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution, antigen mol wt ~85 kDa New, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Dishevelled Antibody / Dishevelled Antibodies
Dvl-1 (3F12) Antibody, sc-8025, mouse IgG2a, 651-695 (m), WB, IP, ELISA, m, r, h ... Dvl-1 (Q-25) Antibody, sc-133525, rabbit IgG, N/A, WB, IP, ELISA, human ...
http://www.scbt.com/table-dishevelled.html...

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disheveled gene | disheveled protein | dsh gene wnt | dsh gene wnt | lrrk2 dishevelled | gene expression DVL | 3f12 dishevelled | antibody BMP-2 rabbit WB IP | Amplification up-regulation and over-expression of DVL-1 the human counterpart of the Drosophila disheveled gene in primary breast cancers | .


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