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DYRK1A
| Symbol: | DYRK1A | | Name(s): | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DYRK, DYRK1, HP86, MNB, MNBH | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18005339 |
Over-expression of DYRK1A in Down syndrome may play a role in accelerating Alzheimer's disease pathogenesis through phosphorylation of beta-amyloid precursor protein (APP). |
| 17906291 |
DYRK1A has a role in the hyperphosphorylation of Tau and an extra copy of the DYRK1A gene contributes to the early onset of Alzheimer disease |
| 17536841 |
DYRK does not require tyrosine phosphorylation for activity in vitro. |
| 16919501 |
There is now compelling evidence that the protein products of two genes on chromosome 21, Down syndrome candidate region 1 (DSCR1) and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), interact functionally. |
| 17135279 |
Our result indicates that DYRK1A could be a key molecule bridging between beta-amyloid production and tau phosphorylation in AD. |
| 12964950 |
Overexpression of DYRK1A induces multinucleation through overduplication of the centrosome during interphase. |
| 15694837 |
encodes a serine-threonine kinase but despite its potential involvement in the neurobiological alterations associated with Down syndrome |
| 14623875 |
characterize cyclin L2 as a highly mobile component of nuclear speckles and suggest that DYRK1A may regulate splicing by phosphorylation of cyclin L2 |
| 15917294 |
DYRK1A may play a critical role in Ras-dependent transducing signals that are required for promoting or maintaining neuronal differentiation |
| 16733250 |
Mnb/Dyrk1A is responsible for in vivo phosphorylation of amphiphysin I at serine-293. | →View more information from publications. |
Recent Publications on DYRK1A: |  |
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.
DYRK1A is a dual-specificity protein kinase that autophosphorylates a... | 29th October, 2009
| Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH
| FEBS J. 2009 Nov;276(21):6324-37. Epub 2009 Oct 1.
DOI Direct Link |
Function and regulation of Dyrk1A: towards understanding Down syndrome.
Down syndrome (DS) is associated with a variety of symptoms, such as... | 23rd October, 2009
| Department of Biology, College of Life Science and Biotechnology, Yonsei
| Cell Mol Life Sci. 2009 Oct;66(20):3235-40. Epub 2009 Aug 14.
DOI Direct Link |
Two New Peltogynoids from Acacia nilotica Delile with Kinase Inhibitory Activity.
Two new peltogynoids, acanilol A ( 1) and acanilol B ( 2), were isolated... | 22nd October, 2009
| Department of Pharmacognosy and Natural Products Chemistry, Faculty of
| Planta Med. 2009 Oct 20.
DOI Direct Link |
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
BACKGROUND: Hyperhomocysteinemia, characterized by increased plasma... | 22nd October, 2009
| University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive
| PLoS One. 2009 Oct 21;4(10):e7540.
DOI Direct Link |
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).
A series of substituted 6-arylquinazolin-4-amines were prepared and... | 20th October, 2009
| NIH Chemical Genomics Center, National Human Genome Research Institute,
| Bioorg Med Chem Lett. 2009 Oct 3.
DOI Direct Link |
→View more research publications. |
DYRK1A results (if any) from reagent suppliers | 
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DYRK1A Antibody #2771
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to human DYRK1A. Antibodies are purified by
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http://www.cellsignal.com/products/2771.html...
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DYRK1A antibody (ab16140) | Abcam
Sheep polyclonal to DYRK1A. DYRK1A, the vertebrate of Drosophilia Minibrain, is a dual-specificity kinase predominately expressed in the central nervous ...
http://www.abcam.com/DYRK1A-antibody-ab16140.html...
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DYRK1A Antibody
Tyr residue (e.g. Tyr312 of DYRK1A) necessary for kinase activity. ... corresponding to human DYRK1A. Antibodies are purified ...
http://www.cellsignal.com/pdf/2771.pdf...
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Dyrk1A (G-19) Antibody sc-12568
See how others have used Dyrk1A (G-19): sc-12568 antibody and or Dyrk1A (G-19) antibody ... The role of overexpressed DYRK1A protein in the early onset of ...
http://www.scbt.com/datasheet-12568-dyrk1a-g-19-antibody.htm...
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DYRK1A Antibody (Center)
Western blot analysis of DYRK1A Antibody (Center) polyclonal antibody (Cat. ... DYRK1A (arrow) was detected using the purified Pab (1:60 dilution). ...
http://www.abgent.com/products/catalog_no/AP7555c...
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Dyrk Antibody / Dyrk Antibodies
Dyrk1A (RR.7) Antibody, sc-100376, mouse IgG2b, FL (h), WB, IP, ELISA, m, h. Dyrk1A (S-21) Antibody, sc-130741, rabbit IgG, N/A, WB, IP, ELISA, human ...
http://www.scbt.com/table-dyrk.html...
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DYRK1A Antibody (N-term)
DYRK1A Antibody (N-term) Cell Function, DYRK1A Antibody (N-term) Neurosciences, DYRK1A Antibody (N-term) Nuclear Signaling, DYRK1A Antibody (N-term) Protein ...
http://www.abgent.com/products/catalog_no/AP7537a...
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