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E2F1


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Symbol:E2F1
Name(s):E2F transcription factor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:E2F-1, RBBP3, RBP3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18328430 Suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer.
18172256 E2F-1 is a potentially novel independent prognostic factor that may identify gastric cancer patients who will likely benefit from adjuvant chemoradiation therapy following curative resection.
18039672 RhoBTB2 up-regulated during drug-induced apoptosis, with this being primarily dependent on E2F1.
18172323 CARM1 is a critical factor in the pathway of estrogen-stimulated breast cancer growth downstream of ERA and AIB1and upstream of the cell cycle regulatory transcription factor E2F1.
18167336 A subset of E2F1 target genes that are specifically repressed by PI3K/Akt signaling, thus distinguishing the E2F1 proliferative or apoptotic function, is identified.
17910524 Clear cell renal cell carcinoma is characterized by the overexpression of E2F1, which is likely a result of a deregulated control of T3-dependent molecular processes.
17908821 E2F1binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells
17913805 Human herpesvirus 6A (HHV-6A) and HHV-6B infection was associated with significant reduction of E2F1/Rb complexing, altered E2F1 localization and cell cycle arrest in T cells.
17686574 ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels
17825503 the E2F1 transcription factor, which is implicated in carcinoma invasiveness, upregulates the expression of PACE4

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHuman apoptosis inhibitor survivin gene, and translated productsE2F transcription factor 1E2F1 (E2F-1) interacts with the BIRC5 (survivin) promoter.-Pubmed
BINDHomo sapiens chromosome 2E2F transcription factor 1E2F1 interacts with the BARD1 promoter.-Pubmed
HPRDbreast cancer 1, early onset isoform 1E2F transcription factor 1--Pubmed
HPRDbreast cancer 1, early onset isoform 1E2F transcription factor 1--Pubmed
BINDbreast cancer 1, early onset isoform 1E2F transcription factor 1BRCA1 associates with E2F-1-Pubmed
BINDHomo sapiens cyclin A2 gene, complete cds.E2F transcription factor 1E2F interacts with the CycA promoter and 5-prime UTR.-Pubmed
HPRDcyclin AE2F transcription factor 1--Pubmed
HPRDcyclin AE2F transcription factor 1--Pubmed
BINDHomo sapiens chromosome 10E2F transcription factor 1E2F1 interacts with the Cdc2 promoter.-Pubmed
BINDHomo sapiens chromosome 17, reference assembly.E2F transcription factor 1E2F1 interacts with the Cdc6 promoter region.-Pubmed

Recent Publications on E2F1:

Pubmed Logo
Transcriptional activation of pref-1 by E2F1 in 3T3 L1 cells.
The E2F gene family appears to regulate the proliferation and...
31st October, 2009
Department of Biology, BMB Rep. 2009 Oct 31;42(10):691-6.
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities.
Although cancers have altered glucose metabolism, termed the Warburg...
29th October, 2009
Authors' Affiliation: Division of Hematology, Department of Medicine, Clin Cancer Res. 2009 Oct 27.
DOI Direct Link
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.
ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that...
29th October, 2009
Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Nat Struct Mol Biol. 2009 Oct;16(10):1086-93. Epub 2009 Sep 27.
DOI Direct Link
E2F1 Expression Predicts Outcome in Korean Women Who Undergo Surgery for Breast Carcinoma.
BACKGROUND: The transcriptional factors E2F1 and E2F2 have been reported...
21st October, 2009
Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University Ann Surg Oncol. 2009 Oct 20.
DOI Direct Link
E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary Tumors.
Rb/E2F is dysregulated in murine and human pituitary tumors. Pituitary...
20th October, 2009
Departments of Medicine (C.Z., K.W., S.G., S.M.) and Pathology (S.B.), Mol Endocrinol. 2009 Oct 16.
DOI Direct Link

View more research publications.

BioNews Results for E2F1

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Apoptosis Cell Biology: Scientists at University of Lausanne, Center for Integrative Genomics detail research in apoptosis cell biology
NewsRX:  Nov 14 2009 6:48AM Matching: e2f1
Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression
Cell Death and Differentiation:  Nov 6 2009 12:02PM Matching: e2f1
E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases
EMBO Journal:  Oct 21 2009 10:39AM Matching: e2f1

Patents:

Patents logo
US Patent No.Title
7238372 Methods for inhibiting tumor cell proliferation
7381526 Assays for drug discovery based on microcompetition with a foreign polynucleotide
7384776 Expression vectors for increasing protein yield from a cell culture and methods of use thereof
7396679 Oncolytic adenovirus
7399851 Composition and method for imaging cells

View more patents.

E2F1 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
E2F1 antibodies. ... E2F1 antibody [1G10]. IP, WB, ICC/IF. Mouse monoclonal ... E2F1 antibody [KH95] (Biotin). IHC-P, WB, ICC/IF, IP. Mouse monoclonal ...
http://www.abcam.com/index.html?t=13756&pt=1&c=3423...

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E2F-1 Antibody #3742
Western blot analysis of extracts from HeLa cells, untransfected (-) or transfected with E2F1 siRNA (+) to silence E2F1 protein expression, using E2F-1
...
http://www.cellsignal.com/products/3742.html...

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E2F1 antibody [KH129] (ab11950) | Abcam
Mouse monoclonal [KH129] to E2F1. E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, ...
http://www.abcam.com/E2F1-antibody-KH129-ab11950.html...

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E2F1 Antibody
Specific antibody for the gene product of E2F1, the protein E2F transcription factor 1. Validated for specificity by gene-silencing with siRNA followed by ...
http://www.piercenet.com/products/browse.cfm?fldID=F31B2780-...

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E2F1 Antibody (S337)
Western blot analysis of anti-E2F1 Antibody (S337) (Cat.#AP7593a) in 293 cell line lysates (35ug/lane). E2F1(arrow) was detected using the purified Pab ...
http://www.abgent.com/products/catalog_no/AP7593a_E2F1_Antib...

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E8901 Monoclonal Anti-E2F1 antibody produced in mouse ~0.5 mg/mL ...
E8901 Monoclonal Anti-E2F1 antibody produced in mouse ~0.5mg/mL, clone KH20, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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E2F1 Transcription Factors - FabGennix Inc. International >> Products
There are 5 types of E2F transcription factors (E2F1-E2F5) that are known to ... The E2F1-selective antibodies were generated against three antigenic ...
http://www.fabgennix.com/prod_details.asp?myproduct=Antibodi...

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Inhibition of drug metabolism by E2F1 | e2f1 siRNA proliferation | ID4 E2F | repression on PI3K and E2F1 | stomach cancer gene e2f1 | e2f transcription factor | nature e2f1 review 2009 | E2F1 mediated AkT phosphorylation | The execution of the transcriptional axis mutant p53 E2F1 and ID4 promotes tumor neo-angiogenesis. | .


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