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E2F2


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Gene DB Home
Symbol:E2F2
Name(s):E2F transcription factor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:E2F-2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17916908 identify a novel E2F-binding site in the survivin promoter and show that mutation of either the p53- or E2F-binding sites is sufficient to increase promoter activity
17588684 Up-regulation of E2F2 was detected in a set of 54 astrocytomas of different grades and significantly associated with malignancy.
12566389 E2F2 has a role in blood pressure regulation via a component of the endothelin system
17341621 Proliferation-promoting E2F transcription factor E2F-2 plays a pivotal role in the tumor biology of ovarian cancer.
12411495 determination of interaction with RYBP and YY1
17135249 E2F1, E2F2, and E2F3 directly bind the promoter of the mir-17-92 cluster, activating its transcription. miR-20a from the mir-17-92 cluster in turn modulates the translation of E2F2 and E2F3, suggesting an autoregulatory feedback loop.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHomo sapiens chromosome 17, reference assembly.E2F transcription factor 2E2F2 interacts with the Cdc6 promoter region.-Pubmed
BINDHomo sapiens chromosome 3E2F transcription factor 2E2F2 interacts with the Cdc25A promoter region.-Pubmed
HPRDcyclin-dependent kinase 3E2F transcription factor 2--Pubmed
HPRDcyclin-dependent kinase 3E2F transcription factor 2--Pubmed
BINDHomo sapiens chromosome 20, reference assembly.E2F transcription factor 2E2F2 interacts with the E2F1 promoter region.-Pubmed
HPRDE2F Transcription factor 2transcription factor Dp-2--Pubmed
HPRDE2F Transcription factor 2transcription factor Dp-1--Pubmed
HPRDE2F Transcription factor 2Sp1 transcription factor--Pubmed
BINDHomo sapiens chromosome 1E2F transcription factor 4E2F4 interacts with the E2F2 promoter.-Pubmed
BINDHomo sapiens chromosome 1retinoblastoma-like 2RBL2 (p130) interacts with the E2F2 promoter.-Pubmed

Recent Publications on E2F2:

Pubmed Logo
Regulation of vascular contractility and blood pressure by the E2F2 transcription factor.
BACKGROUND: Recent studies have identified a polymorphism in the...
30th October, 2009
Assistant Professor, Feinberg Cardiovascular Research Institute, Circulation. 2009 Sep 29;120(13):1213-21. Epub 2009 Sep 14.
DOI Direct Link
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers...
29th October, 2009
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Br J Cancer. 2009 Oct 20;101(8):1461-8. Epub 2009 Sep 8.
DOI Direct Link
E2F1 Expression Predicts Outcome in Korean Women Who Undergo Surgery for Breast Carcinoma.
BACKGROUND: The transcriptional factors E2F1 and E2F2 have been reported...
21st October, 2009
Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University Ann Surg Oncol. 2009 Oct 20.
DOI Direct Link
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.
Differentiation of erythroid cells requires precise control over the cell...
15th October, 2009
Division of Molecular Genetics and Development, Institute for Molecular J Biol Chem. 2009 Jul 31;284(31):20966-74. Epub 2009 May 20.
DOI Direct Link
E2F2 suppresses Myc-induced proliferation and tumorigenesis.
Deregulation of E2F transcriptional activity as a result of alterations in...
3rd October, 2009
The University of Texas MD Anderson Cancer Center, Science Park Research Mol Carcinog. 2009 Oct 1.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7612572 Probe and method of manufacturing a probe
6841385 Transcription factor E2F DNA-binding domain inhibitor peptides and their use
6777177 Mammalian genes involved in viral infection and tumor suppression
6727063 Single nucleotide polymorphisms in genes
6649158 Methods and compositions to induce antitumor response

View more patents.

E2F2 results (if any) from reagent suppliers

Google CSE Logo
E2F2 antibody (ab14292) | Abcam
Chicken polyclonal to E2F2. E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F2 is regulated by complex ...
http://www.abcam.com/E2F2-antibody-ab14292.html...

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MONOCLONAL ANTI-E2F2, CLONE CC11 Purified Mouse Immunoglobulin ...
Monoclonal Anti-E2F2 reacts specifically with human. E2F2 and does not detect the other members ... specifically with E2F2 are useful tools in the study of
...
https://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashe...

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E2F2 antibodies: Chromatin and Nuclear Signaling > Transcription ...
E2F2 antibodies. ... E2F2 antibody [CC11]. IP, WB, GSA. Mouse monoclonal. Reacts with: Hu. Terms and conditions · Legal · Privacy policy ...
http://www.abcam.com/index.html?t=13656&pt=1&c=3579&ei=&mu=r...

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E2F-2 (C-20) Antibody sc-633
Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. Mol.
Cell. ...
http://www.scbt.com/datasheet-633-e2f-2-c-20-antibody.html...

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MONOCLONAL ANTI-E2F1, CLONE KH20 Purified Mouse Immunoglobulin ...
to E2F2 and E2F3) and phosphorylates the relevant DP partner, thereby suppressing E2F DNA ... with E2F2 are useful tools in the study of the detailed
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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E2F-2 (TFE-25) Antibody sc-9967
Mouse, E2f2, 242705, 4 D3, P56931 ... Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. J. Virol. 81: 13191-13199. ...
http://www.scbt.com/datasheet-9967-e2f-2-tfe-25-antibody.htm...

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E2F1 Transcription Factors - FabGennix Inc. International >> Products
A double mutant of E2F1/E2F2 mouse has shown to develop non-autoimmune ... These antibodies do not cross react to E2F2, F3, F4 F5 or F6 proteins. ...
http://www.fabgennix.com/prod_details.asp?myproduct=Antibodi...

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