Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

E2F3


Suggest Content
Advertise Here
Gene DB Home
Symbol:E2F3
Name(s):E2F transcription factor 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp686C18211, E2F-3, KIAA0075, MGC104598
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17925491 requirement of E2F3 for BCR/ABL leukemogenesis
17701752 Study demonstrates the strength of E2F3 as a potential marker for discriminating benign and malignant disease, addressing the current limitations of serum PSA measurements.
12748276 Data suggest that the physical interaction of TFE3 and E2F3 facilitates transcriptional activation of the p68 gene and provides strong evidence for the specificity of E2F function.
16007192 results suggest that DEK and E2F3 are potential targets of 6p gains in retinoblastoma
16938365 E2F3 is overexpressed in 55-70% of squamous cell carcinomas and 79% of adenocarcinomas of the lung. In addition very high level expression of nuclear E2F3 is found in almost all small cell lung cancers analysed.
14716298 In bladder cancer, the E2F3 gene is associated with overexpression of its encoded mRNA transcripts and high levels of E2F3 expression.
15122326 We conclude that E2F3 is frequently amplified and overexpressed in invasively growing bladder cancer (stage pT1-4). E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in a subset of bladder tumors.
12411495 determination of interaction with RYBP and YY1
16909110 E2F3 levels have a critical role in modifying cellular proliferation rate in human bladder and prostate cancer.
17135249 E2F1, E2F2, and E2F3 directly bind the promoter of the mir-17-92 cluster, activating its transcription. miR-20a from the mir-17-92 cluster in turn modulates the translation of E2F2 and E2F3, suggesting an autoregulatory feedback loop.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHuman apoptosis inhibitor survivin gene, and translated productsE2F transcription factor 3E2F3 (E2F-3) interacts with the BIRC5 (survivin) promoter.-Pubmed
BINDHomo sapiens chromosome 10E2F transcription factor 3E2F3 interacts with the Cdc2 promoter.-Pubmed
BINDHomo sapiens chromosome 17, reference assembly.E2F transcription factor 3E2F3 interacts with the Cdc6 promoter.-Pubmed
BINDHomo sapiens chromosome 3E2F transcription factor 3E2F3 interacts with the Cdc25A promoter.-Pubmed
HPRDcyclin-dependent kinase 3E2F transcription factor 3--Pubmed
HPRDcyclin-dependent kinase 3E2F transcription factor 3--Pubmed
HPRDE2F Transcription factor 3transcription factor Dp-2--Pubmed
HPRDE2F Transcription factor 3transcription factor Dp-1--Pubmed
HPRDE2F Transcription factor 3Sp1 transcription factor--Pubmed
HPRDE2F transcription factor 3TFDP1--Pubmed

Recent Publications on E2F3:

Pubmed Logo
Genomic Profiling of MicroRNAs and Messenger RNAs Reveals Hormonal Regulation in MicroRNA expression in Human Endometrium.
MicroRNAs (miRNAs), a class of small non-coding RNAs that regulate gene...
30th October, 2009
Biol Reprod. 2009 Oct 28.
DOI Direct Link
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers...
29th October, 2009
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Br J Cancer. 2009 Oct 20;101(8):1461-8. Epub 2009 Sep 8.
DOI Direct Link
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.
We have previously shown that p107, a member of the retinoblastoma (Rb)...
6th October, 2009
University of Ottawa, Department of Cellular and Molecular Medicine, Mol Cell Biol. 2009 Sep;29(17):4701-13. Epub 2009 Jun 29.
DOI Direct Link
A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.
The phenotypic heterogeneity that characterizes human cancers reflects the...
15th September, 2009
Duke Institute for Genome Sciences and Policy, Department of Molecular PLoS Genet. 2009 Sep;5(9):e1000640. Epub 2009 Sep 11.
DOI Direct Link
Doxycycline enhances the Ras-MAPK signaling and proliferation of mouse thymic epithelial cells.
Depletion of T-cell-dependent immunity is a major consideration for...
2nd September, 2009
Department of Immunology, School of Medical Science and Laboratory J Cell Biochem. 2009 Jun 1;107(3):494-503.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
6890709 Assays, methods and means for modulating e2f activity
6855510 Pharmaceuticals and methods for treating hypoxia and screening methods therefor
6841385 Transcription factor E2F DNA-binding domain inhibitor peptides and their use
6706867 DNA array sequence selection

View more patents.

E2F3 results (if any) from reagent suppliers

Google CSE Logo
E2F3 antibody (ab50917) | Abcam
Rabbit polyclonal to E2F3. E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F 3 is regulated by complex ...
http://www.abcam.com/E2F3-antibody-ab50917.html...

Thumbshot
MONOCLONAL ANTI-E2F3, CLONE PG30 Purified Mouse Immunoglobulin ...
Monoclonal Anti-E2F3 reacts specifically with human. E2F3 and does not detect the other members of ... to E2F2 and E2F3) and phosphorylates the relevant DP
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

Thumbshot
The Abcam catalog
E2F3 antibodies. ... E2F3 antibody [PG30]. IP, WB, GSA. Mouse monoclonal. Reacts with: Hu. Terms and conditions · Legal · Privacy policy ...
http://www.abcam.com/index.html?t=13673&pt=1&c=1050...

Thumbshot
MONOCLONAL ANTI-E2F4, CLONE WUF3 Purified Mouse Immunoglobulin ...
E2F3 and does not detect the other members of the. E2F family. The antibody may be used for ... to E2F2 and E2F3) and phosphorylates the relevant DP ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

Thumbshot
E2F-3 (C-18) Antibody sc-878
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, E2F3, 1871, 6p22.3, NM_001949 ...
http://www.scbt.com/datasheet-878-e2f-3-c-18-antibody.html...

Thumbshot
MONOCLONAL ANTI-E2F1, CLONE KH20 Purified Mouse Immunoglobulin ...
The expression of E2F1, E2F2, and E2F3 genes is very tightly coupled to cell growth. Little or no ... to E2F2 and E2F3) and phosphorylates the relevant DP
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

Thumbshot
E2F-3 (H-110) Antibody sc-22822
Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis. Circ Res. . 96(5): 509-517. ...
http://www.scbt.com/ko/datasheet-22822-e2f-3-h-110-antibody....

Thumbshot

Search Bioportfolio and other Life Science Sites for E2F3, or search for E2F3 on BioPortfolio's antibody search engine.
This page has been viewed 377 times
Recent Search Terms used to find this page:
e2f3 publications | e2f3 gene | E2F3 antibody search | e2f3 | E2F3 binds near to promoter | E2F3 | E2F3 prostate cancer | e2f3 | sp1 e2f3 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.