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E2F4
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17908821 |
E2F4, binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells |
| 17507799 |
By interacting with p130, E2F4 plays a key role in the maintenance of a stable G2 arrest. Increased E2F4 levels and its translocation to the nucleus following genotoxic stress result in downregulation of mitotic genes. |
| 17656449 |
deregulated nuclear E2F4 expression induces apoptosis via multiple pathways in normal intestinal epithelial cells but not in colon cancer cells. |
| 17121828 |
Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism |
| 12055184 |
data point to Tat as an adaptor protein that recruits cellular factors such as E2F-4 to exert its multiple biological activities |
| 12789259 |
We investigated occupancy of ER-alpha promoter by pRb2/p130-E2F4/5-HDAC1-SUV39 H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 complexes, and provided a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of ER-alpha transcription |
| 15964557 |
E2F-a and E2F-c binding sites are involved in the TCR-induced down-regulation of ICBP90 gene transcription |
| 16135806 |
E2F4 is a transcriptional regulator of the cell cycle genes. |
| 12006580 |
regulation of expression of p130, p107 and E2F-4 in human cells |
| 17001309 |
Hypoxia induces substantial p130 dephosphorylation and nuclear accumulation, leading to the formation of E2F4/p130 complexes and increased occupancy of E2F4 and p130 at the RAD51 and BRCA1 promoters. | →View more information from publications. |
Recent Publications on E2F4: |  |
Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex.
Mip130/LIN-9 is part of a large complex that includes homologs of the... | 24th October, 2009
| Department of Pharmacology, University of Illinois, Chicago, IL 60612,
| Exp Cell Res. 2009 Oct 15;315(17):2914-20. Epub 2009 Jul 18.
DOI Direct Link |
LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner.
Recently, the conserved human LINC/DREAM complex has been described as an... | 23rd October, 2009
| Department of Physiological Chemistry I, Biocenter, University of
| FEBS J. 2009 Oct;276(19):5703-16. Epub 2009 Sep 2.
DOI Direct Link |
TRANSCRIPTIONAL DOWNREGULATION OF p27KIP1 THROUGH REGULATION OF E2F FUNCTION DURING LMP1-MEDIATED TRANSFORMATION.
LMP1 induces the phenotypic transformation of fibroblasts and affects... | 16th October, 2009
| Department of Microbiology and Immunology, Chicago Medical School,
| J Virol. 2009 Oct 14.
DOI Direct Link |
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.
Differentiation of erythroid cells requires precise control over the cell... | 15th October, 2009
| Division of Molecular Genetics and Development, Institute for Molecular
| J Biol Chem. 2009 Jul 31;284(31):20966-74. Epub 2009 May 20.
DOI Direct Link |
Mirk regulates the exit of colon cancer cells from quiescence.
Mirk/Dyrk1B is a serine/threonine kinase widely expressed in colon... | 7th October, 2009
| Pathology Department, Upstate Medical University of the State University
| J Biol Chem. 2009 Aug 21;284(34):22916-25. Epub 2009 Jun 19.
DOI Direct Link |
→View more research publications. |
E2F4 results (if any) from reagent suppliers | 
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E2F4 antibody [WUF11] (ab11951) | Abcam
Mouse monoclonal [WUF11] to E2F4. E2Fs are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, ...
http://www.abcam.com/E2F4-antibody-WUF11-ab11951.html...
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E2F4 Monoclonal Antibody : Trial Size | MBL International
E2F4 Monoclonal Antibody : Trial Size. Log in for US prices. Code No: K0094-3S. Datasheet: application/pdf icon. K0094-3S.pdf. ( Email this datasheet ) ...
http://www.mblintl.com/product/K0094-3S...
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E2F4 antibody (ab53060) | Abcam
Rabbit polyclonal to E2F4. E2Fs are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an
...
http://www.abcam.com/E2F4-antibody-ab53060.html...
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MONOCLONAL ANTI-E2F4, CLONE WUF3 Purified Mouse Immunoglobulin ...
Monoclonal Anti-E2F4 (mouse IgG1 isotype) is derived from the WUF3 hybridoma produced by the fusion ... Monoclonal Anti-E2F4 reacts specifically with human
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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E2F4 antibodies: Chromatin and Nuclear Signaling > Transcription ...
E2F4 antibodies. ... E2F4 antibody [4E2F04] (Biotin). IHC-P, WB, GSA, ICC/IF. Mouse monoclonal ... E2F4 antibody [WUF3]. IP, WB, GSA. Mouse monoclonal ...
http://www.abcam.com/index.html?t=13671&pt=1&c=3423&ei=&mu=r...
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E2F-4 (C-108) Antibody sc-512
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene. 26: 2048–2057. View PubMed Entry. Zhang, L. et al. 2006. ...
http://www.scbt.com/datasheet-512-e2f-4-c-108-antibody.html...
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W
Monoclonal Anti-E2F4 antibody produced in mouse ~0.5 mg/mL, clone WUF3, purified immunoglobulin, buffered aqueous solution, WUF3 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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