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E2F5


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Symbol:E2F5
Name(s):E2F transcription factor 5, p130-binding
Type:protein-coding
Organism:Homo sapiens
Synonyms:E2F-5
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16172982 E2F5 protein is down-regulated late in embryogenesis
12789259 We investigated occupancy of ER-alpha promoter by pRb2/p130-E2F4/5-HDAC1-SUV39 H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 complexes, and provided a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of ER-alpha transcription
12860972 EBV LPM1 blocks p16INK4 pathway by promoting nuclear export of E2F-5.
12089160 the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHuman apoptosis inhibitor survivin gene, and translated productsE2F transcription factor 5E2F5 (E2F-5) interacts with the BIRC5 (survivin) promoter.-Pubmed
HPRDE2F transcription factor 5retinoblastoma-like 2--Pubmed
HPRDE2F transcription factor 5transcription factor Dp-1--Pubmed
HPRDE2F transcription factor 5Retinoblastoma like 2--Pubmed
BINDE2F transcription factor 5Homo sapiens v-myc myelocytomatosis viral oncogene homolog gene, complete cds.E2F-5 interacts with the MYC gene P2 promoter region.-Pubmed
BINDE2F transcription factor 5Human metallothionein-IG gene, and translated productsE2F5 interacts with the MT1G promoter.-Pubmed
HPRDE2F transcription factor 5exportin 1--Pubmed
HPRDE2F transcription factor 5exportin 1--Pubmed
BINDE2F transcription factor 5retinoblastoma-like 2E2F-5 interacts with p130.-Pubmed
HPRDE2F transcription factor 5transcription factor Dp-1--Pubmed

Recent Publications on E2F5:

Pubmed Logo
miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon.
Limited information is available concerning the expression and role of...
14th May, 2009
Department of Experimental Oncology and Laboratories, Fondazione Istituto Cancer Res. 2009 Mar 15;69(6):2287-95. Epub 2009 Feb 24.
DOI Direct Link
Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome.
The purpose of the present study is to identify genes that contribute to...
11th April, 2009
Department of Pathology, Tokai University School of Medicine, Isehara, Br J Cancer. 2009 Mar 10;100(5):764-71.
DOI Direct Link
microRNA-449 is a putative regulator of choroid plexus development and function.
microRNAs are short RNA molecules that are often expressed in specific...
28th February, 2009
School of Biological Sciences, University of East Anglia, Norwich, UK. Brain Res. 2009 Jan 23;1250:20-6. Epub 2008 Nov 18.
DOI Direct Link
Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour.
ABSTRACT: BACKGROUND: Although fibroblast growth factor (Fgf) signalling...
31st December, 2008
DevelopmentalBiology Unit UCL Institute of Child Health, 30 Guilford Cerebrospinal Fluid Res. 2008 Dec 29;5:20.
DOI Direct Link
Thyroid hormone - triiodothyronine - has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) - role of E2F4, E2F5 and p107, p130.
ABSTRACT: BACKGROUND: Triiodothyronine regulates proliferation acting as...
19th November, 2008
Department of Biochemistry and Molecular Biology, The Medical Centre of Thyroid Res. 2008 Oct 13;1(1):5.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7601533 Reverse two-hybrid systems
6841385 Transcription factor E2F DNA-binding domain inhibitor peptides and their use
6773883 Prognostic classification of endometrial cancer
6607879 Compositions for the detection of blood cell and immunological response gene expression
6602499 Combination viral-based and gene-based therapy of tumors

View more patents.

E2F5 results (if any) from reagent suppliers

Google CSE Logo
E2F5 antibody (ab22855) | Abcam
Rabbit polyclonal to E2F5. E2F5 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and
...
http://www.abcam.com/E2F5-antibody-ab22855.html...

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E2F-5 (H-111) Antibody sc-1699
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, E2F5, 1875, 8q21.2, NM_001951 ...
http://www.scbt.com/datasheet-1699-e2f-5-h-111-antibody.html...

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E2F5 antibodies: Chromatin and Nuclear Signaling > Transcription ...
E2F5 antibodies. ... E2F5 antibody. WB. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. ab59769 · E2F5 antibody [220D1a]. WB, Dot. Images. Mouse monoclonal ...
http://www.abcam.com/index.html?t=14719&pt=1&c=3423&ei=&mu=r...

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TFDP1 antibody, TFDP1 (transcription factor Dp-1) Antibody, Rabbit ...
Component of the DREAM complex composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54 , MYBL1, MYBL2, RBBP4, RBL2, TFDP1 and TFDP2. ...
http://www.genwaybio.com/product_info.php?products_id=43022...

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MONOCLONAL ANTI-E2F1, CLONE KH20 Purified Mouse Immunoglobulin ...
E2F5, also plays a unique role in the behavioral control of a postmitotic cell, the cerebrospinal ... E2F4 and E2F5 genes seems to be relatively constant ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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Protein and Antibody Solutions Provider - GenWay
E2F5 (E2F transcription factor 5. p130-b... EGF, EGF Human, EGF Human, Pichia, ERK2/MAPK1 Human, ERK2/MAPK1 Human, Esterase D, FAK1 Human, FGF-2 Bovine ...
http://www.genwaybio.com/index.php?cPath=4061...

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E2F1 Transcription Factors - FabGennix Inc. International >> Products
There are 5 types of E2F transcription factors (E2F1-E2F5) that are known to important role in a number of pathological conditions. ...
http://www.fabgennix.com/prod_details.asp?myproduct=Antibodi...

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