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ECT2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17688947 |
This gene was silenced. |
| 16103226 |
Central spindle localization of ECT2 assists division plane positioning and the CYK-4 subunit of centralspindlin acts upstream of RhoA to promote furrow assembly. |
| 16129829 |
MgcRacGAP controls the initiation of cytokinesis by regulating ECT2, which in turn induces the assembly of the contractile ring and triggers the ingression of the cleavage furrow |
| 16778203 |
ECT2 knockdown triggers cell cycle arrest in G1. |
| 14587037 |
XRCC1, CLB6, and BRCT domains of ECT2 play a critical role in regulating cytokinesis |
| 16118207 |
Cdk1 inactivation is sufficient to activate a signaling pathway leading to cytokinesis, which emanates from mitotic spindles and is regulated by ECT2, MgcRacGAP, and RhoA |
| 16803869 |
In mitotic cells Ect2 localizes to the central spindle and to the cell cortex. |
| 15254234 |
ECT2 regulates the polarity complex Par6/Par3/PKCzeta and possibly plays a role in epithelial cell polarity |
| 16247472 |
ECT2 is regulated by Plk1 and CDK1, phosphorylation of ECT2 leads to accumulation of RHOA |
| 16170345 |
a conformational change of ECT2 upon phosphorylation at T341. Therefore, ECT2 activity might be regulated by the phosphorylation status of T341. | →View more information from publications. |
Recent Publications on ECT2: |  |
The arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1.
Dmp1 (Dmtf1) encodes a Myb-like transcription factor implicated in tumor... | 10th October, 2009
| The Departments of Pathology, Wake Forest University Health Sciences,
| Int J Cancer. 2009 Oct 8.
DOI Direct Link |
Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells.
The dynamics of astral and midzone microtubules (MTs) must be separately... | 2nd October, 2009
| Research Institute for Cell Engineering, National Institute of Advanced
| Exp Cell Res. 2009 Oct 1;315(16):2705-14. Epub 2009 Jul 1.
DOI Direct Link |
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Dickkopf 1 (DKK1), an inhibitor of Wnt signaling, not only functions as a... | 14th August, 2009
| Department of Geriatric and Environmental Dermatology, Nagoya City
| J Investig Dermatol Symp Proc. 2009 Aug;14(1):73-5.
DOI Direct Link |
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
Animal cells initiate cytokinesis in parallel with anaphase onset, when an... | 6th August, 2009
| Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New
| PLoS Biol. 2009 May 5;7(5):e1000111. Epub 2009 May 26.
DOI Direct Link |
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
To complete cell division with high fidelity, cytokinesis must be... | 6th August, 2009
| Department of Molecular Genetics and Cell Biology, The University of
| PLoS Biol. 2009 May 5;7(5):e1000110. Epub 2009 May 26.
DOI Direct Link |
→View more research publications. |
ECT2 results (if any) from reagent suppliers | 
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ECT2 antibody (ab4863) reviews | Abcam
29 Apr 2005 ... Goat polyclonal to ECT2. The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=4...
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Ect2 (C-20) Antibody sc-1005
See how others have used Ect2 (C-20): sc-1005 antibody and or Ect2 (C-20) ... The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the ...
http://www.scbt.com/datasheet-1005-ect2-c-20-antibody.html...
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Product Specification Sheet
Background Information: ECT2, also known as epithelial cell transforming sequence 2 oncogene ... microinjection of affinity-purified anti-ECT2 antibody
into ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...
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Ect2 (H-300) Antibody sc-25637
See how others have used Ect2 (H-300): sc-25637 antibody and or Ect2 (H-300) ... Western blot analysis of Ect2 expression in non-transfected: sc-110760 (A) ...
http://www.scbt.com/datasheet-25637-ect2-h-300-antibody.html...
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Specification Sheet
Product Name, Anti-ECT2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution. Product Number, SAB2500341. Product Brand, SIGMA ...
https://www.sigmaaldrich.com/catalog/DataSheetPage.do?brandK...
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Ect2 (m2): 293T Lysate sc-119913
100 µg protein in 200 µl SDS-PAGE buffer; suitable as Western Blotting control for Ect2 antibodies; mouse Ect2 transfected 293T lysate; suitable control ...
http://www.scbt.com/datasheet-119913-ect2-m2-293t-lysate.htm...
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VAV3 antibody (ab21208) | Abcam
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol 173:1828-38 (2008). IHC-P; Human.
...
http://www.abcam.com/VAV3-antibody-ab21208.html...
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