Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18097620 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18199144 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18215356 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18219093 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18239666 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18354102 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17481640 |
ABCA1 expression in human leukocytes and muscle is associated with physical activity and alcohol consumption, respectively |
| 17550732 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17553166 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17608096 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17700364 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17855807 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17923263 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17951323 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18003760 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18164264 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 11238261 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11257261 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11349008 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11809185 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11940086 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12535741 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12600975 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12624133 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12700893 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12860256 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12870173 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14767869 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14962947 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14986172 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15024730 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15135251 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15201080 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15262183 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15288432 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15297675 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15340333 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 15500734 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15520867 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15528481 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15649702 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15657615 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15696473 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15721294 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15829498 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15935359 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 15952113 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15958302 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16030523 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16080812 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16086925 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16120575 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16157450 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16226177 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16313984 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16446539 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16542392 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16596262 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16725228 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16763159 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16770077 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16806540 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16879828 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17001213 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17113061 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17135600 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17268197 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17324514 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17335784 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17368464 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17372331 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17383594 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17407076 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17412755 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12709788 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17430597 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18097620 |
These results suggest that polymorphisms of ABCA1 and ROS1 are determinants of blood pressure and the development of hypertension in Japanese individuals. |
| 18220685 |
ABC-A1 may be more than a determinant of HDL-cholesterol which may provide a link between components of the metabolic syndrome and atherosclerosis. |
| 17992631 |
The interaction of ABCA1 with AOX1 modulates ABCA1-linked cellular functions such as lipid efflux and phagocytosis in hepatocytes (HC), and reduced expression of AOX1 in malignant transformed HC supports the differentiation dependent upregulation of AOX1. |
| 17510949 |
Intronic polymorphism of ABCA1 gene is associated with sporadic Alzheimer's disease |
| 17412755 |
an influence of common ABCA1 functional polymorphisms on age of symptom onset in coronary artery disease patients |
| 18199144 |
Mutations were identified in 5 low-HDL subjects. 4 SNPs in ABCA1 gene promoter identified the C-14T SNP & the TCCT haplotype to be over-represented in low-HDL individuals. Sequence variation in ABCA1 contributes significantly to variation in HDL levels. |
| 17689273 |
Results revealed that TNF-alpha could increase cholesterol content by down-regulating ABCA1 expression, IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression. |
| 17951323 |
3 of 6 nonsynonymous single nucleotide polymorphisms in ATP-binding cassette sub-family A (ABC1) member 1 (ABCA1) predict risk of ischemic heart disease in the general population. |
| 17656736 |
Our results provide a biochemical basis for the HDL biogenesis pathway that involves both ABCA1 and the "high-capacity binding site", supporting a two binding site model for ABCA1-mediated nascent HDL genesis. |
| 17690481 |
results indicate that ABCG5/G8, unlike ABCA1, together with bile acids should participate in sterol efflux on the apical surface of Caco-2 cells. |
| 17510946 |
the relationship between ABCA1 genetic variants and Alzheimer's disease (AD), independently or in concert with the APOE epsilon4 allele |
| 17368464 |
analysis of genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease |
| 17923263 |
R219K polymorphism of ABCA1 related with low HDL in overweight/obese Thai males. |
| 17556657 |
Doxazosin inhibits AP2alpha activity independent of alpha(1)-adrenoceptor blockade and increases the ABCA1 expression and HDL biogenesis |
| 17070530 |
ABCA1 polymorphism is associated with the pathogenesis of coronary heart disease in Germany. |
| 17372331 |
Results suggest that defective ABCA1 function in cholesterol-loaded macrophages is one potential contributor to the impaired reverse cholesterol transport process and the increased coronary heart disease risk in subjects with familial low HDL. |
| 12196520 |
A novel serine (Ser-2054) on the ABCA1 protein crucial for PKA phosphorylation and for regulation of ABCA1 transporter activity. |
| 15024730 |
Several single nucleotide polymorphisms spanning the ABCA1 gene modify Alzheimer disease risk. |
| 12870173 |
results indicate that the K219 allele frequency of adenosine triphosphate binding cassette transporter 1 differs markedly between blacks and whites |
| 15492319 |
ABCA1 is not required for apolipoprotein A-1-mediated endothelial cholesterol efflux from vascular endothelial cells. |
| 15066991 |
ABCA1 is not requied for a positive feedback pathway for stimulation of potentially anti-atherogenic apoE secretion by alpha-helix-containing molecules including apoA-I and apoE |
| 16596262 |
data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in Alzheimer's disease. |
| 17268197 |
ABCA1 gene I823M polymorphism altered plasma HDL-C level and also modified the effect of low-HDL-C on the risk of CAD. |
| 17521614 |
Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver. |
| 12151852 |
REVIEW: ATP-binding cassette transporter A1 and cholesterol trafficking |
| 16709568 |
Fluorescence resonance energy transfer and native plyacrylamide gel electrophoresis analytical techniques were employed to assess the quaternary structure of ABCA1 |
| 17135302 |
ROS and NF-kappaB, but not LXR, mediate the IL-1beta-induced downregulation of ABCA1 via a novel transcriptional mechanism, which might play an important role of proinflammation in the alteration of lipid metabolism. |
| 17287470 |
This is the first study reporting the association of the ATP-binding cassette transporter A1 R230C variant with obesity and obesity-related comorbidities in the Mexican population. |
| 14734645 |
ApoA-1 removes excess cholesterol & phospholipids from macrophages by an active pathway involving ABCA1. The slow component of this efflux is the ABCA1-dependent process. |
| 14576201 |
ABCA1 gene sequence in a proband with very low HDL cholesterol and premature coronary heart disease family history revealed 2 mutations: G5947A (R1851Q) and single thymidine deletion in a polypyrimidine tract 33 to 46 bps upstream from start of exon 47 |
| 16118212 |
intracellular unsaturated acyl-CoA derivatives destabilize ABCA1 by activating a PLD2 signaling pathway |
| 15469992 |
ABCA1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes |
| 16902247 |
ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles |
| 16928680 |
hepatic overexpression of ABCA1 in low density lipoprotein receptor-KO mice leads to: 1) expansion of the pro-atherogenic apoB-lipoprotein cholesterol pool size via enhanced transfer of HDL-cholesterol to apoB-lipoproteins |
| 15163665 |
conclude that intact ATP binding cassette transporter A1 (ABCA1) function is necessary for proper maturation of dense bodies in platelets |
| 15961705 |
dramatic decrease of ABCA1 protein, the key molecule of cholesterol efflux, in atheroma |
| 11855831 |
contributes to the secretion of interleukin 1beta from macrophages |
| 14967823 |
increased palmitate and stearate desaturation by stearoyl-CoA desaturase was associated with the destabilization of ABCA1 by saturated fatty acids palmitate and stearate |
| 16343503 |
Approximately 20% of French-Canadian patients with severe HDL deficiency are associated with a defective ABCA1. |
| 14767869 |
the K219 allele of the ABCA1 gene is an anti-atherogenic allele with increased cholesterol efflux activity |
| 15292375 |
apoA-I mobilizes intracellular cholesterol for the ABCA1-mediated release from the compartment that is under the control of ACAT. The cholesterol mobilization process is presumably related to PKC activation by apoA-I. |
| 15358760 |
SREBP2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells |
| 16855366 |
REVIEW: the presence of ABCA1 and ABCG1 in the AP-3 pathway will have major impact for membrane phospholipid processing and HDL metabolism and their relation to disorders of lysosome-related organelles |
| 15297675 |
tested whether rare sequence variants of ABCA1, APOA1, and LCAT collectively contribute to variation in plasma levels of high density lipoprotein cholesterol; nonsynonymous sequence variants were significantly more common in individuals with low HDL-C |
| 15528463 |
We propose that the decreased level of ABCA1 protein is a key factor in the development of atherosclerotic lesions. |
| 15528481 |
The ABCA1 gene -565C>T polymorphism was associated with coronary atherosclerosis severity. This variant had an effect on ABCA1 promoter activity. Common ABCA1 variants contribute to interindividual variability in atherosclerosis susceptibility & severity. |
| 12084722 |
ABCA1 mutations can disrupt its direct interaction with apolipoprotein A-I. |
| 12562845 |
examine the necessary structural features for a protein to promote lipid efflux by the ABCA1 transporter and find the amphipathic helix is a key structural motif for peptide-mediated lipid efflux from ABCA1, but there is no stereoselective requirement |
| 12804586 |
regulation of ABCA1 mRNA levels exploits the use of alternative transcription start sites |
| 14644402 |
Of special interest was our finding that the effects of compromised ABCA1 function on HDL were more pronounced in women than in men. |
| 14701812 |
HDL(3) promotes ABCA1-mediated lipid efflux entirely through its lipid-poor fraction with pre-beta mobility |
| 14701824 |
the ABCA1 transporter has a role in cellular cAMP signaling with Apolipoprotein A-I |
| 14701850 |
an amphiphilic helical motif is the minimum structural requirement for a protein to stabilize ABCA1 against proteolytic degradation |
| 15102890 |
The reciprocal inhibition of SR-BI and ABCA1 by BLT-4 and glyburide raises the possibility that these proteins may share similar or common steps in their mechanisms of lipid transport. |
| 11950847 |
Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation. |
| 12204794 |
Recent data confirms that a single defective allele in ABCA1 may be assosiated with reduced HDL cholesterol and FHA. |
| 16055210 |
An amino acid substitution in ABCA1 is associated with low levels of HDL and diabetes mellitus, type 2. |
| 16254209 |
Glucocorticoid receptor ligands affected ABCA1 expression and cholesterol efflux from macrophages |
| 14747463 |
ABCA1 converts pools of late endocytic lipids that retain NPC1 to pools that can associate with endocytosed apoA-I, and be released from the cell as nascent high density lipoprotein |
| 15930518 |
The ABCA1-mediated reaction produced two distinct HDLs, large cholesterol-rich and small cholesterol-poor particles, and the former is more prominently dependent on the increase of ABCA1 expression |
| 12111371 |
R1680W mutation associated with Tangier disease, phenotypes variable. |
| 12235128 |
The association of FADD with ABCA1 provides an unexpected link between high density lipoprotein metabolism and an adaptor molecule mainly described in death receptor signal transduction. |
| 16235041 |
A review of functions and mutations of ABCA1 in Tangier disease. |
| 16126721 |
the ABCA1 pathway is impaired by acrolein-induced apoA-I modification |
| 16418537 |
Results show that the products of the apoA-I/ABCA1 interaction include discoidal HDL particles containing different numbers of apoA-I molecules. |
| 16429166 |
Impact of genetic variation on ABCA1 function. |
| 12763760 |
In this study we review how genetic variation at the ABCA1 locus affects its role in the maintenance of lipid homeostasis and the natural progression of atherosclerosis. |
| 14967052 |
A two step model of cholesterol efflux is suggested that can explain the functional interactions of ABCA1 with apoA-I and other cholesterol acceptors, based on formation of a tight complex between ABCA1 and its ligands. |
| 14993242 |
ABCA1 does not differentiate between cholesterol and beta-sitosterol and thus is not responsible for the selectivity of sterol absorption by the intestine |
| 12730295 |
hepatic overexpression of ABCA1 showed a selective increase in HDL cholesterol |
| 15140889 |
probucol inactivates ABCA1 in the plasma membrane with respect to its function in mediating binding of and lipid release by apolipoprotein and with respect to proteolytic degradation by calpain |
| 15358117 |
Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells. |
| 15520867 |
ABC transporter A1 has a role in regulating levels of HDL cholesterol |
| 11861672 |
a novel site in the human ABCA1 promoter involved in the regulation of ABCA1 gene expression. |
| 15574409 |
apolipoprotein A-I chlorination markedly impairs ABCA1-dependent cholesterol transport |
| 16166555 |
mABC1 protein plays a major role in cellular protection against oxidant stress. |
| 16313984 |
ABCA! polymorphisms and prognosis after myocardial infarction were analyzed in a young male cohort. |
| 16410457 |
ABCA1-mediated efflux to serum responds to the pool of lipid-free/poor apolipoproteins |
| 16500904 |
analysis of the biochemical basis of the mechanism for HDL formation mediated by ABCA1 |
| 16730733 |
Suppression of both the ABCA1 and ABCG1 genes may indicate that unsaturated fatty acids suppress not only cholesterol efflux to apoA-I and thereby nascent HDL formation but also HDL-dependent cholesterol efflux from vascular cells. |
| 17020879 |
NPC1 protein function is non-essential for the trafficking and removal of cellular cholesterol by ApoAI if the down-stream defects in ABCA1 and ABCG1 regulation in NPC disease cells are corrected using an LXR agonist |
| 17082211 |
Two genes of the cholesterol efflux system (ABCA1 and ABCG1) were down-regulated in HCAECs exposed to uraemic plasma. |
| 14962947 |
Two polymorphisms were associated with plasma levels of ApoA1, 1 in the promoter (C-564T) and 1 in the coding (R1587K) regions, whereas only 1 polymorphism (R219K) was associated with the risk of myocardial infarction. |
| 11700048 |
function as a regulator rather than an active transporter |
| 12093886 |
Increased ABCA1 activity protects against atherosclerosis. ABCA1(human transgenic)(+)ApoE(-/-) mice developed dramatically smaller, less-complex lesions as compared with their ApoE(-/-) counterparts. |
| 14754908 |
ABCA1 is essential for the biogenesis of high density-sized lipoprotein containing only apoE particles in vivo |
| 15774904 |
Catalytic subunits of SWI/SNF chromatin remodeling complex, BRG-1 and brahma, play significant roles in enhancing LXR/RXR-mediated transcription of ABCA1 via the promoter DR-4 element |
| 15951431 |
the internalization and trafficking of ABCA1 is functionally important in mediating cholesterol efflux from intracellular cholesterol pools |
| 14986172 |
ABCA1 G(-273)C polymorphism has a significant effect on the HDL-C level in the general Japanese population, but not on the incidence of myocardia infarction |
| 16192269 |
beta1-syntrophin acts through a class-I PDZ interaction with the C terminus of ABCA1 to regulate the cellular distribution and activity of the transporter |
| 12813037 |
ABCA1 has a role in the low levels of HDL-cholesterol and overaccumulation of cellular lipids in Niemann-Pick Disease type C |
| 15280376 |
the majority of ABCA1 exists as a tetramer that binds apoA; the homotetrameric ABCA1 complex constitutes the minimum functional unit required for the biogenesis of high density lipoprotein particles. |
| 12709788 |
While genotype-phenotype associations were not reproduced across populations and loci, V825I and M883I were clearly associated with coronary artery disease status in Malays with no effects on HDL-C or apoA1. |
| 12615681 |
Review. Transgenic mice with human ABCA1 genes are used to study its function in cholesterol transport, apo B lipoproteins, and atherosclerosis. |
| 14681836 |
first demonstration of an association between ATP-binding cassette, sub-family A member 1 gene expression and fasting glucose concentration in vivo |
| 15905177 |
analysis of headgroup-specific exposure of phospholipids in ABCA1-expressing cells |
| 15983222 |
Glycolaldehyde and glyoxal strongly inhibited ABCA1-dependent transport of cholesterol from cells to apoA-I, while methylglyoxal had little effect. |
| 11893753 |
Role as a phosphatidylserine translocase |
| 14668333 |
results suggest that the interaction of apolipoproteins with ATP binding cassette transporter A1(ABCA1)-expressing cells activates JAK2 which enhances apolipoprotein interactions with ABCA1 and lipid removal from cells |
| 12176027 |
Dominant expression of ABCA1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands |
| 12928428 |
ABCA1-mediated vesicle release involves lipid raft plasma membrane domains |
| 15158913 |
Both mutations prevent normal trafficking of ABCA1, thereby explaining their inability to mediate apoA1-dependent lipid efflux |
| 16497665 |
oxidation by myeloperoxidase impairs the ability of apoA-I to promote cholesterol efflux by the ABCA1 pathway, suggesting that this oxidative process might contribute to foam cell formation and atherogenesis |
| 16725228 |
This study suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and late-onset Alzheimer's disease. |
| 17383594 |
Rare mutations in ABCA1 are associated with low HDL-C. However, at least 1 ABCA1 polymorphism (eg, E1172D) may contribute to the high HDL-C phenotype. |
| 17510466 |
Interaction of apoA-I with ABCA1 results in the simultaneous generation of pre-beta HDLs of discrete size and chemical composition. |
| 12426219 |
ABCA1 plays an important role in artery wall cell-mediated modification/oxidation of LDL by modulating the release of reactive oxygen species from artery wall cells that are necessary for LDL oxidation. |
| 12706378 |
ABCA1 expression varies among tissues, and cholesterol conversion to hydroxycholesterol is an important mechanism for the maintenance of cholesterol homeostasis in fibroblasts |
| 11929608 |
Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux |
| 12576507 |
Results describe two new point mutations of the ABCA1 gene found in one patient with Tangier disease and the sibling of another Tangier disease patient. |
| 15033469 |
ATP-binding-cassette transporter A1 gene expression in macrophages is downregulated by statins |
| 11940086 |
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels |
| 15851589 |
Deficiency of macrophage ACAT1 accelerates atherosclerosis in apoE-/- mice but has no effect when hypercholesterolemia is corrected by apoE expression. ACAT1 deletion impairs ABCA1-mediated cholesterol efflux in macrophages regardless of apoE expression |
| 15890646 |
cholesterol efflux via the ABCA1/apoA-I pathway is enhanced by the GSL synthesis inhibitor PDMP |
| 16505586 |
ABCA1 is a rate-limiting factor of HDL assembly and is regulated by transcriptional and post-transcriptional factors. Post-transcriptional regulation of ABCA1 involves modulation of its calpain-mediated degradation. |
| 17196163 |
The results suggest the promoting effects of AngII on the forming of foam cells are in a dose-dependent manner via down-regulating the expression of ABCA1. |
| 11752403 |
in the presence of apoE, overexpression of ABCA1 modulates HDL as well as apoB-containing lipoprotein metabolism and reduces atherosclerosis in vivo |
| 14560020 |
These studies indicate a direct role of retinoic acid receptor gamma/retinoid x receptor in induction of macrophage ABCA1. |
| 16207713 |
ABCA1 plays a role in the pathogenesis of parenchymal and cerebrovascular amyloid pathology |
| 12511593 |
ABCA1 is regulated by PEST sequence-mediated calpain proteolysis that appears to be reversed by apolipoprotein-mediated phospholipid efflux |
| 12869555 |
Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. |
| 16157450 |
Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). |
| 16456089 |
ABCA1 upregulation in macrophages inhibits the progression of atherosclerotic lesions |
| 16825673 |
ABCA1 is expressed in keratinocytes, where it is negatively regulated by a decrease in cellular cholesterol levels or altered permeability barrier requirements and regulated by activators of LXR, PPARs, and RXR or increases in cellular cholesterol levels |
| 16901265 |
The role of SREBP-2 in the regulation of ABCA1 transcription via generation of oxysterol ligands for liver X receptor is reported. |
| 17121837 |
ABCA1 plays a significant role in the regulation of neuronal cholesterol efflux to apolipoprotein E discs. |
| 17241464 |
Results show that ABCA1 mRNA expression increased in response to dexamethasone in primary rat hepatocytes however, the effect was absent or inhibitory in human HepG2 cells and THP-1 macrophages due to low glucocorticoid receptor levels. |
| 17553166 |
Our study does not support a major role for the ABCA1 gene as a risk factor for ischaemic stroke |
| 12359250 |
findings suggest an important role for hepatocyte basolateral membrane ABCA1 in the regulation of the levels of intracellular hepatic cholesterol, as well as plasma HDL |
| 12624133 |
The K allele was significantly more frequent in FH subjects without premature CHD than in FH subjects with premature CHD suggesting that the genetic variant R219K in ABCA1 could influence the development and progression of atherosclerosis in FH subjects. |
| 14570867 |
ABCA7 compensates the function of ABCA1 for release of cell cholesterol in a certain condition(s). |
| 12952980 |
ABCA1 is phosphorylated and stabilized in a pathway in which apoA-I activates PKC alpha by PC-PLC-mediated generation of diacylglycerol |
| 12551894 |
Golgi is involved in ABCA1-mediated cholesterol efflux. |
| 12600718 |
Genetic variability of ABCA1 influences development of Alzheimer's disease,possibly by interfering with CNS cholesterol homeostasis. |
| 15721294 |
type 2 diabetes is associated with ABCA1 gene polymorphisms in a Japanese population |
| 14660648 |
association of apolipoprotein A-I with lipids reduces its ability to interact with ATP-binding cassette transporter A1(ABCA1) and the lipid translocase activity of ABCA1 generates alpha-LpA-I-like particles |
| 15817453 |
RhoA has a role in ABCA1-mediated cholesterol efflux |
| 16009332 |
In this report, a relationship between ApoA-I, DM and ABCA1 has been emphasized. |
| 16443932 |
Results suggest that ABCA1 transduces signals from apolipoprotein A-I (apoA-I) by complexing and activating Cdc42 and downstream kinases and, therefore, acts as a full apoA-I receptor. |
| 16806540 |
ABCA1 polymorphisms are associated with varying plasma levels of HDL-C in Pakistani individuals. |
| 15935359 |
The role of high levels of HDL cholesterol in protection against development of atherosclerosis is generally attributed to its role in reverse cholesterol transport, and the ATP binding cassette transporter A1 is a key element of this process. |
| 17335784 |
An obvious association between polymorphisms of ABCA1 gene and AD was found; the risk for AD was significantly decreased in K allele (RK+KK genotypes) or KK homozygote carriers compared with RR genotypes carriers. |
| 16873719 |
generation in vitro of 15 missense mutations that have been described in patients with Tangier disease and familial hypoalphalipoproteinemia. (ABCA1) |
