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NR0B1
| Symbol: | NR0B1 | | Name(s): | nuclear receptor subfamily 0, group B, member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18038713 |
novel DAX-1 mutation was detected in two family members with different phenotype: one live infant with adrenal hypoplasia, his mother, and probably his dead brother |
| 17646707 |
The repressive functions of SHP and DAX-1 have been conserved in fish and mammals although with different transcriptional targets and mechanisms. |
| 17573657 |
Study describes 3 siblings with adrenal hypoplasia congenita, with different phenotypes; molecular analysis detected a novel mutation, a transition of C to T at position 359 in exon 1 of the DAX1 gene, determining a stop codon. |
| 15379426 |
It remains probable that this unusual patient has either a DAX1 or SF1 mutation defect. A Wnt-4 defect was not evaluated. |
| 11748852 |
Identified nine novel NR0B1 mutations in X-linked AHC patients (Y81X, 343delG, 457delT, 629delG, L295P, 926-927delTG, 1130delA, 1141-1155del15, and E428X). |
| 12083815 |
adrenal hypoplasia congenita and multiple pituitary hormone deficiency without mutations in the DAX1 or SF1 genes |
| 16709599 |
DAX1 and small heterodimer partner (SHP) form homodimers individually, as well as DAX1-SHP heterodimers suggesting the possibility of novel functions independent of their coregulator roles. |
| 15084237 |
DAX-1 might modify the AR & ER-beta intracellular location. Because a direct positive relation between the expression of these three receptors was found, the presence of DAX-1 in neoplastic cells might indicate a possible failure of endocrine therapies. |
| 16206264 |
The high levels of DAX1 found in Ewing tumors and its potent transcriptional repressor activity suggest that the oncogenic effect of EWS/FLI1 may be mediated, at least in part, by the up-regulation of DAX1 expression. |
| 16232195 |
DAX-1 may inhibit the proliferation and progression of endometrial carcinoma through inhibition of estrogenic actions, possibly by interacting with estrogen receptors present in carcinoma cells, rather than regulating in situ steroidogenesis | →View more information from publications. |
Recent Publications on NR0B1: |  |
Dax-1 knockdown in mouse embryonic stem cells induces loss of pluripotency and multilineage differentiation.
Dax-1 (Nr0b1) is an orphan member of the nuclear hormone receptor... | 31st October, 2009
| Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 6097,
| Stem Cells. 2009 Jul;27(7):1529-37.
DOI Direct Link |
X-linked congenital adrenal hypoplasia with hypogonadotropic hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 (DAX1) gene.
CONTEXT: X-linked congenital adrenal hypoplasia with hypogonadotropic... | 21st October, 2009
| Department of Medical Genetics, Oslo University Hospital, Ulleval, N-0407
| J Clin Endocrinol Metab. 2009 Oct;94(10):4086-93. Epub 2009 Sep 22.
DOI Direct Link |
The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation.
Zebrafish teeth develop on pharyngeal jaws in the 5th branchial arch, but... | 15th October, 2009
| Department of Pediatrics, David Geffen School of Medicine, UCLA, 10833 Le
| Dev Genes Evol. 2009 Oct 14.
DOI Direct Link |
Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells.
Neuronal nitric oxide synthase (nNOS)-derived nitric oxide (NO) acts as a... | 4th September, 2009
| II. Medizinische Klinik, Technische Universitat Munchen, 81675 Munich,
| Am J Physiol Cell Physiol. 2009 Nov;297(5):C1146-56. Epub 2009 Sep 2.
DOI Direct Link |
GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance.
Ewing's sarcoma is a malignant bone-associated tumor of children and young... | 1st September, 2009
| [1] Department of Oncological Sciences, University of Utah School of
| Oncogene. 2009 Aug 31.
DOI Direct Link |
→View more research publications. |
NR0B1 results (if any) from reagent suppliers | 
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DAX1 (NR0B1) Antibody (N-term)
Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1; DSS-AHC critical region on the X chromosome protein 1; NR0B1; AHC; DAX1 ...
http://www.abgent.com/products/catalog_no/AP2708a_DAX1_NR0B1...
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NR0B1 / Dax1 antibody (ab60144) | Abcam
Rabbit polyclonal to NR0B1 / Dax1. NR0B1 is a receptor that may be a component of a cascade required for development of steroidogenic tissues.
http://www.abcam.com/NR0B1-Dax1-antibody-ab60144.html...
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Human DAX1/NR0B1 MAb (Clone H7431)
NR0B1) is a member of the orphan nuclear receptor family. DAX1 is expressed in the adrenal cortex, ovarian granulosa, theca cells, testicular ...
http://www.rndsystems.com/pdf/PP-H7431-10.pdf...
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NR0B1 / Dax1 antibodies: Developmental Biology > Reproduction ...
NR0B1 / Dax1 antibodies. ... NR0B1 / Dax1 antibody [H7431]. WB, ELISA. Mouse monoclonal. Reacts with: Hu. Predicted: Rat. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=115465&pt=1&c=4592&ei=&mu=...
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DAX1/NR0B1 - R&D Systems
DAX1/NR0B1. Products By Product Type. All Products for this Molecule · Antibodies · Legal; |; Sitemap. United States (change country); |; (800) 343-
7475 ...
http://www.rndsystems.com/molecule_detail.aspx?m=2513...
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Abgent - Stem Cell
AP2720a, DAAM1 Antibody (N-term), WB, IHC, E, H. AP2708b, DAX1 (NR0B1) Antibody (C-term), WB, E, H. AP2708a, DAX1 (NR0B1) Antibody (N-term), WB, E, H ...
http://www.abgent.com/products/category/stem_cell...
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DAX-1 (K-17) Antibody sc-841
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NR0B1, 190, Xp21.2, NM_000475 ...
http://www.scbt.com/datasheet-841-dax-1-k-17-antibody.html...
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