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EDG1
| Symbol: | EDG1 | | Name(s): | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CHEDG1, D1S3362, ECGF1, EDG-1, S1P1, S1PR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17918267 |
FTY720 induces time-dependent modulation of S1P receptors on human OPCs with consequent functional responses that are directly relevant for the remyelination process. |
| 16926156 |
heterotrimeric G protein-dependent ERK1/2 activation is mediated by IGF-1 and IGF-2 by transactivating sphingosine 1-phosphate receptors |
| 15699128 |
Persistent expression of S1P1 receptor by lymphocytes of S1P1 receptor-transgenic mice suppresses delayed-type hypersensitivity and results in production of significantly more IgE antibody (Ab) and less IgG2 Ab than in wild-type mice. |
| 15626732 |
cross-communication between the prototypical barrier-protective S1P and barrier-disruptive PAR1 pathway |
| 17237497 |
FTY720-P targets the S1P1 receptor to the ubiquitinylation and proteasomal degradation pathway |
| 16319133 |
The constitutively active endogenous S1P1 receptor enhances PDGF-induced cell migration. |
| 17331465 |
Sphingosine 1-phosphate-induced inflammatory response genes expression is mediated through S1P(1) and S1P(3) |
| 11915348 |
activates Rho family G proteins and cell motility |
| 15710622 |
endothelial protein C receptor ligation and sphingosine 1-phosphate receptor transactivation results in endothelial cell cytoskeletal rearrangement and barrier protection through activated protein C |
| 11741892 |
phosphorylation of the sphingosine 1-phosphate (SSP) receptor "endothelial differentiation gene 1" (EDG1 or S1P(1)) receptor is increased in response to either SSP or phorbol 12-myristate 13-acetate (PMA) exposure but not lysophosphatidic acid | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Caveolin 1 | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | - | - | Pubmed |
| HPRD | caveolin 1 | Endothelial differentiation gene 1 | - | - | Pubmed |
| HPRD | Endothelial differentiation gene 1 | 5-hydroxytryptamine receptor 1A | - | - | Pubmed |
| HPRD | Endothelial differentiation gene 1 | 5-hydroxytryptamine receptor 1D | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | 5-hydroxytryptamine receptor, 1A | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | Serotonin 1D receptor | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | PDGF receptor, beta | - | - | Pubmed |
| BIND | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | 5-hydroxytryptamine receptor 1A | 5-HT1A interacts with EDG1. This interaction was modeled on a demonstrated interaction between 5-HT1A and EDG1 from an unspecified species. | - | Pubmed |
| BIND | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | 5-hydroxytryptamine receptor 1D | 5-HT1D interacts with EDG1. This interaction was modeled on a demonstrated interaction between 5-HT1D and EDG1 from an unspecified species. | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
Recent Publications on EDG1: |  |
The G allele at the c.-312A>G SNP in the EDG1 gene associated with high marbling in Japanese Black cattle is at a low frequency in breeds not selected for marbling.
ABSTRACT: BACKGROUND: Marbling defined by the amount and distribution of... | 23rd October, 2009
| Oita Prefectural Institute of Animal Industry, Takeda, Oita 878-0201,
| Anim Genet. 2009 Aug;40(4):579. Epub 2009 Mar 20.
DOI Direct Link |
Utilization of the TangoTM {beta}-Arrestin Recruitment Technology for Cell-Based EDG Receptor Assay Development and Interrogation.
Cellular assay development for the endothelial differentiation gene (EDG)... | 4th September, 2009
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| J Biomol Screen. 2009 Sep 2.
DOI Direct Link |
Association of single nucleotide polymorphisms in the endothelial differentiation sphingolipid G-protein-coupled receptor 1 gene with marbling in Japanese Black beef cattle.
Marbling defined by the amount and distribution of intramuscular fat,... | 14th July, 2009
| Laboratory of Animal Breeding and Genetics, Graduate School of
| Anim Genet. 2009 Apr;40(2):209-16. Epub 2008 Dec 30.
DOI Direct Link |
Non-Edg family lysophosphatidic acid (LPA) receptors.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a... | 16th June, 2009
| Department of Biochemistry and Molecular Biology, Faculty of Medicine, The
| Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. Epub 2009 Jun
DOI Direct Link |
Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle.
ABSTRACT: BACKGROUND: Marbling defined by the amount and distribution of... | 8th May, 2009
| Kyoto Cattle Genetics Section, Beef Information & Genetics Institute, Inc,
| BMC Res Notes. 2009 May 7;2:78.
DOI Direct Link |
→View more research publications. |
EDG1 results (if any) from reagent suppliers | 
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