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EDG2
| Symbol: | EDG2 | | Name(s): | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | Gpcr26, LPA1, LPAR1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18325907 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18006645 |
Lysophosphatidic acid receptor 1 may contribute to the pathogenesis of rheumatoid arthritis through the modulation of fibroblast-like synoviocyte migration and cytokine production. |
| 18089805 |
Down-regulation of EDG2 is functionally important to suppression of tumor metastasis in breast neoplasms. |
| 17923111 |
expression of LPA-induced inflammatory response genes is mediated by LPA1 and LPA3 |
| 14696401 |
EDG-2 expression was increased in low-grade adenoma compared with that in normal mucosa (P < 0.001). EDG-2 expression was significantly greater in adenomas with larger diameters (P < 0.001). |
| 12670925 |
LPA acts as a potent stimulator of colon cancer progression, although the binding to LPA1 and LPA2 induces slightly different responses. |
| 16716145 |
These findings demonstrate that trafficking of LPA1 to the nucleus is influenced by cell-matrix interactions and that nuclear LPA1 may be involved in regulating intranuclear protein phosphorylation and signalling. |
| 15292052 |
data suggest that endothelial differentiation gene EDG-7 and EDG-2 lysophosphatidic acid receptors play a diverse role in mesangial cell proliferation |
| 11948806 |
LP(A1) and myelin basic protein colocalized in brain, but oligodendrocyte soma showed stronger signals for LP(A1) than myelinated fibers, whereas the reverse was true for myelin basic protein so LP(A1) may be involved in myelin formation or maintenance. |
| 15755723 |
formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation | →View more information from publications. |
Recent Publications on EDG2: |  |
Lysophosphatidic acid mediates migration of human mesenchymal stem cells stimulated by synovial fluid of patients with rheumatoid arthritis.
Migration of mesenchymal stem cells plays a key role in regeneration of... | 8th September, 2009
| Medical Research Center for Ischemic Tissue Regeneration, the Medical
| Biochim Biophys Acta. 2009 Sep 3.
DOI Direct Link |
Diphenylhydantoin plays a role in gene expression related to cytoskeleton and protein adhesion in human normal palate fibroblasts.
AIMS: Morphogenetic processes during palate development are related to... | 19th August, 2009
| Histology, Embryology and Applied Biology Department, University of
| Pathology. 2009;41(3):261-8.
DOI Direct Link |
Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections.
OBJECTIVES: To replicate a previously reported association with... | 25th June, 2009
| Hospital Clinico Universitario Santiago, Santiago de Compostela, Spain.
| Ann Rheum Dis. 2009 Jun;68(6):1017-21. Epub 2008 Jul 14.
DOI Direct Link |
Non-Edg family lysophosphatidic acid (LPA) receptors.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a... | 16th June, 2009
| Department of Biochemistry and Molecular Biology, Faculty of Medicine, The
| Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. Epub 2009 Jun
DOI Direct Link |
Altered gene and protein expression by Nm23-H1 in metastasis suppression.
Metastasis suppressor genes (MSG) are characterized by their ability to... | 6th May, 2009
| Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for
| Mol Cell Biochem. 2009 Sep;329(1-2):141-8. Epub 2009 May 5.
DOI Direct Link |
→View more research publications. |
EDG2 results (if any) from reagent suppliers | 
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EDG2 antibody (ab23698) | Abcam
Rabbit polyclonal to EDG2. EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of
the ...
http://www.abcam.com/EDG2-antibody-ab23698.html...
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EDG-2 (S-13) Antibody sc-22207
EDG-2 shRNA (h) Lentiviral Particles, sc-43746-V, 200 µl ... See how others have used EDG-2 (S-13): sc-22207 antibody and or EDG-2 (S-13) antibody ...
http://www.scbt.com/datasheet-22207-edg-2-s-13-antibody.html...
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EDG2 Antibody (N-term)
EDG2 Antibody (N-term) Cell Function, EDG2 Antibody (N-term) Neurosciences, EDG2 Antibody (N-term) Cancer, EDG2 Antibody (N-term) Cell Cycle Regulation, ...
http://www.abgent.com/products/catalog_no/AP6138a...
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EDG-2 Antibody / EDG-2 Antibodies
EDG-2 Antibody / EDG-2 Antibodies. ... EDG-2 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-edg-2.html...
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LPA1 C-Terminal Blocking Peptide Endothelial Cell Differentiation ...
The EDG-2, C-terminal blocking peptide is a synthetic. (~2.5 kDa) peptide derived from ... the full length EDG-2 (Endothelial Cell Differentiation ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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EDG-2 (D-15) Antibody sc-22209
goat polyclonal IgG, 200 µg/ml; epitope mapping within an extracellular domain of EDG-2 of human origin; recommended for detection of EDG-2 of m, ...
http://www.scbt.com/datasheet-22209-edg-2-d-15-antibody.html...
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E5017 Anti-LPA1, C-Terminal antibody produced in rabbit Anti-EDG-2 ...
E5017 Anti-LPA1, C-Terminal antibody produced in rabbit ~1mg/mL, IgG fraction of antiserum, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=E501...
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