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EDG3
| Symbol: | EDG3 | | Name(s): | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EDG-3, FLJ37523, LPB3, MGC71696, S1P3, S1PR3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17395891 |
Reults describe the role of mu opioid receptors and S1P3 transactivation in the attenuation of vascular permeability by methylnaltrexone. |
| 17331465 |
Sphingosine 1-phosphate-induced inflammatory response genes expression is mediated through S1P(1) and S1P(3) |
| 12763936 |
a 9-amino acid peptide (KRX-725), derived from the second intracellular loop of S1P3 (EDG3) mimics sphingosine 1-phosphate (S1P) by triggering a Gi-dependent mitogen-activated protein kinase kinase and extracellular signal-regulated kinase signal. |
| 11915348 |
activates Rho family G proteins and cell motility |
| 16527273 |
Expression of the sphingosine 1 phosphate receptor in primary endothelial cells is both sufficient and necessary for the expression of Akt3. |
| 15894172 |
S1P(3) function is not subject to conventional regulation by GRK phosphorylation |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Endothelial differentiation gene 3 | 5-hydroxytryptamine receptor 1A | - | - | Pubmed |
| HPRD | Endothelial differentiation gene 3 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | Endothelial differentiation gene 3 | guanine nucleotide binding protein, q polypeptide | - | - | Pubmed |
| HPRD | Endothelial differentiation gene 3 | guanine nucleotide binding protein, alpha 13 | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | Guanine nucleotide binding protein, alpha 13 | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | G protein, alpha inhibiting 1 | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | Guanine nucleotide binding protein G(q) alpha subunit | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | 5-hydroxytryptamine receptor, 1A | - | - | Pubmed |
| BIND | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | 5-hydroxytryptamine receptor 1A | 5-HT1A interacts with EDG3. This interaction was modeled on a demonstrated interaction between 5-HT1A and EDG3 from an unspecified species. | - | Pubmed |
Recent Publications on EDG3: |  |
EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas.
By qPCR we found that EDG3 and SHC3 were amplified in 60% of ependymomas... | 15th September, 2009
| Neurochirurgia Dipartimento di Scienze Chirurgiche Universita di Pavia
| Cancer Lett. 2009 Sep 11.
DOI Direct Link |
Utilization of the TangoTM {beta}-Arrestin Recruitment Technology for Cell-Based EDG Receptor Assay Development and Interrogation.
Cellular assay development for the endothelial differentiation gene (EDG)... | 4th September, 2009
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| J Biomol Screen. 2009 Sep 2.
DOI Direct Link |
Non-Edg family lysophosphatidic acid (LPA) receptors.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a... | 16th June, 2009
| Department of Biochemistry and Molecular Biology, Faculty of Medicine, The
| Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. Epub 2009 Jun
DOI Direct Link |
Oligomeric procyanidins inhibit cell migration and modulate the expression of migration and proliferation associated genes in human umbilical vascular endothelial cells.
The consumption of flavan-3-ols has been associated with reduced risk of... | 30th April, 2009
| Phytochemicals and Health Programme, Institute of Food Research, Norwich
| Mol Nutr Food Res. 2009 Feb;53(2):266-76.
DOI Direct Link |
Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.
Protease activated receptor 1 (PAR1) signaling can play opposing roles in... | 29th April, 2009
| Department of Immunology and Microbial Science, The Scripps Research
| Blood. 2009 Mar 19;113(12):2859-66. Epub 2009 Jan 13.
DOI Direct Link |
→View more research publications. |
EDG3 results (if any) from reagent suppliers | 
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EDG-3 (H-70) Antibody sc-30024
rabbit polyclonal IgG, 200 µg/ml; epitope corresponding to amino acids 309-378 mapping within a C-terminal cytoplasmic domain of EDG-3 of human origin ...
http://www.scbt.com/datasheet-30024-edg-3-h-70-antibody.html...
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EDG3 antibodies: Signal Transduction > Signaling Pathway > G ...
EDG3 antibodies. ... EDG3 antibody [AS61]. WB. Mouse monoclonal. Reacts with: Hu , Rat. Terms and conditions · Legal · Privacy policy · Investor relations ...
http://www.abcam.com/index.html?t=76617&pt=1&c=2191&ei=&mu=r...
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EDG-3 (V-20) Antibody sc-16076
Western blot analysis of EDG-3 expression in mouse liver extract. sc-16076. EDG- 3 (V-20): sc-16076. Immunofluorescence staining of methanol-fixed Hep G2 ...
http://www.scbt.com/datasheet-16076-edg-3-v-20-antibody.html...
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Cell Line Descriptions Tango™ EDG3-bla U2OS cells contain the ...
The Tango™ EDG3-bla U2OS cells have been functionally validated for Z' factor and EC50 concentrations of. S1P (Figure 1). In addition, Tango™ EDG3-bla U2OS
...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf/GP...
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EDG-3 (H-15) Antibody sc-22210
goat polyclonal IgG, 200 µg/ml; epitope mapping within an extracellular domain of EDG-3 of human origin; recommended for detection of EDG-3 of m, ...
http://www.scbt.com/datasheet-22210-edg-3-h-15-antibody.html...
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Anti-S1P2, C-Terminal antibody produced in rabbit (E7278) - Datasheet
EDG-3. EDG-5 is expressed in cardiovascular and central nervous system tissues, and in all leukocyte- ... EDG-5 and EDG-3 transduce, at least in part, S1P- ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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EDG-3 (G-17) Antibody sc-22211
goat polyclonal IgG, 200 µg/ml; epitope mapping near the C-terminus of EDG-3 of human origin; recommended for detection of EDG-3 of human and, ...
http://www.scbt.com/datasheet-22211-edg-3-g-17-antibody.html...
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