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AHCY
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18211827 |
consider changes in charge and the sterical incompatibility in mutant p.A89V protein as main reason for enzyme malfunction with AdoHcyase deficiency as consequence |
| 15241484 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17892301 |
The mechanism of action of copper on this enzyme sugges a regulative role for copper on the intracellular activity. |
| 17688412 |
We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH, declination of SAM and SAM/SAH ratio and reduced expression of SAHH and MBD2, but increased activity of DNMT3a and DNMT3b affecting DNA methylation |
| 17172447 |
SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells |
| 17447732 |
In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range. |
| 12069606 |
Five active site residues (E156, N181, K186, D190, N191) of AdoHcy hydrolase have been individually mutated to alanine and each engineered enzyme characterized with respect to its redox partial reaction and elimination/addition partial reaction. |
| 12369977 |
a discussion of its hydrolytic activity (review) |
| 17164794 |
R38W and G123R amino-acid exchanges did not bring about major changes to the catalytic rates. However, circular dichroism analysis showed that both polymorphisms effect the thermal stability. |
| 17097637 |
AdoHcy is involved in adenosine-induced apoptosis by altering gene expression. | →View more information from publications. |
Recent Publications on AHCY: |  |
Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.
S-Adenosylhomocysteine hydrolase (AHCY) is the only mammalian enzyme known... | 30th September, 2009
| Division of Clinical Pharmacology, Department of Molecular Pharmacology
| J Neurochem. 2009 Sep;110(6):1806-17. Epub 2009 Jul 8.
DOI Direct Link |
The S-adenosyl-L-homocysteine hydrolase gene ahcY of Agrobacterium radiobacter K84 is required for optimal growth, antibiotic production, and biocontrol of crown gall disease.
Agrobacterium radiobacter K84 is a commercial agent used worldwide to... | 8th August, 2009
| Department of Microbiology, University of Illinois at Urbana-Champaign,
| Mol Plant Microbe Interact. 2009 Jun;22(6):713-24.
DOI Direct Link |
Time course gene expression in the one-carbon metabolism network using HepG2 cell line grown in folate-deficient medium.
The integrated view of the expression of genes involved in... | 25th July, 2009
| Institut Polytechnique LaSalle, EGEAL, F-60026 Beauvais Cedex, France.
| J Nutr Biochem. 2009 Apr;20(4):312-20. Epub 2008 Jul 7.
DOI Direct Link |
LPS-Induced Genes in Intestinal Tissue of the Sea Cucumber Holothuria glaberrima.
Metazoan immunity is mainly associated with specialized cells that are... | 9th July, 2009
| Department of Biology, University of Puerto Rico, Rio Piedras, San Juan,
| PLoS One. 2009 Jul 8;4(7):e6178.
DOI Direct Link |
S-adenosylhomocysteine hydrolase (AHCY) deficiency: two novel mutations with lethal outcome.
This paper reports studies of two novel, allelic missense mutations found... | 7th July, 2009
| Institute Ruder Boskovic, Division of Molecular Medicine, Zagreb, Croatia.
| Hum Mutat. 2009 Apr;30(4):E555-65.
DOI Direct Link |
→View more research publications. |
AHCY results (if any) from reagent suppliers | 
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S adenosylhomocysteine hydrolase (ACHY) Antibody (C-term)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AHCY antibody (C-term) (Cat.#AP2733b), which was peroxidase-conjugated to the
...
http://www.abgent.com/products/catalog_no/AP2733b_S_adenosyl...
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SAHH (W-20) Antibody sc-55759
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, AHCY, 191, 20q11.22, NM_000687 ...
http://www.scbt.com/datasheet-55759-sahh-w-20-antibody.html...
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A5762 Adenine 9-β-D-arabinofuranoside ≥99%
assay, ≥99%. Gene Information, mouse ... Ahcy(269378). storage temp. −20°C. Safety. Hazard Codes, Xn. Risk Statements, 63. Safety Statements, 36/37 ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en...
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SAHH (W-20) Antibody sc-55759
Humano, AHCY, 191, 20q11.22, NM_000687 · P23526 · 180960. camundongo, Ahcy, 269378, 2 H1, P50247, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-55759-sahh-w-20-antibody.ht...
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SAHH (W-20) Antibody sc-55759
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, AHCY, 191, 20q11.22, NM_000687 ...
http://www.scbt.com/ja/datasheet-55759-sahh-w-20-antibody.ht...
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SAHH (W-20) Antibody sc-55759
Humain, AHCY, 191, 20q11.22, NM_000687 · P23526 · 180960. Souris, Ahcy, 269378, 2 H1, P50247, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-55759-sahh-w-20-antibody.ht...
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SAHH (W-20) Antibody sc-55759
Humano, AHCY, 191, 20q11.22, NM_000687 · P23526 · 180960. Ratón, Ahcy, 269378, 2 H1, P50247, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-55759-sahh-w-20-antibody.ht...
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