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EEF1A2


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Symbol:EEF1A2
Name(s):eukaryotic translation elongation factor 1 alpha 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:EEF1AL, EF-1-alpha-2, EF1A, HS1, STN
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17908984 EEF1A2 is highly homologous and functionally similar to the EEF1A1 oncogene, and was found to be restricted only to the normal tissues of the heart, brain, and skeletal muscle
12053177 This is a putative oncogene in ovarian cancer.
16156888 eEF1A2 may have a role in cytoskeletal remodelling or apoptosis in breast neoplasms
17437010 The oncogenicity of eEF1A2 may be related either to its role in protein synthesis or to potential non-canonical functions.
17088255 there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta
15893736 These results indicate that the use of cellular promoters such as those for EF-1alpha and ubiquitin C might direct prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
14588074 Review. EEF1A2 is an important ovarian oncogene. The protein elongation network can activate tumorigenesis and inhibit apoptosis.
17130842 Regulates oncogenesis through Akt-dependent cytoskeletal remodeling.
16369491 Overexpression of EEF1A2 and KCIP-1 is associated with lung adenocarcinoma

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCholinergic receptor, muscarnic 4eukaryotic translation elongation factor 1 alpha 2--Pubmed
HPRDmuscarinic acetylcholine receptor M4Elongation factor 1, alpha 2--Pubmed
BINDcholinergic receptor, muscarinic 4eukaryotic translation elongation factor 1 alpha 2The third intracellular loop of M4 interacts with eEf1A2.-Pubmed
HPRDeukaryotic translation elongation factor 1 alpha 2TNFRSF1A-associated via death domain--Pubmed
HPRDeukaryotic translation elongation factor 1 alpha 2mitogen-activated protein kinase kinase kinase 7 interacting protein 2--Pubmed

Recent Publications on EEF1A2:

Pubmed Logo
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
The eukaryotic elongation factor 1A2 (eEF1A2) is known to retain oncogenic...
8th October, 2009
Department of Pharmacy, College of Pharmacy, and Cancer Research Cancer Res. 2009 Sep 15;69(18):7449-58. Epub 2009 Sep 8.
DOI Direct Link
eEF1A2 as a putative oncogene.
The first evidence for the role of the protein elongation factor eEF1A2 in...
24th September, 2009
National Research Laboratory of Molecular Carcinogenesis and Ann N Y Acad Sci. 2009 Aug;1171:87-93.
DOI Direct Link
The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth.
The formation of a pH gradient, which is characterized by intracellular...
28th August, 2009
Department of Pharmacology and Brain Korea 21 Project for Medical Science, Lab Invest. 2009 Aug;89(8):867-74. Epub 2009 Jun 8.
DOI Direct Link
Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.
BACKGROUND: Despite sharing 92% sequence identity, paralogous human...
29th July, 2009
Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics PLoS One. 2009 Jul 28;4(7):e6315.
DOI Direct Link
Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying-back neuronal pathology.
Wallerian degeneration and dying-back pathology are two well-known...
3rd April, 2009
Centre for Integrative Physiology, College of Medicine, and Veterinary J Anat. 2008 Dec;213(6):633-45.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7585842 Human kunitz-type inhibitor with enhanced antifibrinolytic activity
7531300 Method of diagnosing breast cancer

View more patents.

EEF1A2 results (if any) from reagent suppliers

Google CSE Logo
EEF1A2 antibodies: Cancer > Oncoproteins/suppressors ...
EEF1A2 antibodies. ... Image Abreview Publication. ab82912 · EEF1A2 antibody. WB , ELISA. Images. Rabbit polyclonal. Reacts with: Hu, Ms, Rat ...
http://www.abcam.com/index.html?t=161715&pt=1&c=4332&ei=&mu=...

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EF-1 α2 (T-12) Antibody sc-68482
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, EEF1A2, 1917, 20q13.33, Q05639 ...
http://www.scbt.com/ko/datasheet-68482-ef-1-alpha2-t-12-anti...

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All Ribosome | Abcam
eEF1A2 binding protein antibody. WB. Images. Mouse monoclonal. Reacts with: Hu. ab77043 · eEF1B2 antibody. WB, ELISA. Images. Mouse monoclonal. Reacts with: ...
http://www.abcam.com/index.html?c=895...

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EF Antibody / EF Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. EF (bI-20) Antibody, sc-17416, goat IgG, internal (b), WB, ELISA, Bacillus anthracis ...
http://www.scbt.com/ko/table-ef.html...

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Transcription factor antibodies | Abcam
AF4 antibodies · AF4 proteins and peptides · B MyB antibodies · B MyB proteins and peptides · Bcl6 antibodies · Bcl6 proteins and peptides · EEF1A2 proteins
...
http://www.abcam.com/index.html?pageconfig=resource&rid=1126...

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EF-1α1 (H-300) Antibody sc-28578
ヒト, EEF1A2, 1917, 20q13.33, NM_001958 · Q05639 · 602959. マウス, Eef1a1, 13627 , 9 E1, P10126, N/A. マウス, Eef1a2, 13628, 2 H4, P62631 ...
http://www.scbt.com/ja/datasheet-28578-ef-1alpha1-h-300-anti...

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PhosphoSignature™
EEF1A1; EEF1A2 Elongation factor 1-alpha 1 (Elongation factor Tu). P68104; Q05639. 50. §29; §29. STTTGHLIyK. 2. 1167. 0.9. 0.8-0.9 ...
http://www.cellsignal.com/technologies/phosphoscan/pdfs/PSig...

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