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EEF2


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Gene DB Home
Symbol:EEF2
Name(s):eukaryotic translation elongation factor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:EEF-2, EF2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16520893 Data show that overproduction of elongation factor 2 blocks HIV-1 viral protein R-induced cell death both in fission yeast and human cells.
15534876 inhibition of protein synthesis under high pressure occurs independent of the phosphorylation of eEF-2
16098202 Levels of p-eEF2K were significantly increased, and total eEF2 significantly decreased in Alzheimer disease
16648488 Hypoxia inhibits protein synthesis through a 4EBP1 and EEF2 pathway controlled by mTOR and unbcoupled in breast cancer cells.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDEukaryotic translation elongation factor 2tumor protein p53--Pubmed
HPRDeukaryotic translation elongation factor 2p53--Pubmed
HPRDeukaryotic translation elongation factor 2transient receptor potential cation channel, subfamily M, member 7--Pubmed

Recent Publications on EEF2:

Pubmed Logo
Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells.
The essential amino acids (EAA) activate anabolic signalling through...
3rd November, 2009
Division of Clinical Physiology, School of Graduate Entry Medicine and Amino Acids. 2009 Nov 1.
DOI Direct Link
Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.
Homeostatic regulation of synaptic strength in response to persistent...
23rd October, 2009
Institute of Neuroscience and State Key Laboratory of Neuroscience, J Neurosci. 2009 Oct 21;29(42):13222-31.
DOI Direct Link
Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction.
LKB1 encodes a serine/threonine kinase, which functions upstream of the...
16th October, 2009
Boston University School of Medicine, United States; J Biol Chem. 2009 Oct 14.
DOI Direct Link
Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells.
Muscle protein synthesis is increased after exercise, but evidence is now...
16th October, 2009
School of Graduate Entry Medicine & Health, Division of Clinical J Physiol. 2009 Jul 15;587(Pt 14):3719-27. Epub 2009 May 26.
DOI Direct Link
Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation.
Protein supplementation during human pregnancy does not improve fetal...
1st October, 2009
Perinatal Research Center, Department of Pediatrics, University of Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E638-46. Epub 2009 Jul 14.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7267954 Methods for the detection of variant cayman ataxia nucleic acids
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7169594 Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway

View more patents.

EEF2 results (if any) from reagent suppliers

Google CSE Logo
eEF2 Antibody #2332
Confocal immunofluorescent analysis of HeLa cells using eEF2 Antibody (green). Actin filaments have been labeled with DY-554 phalloidin (red). ...
http://www.cellsignal.com/products/2332.html...

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EEF2 antibody [EP880Y] - C-terminal (ab75748) | Abcam
Rabbit monoclonal [EP880Y] to EEF2 - C-terminal. EEF2 is a member of the GTP- binding translation elongation factor family. This protein is an essential ...
http://www.abcam.com/EEF2-antibody-EP880Y-C-terminal-ab75748...

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Phospho-eEF2 (Thr56) Antibody #2331
Phospho-eEF2 (Thr56) Antibody detects endogenous levels of eEF2 only when phosphorylated at Thr56. It does not recognize eEF2 phosphorylated at other
sites. ...
http://www.cellsignal.com/products/2331.html...

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EEF2 proteins and peptides: Chromatin and Nuclear Signaling > DNA ...
EEF2 proteins and peptides. ... EEF2 proteins and peptides. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication ...
http://www.abcam.com/index.html?t=150029&pt=2&c=899&ei=&mu=r...

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Phospho-eEF2 (Thr56) Antibody
to result in increased phosphorylation of eEF2, and thus to inhibit peptide- chain elongation ... lated eEF2 can be converted to its active nonphosphorylated
...
http://www.cellsignal.com/pdf/2331.pdf...

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eEF-2 - R&D Systems
Modification of eEF-2 by either ADP-ribosylation or by phosphorylation by eEF-2 kinase stops translation. Products By Product Type ...
http://www.rndsystems.com/molecule_detail.aspx?m=3328...

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Phospho-eEF2k (Ser366) Antibody #3691
Eukaryotic elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2, resulting in the inhibition of peptide-chain elongation (1). ...
http://www.cellsignal.com/products/3691.html...

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