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«EGFR

Below is an extended EGFR publications listing. Click here to return to the gene page.

Gene Information from Publications

Publication Link Summary of findings
18172732 EGFR overexpression was found in 87.5% (35/40) of the laryngeal primary tumors and 82.5% (33/40) of the corresponding lymph node metastases. There was a good agreement between the primary tumors and the paired metastases regarding EGFR expression.
17912028 This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets.
18045238 amphiregulin-specific EGF-R fate results from decreased hSprouty2 degradation and reduced Cbl recruitment to underphosphorylated EGF-R, two effects that impair EGF-R trafficking to lysosomes
18211286 examination of role of lipids in HER1/HER2-driven progression of human breast epithelial cells towards malignancy
18161656 AC dinucleotide repeat polymorphism in intron 1 of human EGFR may have a role in breast cancer in certain ethnic groups
18182111 Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer.
18334834 siRNA-mediated knockdown is effective in lung adenocarcinomas with EGFR mutation and those with resistance to gefitinib by acquired mutation in EGFR.
18084281 Results indicate that GEP100 links EGFR signalling to Arf6 activation to induce invasive activities of some breast cancer cells, and hence may contribute to their metastasis and malignancy.
18202784 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18261621 Observational study of gene-disease association. (HuGE Navigator)
18271929 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18283321 Clinical trial of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18309947 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18317468 Genome-wide association study of gene-disease association. (HuGE Navigator)
18325048 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18349392 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18154448 clinical data suggesting that there could be a subpopulation of metastatic colorectal cancer patients that are more liable to benefit from anti-EGFR monoclonal antibodies--REVIEW
18234969 Stimulating human glioblastoma cells with recombinant HGF induces biologically relevant EGFR activation.
18087285 EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma.
18172267 EGFR mutations and the administration of EGFR tyrosine kinase inhibitors during Whole-brain radiation therapy (WBRT) were independent predictors of response to WBRT in brain metastases of lung adenocarcinoma.
18240930 The population of tumor cells with polysomy of chromosome 7 and EGFR locus correlated significantly with histological grade. High-grade astrocytomas (AAs and GBMs) had elevated fractions of tumor cells with polysomy of chromosome 7 and EGFR locus.
17917087 EGFR mutations do not have significant prognostic value in primary resected non-small cell lung cancer
17942395 Amphiregulin is a specific ligand of the EGFR and a potent mitogen for epithelial cells such as breast cancer cell lines.
18057028 These results highlight a role of P2Y(1)R in EGFR-dependent epithelial cell proliferation. P2Y(1)R could potentially mediate both trophic stimuli of basally released nucleotides and first-line mitogenic stimulation upon tissue damage.
18067636 investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas
17849451 TAE226-induced apoptosis in breast cancer cells with overexpressed EGFR.
18245470 study describes activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin
18208799 Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma.
18269588 Neither EGFR nor BMI-1 had significant prognostic impact for basal-like phenotype of breast cancer.
18208805 EGFR overexpression is present in a majority of hepatocellular carcinomas, suggesting a role for EGFR antagonists in therapy. The increased expression does not correlate with an increase in the EGFR gene copy number.
16505411 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16552419 Observational study of gene-disease association. (HuGE Navigator)
16567021 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16757132 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16788380 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16818686 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16956694 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17054433 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17060486 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17092854 Observational study of gene-disease association. (HuGE Navigator)
17102595 Observational study of genotype prevalence. (HuGE Navigator)
17106442 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17112774 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17148776 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17175376 Observational study of gene-disease association. (HuGE Navigator)
17192902 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17219440 Observational study of gene-disease association. (HuGE Navigator)
17224267 Observational study of gene-disease association. (HuGE Navigator)
17227303 Observational study of gene-disease association. (HuGE Navigator)
17285540 Observational study of genotype prevalence, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17285735 Observational study of gene-disease association. (HuGE Navigator)
17303584 Observational study of gene-disease association. (HuGE Navigator)
17321325 Observational study of gene-disease association. (HuGE Navigator)
17337084 Observational study of gene-disease association. (HuGE Navigator)
17354229 Observational study of gene-disease association. (HuGE Navigator)
17368623 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17375033 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17387341 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17409827 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17409862 Observational study of gene-disease association. (HuGE Navigator)
17409866 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17409930 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17429313 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17431338 Observational study of gene-disease association. (HuGE Navigator)
17453292 Observational study of gene-disease association. (HuGE Navigator)
17455987 Observational study of genotype prevalence. (HuGE Navigator)
17473658 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17473659 Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17487277 Observational study of gene-disease association. (HuGE Navigator)
17487844 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17493174 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
17504988 Observational study of gene-disease association. (HuGE Navigator)
17538160 Observational study of gene-disease association. (HuGE Navigator)
11504770 Observational study of gene-disease association. (HuGE Navigator)
12631599 Observational study of genotype prevalence. (HuGE Navigator)
12653106 Observational study of gene-disease association. (HuGE Navigator)
12719950 Observational study of gene-disease association. (HuGE Navigator)
12768436 Observational study of genotype prevalence. (HuGE Navigator)
15063762 Observational study of gene-disease association. (HuGE Navigator)
15540509 Observational study of gene-disease association. (HuGE Navigator)
15701846 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15710947 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15738541 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15829495 Observational study of gene-disease association. (HuGE Navigator)
15837743 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15956035 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15998907 Observational study of gene-disease association. (HuGE Navigator)
16002952 Observational study of gene-disease association. (HuGE Navigator)
16003726 Observational study of gene-disease association. (HuGE Navigator)
16011858 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16018936 Observational study of gene-disease association. (HuGE Navigator)
16030116 Observational study of gene-disease association. (HuGE Navigator)
16032426 Observational study of gene-disease association. (HuGE Navigator)
16043828 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16052218 Observational study of gene-disease association. (HuGE Navigator)
16098254 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16140420 Observational study of gene-disease association. (HuGE Navigator)
16152581 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16198442 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16199108 Observational study of genetic testing. (HuGE Navigator)
16203769 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16240846 Observational study of genotype prevalence. (HuGE Navigator)
16243431 Observational study of gene-disease association. (HuGE Navigator)
16324836 Observational study of genotype prevalence. (HuGE Navigator)
16344724 Observational study of gene-disease association. (HuGE Navigator)
16353158 Observational study of gene-disease association. (HuGE Navigator)
16376942 Observational study of gene-disease association. (HuGE Navigator)
16397024 Observational study of genotype prevalence. (HuGE Navigator)
16449241 Observational study of gene-disease association. (HuGE Navigator)
16461080 Observational study of gene-disease association. (HuGE Navigator)
16467085 Observational study of genetic testing. (HuGE Navigator)
16467097 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17575224 Observational study of gene-disease association. (HuGE Navigator)
17580276 Observational study of gene-disease association. (HuGE Navigator)
17597605 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17607119 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17610986 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17626639 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17644807 Observational study of gene-disease association. (HuGE Navigator)
17661145 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17686547 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17690890 Observational study of gene-disease association. (HuGE Navigator)
17713473 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17760253 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17760255 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17761979 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17845757 Observational study of gene-disease association. (HuGE Navigator)
17848912 Observational study of pharmacogenomic / toxicogenomic and genetic testing. (HuGE Navigator)
17852426 Observational study of gene-disease association. (HuGE Navigator)
17875767 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17904685 Observational study of genotype prevalence. (HuGE Navigator)
17908966 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17912028 Observational study of gene-disease association. (HuGE Navigator)
17932690 Observational study of gene-disease association. (HuGE Navigator)
17941001 Observational study of gene-disease association. (HuGE Navigator)
17949425 Observational study of genotype prevalence. (HuGE Navigator)
17956637 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18161656 Observational study of gene-disease association. (HuGE Navigator)
18176089 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18186271 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17548322 Observational study of genotype prevalence. (HuGE Navigator)
16503086 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18199332 EGFR structural alterations are rare in gastric carcinoma, but whenever present, it leads to tumour growth.
18199957 These findings implicate the ErbB pathway in vestibular schwannoma growth
17998090 CONCLUSION: [111In]DTPA-hEGF is translocated to the nucleus of BC cells complexed with EGFR and importin beta1.
18028876 The activation of PAR-2 expressed by human intestinal epithelial cells enhances mucin secretion, a component of the intestinal innate defence, via a pathway involving EGFR transactivation.
17686547 EGFR insertion mutation in exon 20 could not be ignored from Japanese lung cancers
18216322 EGFR activation is the cause of both hyperplastic growth and VDR reduction in secondary parathyroidism hyperplasia
17922051 The presence of neuroendocrine cells may have an effect on the expression of TGF-alpha and EGFR in gastric adenocarcinoma, and the autocrine mechanism between TGF-alpha and EGFR plays an important role in the prognosis of gastric carcinoma.
18199554 Cell line genetic heterogeneity and/or multiple determinants modulate the role played by EGFR/HER2 in regulating cell proliferation.
17989321 This is the first time EGFR expression has been tracked meaningfully and developmentally from the normal condition through disease progression using in vitro, xenograft, and matched normal and tumor samples.
18186961 EGFR mutations in carcinogenesis of lung adenocarcinoma: distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma
18032821 Amplifications within regulatory sequences of egfr are associated with the expression of eps15 and caveolin-1; EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK seems to present a major molecular pathway in progression of breast phyllodes tumours.
18032824 AP-1 and NF-kappaB transcription factors are activated and EGF-R is expressed in these cells and associated with COX-2 and VEGF production.
18060032 EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment.
18097577 heterozygous and synonymous transition of the EGFR gene and low EGFR expression levels of mRNA and protein in squamous cell carcinomas of the head and neck (SCCHN) may be reliable predictors of high sensitivity in SCCHN patients to gefitinib.
16899617 alterations within the tyrosine kinase domain and expression of EGFRvIII are rare events in bladder cancer
18083120 This study demonstrates that ADV-Avi/biotin-PEG-EGF construct systems can be applied for cell-specific delivery of ADV with simultaneously reducing innate immune responses.
16818686 Patients with non-small cell lung cancer and EGFR exon 19 deletions have a longer survival following treatment with gefitinib or erlotinib compared with those with the L858R mutation
17913857 Inhibitory activity of cetuximab on epidermal growth factor receptor mutations is associated with non small cell lung cancers
18089646 EGFR mutations were frequently found in lung adenocarcinoma with ground-glass opacity (GGO) on High-Resolution CT in this study.
18180459 oncogenic EGFR and c-Met have roles in pathways mediating drug response
17805209 Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine.
17941001 The serum CEA level appears to be closely associated with the presence of EGFR gene mutations in patients with pulmonary adenocarcinomas.
18006781 EGFR expression, mutations, polymorphisms, and gene amplification contribute to to the pharmacodynamics of EGFR inhibitors.
17714760 EGFR may play an important role in the pathogenesis and phenotype of Congenital cystic airway malformation/congenital pulmonary airway malformation.
18154814 Overexpression of EGFR in lung adenocarcinomas with components of BAC histology correlate with never-smoker status and improved overall survival and disease-free interval.
17018617 activating mutations in the TKD domain of EGFR contribute to radiosensitivity of non-small-cell lung carcinoma
17638075 GM3 has an effect on kinase associated with EGFR
18000506 The clinical relevance of 'other' EGFR mutation variants remains uncertain and requires further assessment.
15923435 Immunohistochemical profiling of colorectal cancer seems to be a promising approach, not only to define prognostic impact, but also to detail proliferation-related molecular interplays between EGFr and Cox-2 pathways.
18089823 development of PF00299804 as treatment for cancers with mutations and/or amplifications of ERBB family members.
18093943 MET amplification occurs independently of EGFR(T790M) mutations in lung adenocarcinoma
17721266 EGFR immunoreactivity with basal cytoplasmic pattern was exclusively seen in terminal respiratory unit type lung adenocarcinoma and a subset of these cases was seen with EGFR mutations in the responders to EGFR inhibitor therapy
17655843 In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation.
17956637 These results suggest that the EGFR polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer.
17974918 The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.
17991782 examination of rate of association reactions between Grb2 and epidermal growth factor receptor
17690890 Study indicated that that mutations within the tyrosine kinase domain of EGFR and expression of EGFRvIII (a truncated EGFR variant) are rare events in bladder cancer and therefore do not contribute to the malignant phenotype of this tumor.
17918158 curcumin and FOLFOX work through attenuation of the EGFR and IGF-1R signaling pathways
17918184 EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells
17964790 we have shown no expression of ErbB-1 in vestibular schwannomas
17947472 Wnt and epidermal growth factor receptor signaling pathways are altered through aberrant methylation and mutation in non small cell lung cancer
17673923 CISH (chromogenic in situ hybridization) is an alternative assay to FISH in determining EGFR copy number.
17922974 CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation than in lung cancer without EGFR mutation
18025312 Up-regulation of the EGFR cascade may have an important role regarding mucus production in the sinus mucosa of patients with CRS and CRS/NP associated with hyperplasia and metaplasia of epithelial goblet cells
17908966 sex and smoking status could influence the EGFR mutational spectrum
17881446 induction of p50/p50/Bcl-3 complexes by latent membrane protein 1 (LMP1) C-terminal activating region 1 mediates LMP1-induced epidermal growth factor receptor upregulation
17537621 delE746-A750+L858R double activating EGFR mutations exist in Chinese non-small cell lung cancer patients and both locate on the same allele
17823122 results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands
17112774 EGFR polymorphisms may be associated with clinical outcome in patients treated with chemoradiation.
17177598 Results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma.
17950068 Increased EGFR gene copy number and elevated EGF levels are present in a significant proportion of pancreatic cancer patients, and this may reflect increased EGFR pathway dependence with improved sensitivity to EGFR-targeted therapy.
17784875 Regarding EGFR, no specific mutation was detected in five of the six patients with lung cancer whereas one female patient who had never smoked had a missense mutation.
17962724 No previouly described somatic EGFR mutations were found in head and neck squamous cell carcinoma DNA, but other DNA sequence variations were found in 9 of 31 patients. Activating EGFR mutations seem to be a rare event in Spanish HNSCC patients.
17525275 In vivo, EGFR signaling is hyperactive in tumor cells of skin SCC but not of BCC, and in nearby asymptomatic epidermis of both tumor types. Hyperactivation is due to upregulation of EGFR ligands AREG, HBEGF and TGFA, and downregulation of BTC
17685929 study investigated EGFR protein expression & gene mutations in exons 18, 19 and 21 in 40 renal angiomyolipomas (AML); no EGFR gene mutations of TK domain were detected and strong immunostaining was found in 5% of the renal AML cases
17699773 study found that EGFR down-regulation was impaired in two non-small cell lung cancers with EGFR tyrosine kinase domain mutations; the mutant receptors were poorly ubiquitylated and exhibited decreased association with the ubiquitin ligase Cbl
17600311 EGFR signalling plays a central role in cyclooxygenase-2 induction by transforming growth factor-beta 1 in human bronchial epithelial cells.
17631646 ZD6474 treatment inhibited EGFR phosphorylation and led to a dose- and time-dependent decrease in nasopharyngeal carcinoma cell
16912195 EGFR somatic mutations directly influence both erlotinib cancer cell sensitivity and cellular transformation.
17885502 upregulation of EGFR expression in a few warty and basaloid HG-VIN cases and in many SCCs of the vulva.
17486068 Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
17712488 Reduction of sperm motility by tryptase through the PAR-2 receptor involves epidermal growth factor receptor pathways.
16912157 T790M mutation is sometimes present in a minor population of tumor cells during the development of non-small cell lung cancer.
17652160 These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities.
17643426 HGF induces transactivation of the EGFR in epithelial cells, and this is a prerequisite for induction of full motility.
17597605 In Chinese lung cancer patients, a low number of CA repeats in intron 1 of the EGF receptor gene is associated with a better clinical outcome during therapy with gefitinib.
17972518 Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas.
17870017 The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR.
17907599 We report the histological and genetic study of two glioblastomas, one case arising de novo and the other case arising 3 years after a previously diagnosed anaplastic astrocytoma, with concurrent EGFR amplification and TP-53 mutation
17594688 Amplification of the EGFR gene and polysomy 7 are frequent alterations in primary melanomas and are associated with bad prognosis
17334773 In a novel culture system normal human adult melanocytes expressed both EGF receptor (EGFR) mRNA and protein and EGF showed a dose dependent mitogenic effect on the cells
17508947 Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from male and female Japanese patients.
17804738 Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance.
17575133 study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking
17646270 EGFR mutation and gene amplification is asociated with clear cell sarcoma of the kidney
17643093 Fluorescence in situ hybridization/immunohistochemistry analysis of EGFR may be a useful ancillary tool to classify difficult cytology cases and inform clinicians arranging targeted chemotherapy.
17643098 No correlation between epidermal growth factor receptor protein overexpression and epidermal growth factor receptor gene amplification in gastrointestinal stromal tumors.
17822324 Overexpression of EGFR is associated with astrocytic tumor pathogenesis and progression
17453292 Shorter EGFR intron 1 CA repeat length is associated with worse pancreatic cancer clinical prognosis and in vitro response to erlotinib.
17618248 EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas.
16795991 A subset of pancreatic ductal adenocarcinomas is characterized by EGFR gene numerical alterations including sporadic cases of amplification or absence of one allele (maybe due to gene deletion or intragenic point mutation and allelic silence).
17566601 It seems that continued EGFR tyrosine kinase inhibition may be beneficial to EGFR-mutant lung cancers.
17595327 OSU-03012 prevents YBX1 from inducing EGFR.
16103229 These findings suggest a mechanism by which filopodia detect the presence and concentration of effector molecules far from the cell body and mediate cellular responses via directed transport of activated receptors.
17661145 When combining thymidylate synthase and epidermal growth factor A61G genotype analysis, a small subgroup with a complete pathologic response rate of 100 percent was identified.
17516110 EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system.
17548351 Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38
17495959 EGFR/Akt pathway mitigated G2/M arrest in human HaCaT keratinocytes and normal human keratinocytes treated with low doses of UVA irradiation.
17622245 The combination of cetuximab and trastuzumab could induce synergistic antiproliferative effects in several oesophageal Squamous cell carcinoma cell lines with EGFR and HER-2 expression.
17372273 the long lifetime of EGFRvIII, mutant variant of EGFR is caused by inefficient internalization and impaired sorting to lysosomes due to lack of effective ubiquitinylation.
17607370 In NSCLC cases with wt- or mutant KRAS, downregulation of EGFR expression was a rare event although upregulation in bone metastases was observed more frequently in wt K-RAS cases.
17575224 the R497K polymorphism of the EGFR could be a key determinant for reduced tumor recurrence and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma
17573511 EGFR mutation can easily be detected in metastatic lymph nodes sampled by EBUS-TBNA.
16685269 Final outcome of bladder cancer patients with high HER1- and HER2-expressing tumors depends on the expression of HER3 AND HER4.
17644807 Adenin/guanine polymorphisms are not associated with endometrial cancer in a Japanese population.
17459062 Frequencies of EGFR mutations were similar in both the alveolar and bronchial types of lung cancer
17545148 EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation
17646646 activating phosphorylation site on the c-Met receptor was found to be highly responsive to EGFRvIII levels, indicating cross-activation of the c-Met receptor tyrosine kinase by EGFRvIII
17591931 In bronchioalveolar carcinoma/adenocarcinoma with bronchioalveolar features mucinous differentiation was significantly correlated with the absence of EGFR mutation and presence of KRAS mutation.
17607119 EGFR mutations were therefore significantly associated with a better PFS in the first-line cytotoxic chemotherapy regimens.
17649787 acquired resistance against both erlotinib, as well as gefitinib was most likely a result of tumor cells acquiring the T790M mutations
17650314 CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term.
17534846 it is suggested that atypical adenomatous hyperplasia (AAH) could develop by either KRAS or EGFR gene mutation, but AAH harbouring a KRAS gene mutation might not progress further to an invasive cancer
17626639 Neither mutation of EGFR nor increased copy number of EGFR or HER2 was diagnostic of response to gefitinib.
17581404 Data support that there are significant differences between EGFR and COX-2 expressions in the 3 different histogenetic types of cervical cancer.
17237147 Directed trafficking of plasma membrane EGFR is an essential element of signal transduction leading to p42/p44 MAP kinase activation.
17525128 E2 can activate a linear pathway involving the sequential activation of IGF-IR, MMP, HB-EGF, EGFR, and MAPK in MCF-7 breast cancer cells
17671201 Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
17611648 Decreased intratumoral EGFR expression and the absence of activated EGFR suggests that EGFR inhibition might not be an ideal target for antibody therapy.
17390041 Comparative genomic hybridization and immunohistochemical assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas, one oligoastrocytoma and 23 high-grade astrocytomas is reported.
17509661 Two somatic alterations (E829E and R831C) were identified in the cytoplasmic domain of the EGFR gene in 1 of 10 osteosarcoma samples.
17562788 Shiga toxin trafficking to the Golgi is controlled by several Rab GAPs and their target Rabs and this process is discrete from ligand-induced EGFR trafficking. RabGAP-5 was unique among the GAPs tested and reduced the uptake of EGF but not Shiga toxin
17761979 EGFR mutation status influenced the effect of adjuvant chemotherapy with uracil-tegafur.
17219440 The number of dinucleotide repeats in this receptor identifies a possible susceptible population to lung cancer.
17475774 Integrin-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGFR by signaling downstream to Erk.
12686539 EGFR/HER2 heterodimers traffic as single entities; levels of HER2 in normal cells are barely at the threshold necessary to drive efficient heterodimerization
12757445 Seasonal allergic rhinitis subject showed significant elevation in EGFR expression, consistent with the observation of mucus hypersecretion in allergic rhinitis.
15652339 the acceleration of EBV LMP1 on the G1/S transition via the nuclear accumulation of EGFR was critical in the process of nasopharyngeal carcinoma
15772959 Increased levels of EGFR were significantly associated with adult soft tissue sarcomas
15920544 Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules.
15921680 These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer.
12134064 These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling.
12134089 These results indicate that epidermal growth factor (EGF) receptors can form a ligand-independent inactive dimer and that receptor dimerization and activation are mechanistically distinct and separable events.
15748904 The optimization and specification of therapeutic approaches based on erbB-receptor targeting requires to account for EGFR coexpression as well as the potential presence of erbB-receptor relevant growth factors.
17126326 These results suggest that the secreted Hsp70 mediates the cross-communication of Toll like receptor and epidermal growth factor receptor signaling systems in A431 cells.
17285230 Overexpression of the EGFR is associated with astrocytomas
17545553 epidermal growth factor receptor D761Y mutation has a role in response to tyrosine kinase inhibitors
14512423 ganglioside GM3 inhibits integrin-induced, ligand-independent epidermal growth factor receptor phosphorylation (cross-talk) through suppression of Src family kinase and phosphatidylinositol 3-kinase signaling
16203769 EGFR mutation plays an important role in pathogenesis of lung adenocarcinoma
15226397 EGF receptor traffic is disrupted by farnesyltransferase inhibitors through modulation of the RhoB GTPase
15735691 YB-1 overexpression can induce EGF independence in human mammary epithelial cells via activation of the EGFR pathway
15735700 HDL blocks neuroblastoma differentiation by inhibition of EGFR
16870303 epidermal growth factor receptor has a role in response to gefitinib treatment in patients with non-small cell lung cancer
17307332 Conventional PKC isoforms, especially PKCalpha, mediate feedback inhibition of G-protein-coupled receptor -induced EGFR transactivation.
17381163 Results show epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding.
17453000 Potentially interesting value of the serum levels of sEGFR and EGF, especially when combined, as markers for non-small cell lung cancer and head and neck cancer.
17462600 These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity.
12152785 Differential EGFR patterns by interphase cytogenetics in malignant peripheral nerve sheath tumor and morphologically similar spindle cell neoplasms.
12444032 hydrogen peroxide increases cPLA(2) activity through its phosphorylation utilizing an epithelial growth factor/Ras/extracellular signal-regulated kinase and p38 pathway.
12487410 Expression of the invasive phenotype in breast epithelial cells requires increased EGF receptor signaling, involving both PI 3-kinase and Erk 1,2 activities, which leads to enhanced secretion of MMP-9 and transcription of invasion-related genes.
15798095 regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells
15994311 Decorin causes EGFR internalization via caveolae
16240846 The frequency of CA allele combinations was assessed in healthy women from Poland; results provide new data on EGFR microsatellite instability and may contribute to the understanding of EGFR gene expression regulation.
16242075 the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells
17183836 EGFR positivity was observed in all the cases (100%) of benign prostatic hypertrophy (BPH) and prostatic intraepithelial neoplasia (PIN) and in only 10 cases (28.5%) of prostatic carcinoma.
11788593 effects of receptor-selective retinoid ligands on EGFR-associated signal transduction
17349623 GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors.
12517803 activation regulates mutation and epidermal growth factor receptor activation regulates vascular endothelial growth factor mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter.
15248827 betacellulin may play a role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas.
15485674 EGF signalling amplification is induced by dynamic clustering of EGFR
16305343 data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer
16472761 EGFR signaling pathway negatively regulates prostate specific antigen expression which may be induced by the alteration of androgen expression via the PI3K-Akt pathway in LNCaP C-81 cells
16569667 Healing of wounds in sheets of corneal epithelial cells is absolutely dependent on epidermal growth factor receptor signaling, and the present data suggest that its activation is a result of wound-induced phospholipase D activation.
16923119 These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl.
17053785 fine-tuning mechanism of Par3 in epithelial tight junction assembly controlled by the EGF receptor-SFK signaling pathway.
17157295 These findings unmask an EGF-sensitive checkpoint, helping to understand the link between sustained EGFR signalling, proliferation and the acquisition of a radioresistant phenotype in cancer cells.
17186532 Epidermal growth factor receptor mutations are associated with adenosquamous carcinoma of the lung
17196962 Motogenetic activation by EGF requires the concomitant functionality of EGFR and the hyaluronan receptor CD44, whereas activation by TGF-alpha requires EGFR and integrin alphavbeta3.
17200338 somatic alterations in p53 and EGFR have roles in progression of primary lung cancer
12354760 caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation.
14507652 Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas.
15042583 The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy.
11897506 estrogen transactivates the epidermal growth factor receptor (EGFR) to MAP K signaling axis via GPR30;implications for breast cancer biology
15950906 EGFR physically interacts with signal transducers and activators of transcription 3 in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase.
12456372 Mutual interaction of EGFR with c-Src is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review.
12930839 EGF receptor down-regulation by UVA may play an important role in the execution of the cell suicide program by attenuating its anti-apoptotic function
12829707 Ligand-induced EGFR degradation is preceded by proteasome-dependent EGFR de-ubiquitination.
15982634 Our findings suggest that extracellular H(2)O(2) generated by EGFR-ligand interaction permeates the plasma membrane and inhibits EGFR-associated tyrosine phosphatase activity.
16799709 The majority of oral squamous cell carcinomas highly express EGFR and p-EGFR, and a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion.
17255257 PTEN tumor-suppressor protein has a role in response to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma
11853560 Calmodulin binds to the EGFR
12105206 determination of decorin binding site
13679441 These results indicate that the EGFR signaling pathway is involved in urothelial regeneration.
13679857 Mitogenic effects of gastrin-releasing peptide in head and neck squamous cells are mediated by activation of EGFR.
15389641 GqPCR-induced FAK activation is mediated by via a pathway involving transactivation of the EGFr and alterations in the actin cytoskeleton.
14978035 a novel and important role for metalloprotease activation and EGFR transmodulation in mediating the cellular response to TNF
16642476 Frequent EGFR mutations is associated with brain metastases of lung adenocarcinoma
16687414 lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF
16741920 These findings are consistent with a model in which ErbB1 expression increases during development of the androgen-independent state. Drugs targeted toward ErbB signaling could be of therapeutic relevance in the management of advanced prostatic carcinoma.
16750403 Results describe a relationship between the effects of epidermal growth factor (EGF) on cell proliferation and levels of EGF receptor expression in a cell line expressing different levels of EGFR caused by different concentrations of EGF treatment.
16785991 The data suggest that prolactin synergistically augments epidermal growth factor signaling in T47D breast cancer cells at least in part by lessening EGF-induced epidermal growth factor receptor downregulation.
16936259 EGFR is required for UVB-mediated induction of multiple signaling pathways that are known to mediate tumor formation in skin.
16984414 cells surviving an attack by alpha toxin can be induced to proliferate via recruitment of an EGFR-dependent signalling pathway
11953893 Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length.
12642595 data indicate that growth hormone, by activating extracellular signal related kinases, can modulate epidermal growth factor-induced epidermal growth factor receptor trafficking and signaling
17403676 Rin1 regulates EGFR degradation in cooperation with STAM
15962011 EGFR downregulation is inhibited by Sprouty2 targeting both the Cbl and CIN85 pathways.
11994282 blocking of ubiquitination by inhibiting Src family kinases
15082004 Intensive staining of EGF-R is associated with invasive tumours of bladder
15337756 Data show that activation of ADAM-17 results in discrete cellular responses, while G protein-coupled receptor agonists promote activation of the Ras/MAPK pathway and cell proliferation via the epidermal growth factor receptor.
15815931 data suggest that mutations of epidermal growth factor receptor (EGFR) and K-RAS genes might separately, but not cooperatively, contribute to lung adenocarcinoma pathogenesis
12388817 Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors
12722480 The expression of this protein was not different in the clone cell variants or the A431 parental line.
14607699 findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors
16738552 analysis of proteins that bind to and interact with EGFR
17596643 EGFR and K-ras mutations may have a role in progression of resected non-small-cell lung cancer
16246327 EGF-R fate is controlled by a checkpoint downstream of receptor ubiquitination whose regulation by the Cbl RF tail may require Sprouty2 degradation.
16373414 PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR.
16622417 PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin and increased epidermal growth factor receptor (EGFR) endocytosis at physiological EGF concentrations.
14704150 involvement urokinase plasminogen activator secretion and cell motility in breast cancer cells
14718570 the adhesion-dependent activation of EGF receptor signaling is promoted by L1-type CAMs in vitro and in vivo
15010475 Trypsin exerts robust trophic action on colon cancer cells and underline the critical role of EGF-R transactivation.
15245434 Human leukocyte elastase induces keratinocyte proliferation by proteolytic activation of an EGFR signaling cascade involving TGF-alpha.
15896781 heterogeneity in the density of EGFR due to localization in certain regions of the plasma membrane, which has been experimentally reported, can also lead to concave up shape of the Scatchard plot of the EGF binding on EGFR
16299810 EGFR, in addition to E2F1, target sites induce B-Myb promoter
16319309 These findings reveal a new role for EGFR in the postnatal brain and open new avenues to optimize cell engraftment for brain repair.
11751923 The data presented here demonstrate that, in contrast to activation by the cytokine, growth hormone (GH), the activation of STAT5b by the growth factor, epidermal growth factor (EGF), requires overexpression of the EGF receptor (EGFR).
12006662 novel mechanism of EGFR internalization that does not require ligand binding, receptor kinase activity, or ubiquitylation and does not direct the receptor into a degradative pathway
15524283 regulation of LMP1 on the nuclear translocation of EGFR is critical for the process of nasopharyngeal carcinoma
12897150 endosomal epidermal growth factor receptor stimulates cell growth
15447984 serum epidermal growth factor receptor and HER2 have roles in response of advanced non-small cell lung cancer to chemotherapy
16010411 EGFR expression was associated with improved survival.
16098254 Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy.
15967120 Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
16331686 Findings disclose a cross-talk between the COX-2/PGE(2)/EP(1) and EGFR/c-Met signaling pathways that coordinately regulate human hepatocellular carcinoma cell invasion.
16398612 Antibodies from naive human scFv (single-chain Fv) phage display libraries provide a valuable and potentially clinically relevant panel of agents to target the members of the EGFR family.
16567021 a wide spectrum of somatic EGFR TK mutations reporting a relatively high incidence (15%) in NSCLC patients of Greek and Czech origin.
16584205 An EGF mutant, designated WVR/EGF/IADIQ, gained high affinity for ErbB3 & showed concomitant ErbB3 activation through ErbB2.ErbB3 heterodimers similar to the natural ErbB3 ligand NRG1beta, while the capacity to bind & activate ErbB1 was fully maintained.
16641105 results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested
16778986 These data demonstrate that sterile wounding initiates an innate immune response through activation of the epidermal growth factor receptor that increases resistance to overt infection and microbial colonization.
16859684 These results demonstrate that both clathrin-positive and clathrin-negative electron dense coats exist on endosomes and are involved in endosomal sorting of the EGFR.
17182860 These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR.
17289890 EGFR overexpression in small cell carcinoma of the urinary bladder does not seem to be caused by gene amplification
17514628 In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression.
11875501 data demonstrate that prostaglandin E2 transactivates EGFR and triggers mitogenic signaling in gastric epithelial and colon cancer cells as well as in rat gastric mucosa in vivo
11983694 Src-dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and zinc-induced Ras activation
15342520 The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor in mice is strongly dependent on genetic background.
15828871 Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element.
16082153 fibrin can support the wound healing process of the epidermis via the TGF-alpha/EGF-R pathway
12517767 targeting in cancer, involved in apoptosis (REVIEW)
17505415 EGFR mutations in exon 21 are early events in small bronchiolalveolar carcinomas, while exon 19 mutations are later events occurring in adenocarcinomas of various types.
17538889 Infection of AGS cells by H. pylori significantly increased EGFR mRNA and protein levels.
15057284 EGFR regulation by E-cadherin was associated with complex formation between EGFR and E-cadherin that depended on the extracellular domain of E-cadherin but was independent of beta-catenin binding or p120-catenin binding
11966576 epidermal growth factor receptor activity on fertilization capacity of testicular harvested spermatozoa
12586780 results demonstrate that tamoxifen resistant MCF-7 cell growth is mediated by the autocrine release and action of an epidermal growth factor receptor-specific ligand inducing preferential epidermal growth factor receptor/c-erbB2 dimerization
12606946 Exogenous OPN increased EGFR mRNA expression, as well as EGFR kinase activity. Inhibition of EGFR significantly impaired the cell migration response to OPN.
12664617 Human colon carcinoma cells that overexpress cyclooxygenase exhibit growth stimulation and induction of this protein.
12746449 carboxyl-terminal mutation of the epidermal growth factor receptor alters tyrosine kinase activity and substrate specificity
12746839 androgens promote an increase in the activity of the epidermal growth factor (EGF)-network by increasing ErbB1 levels, and this activity of is essential for androgen-induced proliferation and survival of the prostate cancer LNCaP cell line.
14701753 SHP-2/Gab1 association is critical for linking EGFR to NF-kappaB transcriptional activity via the PI3-kinase/Akt signaling axis in glioblastoma cells
14702346 sorting of endocytosed epidermal growth factor receptor into the degradation pathway requires both its kinase activity and actin-binding domain
15364923 Results describe the role of epidermal growth factor receptor regulation in antiapoptosis, cell migration, and cell proliferation.
15383630 data explain how thrombin exerts robust trophic action on colon cancer cells and underline the critical role of EGFR transactivation
15366372 Egfr Wa5 is a novel ENU-induced antimorphic allele caused by a kinase-dead receptor acting as a dominant negative
15572377 HER2-mediated effects on EGFR dimerization and trafficking were sufficient to explain the observed HER2-mediated amplification of epidermal growth factor-induced ERK signaling
15618223 PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells
15652750 Data show that expression of epidermal growth factor receptors (EGFR) in transgenic mouse Schwann cells elicited features of neurofibromas, supporting the relevance of EGFR to peripheral nerve tumor formation.
15708852 Tyr-992 and Tyr-1173 are required for phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2
15837743 Using the LightCycler PCR assay, the EGFR L858R mutation status might correlate with gender, pathologic subtypes, and gefitinib sensitivity of lung cancers.
15963982 overexpression of the active form of the small GTPase RhoA induces the activation of Epidermal Growth Factor Receptor and promotes cell motility
16037379 Existence of unidirectional IGF-IR/EGFR cross-talk mechanism whereby IGF-II, acting through IGF-IR, regulates basal and ligand-activated EGFR signaling and cell proliferation in a c-SRC-dependent manner in tamoxifen-resistant breast cancer.
12161422 Results show that the juxtamembrane region of the epidermal growth factor receptor is necessary for accurate polarized expression of the native molecule.
12743604 Loss of PTEN/MMAC1/TEP in tumor cells expression this protein counteracts the antitumor action of EGFR tyrosine kinase inhibitors.
15039424 epidermal growth factor receptor and CD95 activation are triggered by Src family kinase Yes
15254267 amphiregulin- and ErbB1-dependent mechanism by which autocrine ERK activation is maintained in normal keratinocytes
15788655 Mutations in the tyrosine kinase domain of the epidermal growth factor receptor is associated with non-small cell lung cancer
16151725 findings suggest that overexpression of EGFR in glioblastomas in Chinese patients may be associated closely with the patients age but not with the tumors' pathological pathway.
16161046 Overexpression of EGFR was significantly correlated with depth of invasion of the tumor
16353158 EGFR mutations may contribute to the development of bronchioloaveolar carcinoma and are one of the early genetic alterations in multistage carcinogenic processes of lung adenocarcinoma
15705969 Data suggest the possibility of a mechanically activated epidermal growth factor receptor (EGFR) autocrine feedback loop involving selected EGFR ligands.
16401639 ERBB3 is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, but the NEU/EGFR dimer does not appear to play a significant role in prostate cancer
14520461 Up-regulation of EGFR is associated with renal cell carcinoma
16226114 EGFR expression status in lung cancer correlates with its mutation.
12429742 mediation of synergism with c-src by STAT5b
15749523 EGFR gene 2073*T-related genotypes and allele are associated with higher susceptibilities to endometriosis and leiomyoma
12243760 Data indicate that phospholipase A2 downregulates the EGF receptor-mediated intracellular signal transduction that may be mediated by arachidonic acid and/or ceramide.
12381737 determination of whether G protein-coupled receptor kinase-2 can phosphorylate and desensitize epidermal growth factor receptor
15736426 Findings provide evidence that STAT 3 signal activity in head and neck carcinomas, which is partially responsible for proliferative activity, can be controlled via the EGFR.
12819035 Data show that stimulation of epidermal growth factor receptors differentially regulates chemokine expression in keratinocytes.
12223352 findings suggest an increase in functional TGF-alpha and activation of the EGFr in response to IFN-gamma
15337524 Syk acts a negative control element of EGFR signalling.
12782602 Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.
14729599 the relationship between the egfr polymorphism and breast cancer risk
15590694 The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5.
12192610 EGF receptor expression was elevated in the prefrontal cortex in schizophrenic
12794748 HEGFR was expressed in the subventricular zone embryologically
12795333 Epidermal growth factor receptor negatively regulates intracellular kinase activation in the absence of ligand
15870435 High EGFR gene copy number identified by FISH may be an effective molecular predictor for gefitinib efficacy in advanced NSCLC.
16033132 Chromogenic in situ hybridization analysis and morphology identified 22 small cell (SCGBM) and 22 non-small cell glioblastoma (NSCGBM), and 12 cases of a mixed phenotype.
16077899 Overall, these data suggest that GRK2 has a regulatory role in EGF-induced ERK/MAPK activation.
16184431 simulation results show the formation of a channel under Thr766 following the movement of the side chain of Gln767 away from the hinge in EGFR
16200342 Intratumoral variation of epidermal growth factor receptor (EGFR) expression in glioblastoma multiforme was examined, and radionuclide labelled substances that bind specifically to EGFR were considered for intracavitary therapy.
15211117 The cytoplasmic overexpression of EGFr plays a significant role in the progression of pancreatic ductal adenocarcinoma, especially in the invasion and acquisition of aggressive clinical behavior.
12234920 Data show that human sprouty2 potentiates epidermal growth factor receptor signalling by specifically intercepting c-Cbl-mediated effects on receptor down-regulation.
12479108 EGFR, DI, and the diploid are valuable targets for judging metastasis and recurrence of gastric cancer before and after operation.
12579331 Expression of EGFR seems to play an important role in metastasis, especially liver metastasis and recurrence of pancreatic cancer.
14557654 lysosomal degradation by adenovirus E3 RIDalpha protein dependent on specific domains
15623594 High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness
15701846 Epidermal growth factor receptor gene polymorphisms have higher risk of pelvic recurrence in patients with rectal cancer treated with chemoradiation
15701973 stimulation of the EGFR pathway is one mechanism by which the bone marrow microenvironment may contribute to the growth and survival of B-cell acute leukemia
16098054 results show that EGFR are present on normal human melanocytes
16126727 thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II
16105874 Data show that epidermal growth factor receptor dileucine motif 679-LL is an alpha-helical stabilizing motif that regulates a predominant step during lysosomal sorting, involving intracellular retention under both sub-saturating and saturating conditions.
16240219 the effect of interleukin-8 (IL-8) induced by H. pylori infection on EGFR transactivation and epithelial cell growth
16275144 Ubiquitination of EGFR at late stages of endocytosis was significantly lower than that in control cells. Highly ubiquitinated forms of EGFR demonstrated more sensitivity to MG132 treatment.
16407214 Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking
16503085 Epidermal growth factor receptor gene mutation is associated with adenocarcinomas of the lung
16507511 In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation.
16524970 EGFR expression is not stable during metastatic progression in a significant proportion of non-small-cell-lung cancer patients.
16524971 Understanding of EGFR identity in colorectal cancer which could be useful in reconsidering the predictive tools for the identification of tumors putatively responsive to EGFR targeted therapy.
16525633 EGFR expression in bladder cancer cells was associated with up-regulation of ID-1 and cancer staging.
16552725 Our work sheds light into the nature and regulation of the nuclear EGFR pathway and provides a plausible mechanism by which cells shuttle cell-surface EGFR and potentially other RTKs through the nuclear pore complex and into the nuclear compartment.
16574793 seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways
16597832 Circular dichroism spectroscopy indicated that the EGFR C-terminal domain possessed a significant level of secondary structure in the form of alpha-helices and beta-sheets, with a marginal change in beta-sheet content occurring upon phosphorylation.
16685454 RNa silencing had no inhibitory effect on cell proliferation, migration and activation status of EGFR-coupled signaling cascades in glioma cells.
16835231 Data show that decorin protein core inhibits tumor xenograft growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation.
16806170 Induction of keratinocyte migration is conveyed through EGFR, promoted by endogenous HB-EGF and requires GSK-3alpha activity.
16914641 ITSN forms a complex with Cbl in vivo mediated by the Src homology (SH) 3 domains binding to the Pro-rich COOH terminus of Cbl. This interaction stimulates the ubiquitylation and degradation of the activated EGFR.
17102595 EGFR intron 1 polymorphism may influence response to treatment with tyrosine kinase inhibitors in breast cancer.
17149366 Inhibition of EGFR activity decreases cell migration involved in insulin-induced wound repair. Insulin stimulates wound healing in corneal epithelium by activating EGFR. This points to novel insulin signaling pathway during corneal wound healing.
17092939 EGFR on the cell surface of cancer cells must exist as an untethered dimer that adopts a previously unreported conformation that is inactive which may provide synergy between monoclonal antibodies and AG1478 in a xenograft model.
17121848 UBPY-mediated EGFR de-ubiquitination promotes EGFR degradation
17228128 EGFR targeted strategies for pancreatic cancer
17192792 EGFR gene amplification is frequently present in prostatic phyllodes tumors in humans.
17214962 These results suggest that in AGS cells, DC transactivates EGFR through M-BAR- and ADAM/HB-EGF-dependent mechanisms.
17234718 The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells.
17290443 Our results show EGFR mutations did not occur in these patients suggesting that gefitinib is unlikely to be effective in patients with tumors not harboring specific EGFR TK domain.
17409862 There is a distinct clinical profile for NSCLC patients with the EGFR mutation
17440163 Inhibition of the EGFR signaling pathway reduces ductal carcinoma in situ mammosphere-forming efficiency.
17493174 Results show a a significant correlation between the EGFR L858R mutation and the expression of p-Akt and suggest that the activation of Akt is dependent on EGFR mutation pattern.
17493236 Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways.
12435727 mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
12828935 The results suggest that activation and nuclear localization of EGFR may be needed for induction of NOS-2 in response to elevated intraocular pressure in glaucomatous optic neuropathy.
12955084 depending on their localization, oxytocin receptors transactivate EGFR and activate ERK1/2 using different signalling intermediates. The final outcome is a different temporal pattern of EGFR and ERK1/2 phosphorylation
15143334 Overexpression of EGFR was observed in only a small fraction of colorectal carcinomas, but were frequently accompanied by gene amplification.
15221011 The tumor-specific mutation of epidermal growth factor receptor promotes cells survival and dimerization with the wild-type EGFR.
12218189 Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.
15166495 Endothelial cell vessel assembly requires EGFR signaling transduction pathways.
15219825 transactivation through CCR3 is a critical pathway that elicits mitogen-activated protein kinase activation and cytokine production in bronchial epithelial cells
15219850 trans-activation by calcium-sensing receptor
15358139 Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.
15540509 For genotype of EGFR gene Bsr I polymorphism, there was statistically significant differences between systemic lupus erythematosus and controls. In addition, there was significant association between the two groups in allelic frequency of the T allele.
15621729 epidermal growth factor receptor interacts with gastrointestinal peptide hormone receptors to regulate mitogenic signaling and cell migration [review]
15469991 NHERF stabilizes EGFR at the cell surface and slows the rate of endocytosis without affecting recycling
15665299 In addition to EGFR mutations, other factors in non-small cell lung carcinoma cells, such as high expression of ErbB family members, may constitutively activate AKT and sensitize cells to EGFR inhibitors.
15665312 Expression of nuclear EGFR correlated positively with increased levels of cyclin D1 and Ki-67, both are indicators for cell proliferation for prognosis of breast cancer.
15166244 the epidermal growth factor receptor has a role in activating ERK with extracellular oxidation by taurine chloramine
15469987 a novel regulatory role for Galphas in EGF receptor degradation and provide mechanistic insights into the function of Galphas in endocytic sorting
15665278 A common polymorphism in the EGFR promoter was associated with altered promoter activity and gene expression both in vitro and in vivo.
16237757 LPA acts upstream of various receptor tyrosine kinases and COX-2, and thus may act as a potent stimulator of colorectal cancer.
16273187 Breast carcinomas with squamous differentiation are a distinct subgroup of breast tumors with a very high frequency of EGFR expression
16355407 An EGFR mutant with four amino acid changes exhibited binding to the conformationally-specific monoclonal antibodies. and human epidermal growth factor
16293617 Activation of erbB1 leads to phosphorylation of protein phosphatase 2A, inhibiting its activity, which provides a rapid means of sensing the loss of epithelial integrity and subsequently restoring barrier function.
16314000 In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation.
16382132 EGFR-induced signaling and Grb2 are essential for formation of clathrin-coated pits accommodating the EGFR, while activation of MAPK and PI3K is not required.
16445385 Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells.
16414009 IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation
16514409 The existence of mutations in the tyrosine kinase domain of the EGFR gene in a small subset of synovial sarcomas suggests that only few patients may profit from the tyrosine kinase inhibitor therapy.
16531225 The steric hindrance created by the antibody near the EGFR dimer interface interferes with receptor dimerization, and we postulate this as the structural origin for the antitumor effect of mAb 806.
16543144 Taken together, these data provide direct evidence for the role of EGFR ubiquitination in receptor targeting to the lysosome and implicate Lys63-linked polyubiquitin chains in this sorting process.
16554736 EGFR mutation and gene amplification potentially have impact on the responsiveness to EGFR targeting agents in ovarian cancer.
16555991 Mutations in EGFR is associated with Non-Small-Cell Lung Carcinoma
16565089 CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression
16596188 overexpression of epidermal growth factor receptor due to missense mutation and single nucleotide polymorphisms is associated with gastrointestinal tract tumor
16596194 Significant higher expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor are associated with neuroendocrine tumors
16637508 The aim of this review is the biology of the EGFR and its use as a target for a new class of anticancer agents for colorectal cancer.Results available so far demonstrated a manageable and acceptable toxicity profile and a promising level of activity.
16702213 periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways
16702519 No change in expression levels of EGFR was seen in the histologic progression to esophageal adenocarcinoma.
16729043 EGFR functions as control center & integration site for signaling processes, involving stimulation with EGF. It has 6 docking sites for Grb2 and is a direct binding partner of STAT5.
16735510 EGF stimulates receptor neddylation, which enhances subsequent ubiquitylation, as well as sorting of EGFR for degradation
16777603 The CDK/cyclin-like complex formed by two kinase domains thus explains the activation of EGFR-family receptors by homo- or heterodimerization.
16845329 Significantly elevated epidermal growth factor receptor is associated with metastatic malignant melanoma patients with an inverse correlation between EGF-R and IL-6 levels.
16885506 The -216T allele was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25).
16904111 Data show that treatment of tumor cell lines with the epidermal growth factor receptor-specific inhibitor cetuximab results in paradox phosphorylation of tyrosine 1173 in the receptor.
17054433 the impacts of smoking and sex on the risk of EGFRmut non-small-cell lung cancers (NSCLC) are different from those for EGFRwt NSCLC
17142315 N-linked glycan with GlcNAc termini linked to EGFR is the target to interact with ganglioside GM3, causing inhibition of EGF-induced EGFR tyrosine kinase
17215517 This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon.
17238183 Mutations in epidermal growth factor receptor is associated with lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas
17310847 No siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma.
17311283 Tenascin C repeat Ten14 in monomeric form does not bind EGFR with sufficient stability so as to induce degradation of receptor, or undergo EGFR-mediated internalization over either the short (20 min) or long (48 h) term
17311890 Aldosterone leads to enhanced EGFR expression via interaction with EGFR promoter, which is mineralocorticoid receptor specific and could contribute to the aldosterone-induced increase in fibronectin abundance.
17328268 Alterations in PTEN and amplification of EGFR are uncommon in pediatric malignant gliomas, in contrast to adult malignant gliomas.
17337084 The presence of EGFR mutations had no effect on survival.
17425591 Our findings suggest that the balance between hepsin and its inhibitor, HAI-2, may have prognostic value in RCC.
17453416 Role of lipid rafts in EGFR-mediated cancer cell chemotaxis.
17455141 Mutations in the EGFR tyrosine kinase domain correlate with the clinical response to Gefitinib in lung cancer patients.
17455987 examinination of distributions of three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers
11968000 results suggest a potential mechanism by which maintenance of low levels of EGFR expression and subsequent EGFR upregulation may be attributed to the loss of transcriptional repression of EGFR gene expression in hormone-dependent breast cancer cells
12147707 Rac activation upon cell-cell contact formation is dependent on signaling from here
12939263 EGFR is an aldosterone-induced protein and is involved in the manifold (patho)biological actions of aldosterone
14660604 transactivation of the EGFr is required for the full expression of cAMP-dependent Cl- secretory responses
11912208 Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase
12446727 EGF receptor is activated in a pathway that requires ARF4 to induce phospholipase D2
12534349 role in mediating thromboxane A2-dependent -signal-regulated kinase activation
12673202 Overexpression of an introduced EGFR, under an E1A-insensitive heterologous promoter, blocked E1A induction of apoptosis in SCC cells. E1A-mediated EGFR downregulation appears to be the cause not consequence of E1A-induced apoptosis in these cells.
14551192 the EGF receptor is abundantly expressed in epithelioid vascular smooth muscle cells and the activation of this receptor results in cell cycle arrest through activation of the mitogen-activated protein kinase pathway
14977086 A significantly higher frequency of EGFR expression occurred in PC than in AC glottic cancer.
14734462 Overexpression of EGFR is associated with recurrent non-small cell lung cancer
14988406 Sustained hyaluronan depolymerization is expected to cause tissue kallikrein activation, EGF release, and EGFR signaling.
15192046 The overall time-dependent activation of EGFR autophosphorylation was identical in cells treated with 1 nm BTC or 1.5 nm EGF.
15271882 novel mechanism by which IGF-I induces ERK activation in a manner that is dependent on the basal level of EGFR-TK activity, but is independent of receptor transactivation.
15054105 PPARgamma and EGFR signalling have roles in urothelial terminal differentiation
15215236 epidermal growth factor receptor is dephosphorylated at endomembranes after ligand-mediated endocytosis
15709185 EGFR mutations were significantly related to histology and smoke exposure and were a strong predictive factor for gefitinib responsiveness in non-small cell lung cancers.
15672448 Cpd 5-caused ERK phosphorylation is probably regulated by both EGFR-dependent and EGFR-independent pathways.
15082764 Data show that epidermal growth factor receptor signaling results in phosphorylation of CUG-BP1, and leads to increased binding of CUG-BP1 to CCAAT/enhancer binding protein beta (C/EBP beta) mRNA and elevated expression of the C/EBPbeta LIP isoform.
15986432 PTEN protein could inhibit cell invasion even in the presence of the constitutively active epidermal growth factor receptor(EGFR)
16318625 spatially distributed Monte Carlo based simulation framework to enable the simulation of in vivo receptor diffusion and dimerization
16353237 Theaflavin-3, 3'-digallate may exert chemopreventive effects through the downregulation of the EGFR.
14506242 Infection of primary cells with adenoviruses carrying the relevant point mutations confirmed the crucial role of putative YXX Phi and dileucine (LL) transport motifs within Ad2 10.4-14.5 for down-regulation of Fas, TRAIL-R1, TRAIL-R2, and EGFR.
15100232 misfolding of the LDLR epidermal growth factor-AB pair results from low density lipoprotein receptor familial hypercholesterolemia mutations
16109531 EGFR antisense-odn can significantly inhibit proliferation of human hepatoma cells, indicating that EGFR may play important role in development of hepatoma and will be new target for its treatment.
11831486 CsA affects EGF-r metabolism in gingival keratinocytes resulting in an increased number of cell surface receptors
16278215 RhoB is essential in regulating keratinocyte cell survival after UVB exposure through epidermal growth factor receptor signaling
12397069 ligand-independent activation of the epidermal growth factor receptor is triggered by cholesterol depletion from the plasma membrane
11814623 this study, 11 analogs of a fragment of the B-loop of EGF-related peptides from several species were synthesized to study binding to A431 human epidermoid carcinoma using both 125I-EGF and [3'4'-3H-Tyr(22,29), Abu(20,31)]EGF(20-31)-NH(2).
12180964 Stimulation of cells with EGF rapidly leads to phosphorylation of Hrs, raising the question whether the EGF receptor tyrosine kinase phosphorylates Hrs directly. Several downstream kinases, rather than the active receptor kinase are responsible.
12181310 These results demonstrate that 1,25(OH)(2)D(3) alters EGFR membrane trafficking and down-regulates EGFR growth signaling.
12582944 in glioblastoma multiforme patients a complex relationship exists between epidermal growth factor receptor expression and age
12708474 EGFRvIII expressed in human tumors is phosphorylated and hence activated; sustained activation of EGFRvIII is implicated in the pathogenesis of non-small cell lung cancers
12708492 ZO-1 bound to EGFR irrespective of the phosphorylation status of EGFR. EGFR associated ZO-1 was highly tyrosine-phosphorylated only in primary colorectal cancers but was dephosphorylated in the liver-metastasized cancers.
14670955 data suggest that agonist-induced binding of Src kinase to the Src homology 3 binding sites in the P2Y(2) purinergic receptor facilitates Src activation and allows Src to efficiently phosphorylate the epidermal growth factor receptor
11796728 Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides
12167618 The results of this study indicate that dual inhibition of focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) signaling pathways can cooperatively enhance apoptosis in breast cancers.
15253134 The epidermal growth factor receptor (EGFR) is one of signalling pathways activated during premalignant proliferative changes in the airway epithelium.
12754350 EGFR gene expression is identified in recurrent glioblastoma multiforme
12900408 EGFR has a role in beta2 tyrosine phosphorylation of AP-2 by interacting at receptor 974YRAL and di-leucine motifs
11894095 Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
12615082 Five autophosphorylation sites in the extra-kinase C-terminal domain of EGFR are not required for the ability of EGFR to induce morphological differentiation of PC12 cells.
12681285 Data show that by using RNA interference , the expression of endogenous erbB1 can be specifically and extensively suppressed in A431 human epidermoid carcinoma cells.
15335267 In patients with breast cancer, most CNS metastatic tumor deposits showed expression for either EGFR or HER-2/neu, and less often for both.
12603863 Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. This inhibition was specific for the erbB receptor family and specific for ultraviolet-B-induced apoptosis.
12694196 Nitric oxide and nitric oxide donors induce EGF receptor phosphorylations, in A431 tumor cells.
12733059 Results suggest that epidermal growth factor receptor and protein kinase C activation are involved in 12- O-tetradecanoylphorbol-13-acetate-induced cell signaling for modulation of cadherin-dependent cell-cell adhesion and cell shape in Caco-2 cells.
12018405 Dephosphorylation of the EGFR and the consequent suppression of EGFR signalling. Review.
12657642 propose a role of Ent-1 in the trafficking of EGFR to down-regulate intestinal mitogenic signals, highlighting the mechanisms of cell growth arrest associated with enterocytic differentiation
15522239 Data demonstrate that the alpha-hemolysin elevates the activity of receptor-like protein tyrosine phosphatase sigma (rPTPsigma).
15556944 Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation
15746034 Findings suggest that a distinct minority of colorectal adenocarcinomas exhibit somatic mutations of EGFR, and these tumors may be susceptible to gefitinib treatment.
15755902 HB-EGF/HER-1 signaling is relevant to mesenchymal stem cell biology, by regulating both proliferation and differentiation
15956035 Active mutation of the EGFR kinase domain was strongly associated with response to gefitinib
16115866 EGFR signaling has a role in regulating host defense and immune response by tightly controlling TLR2 induction during bacterial infections
16105029 The effects of high glucose on proximal tubular cells proliferation, reduced apoptosis and increased NHE3 mRNA levels are mediated by EGFR-dependent up-regulation of SGK-1.
16144838 Two tyrosine residues in the C terminus of human TRPC4 phosphorylated following epidermal growth factor (EGF) receptor stimulation of COS-7 cells.
16488447 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) can induce the clustering of epidermal growth factor receptor (EGFR) in human amnion FL cells.
16545487 Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells.
16609018 The Epidermal Growth Factor Receptor represent independents prognostic marker for intracranial ependymomas to identify patient subgroups with different risk profiles in further clinical investigations.
16609045 The Increased expression of erbB-1 was associated with increased levels of Ki-67 and MCM2 expression, and combined overexpression of these receptors was associated with the highest levels of proliferation, suggesting a synergistic effect.
16629834 96% of tumor samples were positive for EGFR expression; 63% were positive for activated EGFR; 76% were positive for activated Akt; and 96% were positive for activated ERK1/2.
16648628 the versican G3 domain regulates neuronal attachment, neurite outgrowth, and synaptic function of hippocampal neurons via EGFR-dependent and -independent signaling pathways
16803894 Ymer functions as a novel inhibitor for the down-regulation of the EGF receptor and plays a crucial role for regulating the amount of the EGF receptor on the cell surface membrane
16820093 the production of TGF-alpha by HRCC cells leads to the activation of EGFR on tumor-associated endothelial cells that serve as an essential target for therapy with tyrosine kinase inhibitors
16847054 Data show that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor-1alpha up-regulation, mediated by epidermal growth factor (EGF) receptor signaling in EGF-treated cancer cells.
16968809 somatic mutations in EGFR quantitatively differ in pharmacology and signaling properties
16979526 The findings of EGFR abnormalities in lung cancer have supported the notion that different molecular mechanisms and pathways are involved in the pathogenesis of lung cancer arising in never and ever smokers.
16983337 receptor stability is regulated by MUC1 expression
17047316 In midgut carcinoid tumor stroma PDGFRalpha was expressed in 35%, PDGFRbeta in 94% and EGFR in 9%.
17143527 Since the EGF receptor is often overexpressed in skin cancers, it might be possible to significantly reduce the proliferative potential of these cells making them good targets for laser-pulsed UV light treatment.
17143531 Mutations and amplification/overdose in the EGFR gene are present in low-grade oligodendroglial tumours, and may contribute to the development of these brain neoplasms.
17111374 The expression of EGFR in postmitotic, terminally differentiated adult retinal neurons suggests that EGFR has pleiotropic functions.
17142003 EGFR mutations in esophageal carcinoma are rare but do exist, and thus gefitinib could be included in esophageal cancer treatment regimens by selecting those patients who possess such mutations.
17148666 An inflammation-dependent EGF-R cascade causes overproduction of the gel-forming mucin MUC5AC, which accumulates in cholesterol gallstone disease. The ability to interrupt this cascade is of potential interest in the prevention of cholesterol gallstones.
17210462 Detailed pharmacokinetic characterization of this bioprobe could assist in the development of a kinetic model that would afford accurate measurement of EGFR content in tumors.
17227756 long term treatment with epidermal growth factor (EGF) leads to a marked increase in the levels of ADAM17, which also increases the shedding of several substrates of ADAM17, including the desmosomal cadherin Dsg-2
17227773 W-13 calmodulin inhibitor has a role in epidermal growth factor receptor activation
17339316 protein-tyrosine phosphatase 1B governs differential recruitment of signaling pathways involved in EGFR regulation of epithelial ion transport.
17354229 incidence of somatic mutations in the tyrosine kinase domains of EGFR was very low and the increased gene copy number of EGFR did not significantly influence survival of pancreatic adenocarcinoma patients
17369752 EGFR is hypermethylated and silenced in a subset of solid tumor cell lines and primary tumor specimens, and cotreatment with decitabine and gefitinib has an additive effect only in EGFR methylated breast cancer cell lines.
17448210 present results suggest that it is not a useful indicator of prognosis in oral squamous cell carcinoma
17482563 Targeting EGFR is a novel strategy against neuroblastoma.
17510392 observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer
17545606 Study has identified a subset of naturally occurring EGFR mutations that lack a critical radioprotective function of EGFR, providing valuable insights on how the EGFR mediates cell survival in response to radiation in NSCLC cell lines.
17580276 among adenocarcinomas, nonmucinous and mucinous bronchioloalveolar carcinoma components were significantly associated with EGFR and K-ras gene mutations, respectively
14530278 cholesterol depletion with cyclodextrin induced an increase in both basal and EGF-stimulated EGF receptor phosphorylation, at specific tyrosine sites, that was associated with an increase in the intrinsic kinase activity of the EGF receptor kinase.
12953099 EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis.
15185528 Statistically significant relation existed between the ovarian cancer metastatic potential and EGFR expression level.
12127695 Expression of this molecule and its correlation with prognostic markers in patients with head and neck tumors
12297049 Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.
12297050 Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
12825853 Data support that EGFR and HER-2/neu play an important role in cell cycle control in ductal carcinoma in situ.
11916499 contig map for the EGFR region and markers positioned on its associated physical map to the analysis of 7p11.2 amplifications in a series of glioblastomas.
12654182 Expression of EGF and EGFR is involved in the gallbladder carcinogenesis, and is related to high activity of cell proliferation.
12814937 Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta.
15031710 whole gene amplifications of egfr are rare in invasive breast cancer and explain protein overexpression in only about 12.5% of invasive breast cancer cases
15182358 Data demonstrate that at least four different sets of endogenously expressed gangliosides, including GD3, did not have a significant effect on epidermal growth factor receptor distribution in the plasma membrane.
15519654 cholangiocarcinoma cells exhibit sustained EGFR activation due to defective receptor internalization
12653106 EGFR microsatellite polymorphism is associated with autosomal dominant polycystic kidney disease.
14690686 results support a structural model for oligomerization of EGF receptors in which dimers are positioned head-to-head with respect to the ligand-binding site
15233293 c-erbB-2 and EGF-R are overexpressed in breast neoplasms and have an inverse association with Estrogen Receptor expression
15741570 Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers.
15913841 analysis of EGFR mutations in malignant pleural effusion of non-small cell lung cancer (case report)
16103736 This study suggests that coexpression of LN-5 gamma2 and EGFR is closely related to the progression and poor prognosis of esophageal SCC.
16322287 Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in non-small cell lung cancer
16303044 data suggest that the EGFR immunopositivity can be considered as reliable predictors of disease stage in urine ThinPrep (TP) specimens.
16443754 phosphatidylinositol 4-kinase IIalpha is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor.
16489645 Data show that c-erbB-1 and c-erbB-2 are differentially regulated in cancers of the papilla of Vater and pancreas, suggesting that the two types of cancer are biologically different.
16521222 COX-2 and EGFR may be cooperative in the stepwise progression from Barrett's esophagus to adenocarcinoma, thereby leading to carcinogenesis.
16543231 The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9.
16551849 Data provide the first evidence of somatic mutations of the EGFR gene in bile duct carcinoma.
16571657 Salient features of the structural model for EGFR regulation and argue that the intramolecular tether provides only limited autoinhibitory control of EGFR activity.
16574647 the trophic properties of gastrin in colorectal cancer may be mediated in part by transactivation of the EGFR and phosphorylation of ERK1/2, leading to degradation of PPARgamma protein and a decrease in PPARgamma activation
16646071 patients with mutant-type EGFR might be treated with EGFR-TKIs before any other drugs
16683917 role for p38 MAP kinase in the regulation of EGFR endocytosis
16786197 These results demonstrated that cell surface beta1,4GT1 may negatively regulate cell survival possibly through inhibiting and modulating EGFR signaling pathway.
16842869 the disulfide-bonded structure of the membrane-proximal portion of the EGF receptor, rather than its primary sequence, is important for EGF binding and signaling but is not involved in localizing the receptor to lipid rafts
16857803 analysis of activating mutations within EGFR in both esophageal and pancreatic adenocarcinomas and a model of the role of EGFR signaling in neoplasms
16970944 transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2)
17164758 The EGFR protein was carried out in 71 of these cases, nonproliferative benign breast disease, proliferative BBD without atypia, proliferative BBD with atypia, carcinoma in situ (n=15) or invasive carcinoma.
17177839 Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins
17321325 Findings suggest that the EGFR mutation is frequent in Korean lung cancer patients.
17362940 This study is the first to demonstrate that EGFR is implicated in IFNgamma-dependent signaling pathways.
17368623 Analysis of tumor EGFR mutations in patients with NSCLC could be used to identify patients suitable for treatment with gefitinib to obtain optimum response and disease control rates.
17390112 analysis of specimens from patients with cancer of unknown primary for EGFR gene mutation, gene amplification, transcriptional regulation as well as protein expression
17549361 Overexpression of EGFR and HER-2 is associated with pancreatic ductal adenocarcinoma
17549377 Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas
17616668 EGFR activation in malignant gliomas can transcriptionally activate COX-2 expression in a process that requires p38-MAPK and Sp1/Sp3
11886870 sequestration in non-caveolar lipid rafts inhibits lipid binding
12643788 Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 & ERCC1 in DU145 & LNCaP prostate carcinoma through MAPK signaling indicating a capacity of the EGFR-ERK signaling to modulate DNA repair in cancer cells.
12527890 TPA-induced AP-1 activation requires EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation.
12824187 PGE2 regulates cell migration via the EGFR, and affects cell division and neoplasm invasiveneess.
14632199 heregulin/EGFR system as a possible important physiologic growth regulatory system in melanocytes in which multiple deregulations may occur during progression toward melanoma, all resulting in, or indicating, growth factor independence.
14977838 EGFR and COX-2 cooperate to promote cervical neoplasm progression
12607604 Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region.
14688027 The Id-1-induced androgen-independent prostate cancer cell growth was correlated with up-regulation of EGF-R.
14960328 CaM co-immunoprecipitates with EGF-activated and non-activated receptors
15026342 Cell surface expression of EGFR is associated with osteosarcoma pathogenesis
15269346 In each of these gliomas, the founding molecule was generated by a simple event that circularizes a chromosome fragment overlapping the epidermal growth factor receptor gene.
15254682 EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck
15592685 These results suggest that EGFR amplification is a relatively rare event in larynx carcinogenesis that obviously does not predispose to tumor progression.
15791567 data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression
15897877 autocrine and/or paracrine NRG-1/erbB signaling promotes neoplastic Schwann cell proliferation
12023273 second cysteine-rich region contains targeting information for caveolae/rafts
16000298 Data show that blockade of epidermal growth factor receptor import into the nucleus also blocks radiation-induced activation of DNA-PK, inhibits DNA repair, and increases radiosensitivity of treated cells.
16263120 These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization.
16278407 EGFR expression and signaling does not seeme to be affected by treatment with erlotinib or gefitinib
11935304 EGFR is often strongly expressed and is a potential therapeutic target in patients with malignant thymic tumors
12419588 Cell proliferation, nuclear ploidy, and EGFr and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma.
15123705 Results provide an explanation for cell surface receptor cross-talk involving the Met receptor and link G protein-coupled receptors and the epidermal growth factor receptor to the oncogenic potential of Met signaling in human carcinoma cells.
15213840 EGFR, PYK2, Yes, and SHP-2 are involved in transduction of the TF/FVIIa signal possibly via transactivation of the EGF receptor.
12683217 The study found that over-expression of EGFR occurred more often in cases of cervical cancer (50%) compared to breast cancer cases (36%), while in breast cancer EGFR expression correlated significantly with metastasis of the lymph nodes.
14506149 ERBB1 is overexpressed and may play a role in high-grade diffusely infiltrative pediatric brain stem glioma
12871937 PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor.
15253384 an interrelationship is now known to exist between the IGF and EGF receptors [review]
11992543 Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines.
12429632 epidermal growth factor receptor may have a role in disease relapse and progression to androgen-independence in human prostate cancer
12556561 the mechanism of attenuated ERK signaling in EGFR-overexpressing cells is a sequestration of ERKs at the cell membrane in EGFR-containing complexes.
15134305 P. 445:"The EGF receptor (EGFR), a glycoprotein of 170 kDA, has also been intensily studied and finally located on chromosome 17, region p13l13-q22."
15302576 EGFR signaling involves reinforcing altered gene expression of uPAR,thus further inducing cell motility.
12133497 Detection of serum epidermal growth factor receptor in the diagnosis of proliferation of pituitary adenomas
12734385 signaling intensity determines intracellular protein interactions, ubiquitination, and internalization
12844146 Data show that detachment-induced expression of Bim requires a lack of beta(1)-integrin engagement, downregulation of EGF receptor (EGFR) expression and inhibition of Erk signalling.
14764825 PGF(2 alpha)-FP receptor may promote endometrial tumorigenesis via phospholipase C-mediated phosphorylation of EGF receptor and MAPK signaling pathways.
15545271 protein kinase B/Akt phosphorylation is stimulated by mechanical stretch in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor
15580296 therapeutic potential of siRNA to impact DeltaEGFR as a glioma-specific target
12568494 Review. Mucin transcription in response to both gram-positive bacteria and tobacco smoke is mediated through activation of the epidermal growth factor receptor (EGFR).
12754251 findings establish Cbl protein as the major endogenous ubiquitin ligase responsible for epidermal growth factor receptor degradation
12604776 EGFR binds to c-src and has a role in oncogenesis
15300588 IL-1beta-dependent prolonged EGFR transactivation involves multiple pathways, including an IL-8-dependent pathway.
15635092 Grb2-mediated recruitment of the functional RING domain of Cbl to the EGFR is essential and sufficient to support receptor endocytosis
15784896 decreased EGF receptor tyrosine phosphorylation and aberrant recruitment of the adaptor proteins ShcA and Grb2 to the EGF receptor in cells harbouring the hepatitis C virus subgenomic replicon
15844661 epidermal growth factor receptor is activated by imatinib mesylate, resulting in cyclooxygenase-2 induction and prostaglandin E2 accumulation
15994331 analysis of ligand-induced dimer-tetramer transition during the epidermal growth factor receptor activation of the cell surface
12099696 Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF
14681060 E-cadherin and epidermal growth factor receptor (EGFR) are associated in mammary epithelial cells and that E-cadherin engagement in these cells induces transient activation of EGFR, as previously seen in keratinocytes.
14711810 EGFR and ErbB-2 have roles in ligand-dependent apoptosis that could be a natural mechanism to protect tissues from unrestricted proliferation
15298855 Carbon black causes oxidative stress-mediated proliferation of airway epithelium, involving activation of EGF-R.
15657358 An inhibitor of this and of the mTOR pathwway inhibits growth of glioma in a xenograft mousse model.
15855163 study reveals a novel cross-talk between the EP1 receptor and EGFR signaling that synergistically promotes cancer cell growth and invasion
16061871 analysis of activating mutations in catalytic domain of EGFR in 3.5% (2 of 57) of ovarian cancers
16198442 The patients with mutations of EGFR to have a more favorable prognosis than those with wild type (p=0.033).
16213893 The mechanism of deoxycholic acid-induced EGFR activation is ligand-dependent and is controlled, at least in part, at the level of amphiregulin release from the basolateral cell membrane.
16258541 Acquisition of resistance to tyrosine kinase inhibitors in non-small cell lung cancer is linked to a specific secondary somatic mutation, EGFR T790M.
16424381 Reactive Oxygen Species-induced Goblet Cell metaplasia in normal human bronchial epithelial cells is associated with Hyaluronan depolymerization and Epidermal Growth Factor (EGF) processing by Tissue Kallikrein followed by EGF Receptor signaling.
16424019 study provides a new insight into oncogenic signaling by EGFRvIII and improves our understanding of how autocrine loops are generated in glioma
16453019 Data show that long-term ciliated cell hyperplasia and activation of epidermal growth factor receptor signaling coincide with mucous cell metaplasia after respiratory viral clearance in airways.
16478662 Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways.
16533793 Epidermal growth factor receptor and KRAS mutation patterns is associated with non-small cell lung cancer patients
16715136 EGF receptor trafficking and signaling occur through a subset of signaling molecules including p44/42 MAPK and Gab1.
16788982 EGFRvIII expression may regulate phenotypic plasticity in ovarian cancer and thereby contribute to more aggressive disease
16937526 analysis of the mechanisms of action of EGFR-TK-inhibition in hepatocellular cancer cells by erlotinib
17016520 The phosphorylation sites that are most strongly correlated with migration & proliferation were identified, eg. EGFR Y1173 correlates with proliferation.
17052295 In this article, we review efforts that have been undertaken to identify genomic determinants of drug susceptibility to EGFR tyrosine kinase inhibitors, with particular focus on the role of gene mutations.
17178880 Combined blockade of both epidermal growth factor receptors and G protein coupled recaptors (GPCRs) may be a strategy to treat cancers, including head and neck squamous cell carcinoma that shows cross-talk between GPCR and EGFR signaling pathways.
17339338 integrin alpha1beta1-EGFR cross talk is a key step in negatively regulating Rac1 activation, reactive oxygen species production, and excessive collagen synthesis
17373877 REVIEW: The expression of EGFR in glioimas and its potential as a drug target in these tumors are discussed.
17475671 These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14.
17525275 Results demonstrate that ErbB1 signaling is hyperactive in squamous cell carcinoma cells, but not basal cell carcinoma cells.
17616694 endothelin A receptor and epidermal growth factor receptor are targeted by the combination of ZD4054 and gefitinib in ovarian carcinoma
17616711 EGCG inhibits the binding of EGF to the EGFR and the subsequent dimerization and activation of the EGFR by altering membrane organization
12879076 EGFR is a necessary component for HCMV-triggered signalling and viral entry
12925580 Results demonstrate that mice humanised for epidermal growth factor receptor (EGFR) display tissue-specific hypomorphic phenotypes and describe a novel function for EGFR in bone development.
12704666 deltaEGFR may contribute to glioblastoma development
14647423 demonstration that metalloproteinase-mediated transactivation of the EGFR is a key mechanism of the cellular signalling network that promotes MAPK activation as well as tumour cell migration and invasion
15118073 A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib.
15118125 somatic mutations of EGFR were found in 15 of 58 non-small cell lung cancer tumors from Japan and 1 of 61 from the United States; EGFR mutations may predict sensitivity to gefitinib
12508124 Levels of this receptor are lowered in cryptorchism.
15284455 mutant EGFRs selectively transduce survival signals on which nonsmall cell lung cancers become dependent
15282549 Upregulation of leucine-rich repeats and immunoglobulin-like domains 1 is followed by enhanced ubiquitylation and degradation of EGFR
15494003 analysis of conformations of the epidermal growth factor receptor and antibody binding [review]
15541730 Our results suggest a novel role for the juxtamembrane domain (JM) of EGFR in mediating intracellular dimerization and thus receptor kinase activation and function.
15542601 role for EGFR activity in the lifespan and inflammatory potential of RSV-infected epithelial cells
15562026 EGFR is increased by cAMP, a potent inducer of decidualization of the endometrial stroma.
12399475 Endocytosis is regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre.
14963038 EGFR and c-Src-mediated Stat-3 activation is facilitated by Pyk2
15205458 EGFR inhibition promotes desmosome assembly in oral squamous cell carcinoma cells, resulting in increased cell-cell adhesion
15797859 p38 mediates EGF receptor activation after oxidant injury; Src activates MMK3, which, in turn, activates p38; and the EGF receptor signaling pathway plays a critical role in renal epithelial cell dedifferentiation
15829704 the EGF receptor plays a central role in the signaling pathway that links albumin to the activation of ERK1/ERK2 and increased expression of IL-8
15829568 The membrane-anchoring domain of EGFR ligands dictates their ability to operate in juxtacrine mode.
15967033 EGFR may have a role in recurrence of rectal cancer after radiotherapy and surgery
16263724 RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes
16282324 rab7 regulates the endocytic trafficking of the EGF.EGFR complex by regulating its lysosomal degradation
16614884 High epidermal growth factor receptor is associated with disease recurrence in colon cancer patients
16707764 Gefitinib-sensitizing mutations in the EGFR gene were found in human esophageal tumors.
16815198 ERBB-1 amplification is uncommon and appears to be late event in the development of ethmoid sinus adenocarcinoma.
16849327 EGF receptor is activated in human keratinocytes by oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation
16964397 EGFR and TrkB crosstalk each other in response to EGF and BDNF, leading to cell survival pathway activation in ovarian cancer cells.
16980555 IL-13 and EGFR pathways make critical but quite distinct contributions to gene regulation in airway epithelial cells, and that both pathways affect expression of the key transcription factor, FOXA2, a known regulator of mucus production.
17023689 The effects of house dust mite allergen and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium, was examined.
17062641 Serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met)[p145met]
17130473 Even a modest attenuation of EGF-R signaling leads to a severe defect in postnatal growth of the beta-cells, which leads to the development of diabetes in transgenic mice.
17146284 S100beta-v-erbB transgenic rats may serve as a useful animal model for the identification of EGFR-related molecular targets and as a tool for the assessment of novel therapeutic approaches.
17158592 Review. Excessive EGFR signalling plays a critical role in NSCLC tumorigenesis in patients harbouring an EGFR mutation. Mutant EGFRs drive the growth of cancer cells & maintain their malignant phenotype by selective activation of Akt & STAT pathways.
17203166 EGFR gene mutation does not change the effect of gefitinib in non-small cell lung cancer cells
17203167 EGFRvIII mutation in lung cancer is correlated with increased expression of EGFR
17211865 Overexpression of epidermal growth factor receptor is associated with esophageal and esophagogastric junction adenocarcinomas
17261767 Estradiol receptor alpha and androgen receptor upregulate EGFR phosphorylation.
17284372 Targeting of EGFR to determine molecular alterations of this gene may be useful in the management of patients with brain metastases.
17307140 EGFR depletion induced enhancement of IGF1R ubiquitylation and degradation.
17320394 EGFR signaling is controlled by a novel mechanism involving trafficking-dependent alterations in receptor compartmentalization.
17320820 EGFR cannot compensate for IGF1R depletion.
17332501 overexpression of spartin results in a prominent decrease in EGFR degradation
17335953 decorin is taken up by more than one endocytic pathway; uptake depends on EGFR signaling rather than trafficking along the same pathway
17431415 propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement
17469127 Lipid raft cholesterol regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK pathways.
17487398 EGFR pathway, EGFR mutation and/or amplification, may be involved in lung carcinogenesis.
17548604 Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC.
17548638 MIP-3alpha-mediated ERK1/2 activation in Caco-2 cells appeared to require metalloproteinase-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR.
16969069 different EGF receptor mutations exert various negative mechanisms that have the potential to modify receptor internalization and may involve resistance to tyrosine kinase inhibitors in cancers [EGFRvIII, EGF Receptor VIII]
17223314 no evidence to support the hypothesis that the +61 A-G polymorphism of EGFR is involved in the non-melanocytic skin tumor development in transplanted subjects undergoing immunosuppressive treatment
15556605 S1P transactivates c-Met and EGFR in gastric cancer cells.
15767552 EGFR-related protein (ERRP) is a 53 to 55 kDa protein that is a natural inhibitor of EGFRs in human but not in mouse or rat cells.
12954170 identification of ligand-induced site-specific phosphorylation of epidermal growth factor receptor
12532415 SKMG-3 cells produced high levels of EGFR protein. Signals from overexpressed EGFRs contribute to the constitutive phosphorylation of Erk, but these signals may not be required for the constitutive activation of PI3K or AKT1.
11533659 EGFR has been detected in the nucleus and might function as a transcription factor to activate gene transcription.
12135609 ErbB1 and ErbB2 employ different mechanisms of plasma membrane targeting during keratinocyte differentiation; cytoskeletal association may facilitate the coupling of activated ErbB1 and ERK.
11467954 A truncated form of the hEGFR ectodomain comprising residues 1-501, unlike the full-length hEGFR ectodomain (residues 1-621), binds hEGF and hTGF-alpha with high affinity and is a competitive inhibitor of EGF-stimulated mitogenesis.
11531336 Chemical/biological model for EGFR activation.
 

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