Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18172732 |
EGFR overexpression was found in 87.5% (35/40) of the laryngeal primary tumors and 82.5% (33/40) of the corresponding lymph node metastases. There was a good agreement between the primary tumors and the paired metastases regarding EGFR expression. |
| 17912028 |
This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets. |
| 18045238 |
amphiregulin-specific EGF-R fate results from decreased hSprouty2 degradation and reduced Cbl recruitment to underphosphorylated EGF-R, two effects that impair EGF-R trafficking to lysosomes |
| 18211286 |
examination of role of lipids in HER1/HER2-driven progression of human breast epithelial cells towards malignancy |
| 18161656 |
AC dinucleotide repeat polymorphism in intron 1 of human EGFR may have a role in breast cancer in certain ethnic groups |
| 18182111 |
Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer. |
| 18334834 |
siRNA-mediated knockdown is effective in lung adenocarcinomas with EGFR mutation and those with resistance to gefitinib by acquired mutation in EGFR. |
| 18084281 |
Results indicate that GEP100 links EGFR signalling to Arf6 activation to induce invasive activities of some breast cancer cells, and hence may contribute to their metastasis and malignancy. |
| 18202784 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18261621 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18271929 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18283321 |
Clinical trial of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18309947 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18317468 |
Genome-wide association study of gene-disease association. (HuGE Navigator) |
| 18325048 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18349392 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18154448 |
clinical data suggesting that there could be a subpopulation of metastatic colorectal cancer patients that are more liable to benefit from anti-EGFR monoclonal antibodies--REVIEW |
| 18234969 |
Stimulating human glioblastoma cells with recombinant HGF induces biologically relevant EGFR activation. |
| 18087285 |
EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma. |
| 18172267 |
EGFR mutations and the administration of EGFR tyrosine kinase inhibitors during Whole-brain radiation therapy (WBRT) were independent predictors of response to WBRT in brain metastases of lung adenocarcinoma. |
| 18240930 |
The population of tumor cells with polysomy of chromosome 7 and EGFR locus correlated significantly with histological grade. High-grade astrocytomas (AAs and GBMs) had elevated fractions of tumor cells with polysomy of chromosome 7 and EGFR locus. |
| 17917087 |
EGFR mutations do not have significant prognostic value in primary resected non-small cell lung cancer |
| 17942395 |
Amphiregulin is a specific ligand of the EGFR and a potent mitogen for epithelial cells such as breast cancer cell lines. |
| 18057028 |
These results highlight a role of P2Y(1)R in EGFR-dependent epithelial cell proliferation. P2Y(1)R could potentially mediate both trophic stimuli of basally released nucleotides and first-line mitogenic stimulation upon tissue damage. |
| 18067636 |
investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas |
| 17849451 |
TAE226-induced apoptosis in breast cancer cells with overexpressed EGFR. |
| 18245470 |
study describes activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin |
| 18208799 |
Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma. |
| 18269588 |
Neither EGFR nor BMI-1 had significant prognostic impact for basal-like phenotype of breast cancer. |
| 18208805 |
EGFR overexpression is present in a majority of hepatocellular carcinomas, suggesting a role for EGFR antagonists in therapy. The increased expression does not correlate with an increase in the EGFR gene copy number. |
| 16505411 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16552419 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16567021 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16757132 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16788380 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16818686 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16956694 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17054433 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17060486 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17092854 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17102595 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17106442 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17112774 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17148776 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17175376 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17192902 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17219440 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17224267 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17227303 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17285540 |
Observational study of genotype prevalence, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17285735 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17303584 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17321325 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17337084 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17354229 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17368623 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17375033 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17387341 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17409827 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17409862 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17409866 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17409930 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17429313 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17431338 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17453292 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17455987 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17473658 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17473659 |
Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17487277 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17487844 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17493174 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 17504988 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17538160 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11504770 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12631599 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12653106 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12719950 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12768436 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15063762 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15540509 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15701846 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15710947 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15738541 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15829495 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15837743 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15956035 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15998907 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16002952 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16003726 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16011858 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16018936 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16030116 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16032426 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16043828 |
Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16052218 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16098254 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16140420 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16152581 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16198442 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16199108 |
Observational study of genetic testing. (HuGE Navigator) |
| 16203769 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16240846 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16243431 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16324836 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16344724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16353158 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16376942 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16397024 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16449241 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16461080 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16467085 |
Observational study of genetic testing. (HuGE Navigator) |
| 16467097 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17575224 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17580276 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17597605 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17607119 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17610986 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17626639 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17644807 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17661145 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17686547 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17690890 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17713473 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17760253 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17760255 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17761979 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17845757 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17848912 |
Observational study of pharmacogenomic / toxicogenomic and genetic testing. (HuGE Navigator) |
| 17852426 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17875767 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17904685 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17908966 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17912028 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17932690 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17941001 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17949425 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17956637 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18161656 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18176089 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18186271 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17548322 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16503086 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18199332 |
EGFR structural alterations are rare in gastric carcinoma, but whenever present, it leads to tumour growth. |
| 18199957 |
These findings implicate the ErbB pathway in vestibular schwannoma growth |
| 17998090 |
CONCLUSION: [111In]DTPA-hEGF is translocated to the nucleus of BC cells complexed with EGFR and importin beta1. |
| 18028876 |
The activation of PAR-2 expressed by human intestinal epithelial cells enhances mucin secretion, a component of the intestinal innate defence, via a pathway involving EGFR transactivation. |
| 17686547 |
EGFR insertion mutation in exon 20 could not be ignored from Japanese lung cancers |
| 18216322 |
EGFR activation is the cause of both hyperplastic growth and VDR reduction in secondary parathyroidism hyperplasia |
| 17922051 |
The presence of neuroendocrine cells may have an effect on the expression of TGF-alpha and EGFR in gastric adenocarcinoma, and the autocrine mechanism between TGF-alpha and EGFR plays an important role in the prognosis of gastric carcinoma. |
| 18199554 |
Cell line genetic heterogeneity and/or multiple determinants modulate the role played by EGFR/HER2 in regulating cell proliferation. |
| 17989321 |
This is the first time EGFR expression has been tracked meaningfully and developmentally from the normal condition through disease progression using in vitro, xenograft, and matched normal and tumor samples. |
| 18186961 |
EGFR mutations in carcinogenesis of lung adenocarcinoma: distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma |
| 18032821 |
Amplifications within regulatory sequences of egfr are associated with the expression of eps15 and caveolin-1; EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK seems to present a major molecular pathway in progression of breast phyllodes tumours. |
| 18032824 |
AP-1 and NF-kappaB transcription factors are activated and EGF-R is expressed in these cells and associated with COX-2 and VEGF production. |
| 18060032 |
EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment. |
| 18097577 |
heterozygous and synonymous transition of the EGFR gene and low EGFR expression levels of mRNA and protein in squamous cell carcinomas of the head and neck (SCCHN) may be reliable predictors of high sensitivity in SCCHN patients to gefitinib. |
| 16899617 |
alterations within the tyrosine kinase domain and expression of EGFRvIII are rare events in bladder cancer |
| 18083120 |
This study demonstrates that ADV-Avi/biotin-PEG-EGF construct systems can be applied for cell-specific delivery of ADV with simultaneously reducing innate immune responses. |
| 16818686 |
Patients with non-small cell lung cancer and EGFR exon 19 deletions have a longer survival following treatment with gefitinib or erlotinib compared with those with the L858R mutation |
| 17913857 |
Inhibitory activity of cetuximab on epidermal growth factor receptor mutations is associated with non small cell lung cancers |
| 18089646 |
EGFR mutations were frequently found in lung adenocarcinoma with ground-glass opacity (GGO) on High-Resolution CT in this study. |
| 18180459 |
oncogenic EGFR and c-Met have roles in pathways mediating drug response |
| 17805209 |
Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine. |
| 17941001 |
The serum CEA level appears to be closely associated with the presence of EGFR gene mutations in patients with pulmonary adenocarcinomas. |
| 18006781 |
EGFR expression, mutations, polymorphisms, and gene amplification contribute to to the pharmacodynamics of EGFR inhibitors. |
| 17714760 |
EGFR may play an important role in the pathogenesis and phenotype of Congenital cystic airway malformation/congenital pulmonary airway malformation. |
| 18154814 |
Overexpression of EGFR in lung adenocarcinomas with components of BAC histology correlate with never-smoker status and improved overall survival and disease-free interval. |
| 17018617 |
activating mutations in the TKD domain of EGFR contribute to radiosensitivity of non-small-cell lung carcinoma |
| 17638075 |
GM3 has an effect on kinase associated with EGFR |
| 18000506 |
The clinical relevance of 'other' EGFR mutation variants remains uncertain and requires further assessment. |
| 15923435 |
Immunohistochemical profiling of colorectal cancer seems to be a promising approach, not only to define prognostic impact, but also to detail proliferation-related molecular interplays between EGFr and Cox-2 pathways. |
| 18089823 |
development of PF00299804 as treatment for cancers with mutations and/or amplifications of ERBB family members. |
| 18093943 |
MET amplification occurs independently of EGFR(T790M) mutations in lung adenocarcinoma |
| 17721266 |
EGFR immunoreactivity with basal cytoplasmic pattern was exclusively seen in terminal respiratory unit type lung adenocarcinoma and a subset of these cases was seen with EGFR mutations in the responders to EGFR inhibitor therapy |
| 17655843 |
In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation. |
| 17956637 |
These results suggest that the EGFR polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer. |
| 17974918 |
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. |
| 17991782 |
examination of rate of association reactions between Grb2 and epidermal growth factor receptor |
| 17690890 |
Study indicated that that mutations within the tyrosine kinase domain of EGFR and expression of EGFRvIII (a truncated EGFR variant) are rare events in bladder cancer and therefore do not contribute to the malignant phenotype of this tumor. |
| 17918158 |
curcumin and FOLFOX work through attenuation of the EGFR and IGF-1R signaling pathways |
| 17918184 |
EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells |
| 17964790 |
we have shown no expression of ErbB-1 in vestibular schwannomas |
| 17947472 |
Wnt and epidermal growth factor receptor signaling pathways are altered through aberrant methylation and mutation in non small cell lung cancer |
| 17673923 |
CISH (chromogenic in situ hybridization) is an alternative assay to FISH in determining EGFR copy number. |
| 17922974 |
CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation than in lung cancer without EGFR mutation |
| 18025312 |
Up-regulation of the EGFR cascade may have an important role regarding mucus production in the sinus mucosa of patients with CRS and CRS/NP associated with hyperplasia and metaplasia of epithelial goblet cells |
| 17908966 |
sex and smoking status could influence the EGFR mutational spectrum |
| 17881446 |
induction of p50/p50/Bcl-3 complexes by latent membrane protein 1 (LMP1) C-terminal activating region 1 mediates LMP1-induced epidermal growth factor receptor upregulation |
| 17537621 |
delE746-A750+L858R double activating EGFR mutations exist in Chinese non-small cell lung cancer patients and both locate on the same allele |
| 17823122 |
results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands |
| 17112774 |
EGFR polymorphisms may be associated with clinical outcome in patients treated with chemoradiation. |
| 17177598 |
Results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma. |
| 17950068 |
Increased EGFR gene copy number and elevated EGF levels are present in a significant proportion of pancreatic cancer patients, and this may reflect increased EGFR pathway dependence with improved sensitivity to EGFR-targeted therapy. |
| 17784875 |
Regarding EGFR, no specific mutation was detected in five of the six patients with lung cancer whereas one female patient who had never smoked had a missense mutation. |
| 17962724 |
No previouly described somatic EGFR mutations were found in head and neck squamous cell carcinoma DNA, but other DNA sequence variations were found in 9 of 31 patients. Activating EGFR mutations seem to be a rare event in Spanish HNSCC patients. |
| 17525275 |
In vivo, EGFR signaling is hyperactive in tumor cells of skin SCC but not of BCC, and in nearby asymptomatic epidermis of both tumor types. Hyperactivation is due to upregulation of EGFR ligands AREG, HBEGF and TGFA, and downregulation of BTC |
| 17685929 |
study investigated EGFR protein expression & gene mutations in exons 18, 19 and 21 in 40 renal angiomyolipomas (AML); no EGFR gene mutations of TK domain were detected and strong immunostaining was found in 5% of the renal AML cases |
| 17699773 |
study found that EGFR down-regulation was impaired in two non-small cell lung cancers with EGFR tyrosine kinase domain mutations; the mutant receptors were poorly ubiquitylated and exhibited decreased association with the ubiquitin ligase Cbl |
| 17600311 |
EGFR signalling plays a central role in cyclooxygenase-2 induction by transforming growth factor-beta 1 in human bronchial epithelial cells. |
| 17631646 |
ZD6474 treatment inhibited EGFR phosphorylation and led to a dose- and time-dependent decrease in nasopharyngeal carcinoma cell |
| 16912195 |
EGFR somatic mutations directly influence both erlotinib cancer cell sensitivity and cellular transformation. |
| 17885502 |
upregulation of EGFR expression in a few warty and basaloid HG-VIN cases and in many SCCs of the vulva. |
| 17486068 |
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling |
| 17712488 |
Reduction of sperm motility by tryptase through the PAR-2 receptor involves epidermal growth factor receptor pathways. |
| 16912157 |
T790M mutation is sometimes present in a minor population of tumor cells during the development of non-small cell lung cancer. |
| 17652160 |
These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities. |
| 17643426 |
HGF induces transactivation of the EGFR in epithelial cells, and this is a prerequisite for induction of full motility. |
| 17597605 |
In Chinese lung cancer patients, a low number of CA repeats in intron 1 of the EGF receptor gene is associated with a better clinical outcome during therapy with gefitinib. |
| 17972518 |
Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas. |
| 17870017 |
The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR. |
| 17907599 |
We report the histological and genetic study of two glioblastomas, one case arising de novo and the other case arising 3 years after a previously diagnosed anaplastic astrocytoma, with concurrent EGFR amplification and TP-53 mutation |
| 17594688 |
Amplification of the EGFR gene and polysomy 7 are frequent alterations in primary melanomas and are associated with bad prognosis |
| 17334773 |
In a novel culture system normal human adult melanocytes expressed both EGF receptor (EGFR) mRNA and protein and EGF showed a dose dependent mitogenic effect on the cells |
| 17508947 |
Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from male and female Japanese patients. |
| 17804738 |
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance. |
| 17575133 |
study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking |
| 17646270 |
EGFR mutation and gene amplification is asociated with clear cell sarcoma of the kidney |
| 17643093 |
Fluorescence in situ hybridization/immunohistochemistry analysis of EGFR may be a useful ancillary tool to classify difficult cytology cases and inform clinicians arranging targeted chemotherapy. |
| 17643098 |
No correlation between epidermal growth factor receptor protein overexpression and epidermal growth factor receptor gene amplification in gastrointestinal stromal tumors. |
| 17822324 |
Overexpression of EGFR is associated with astrocytic tumor pathogenesis and progression |
| 17453292 |
Shorter EGFR intron 1 CA repeat length is associated with worse pancreatic cancer clinical prognosis and in vitro response to erlotinib. |
| 17618248 |
EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas. |
| 16795991 |
A subset of pancreatic ductal adenocarcinomas is characterized by EGFR gene numerical alterations including sporadic cases of amplification or absence of one allele (maybe due to gene deletion or intragenic point mutation and allelic silence). |
| 17566601 |
It seems that continued EGFR tyrosine kinase inhibition may be beneficial to EGFR-mutant lung cancers. |
| 17595327 |
OSU-03012 prevents YBX1 from inducing EGFR. |
| 16103229 |
These findings suggest a mechanism by which filopodia detect the presence and concentration of effector molecules far from the cell body and mediate cellular responses via directed transport of activated receptors. |
| 17661145 |
When combining thymidylate synthase and epidermal growth factor A61G genotype analysis, a small subgroup with a complete pathologic response rate of 100 percent was identified. |
| 17516110 |
EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. |
| 17548351 |
Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38 |
| 17495959 |
EGFR/Akt pathway mitigated G2/M arrest in human HaCaT keratinocytes and normal human keratinocytes treated with low doses of UVA irradiation. |
| 17622245 |
The combination of cetuximab and trastuzumab could induce synergistic antiproliferative effects in several oesophageal Squamous cell carcinoma cell lines with EGFR and HER-2 expression. |
| 17372273 |
the long lifetime of EGFRvIII, mutant variant of EGFR is caused by inefficient internalization and impaired sorting to lysosomes due to lack of effective ubiquitinylation. |
| 17607370 |
In NSCLC cases with wt- or mutant KRAS, downregulation of EGFR expression was a rare event although upregulation in bone metastases was observed more frequently in wt K-RAS cases. |
| 17575224 |
the R497K polymorphism of the EGFR could be a key determinant for reduced tumor recurrence and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma |
| 17573511 |
EGFR mutation can easily be detected in metastatic lymph nodes sampled by EBUS-TBNA. |
| 16685269 |
Final outcome of bladder cancer patients with high HER1- and HER2-expressing tumors depends on the expression of HER3 AND HER4. |
| 17644807 |
Adenin/guanine polymorphisms are not associated with endometrial cancer in a Japanese population. |
| 17459062 |
Frequencies of EGFR mutations were similar in both the alveolar and bronchial types of lung cancer |
| 17545148 |
EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation |
| 17646646 |
activating phosphorylation site on the c-Met receptor was found to be highly responsive to EGFRvIII levels, indicating cross-activation of the c-Met receptor tyrosine kinase by EGFRvIII |
| 17591931 |
In bronchioalveolar carcinoma/adenocarcinoma with bronchioalveolar features mucinous differentiation was significantly correlated with the absence of EGFR mutation and presence of KRAS mutation. |
| 17607119 |
EGFR mutations were therefore significantly associated with a better PFS in the first-line cytotoxic chemotherapy regimens. |
| 17649787 |
acquired resistance against both erlotinib, as well as gefitinib was most likely a result of tumor cells acquiring the T790M mutations |
| 17650314 |
CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term. |
| 17534846 |
it is suggested that atypical adenomatous hyperplasia (AAH) could develop by either KRAS or EGFR gene mutation, but AAH harbouring a KRAS gene mutation might not progress further to an invasive cancer |
| 17626639 |
Neither mutation of EGFR nor increased copy number of EGFR or HER2 was diagnostic of response to gefitinib. |
| 17581404 |
Data support that there are significant differences between EGFR and COX-2 expressions in the 3 different histogenetic types of cervical cancer. |
| 17237147 |
Directed trafficking of plasma membrane EGFR is an essential element of signal transduction leading to p42/p44 MAP kinase activation. |
| 17525128 |
E2 can activate a linear pathway involving the sequential activation of IGF-IR, MMP, HB-EGF, EGFR, and MAPK in MCF-7 breast cancer cells |
| 17671201 |
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation |
| 17611648 |
Decreased intratumoral EGFR expression and the absence of activated EGFR suggests that EGFR inhibition might not be an ideal target for antibody therapy. |
| 17390041 |
Comparative genomic hybridization and immunohistochemical assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas, one oligoastrocytoma and 23 high-grade astrocytomas is reported. |
| 17509661 |
Two somatic alterations (E829E and R831C) were identified in the cytoplasmic domain of the EGFR gene in 1 of 10 osteosarcoma samples. |
| 17562788 |
Shiga toxin trafficking to the Golgi is controlled by several Rab GAPs and their target Rabs and this process is discrete from ligand-induced EGFR trafficking. RabGAP-5 was unique among the GAPs tested and reduced the uptake of EGF but not Shiga toxin |
| 17761979 |
EGFR mutation status influenced the effect of adjuvant chemotherapy with uracil-tegafur. |
| 17219440 |
The number of dinucleotide repeats in this receptor identifies a possible susceptible population to lung cancer. |
| 17475774 |
Integrin-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGFR by signaling downstream to Erk. |
| 12686539 |
EGFR/HER2 heterodimers traffic as single entities; levels of HER2 in normal cells are barely at the threshold necessary to drive efficient heterodimerization |
| 12757445 |
Seasonal allergic rhinitis subject showed significant elevation in EGFR expression, consistent with the observation of mucus hypersecretion in allergic rhinitis. |
| 15652339 |
the acceleration of EBV LMP1 on the G1/S transition via the nuclear accumulation of EGFR was critical in the process of nasopharyngeal carcinoma |
| 15772959 |
Increased levels of EGFR were significantly associated with adult soft tissue sarcomas |
| 15920544 |
Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules. |
| 15921680 |
These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer. |
| 12134064 |
These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling. |
| 12134089 |
These results indicate that epidermal growth factor (EGF) receptors can form a ligand-independent inactive dimer and that receptor dimerization and activation are mechanistically distinct and separable events. |
| 15748904 |
The optimization and specification of therapeutic approaches based on erbB-receptor targeting requires to account for EGFR coexpression as well as the potential presence of erbB-receptor relevant growth factors. |
| 17126326 |
These results suggest that the secreted Hsp70 mediates the cross-communication of Toll like receptor and epidermal growth factor receptor signaling systems in A431 cells. |
| 17285230 |
Overexpression of the EGFR is associated with astrocytomas |
| 17545553 |
epidermal growth factor receptor D761Y mutation has a role in response to tyrosine kinase inhibitors |
| 14512423 |
ganglioside GM3 inhibits integrin-induced, ligand-independent epidermal growth factor receptor phosphorylation (cross-talk) through suppression of Src family kinase and phosphatidylinositol 3-kinase signaling |
| 16203769 |
EGFR mutation plays an important role in pathogenesis of lung adenocarcinoma |
| 15226397 |
EGF receptor traffic is disrupted by farnesyltransferase inhibitors through modulation of the RhoB GTPase |
| 15735691 |
YB-1 overexpression can induce EGF independence in human mammary epithelial cells via activation of the EGFR pathway |
| 15735700 |
HDL blocks neuroblastoma differentiation by inhibition of EGFR |
| 16870303 |
epidermal growth factor receptor has a role in response to gefitinib treatment in patients with non-small cell lung cancer |
| 17307332 |
Conventional PKC isoforms, especially PKCalpha, mediate feedback inhibition of G-protein-coupled receptor -induced EGFR transactivation. |
| 17381163 |
Results show epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding. |
| 17453000 |
Potentially interesting value of the serum levels of sEGFR and EGF, especially when combined, as markers for non-small cell lung cancer and head and neck cancer. |
| 17462600 |
These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity. |
| 12152785 |
Differential EGFR patterns by interphase cytogenetics in malignant peripheral nerve sheath tumor and morphologically similar spindle cell neoplasms. |
| 12444032 |
hydrogen peroxide increases cPLA(2) activity through its phosphorylation utilizing an epithelial growth factor/Ras/extracellular signal-regulated kinase and p38 pathway. |
| 12487410 |
Expression of the invasive phenotype in breast epithelial cells requires increased EGF receptor signaling, involving both PI 3-kinase and Erk 1,2 activities, which leads to enhanced secretion of MMP-9 and transcription of invasion-related genes. |
| 15798095 |
regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells |
| 15994311 |
Decorin causes EGFR internalization via caveolae |
| 16240846 |
The frequency of CA allele combinations was assessed in healthy women from Poland; results provide new data on EGFR microsatellite instability and may contribute to the understanding of EGFR gene expression regulation. |
| 16242075 |
the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells |
| 17183836 |
EGFR positivity was observed in all the cases (100%) of benign prostatic hypertrophy (BPH) and prostatic intraepithelial neoplasia (PIN) and in only 10 cases (28.5%) of prostatic carcinoma. |
| 11788593 |
effects of receptor-selective retinoid ligands on EGFR-associated signal transduction |
| 17349623 |
GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors. |
| 12517803 |
activation regulates mutation and epidermal growth factor receptor activation regulates vascular endothelial growth factor mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. |
| 15248827 |
betacellulin may play a role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas. |
| 15485674 |
EGF signalling amplification is induced by dynamic clustering of EGFR |
| 16305343 |
data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer |
| 16472761 |
EGFR signaling pathway negatively regulates prostate specific antigen expression which may be induced by the alteration of androgen expression via the PI3K-Akt pathway in LNCaP C-81 cells |
| 16569667 |
Healing of wounds in sheets of corneal epithelial cells is absolutely dependent on epidermal growth factor receptor signaling, and the present data suggest that its activation is a result of wound-induced phospholipase D activation. |
| 16923119 |
These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. |
| 17053785 |
fine-tuning mechanism of Par3 in epithelial tight junction assembly controlled by the EGF receptor-SFK signaling pathway. |
| 17157295 |
These findings unmask an EGF-sensitive checkpoint, helping to understand the link between sustained EGFR signalling, proliferation and the acquisition of a radioresistant phenotype in cancer cells. |
| 17186532 |
Epidermal growth factor receptor mutations are associated with adenosquamous carcinoma of the lung |
| 17196962 |
Motogenetic activation by EGF requires the concomitant functionality of EGFR and the hyaluronan receptor CD44, whereas activation by TGF-alpha requires EGFR and integrin alphavbeta3. |
| 17200338 |
somatic alterations in p53 and EGFR have roles in progression of primary lung cancer |
| 12354760 |
caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation. |
| 14507652 |
Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. |
| 15042583 |
The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy. |
| 11897506 |
estrogen transactivates the epidermal growth factor receptor (EGFR) to MAP K signaling axis via GPR30;implications for breast cancer biology |
| 15950906 |
EGFR physically interacts with signal transducers and activators of transcription 3 in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase. |
| 12456372 |
Mutual interaction of EGFR with c-Src is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review. |
| 12930839 |
EGF receptor down-regulation by UVA may play an important role in the execution of the cell suicide program by attenuating its anti-apoptotic function |
| 12829707 |
Ligand-induced EGFR degradation is preceded by proteasome-dependent EGFR de-ubiquitination. |
| 15982634 |
Our findings suggest that extracellular H(2)O(2) generated by EGFR-ligand interaction permeates the plasma membrane and inhibits EGFR-associated tyrosine phosphatase activity. |
| 16799709 |
The majority of oral squamous cell carcinomas highly express EGFR and p-EGFR, and a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion. |
| 17255257 |
PTEN tumor-suppressor protein has a role in response to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma |
| 11853560 |
Calmodulin binds to the EGFR |
| 12105206 |
determination of decorin binding site |
| 13679441 |
These results indicate that the EGFR signaling pathway is involved in urothelial regeneration. |
| 13679857 |
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cells are mediated by activation of EGFR. |
| 15389641 |
GqPCR-induced FAK activation is mediated by via a pathway involving transactivation of the EGFr and alterations in the actin cytoskeleton. |
| 14978035 |
a novel and important role for metalloprotease activation and EGFR transmodulation in mediating the cellular response to TNF |
| 16642476 |
Frequent EGFR mutations is associated with brain metastases of lung adenocarcinoma |
| 16687414 |
lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF |
| 16741920 |
These findings are consistent with a model in which ErbB1 expression increases during development of the androgen-independent state. Drugs targeted toward ErbB signaling could be of therapeutic relevance in the management of advanced prostatic carcinoma. |
| 16750403 |
Results describe a relationship between the effects of epidermal growth factor (EGF) on cell proliferation and levels of EGF receptor expression in a cell line expressing different levels of EGFR caused by different concentrations of EGF treatment. |
| 16785991 |
The data suggest that prolactin synergistically augments epidermal growth factor signaling in T47D breast cancer cells at least in part by lessening EGF-induced epidermal growth factor receptor downregulation. |
| 16936259 |
EGFR is required for UVB-mediated induction of multiple signaling pathways that are known to mediate tumor formation in skin. |
| 16984414 |
cells surviving an attack by alpha toxin can be induced to proliferate via recruitment of an EGFR-dependent signalling pathway |
| 11953893 |
Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length. |
| 12642595 |
data indicate that growth hormone, by activating extracellular signal related kinases, can modulate epidermal growth factor-induced epidermal growth factor receptor trafficking and signaling |
| 17403676 |
Rin1 regulates EGFR degradation in cooperation with STAM |
| 15962011 |
EGFR downregulation is inhibited by Sprouty2 targeting both the Cbl and CIN85 pathways. |
| 11994282 |
blocking of ubiquitination by inhibiting Src family kinases |
| 15082004 |
Intensive staining of EGF-R is associated with invasive tumours of bladder |
| 15337756 |
Data show that activation of ADAM-17 results in discrete cellular responses, while G protein-coupled receptor agonists promote activation of the Ras/MAPK pathway and cell proliferation via the epidermal growth factor receptor. |
| 15815931 |
data suggest that mutations of epidermal growth factor receptor (EGFR) and K-RAS genes might separately, but not cooperatively, contribute to lung adenocarcinoma pathogenesis |
| 12388817 |
Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors |
| 12722480 |
The expression of this protein was not different in the clone cell variants or the A431 parental line. |
| 14607699 |
findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors |
| 16738552 |
analysis of proteins that bind to and interact with EGFR |
| 17596643 |
EGFR and K-ras mutations may have a role in progression of resected non-small-cell lung cancer |
| 16246327 |
EGF-R fate is controlled by a checkpoint downstream of receptor ubiquitination whose regulation by the Cbl RF tail may require Sprouty2 degradation. |
| 16373414 |
PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR. |
| 16622417 |
PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin and increased epidermal growth factor receptor (EGFR) endocytosis at physiological EGF concentrations. |
| 14704150 |
involvement urokinase plasminogen activator secretion and cell motility in breast cancer cells |
| 14718570 |
the adhesion-dependent activation of EGF receptor signaling is promoted by L1-type CAMs in vitro and in vivo |
| 15010475 |
Trypsin exerts robust trophic action on colon cancer cells and underline the critical role of EGF-R transactivation. |
| 15245434 |
Human leukocyte elastase induces keratinocyte proliferation by proteolytic activation of an EGFR signaling cascade involving TGF-alpha. |
| 15896781 |
heterogeneity in the density of EGFR due to localization in certain regions of the plasma membrane, which has been experimentally reported, can also lead to concave up shape of the Scatchard plot of the EGF binding on EGFR |
| 16299810 |
EGFR, in addition to E2F1, target sites induce B-Myb promoter |
| 16319309 |
These findings reveal a new role for EGFR in the postnatal brain and open new avenues to optimize cell engraftment for brain repair. |
| 11751923 |
The data presented here demonstrate that, in contrast to activation by the cytokine, growth hormone (GH), the activation of STAT5b by the growth factor, epidermal growth factor (EGF), requires overexpression of the EGF receptor (EGFR). |
| 12006662 |
novel mechanism of EGFR internalization that does not require ligand binding, receptor kinase activity, or ubiquitylation and does not direct the receptor into a degradative pathway |
| 15524283 |
regulation of LMP1 on the nuclear translocation of EGFR is critical for the process of nasopharyngeal carcinoma |
| 12897150 |
endosomal epidermal growth factor receptor stimulates cell growth |
| 15447984 |
serum epidermal growth factor receptor and HER2 have roles in response of advanced non-small cell lung cancer to chemotherapy |
| 16010411 |
EGFR expression was associated with improved survival. |
| 16098254 |
Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy. |
| 15967120 |
Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells |
| 16331686 |
Findings disclose a cross-talk between the COX-2/PGE(2)/EP(1) and EGFR/c-Met signaling pathways that coordinately regulate human hepatocellular carcinoma cell invasion. |
| 16398612 |
Antibodies from naive human scFv (single-chain Fv) phage display libraries provide a valuable and potentially clinically relevant panel of agents to target the members of the EGFR family. |
| 16567021 |
a wide spectrum of somatic EGFR TK mutations reporting a relatively high incidence (15%) in NSCLC patients of Greek and Czech origin. |
| 16584205 |
An EGF mutant, designated WVR/EGF/IADIQ, gained high affinity for ErbB3 & showed concomitant ErbB3 activation through ErbB2.ErbB3 heterodimers similar to the natural ErbB3 ligand NRG1beta, while the capacity to bind & activate ErbB1 was fully maintained. |
| 16641105 |
results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested |
| 16778986 |
