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EGR1
| Symbol: | EGR1 | | Name(s): | early growth response 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18068676 |
Intact SP1-binding sites are essential for promoter activity, whereas EGR-1 suppresses the transcription of the human SREBP-1a promoter |
| 18027854 |
Egr-1 negatively regulates survivin expression and sensitizes cell lines to TRAIL-induced apoptosis |
| 17975260 |
These results indicate that EGR1 is a key player in coordinated down-regulation of genes in leiomyoma. |
| 18324520 |
APE1 regulated PTEN expression is mediated by Egr-1. |
| 17631285 |
Our data demonstrate that IL-1beta-induced Id2 expression in VSMC is mediated by the transcription factor Egr-1 in VSMC. |
| 18067864 |
These results suggest that elevated expression and activity of PLD attenuate phorbol myristate acetate-induced Egr-1 expression via PI3K pathway. |
| 18171299 |
The greatest reduction in the number of C. pneumoniae inclusions was due to the silencing of the gene coding for the transcription factor early growth response 1, which decreased the number of inclusions by 38.6% |
| 18174470 |
Prolonged exposure to heme, as may be observed after plaque rupture in atherosclerotic disease, leads to dysregulation and prolonged elevated Egr-1 expression that contributes to atherosclerotic progression |
| 17967787 |
Hemin increased Egr-1 expression (mRNA, protein) within 30 minutes and ERK-1/2 phosphorylation and nuclear translocation within 5 minutes |
| 17599039 |
Constitutive expression of Egr-1 transgene abrogates E2F-1 oncogene-mediated block in differentiation of murine myeloblastic leukemia cells, allowing the cells to differentiate into functionally mature macrophages that subsequently undergo apoptosis. | →View more information from publications. |
Recent Publications on EGR1: |  |
Identifying Genes for Establishing a Multigenic Test for Hepatocellular Carcinoma Surveillance in Hepatitis C Virus-Positive Cirrhotic Patients.
In this study, we used the Affymetrix HG-U133A version 2.0 GeneChips to... | 29th October, 2009
| 1Department of Biostatistics, 2Massey Cancer Center, 3Division of
| Cancer Epidemiol Biomarkers Prev. 2009 Oct 27.
DOI Direct Link |
Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition.
Zinc protoporphyrin IX (ZnPP), an endogenous heme analogue that inhibits... | 24th October, 2009
| Children's hospital of philadelphia, United States.
| J Biol Chem. 2009 Oct 22.
DOI Direct Link |
Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts.
G-protein coupled receptors are thought to transmit extracellular signals... | 21st October, 2009
| Washington university School of Medicine, United States.
| J Biol Chem. 2009 Oct 19.
DOI Direct Link |
Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8 mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy.
IL-8 produced by prostate cancer cells may be responsible for the... | 20th October, 2009
| University of Science & Technology of China;
| J Biol Chem. 2009 Oct 16.
DOI Direct Link |
Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli.
The GADD45 family of proteins consists of three small proteins, GADD45A,... | 17th October, 2009
| Fels Institute for Cancer Research and Molecular Biology, Temple
| J Cell Biochem. 2009 Oct 15.
DOI Direct Link |
→View more research publications. |
EGR1 results (if any) from reagent suppliers | 
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