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EIF4EBP1
| Symbol: | EIF4EBP1 | | Name(s): | eukaryotic translation initiation factor 4E binding protein 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | 4EBP1, BP-1, MGC4316, PHAS-I | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18280804 |
treatment of acute promyelocytic leukemia (APL)-derived NB4 cells with all-trans-retinoic acid results in dissociation of the translational repressor 4E-BP1 from the eukaryotic initiation factor eIF4E, and subsequent formation of eIF4G-eIF4E complexes. |
| 17653084 |
The phosphorylation of 4E-BP1 may play a dual role in the regulation of protein synthesis, both reducing the affinity of 4E-BP1 for eIF4E and promoting the conversion of 4E-BP1 to alternative, polyubiquitinated forms. |
| 17724476 |
Key regulator of cyclin D1 expression. |
| 17601486 |
These results demonstrate that "pure" isoprenoids and genistein differentially impact cap-dependent translation in tumor cell lines. |
| 17604271 |
PRAS40 acts downstream of mTORC1 but upstream of its effectors, such as S6K1 and 4E-BP1 |
| 17699757 |
Phosphorylated 4E-BP1 (p-4E-BP1) expression in tumors is associated with malignant progression and an adverse prognosis regardless of the upstream oncogenic alterations. |
| 12820960 |
Rheb is a mediator of 4EBP1. |
| 17114181 |
mTOR-dependent pathways have roles in IFN signaling and 4E-BP1 and TSC1-TSC2 are key components in the generation of IFN-dependent biological responses |
| 17200342 |
4E-binding protein 1 has a role in progression of breast neoplasms through cell signaling |
| 11847216 |
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. | →View more information from publications. |
Recent Publications on EIF4EBP1: |  |
[Stress responses in pancreatic beta-cells: roles of translational control]
BACKGROUND: Curcumin, a natural polyphenol product of the plant Curcuma... | 23rd October, 2009
| Division of Diabetes and Metabolism, Department of Medicine, Nihon
| Seikagaku. 2009 Jun;81(6):474-85.
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Mammalian target of rapamycin is activated in association with myometrial proliferation during pregnancy.
The adaptive growth of the uterus during gestation involves gradual... | 23rd October, 2009
| Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto,
| Endocrinology. 2009 Oct;150(10):4672-80. Epub 2009 Jul 9.
DOI Direct Link |
Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine.
The mammalian target of rapamycin (mTOR) kinase is a key regulator of cell... | 17th October, 2009
| Departments of aHematology bExperimental Hematology, Medical University of
| Anticancer Drugs. 2009 Sep;20(8):693-701.
DOI Direct Link |
Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling.
BACKGROUND: Curcumin, a natural polyphenol product of the plant Curcuma... | 1st October, 2009
| Department of Surgery, The University of Texas Medical Branch, Galveston,
| Anticancer Res. 2009 Aug;29(8):3185-90.
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Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain.
The incidence of brain metastasis is rising and poses a severe clinical... | 29th September, 2009
| Department of Molecular and Experimental Medicine, The Scripps Research
| Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10666-71. Epub 2009 Jun 16.
DOI Direct Link |
→View more research publications. |
EIF4EBP1 results (if any) from reagent suppliers | 
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eIF4EBP1 antibody (ab2606) | Abcam
Rabbit polyclonal to eIF4EBP1. eIF4EBP1 (eukaryotic translation Initiation Factor 4E Binding Protein 1) recognizes and binds the ...
http://www.abcam.com/eIF4EBP1-antibody-ab2606.html...
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EIF4EBP1 Antibody (T36)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with EIF4EBP1 Antibody (T36) (Cat.#AP1981b), which was peroxidase-conjugated to ...
http://www.abgent.com/products/catalog_no/AP1981b_EIF4EBP1_A...
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4E-BP1 Monoclonal Antibody eukaryotic translation Initiation ...
Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation ... Non phosphorylated eIF4EBP1 will bind strongly to eIF4E
while(24kDa), ...
http://www.prosci-inc.com/shop/catalog1/4E-BP1-Monoclonal-An...
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EIF4EBP1 Antibody(S111)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with EIF4EBP1 Antibody (S111), which was peroxidase-conjugated to the secondary ...
http://www.abgent.com/products/catalog_no/AP1981d_EIF4EBP1_A...
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p-4E-BP1/2/3 (Thr 36) Antibody sc-101624
Mouse, Eif4ebp1, 13685, 8 A2, Q60876, N/A. Mouse, Eif4ebp2, 13688, 10 B4, P70445 , N/A. Mouse, Eif4ebp3, 108112, 18 B2, Q80VV3 ...
http://www.scbt.com/datasheet-101624-p-4e-bp1-2-3-thr-36-ant...
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Phospho-EIF4EBP1-pT36 Antibody
Dot blot analysis of anti-EIF4EBP1-pT36 Phospho-specific Pab (Cat.#AP3416a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per ...
http://www.abgent.com/products/catalog_no/AP3417a_Phospho_EI...
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p-4E-BP1 (Ser 65/Thr 70) Antibody sc-12884
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, EIF4EBP1, 1978, 8p12, NM_004095 ...
http://www.scbt.com/datasheet-12884-p-4e-bp1-ser-65-thr-70-a...
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