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ELA1


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Gene DB Home
Symbol:ELA1
Name(s):elastase 1, pancreatic
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17989309 Fecal fat excretion is increased in patients with type 2 diabetes with fecal elastase deficiency.
17103488 Patients with type 1 diabetes and low fecal elastase 1 concentrations were succesfully treatted with pancretin.
15351720 pancreatic elastase induced proinflammatory effects are mediated by TLR4 and NF-kappaB in human myeloid cells
15277440 As an independent variable, correlated with C-peptide and HBA1c levels in type 1 diabetes.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursorelastase 1, pancreatic--Pubmed
HPRDalpha-2-macroglobulin precursorelastase 1, pancreatic--Pubmed
HPRDalpha-1-antichymotrypsin, precursorelastase 1, pancreatic--Pubmed
HPRDalpha-1-antichymotrypsin, precursorelastase 1, pancreatic--Pubmed
HPRDcasein betaelastase 1, pancreatic--Pubmed
HPRDcasein betaelastase 1, pancreatic--Pubmed

Recent Publications on ELA1:

Pubmed Logo
Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB.
The transcription factor FosB is induced in neurons of the medial preoptic...
9th August, 2008
Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Brain Res. 2008 May 23;1211:57-71. Epub 2008 Mar 18.
DOI Direct Link
Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development.
Glucocorticoids play a vital role in fetal respiratory development and act...
26th February, 2008
Department of Biochemistry and Molecular Biology, Monash University, J Physiol. 2007 Nov 15;585(Pt 1):187-201. Epub 2007 Sep 27.
DOI Direct Link
ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
Treatment of yeast and human cells with DNA-damaging agents elicits lysine...
9th May, 2007
University of Texas Medical Branch at Galveston, 301 University Blvd., Mol Cell Biol. 2007 Apr;27(8):3211-6. Epub 2007 Feb 12.
DOI Direct Link
Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.
BACKGROUND: The archetypal mammalian elastase (ELA1) is not expressed in...
17th June, 2006
Department of Molecular and Cell Biology, Goldman School of Dental Pancreatology. 2006;6(1-2):117-22. Epub 2005 Dec 1.
DOI Direct Link
Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.
Development of hypertension stems from both environmental and genetic...
28th September, 2005
Division of Intramural Research, National Center for Toxicogenomics, Am J Physiol Renal Physiol. 2005 Sep;289(3):F552-61. Epub 2005 Mar 29.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Use of Formula Fortified With DHA in Infants With Cystic Fibrosis
Cystic Fibrosis

Patents:

Patents logo
US Patent No.Title
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7179619 Methods and compositions for inhibiting herpesviral replication
6567669 Location estimation of one or more transmitters based on signals transmitted therefrom
6538173 Compositions and methods for wound healing
6476188 Clock gene and methods of use thereof

View more patents.

ELA1 results (if any) from reagent suppliers

Google CSE Logo
ELA1 elastase 1, pancreatic
Official Symbol. ELA1. Species. Homo sapiens. Entrez Gene ID. 1990. Alternate Symbol. ELA1. Other Designations. pancreatic elastase I. Refseq ID(s) ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

Thumbshot
Elastase-1 (207E10) Antibody sc-101403
ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ELA1, 1990, 12q13.13, NM_001971 · Q9UNI1 ...
http://www.scbt.com/datasheet-101403-elastase-1-207e10-antib...

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Ela1 elastase 1, pancreatic
Ela1. Species. Rattus norvegicus. Entrez Gene ID. 24331. Alternate Symbol. Ela1; ELA1; ELAI1; RATELAI1. Refseq ID(s). NM_012552. Accession No.(s) ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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Inteligência Artificial
ama(Ela2,Ela1). Desta forma, seria verdadeira a questão: ?- amiga_intima(maria, joana). yes. E falsa a questão: ?- amiga_intima(maria,clara). ...
http://members.tripod.com/the_dark_ages/prolog.htm...

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SI13100 MISSION siRNA Human Gene Family Panels Protease Panel, 379 ...
... DPP3(10072), DPP4(1803), DPP7(29952), DPP8(54878), DPP9(91039), ECE1(1889), ECE2(9718), ECEL1(9427), ELA1(1990), ELA2(1991), ELA2A(63036), ELA2B(51032), ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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