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A2M


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Symbol:A2M
Name(s):alpha-2-macroglobulin
Type:protein-coding
Organism:Homo sapiens
Synonyms:CPAMD5, DKFZp779B086, FWP007, S863-7, alpha 2M
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18171086 alpha2M is a newly discovered and unique member of a small group of abundant extracellular proteins with chaperone properties
11036822 Observational study of gene-disease association. (HuGE Navigator)
11058789 Observational study of gene-disease association. (HuGE Navigator)
11099722 Observational study of gene-disease association. (HuGE Navigator)
11121179 Observational study of gene-disease association. (HuGE Navigator)
11166925 Observational study of gene-disease association. (HuGE Navigator)
11231028 Observational study of gene-disease association. (HuGE Navigator)
11281447 Observational study of gene-disease association. (HuGE Navigator)
11290389 Observational study of gene-disease association. (HuGE Navigator)
11436125 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDMacroglobulin, alpha 2leptin precursor--Pubmed
HPRDMacroglobulin, alpha 2interleukin 1, beta proprotein--Pubmed
HPRDMacroglobulin, alpha 2a disintegrin and metalloprotease with thrombospondin motifs-1 preproprotein--Pubmed
HPRDMacroglobulin, alpha 2ADAM metallopeptidase domain 19 isoform 1 preproprotein--Pubmed
HPRDalpha-2-macroglobulin precursorInterleukin 1, beta--Pubmed
HPRDalpha-2-macroglobulin precursorLeptin--Pubmed
HPRDalpha-2-macroglobulin precursorADAMTS1--Pubmed
HPRDalpha-2-macroglobulin precursorADAM 19--Pubmed
HPRDalpha-2-macroglobulin precursorHuman pregnancy-associated endometrial alpha2-globulin mRNA, and translated products--Pubmed
HPRDalpha-2-macroglobulin precursorHuman pregnancy-associated endometrial alpha2-globulin mRNA, and translated products--Pubmed

Recent Publications on A2M:

Pubmed Logo
Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease.
A total sample of 169 AD patients, and 264 age- and sex-matched unrelated...
10th October, 2009
Department of Geriatrics, Center for Aging Brain, University of Bari, Neurobiol Aging. 2009 Sep;30(9):1518-20. Epub 2008 Jan 10.
DOI Direct Link
The effect of matrix metalloproteinase inhibition on tendon-to-bone healing in a rotator cuff repair model.
HYPOTHESIS: Recent studies have demonstrated a potentially critical role...
6th October, 2009
Sports Medicine and Shoulder Surgery, Laboratory for Soft Tissue Research, J Shoulder Elbow Surg. 2009 Sep 30.
DOI Direct Link
An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
Alzheimer's disease (AD) is the most common form of progressive dementia...
17th September, 2009
Department of Molecular Physiology and Biophysics and Center for Human Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):721-35.
DOI Direct Link
Tracheobronchial protease inhibitors, body surface area burns, and mortality in smoke inhalation.
The objective of this study was to assess tracheobronchial protease...
21st August, 2009
University of Arizona Mel and Enid Zuckerman College of Public Health, J Burn Care Res. 2009 Sep-Oct;30(5):824-31.
DOI Direct Link
Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals.
Risk alleles for age-related diseases are expected to decrease in...
30th July, 2009
Institute of Clinical Molecular Biology, Christian-Albrechts University Eur J Hum Genet. 2009 Jul 29.
DOI Direct Link

View more research publications.

Press Releases on A2M:

BioPortfolio Logo
Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 8th June, 2009 Quest Diagnostics Incorporated

MADISON, N.J., June 8 /PRNewswire-FirstCall/ -- A study in the June issue of Clinical Gastroenterology and Hepatology, published by Elsevier, demonstrates that the Hepascore(TM)

Clinical Trials:

Clinical Trials Logo
Phase 2 Proof-of-Concept Study of the Safety and Efficacy of Alfimeprase to Rapidly Open Arteries and Restore Brain Function Following a Stroke

Patents:

Patents logo
US Patent No.Title
6995014 Transgenic plants expressing assembled secretory antibodies
7189507 Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7209110 Active matrix type display device
7209835 Algorithmic testing in laboratory medicine

View more patents.

A2M results (if any) from reagent suppliers

Google CSE Logo
GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
Western Blot analysis of A2M expression in transfected 293T cell line by A2M ... A2M is implicated in Alzheimer disease (AD) due to its ability to mediate ...
http://www.genetex.com/WebPage/Product/ProductDetail.aspx?Ca...

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HPA002265 Anti-A2M antibody produced in rabbit Prestige Antibodies ...
HPA002265 Anti-A2M antibody produced in rabbit Prestige Antibodies Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en...

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Rat A2M ELISA
Rat Alpha 2-Macroglobulin ELISA Kit E-25A2M rat alpha 2-macroglobulin anti-rat alpha 2-macroglobulin rat macroglobulin Rat A2M ELISA Rat Alpha ...
http://www.icllab.com/ccp2058-rat-alpha-2-macroglobulin-elis...

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CANINE CRP
the anti-A2M. antibodies which have been adsorbed to the surface of polystyrene microtitre wells. .... for specific A2M require meticulous quality control. ...
http://www.genwaybio.com/images/gw_tds/elisa_kits/40-374-130...

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GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
A2M antibody (alpha-2-macroglobulin), GTX101404, Rabbit PAb, WB, 100 μl, USD $239.00, -. A2M antibody (alpha-2-macroglobulin), GTX101417, Rabbit ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

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Product: Anti-ACP33 (Human), Affinity-purified Polyclonal IgY ...
Alpha 2-Macroglobulin (A2M) is a major protease inhibitor in serum and an ... Macroglobulin present in samples react with the anti-A2M. antibodies which ...
http://www.genwaybio.com/images/gw_tds/elisa_kits/40-374-130...

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Monoclonal Anti-Human IgA1—Biotin Conjugate antibody produced in ...
two antithetical allotypes A2m (1) and A2m (2) are known. The major immunoglobulin of human exocrine fluids is dimeric IgA coupled covalently to an
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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