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ABCA2


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Symbol:ABCA2
Name(s):ATP-binding cassette, sub-family A (ABC1), member 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:ABC2, MGC129761
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18336955 Observational study of gene-disease association. (HuGE Navigator)
16752360 Observational study of gene-disease association. (HuGE Navigator)
15850583 the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas
15649702 Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples.
12560508 Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors.
12363033 roles for this largest known ABC protein in neural transmembrane lipid export
16752360 Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease.
15093135 It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues.
15155565 Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDATP-binding cassette, sub-family A, member 2 isoform aCDK5 regulatory subunit associated protein 2--Pubmed

Recent Publications on ABCA2:

Pubmed Logo
Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human.
While P-glycoprotein (PGP, ABCB1) is known to play an important role in...
2nd September, 2009
XenoPort, Inc., 3410 Central Expressway, Santa Clara, CA 95051, USA. Pharmacol Res. 2009 Jun;59(6):404-13. Epub 2009 Feb 24.
DOI Direct Link
Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster.
The fetus has a high requirement for cholesterol and synthesizes...
13th August, 2009
Department of Pathology and Laboratory Medicine, University of Cincinnati J Lipid Res. 2009 Jun;50(6):1146-55. Epub 2009 Jan 3.
DOI Direct Link
[Expression of ATP-binding cassette transporter genes in nasopharyngeal carcinoma]
OBJECTIVE: To explore the differences in the expression of the ATP-binding...
3rd April, 2009
Cancer Research Institute, Southern Medical University, Guangzhou 510515, Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):449-52.
ABCA2 as a therapeutic target in cancer and nervous system disorders.
BACKGROUND: Overexpression of ATP-binding cassette (ABC) transporters is a...
18th April, 2008
Medical University of South Carolina, Department of Cell and Molecular Expert Opin Ther Targets. 2008 Apr;12(4):491-504.
DOI Direct Link
Role of ATP-binding cassette transporters in brain lipid transport and neurological disease.
The brain is lipid-rich compared to other organs and although previous...
15th March, 2008
Prince of Wales Medical Research Institute, Sydney, New South Wales, J Neurochem. 2008 Mar;104(5):1145-66. Epub 2007 Oct 31.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7485468 Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
7426441 Methods for determining renal toxins
7415358 Molecular toxicology modeling

ABCA2 results (if any) from reagent suppliers

Google CSE Logo
ABCA2 antibody [9A2-51.3] (ab80280) | Abcam
Rat monoclonal [9A2-51.3] to ABCA2. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) ...
http://www.abcam.com/ABCA2-antibody-9A2-51-3-ab80280.html...

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ABCA2 Antibody ABCA2
ABCA2 antibody was raised against a synthetic peptide of ABCA2.,
http://www.prosci-inc.com/shop/catalog1/ABCA2-Antibody-p-276...

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ABCA2 (9A2) Antibody sc-130575
rat monoclonal IgG, 200µg/ml; raised against ABCA2 of mouse origin; recommended for detection of ABCA2 of mouse origin by IP, IF and FCM ...
http://www.scbt.com/datasheet-130575-abca2-9a2-antibody.html...

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ABCA2 antibodies: Cardiovascular > Lipids / Lipoproteins > Lipid ...
ABCA2 antibodies. ... ABCA2 antibody [9A251.3] (Phycoerythrin). Flow Cyt. Images . Rat monoclonal. Phycoerythrin conjugated ...
http://www.abcam.com/index.html?t=250649&pt=1&c=855&ei=&mu=r...

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ABC Antibody / ABC Antibodies
ABCA2 (N-19) Antibody, sc-48440, goat IgG, N-terminus (h), WB, IF, ELISA, m, r, h. ABCA2 (9A2) Antibody, sc-130575, rat IgG, FL (m), IP, IF, FCM, mouse ...
http://www.scbt.com/table-abc.html...

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Neurobiology Antibodies :: Page 1
ABCA1 Monoclonal Antibody, 49-889, M, C, E, WB, IHC, ATP-Binding Cassette, Sub- Family A. ABCA2 Antibody, 46-787, H, M, R, E, ABCA2 ...
http://www.prosci-inc.com/shop/catalog1/Neurobiology-Antibod...

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ABCA2 siRNA (r) sc-156054
Click here for details. suitable control antibody: ABCA2 (N-19): sc-48440; sqRT- PCR Primer also available: ABCA2 (r)-PR: sc-156054-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-156054-abca2-sirna-r.html...

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