Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18083712 |
PGE(2) via EP(2) and EP(4) activates the cAMP-->PKA-->CREB pathway leading to enhanced CYP19 transcription and increased aromatase activity through BRCA1 and p300 |
| 18243116 |
that Skp2 controls p300-p53 signaling pathways in cancer cells, making Skp2 a potential molecular target for cancer therapy. |
| 16704985 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17761950 |
demonstrate the distinct regulatory mechanisms of p300 and TR3 on retinoid X receptor-alpha acetylation |
| 18070920 |
These data reveal that phosphorylation of CREB is not sufficient for CBP/p300 recruitment and transcriptional activation. |
| 17707401 |
These results provide evidence for a model in which Tax and pCREB bind distinct surfaces of KIX for effective CBP/p300 recruitment to the HTLV-1 promoter. |
| 17623675 |
ERK2-mediated C-terminal serine phosphorylation of p300 was a key event in the regulation of EGF-induced keratin 16 expression. |
| 17226766 |
p72 RNA helicase may not only be involved in the p53-Mdm2 regulatory loop, but also profoundly impact on the transcriptome through various CBP/p300 and P/CAF interacting proteins. |
| 17299436 |
EP300 mutations could be underdiagnosed because they may result in phenotypes different from classical Rubinstein-Taybi syndrome. |
| 15806138 |
TCF4 expression mediated by beta-catenin/p300 may be important for initial steps during trans-differentiation of endometrial carcinoma cells. |
| 12972427 |
p300 has a role in the trans-repression of beta-catenin signaling by nuclear receptors and their ligands |
| 15075319 |
activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP. |
| 15943569 |
data indicate that p12I appears to play a vital role in HTLV-1-mediated T cell activation by activating calcium-mediated transcription and augmenting the amounts of p300 within T lymphocytes |
| 15066326 |
Hypermethylation of p300 promoter is not an important mechanism in leukemogenesis |
| 15649887 |
Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. |
| 17438265 |
A complex between tetrameric p53 and p300 in which four domains of p300 wrap around the four transactivation domains of p53. |
| 15890677 |
p300 directly acetylates lysines in the carboxyl-terminal region of Foxo1 in vivo and in vitro, and potently stimulates Foxo1-induced transcription of IGF-binding protein-1. |
| 16922677 |
HDAC4 (histone deacetylase 4) and p300, a known HAT (histone acetyltransferase), reversibly controlled the activity of the IL-5 promoter in vivo and in vitro, with a concurrent alteration of histone H3 acetylation status at the promoter regions. |
| 12368347 |
suggest an important role of p300 in regulation of HPV8 gene expression and reveal a new mechanism by which E2 may be recruited to a promoter to activate transcription without sequence specific DNA binding |
| 14630807 |
p300 is the predominant coactivator that is essential for COX-2 transcriptional activation by proinflammatory mediators. |
| 16687403 |
Tat-mediated activation of the HIV promoter requires the SWI/SNF complex in synergy with the coactivator p300. |
| 12162806 |
MDMX dramatically inhibits the acetylation of p53 induced by both endogenous and ectopically expressed p300/CBP. |
| 12473110 |
p300/CBP binds to IRF3, enabling it to act as a transcription factor |
| 17403783 |
p300-mediated acetylation of p53 requires Bat3 |
| 15509808 |
IRF-1-p300 interface as an allosteric modifier of DNA-dependent acetylation of p53 at the p21 promoter |
| 15117818 |
p300 markedly potentiates the binding of NFATc1 to the bcl-2 NFAT element by interacting with NFATc1 in an E1A-dependent manner. |
| 16622451 |
loss of p300 in HCT116 cells results in potentially aggressive phenotype characterized by reduced adhesion and increased migration |
| 12482985 |
our results indicate an important role for Mediator, as well as its functional interplay with p300/CBP-SRC, in the enhancement of ERalpha-dependent transcription with chromatin templates |
| 15615775 |
The p300-CBP coactivator had a stabilizing effect on the formation of the complex between HIF-1alpha and its DNA-binding partner, Arnt. |
| 11773079 |
CBP/p300 and NcoA/SRC1a may function in a common pathway to regulate STAT3 transcriptional activity. |
| 15964811 |
Histone acetyltransferase activity of p300 is required for transcriptional repression by PZLF. |
| 11782371 |
p300 Modulates the BRCA1 inhibition of estrogen receptor activity |
| 14550555 |
EWS-ER81 and EWS-Fli-1 interact with and thereby activate the MMP-1 promoter, which is potentiated by the cofactor p300 and the proto-oncoprotein c-Jun. |
| 15138260 |
Data show that RUNX3 is a target of the acetyltransferase activity of p300 acetyltransferase. |
| 14612423 |
p300-mediated acetylation can be highly constrained by substrate conformation in vivo |
| 15123817 |
p300 is a key regulator of the p53 response and suggest that p300 inhibition could be used to modulate chemotherapy |
| 12960163 |
p300 has a role in NF-kappaB-dependent gene expression along with PARP-1 |
| 15705864 |
Transfection of p300 into prostate cancer cells specifically increases mRNA and protein levels of nuclear matrix peptides lamins A and C. |
| 12696060 |
Loss of EP300 was not statistically significant selection in cancer cells stratified by various criteria for the concordant loss of EP300 and CREBBP. |
| 12914934 |
S-nitrosation of Cys-800 stimulates the recruitment of p300 co-activator protein to the HIF-1alpha C-terminal domain |
| 17126870 |
hypothesized that HSV-1 ICP0 recruits activated IRF-3 & CBP/p300 to nuclear structures, away from host chromatin; this leads to inactivation & accelerated degradation of IRF-3, resulting in reduced transcription of IFN-beta & inhibition of host response |
| 17272271 |
Role for p300 acetyltransferase includes the modulation of chromatin structure and function during DNA metabolic events as well as for transcription. |
| 17410209 |
CBP/p300 has an evolutionarily conserved role as a buffer regulating TCF-beta-cat/Arm binding. |
| 12690203 |
generation of the polyubiquitinated forms of p53 that are targeted for proteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300 |
| 12789259 |
We investigated occupancy of ER-alpha promoter by pRb2/p130-E2F4/5-HDAC1-SUV39 H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 complexes, and provided a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of ER-alpha transcription |
| 12941701 |
p300 plays a role in formation of the TBP-TFIIA-containing basal transcription complex, TAC. |
| 15632193 |
SIRT1 deacetylation and repression of p300 involves specific lysine residues in the cell cycle regulatory domain 1 |
| 12588875 |
MAPK signaling facilitates HIF1a and HIF2a activation through p300/CBP |
| 15965232 |
p300 regulates p63-dependent transcription of p21 |
| 16582966 |
In cells transfected with both IRF-2 and p300/CBP-associated factor , IRF-2 associated with endogenous nucleolin. |
| 17220215 |
The patients with EP300 mutations displayed the typical facial gestalt and malformation pattern compatible with the diagnosis of Rubinstein-Taybi syndrome. |
| 17469184 |
These results indicate that impaired competition with p300 is the possible cause of dysfunction of c-Ski/SnoN in scleroderma fibroblasts and that this might contribute to maintenance of the autocrine TGFbeta loop in this disease. |
| 15718293 |
A novel and unique PAX8 mutation provides evidence for a crucial role of the p300 coactivator in mediating the functional synergism between PAX8 and TTF-1 in thyroid-specific gene expression. |
| 15951563 |
cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300. |
| 16109717 |
Sox9 and p300 interact with chromatin and activates transcription via regulation of chromatin modification |
| 15337767 |
the IHD scaffold is an independent LXXLL peptide-binding domain within the p300 protein, complementing the known peptide-binding domains including IBiD, C/H1, and C/H3 |
| 11909954 |
Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes. |
| 12917345 |
ER81 is acetylated by two coactivators/acetyltransferases, p300 and p300- and CBP-associated factor (P/CAF) . Whereas p300 acetylates two lysine residues (K33 and K116) within the ER81 N-terminal transactivation domain, P/CAF targets only K116. |
| 15224190 |
a new insight into the molecular mechanisms by which the critical concentration of p300 protein is regulated and suggests a role for Akt in control of various cellular activities through the transcriptional coactivator p300 |
| 12107188 |
p300 and TATA-binding protein-free TAF-containing complex cooperate during transcriptional activation |
| 16630816 |
Data shpw that SII is a major component of chromatin transcription and strongly synergizes with p300 (histone acetylation) at a step subsequent to preinitiation complex formation. |
| 16636310 |
Data show that nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells. |
| 16708385 |
the transcription factor p300 is a potential repressor of telomerase activation and histone acetylation in the context of E6 expression |
| 16809786 |
coordinated binding of Zac zinc fingers and C terminus to p300 regulates HAT function by increasing histone and acetyl coenzyme A affinities and catalytic activity |
| 17065349 |
Transcriptional coactivator p300 may regulate fibronectin expression via PARP and NF-kappaB activation in diabetes. |
| 17382325 |
Asparagine hydroxylation and S-nitrosylation of HIF-1alpha decrease p300 binding, while its phosphorylation does not affect p300 binding, which was reconfirmed by competitive inhibition analyses using mutant peptides. |
| 11940655 |
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. |
| 11940656 |
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. |
| 14605447 |
forms complex with SATB1 which binds to the 5' upstream AT-rich region in the bp -115 to bp -106 segment represses the gp91(phox) promoter activity |
| 16696975 |
DEK interacts with histones and exerts a potent inhibitory effect on both p300 and PCAF-mediated histone acetyltransferase activity and transcription. |
| 17250547 |
MITF evokes transcription of a paradigmatic MITF target tyrosinase and show that the adenoviral E1A protein represses the MITF-driven transcription in these cells. |
| 11983172 |
In vitro assays show an indispensable role for H3 and H4 tails, especially major lysine substrates, in p300-dependent transcriptional activation, as well as activator-targeted acetylation of promoter-proximal histone tails by p300. |
| 15706485 |
We extended the search for mutations to the EP300 gene and showed that mutations in EP300 also cause this disorder. These are the first mutations identified in EP300 for a congenital disorder. |
| 12242694 |
results suggest that all-trans-retinoic acid and retinoic acid receptors regulate growth arrest of human mammary epithelial cells and modulate CBP/p300 protein expression |
| 12604599 |
Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. |
| 15917652 |
We report a novel, noncompetitive mechanism linking acetylation and ubiquitination, in which the association of transcription factor E2F-1 with the cellular coactivator and acetyltransferase p300 determines its acetylation and subsequent ubiquitination. |
| 11931769 |
Results demonstrate that phosphorylation of p65 determines whether it associates with either CBP or HDAC-1, ensuring that only p65 entering the nucleus from cytoplasmic NF-kappa B:Ikappa B complexes can activate transcription. |
| 12970734 |
we show that E7 can abolish the p300-mediated E2 transactivation function, suggesting that complex formation between E7 and p300 may contribute to the regulation of E2 transcriptional activity. |
| 12453427 |
p300 plays a critical regulatory role in base excision repair |
| 12646247 |
in human mammary epithelial cells, CBP/p300 were both modulated by an all-trans-retinoic acid (ATRA) signaling pathway and were required for a normal response to ATRA |
| 12732631 |
CBP and p300 function as co-activators of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation. |
| 16581781 |
GABPA and EP300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells. |
| 16704985 |
PPARGC1A, PPARGC1B, and EP300 may have roles for familial breast cancer susceptibility |
| 16804902 |
Levels of expression of CtBP and p300 are critical for the action of SNAIL and ZEB1, which have a pivotal role in levels of epithelial-mesenchymsal transitionin human colon carcinoma. |
| 11940591 |
The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. |
| 12101186 |
CBP-p300 plays a role in regulating p450scc expression with TReP-132 and steroidogenic factor-1 |
| 15701643 |
p300 is essential for SENP1 to enhance c-Jun-dependent transcription because SENP1 can desumoylate the CRD1 domain of p300, thereby releasing the cis-repression of CRD1 on p300 |
| 16219772 |
both p300 and CBP increase ATF4 transcriptional activity |
| 16461764 |
point mutations are uncommon in patients with myeloproliferative disorders |
| 16672693 |
Role for p300 in promoting cell survival, which is independent of its acetyltransferase activity and acts at least in part through FGF-1. |
| 15641773 |
Both TAZ domains of CREB-binding proteins CBP and p300 in the presence of stoichiometric concentrations of zinc adopt a well-defined structure in solution in the absence of binding partners. |
| 15345715 |
Ectopically expressed p300 reverses the p53 mediated suppression of TGF-b-induced Type I collagen synthesis in fibroblasts. |
| 11134049 |
p300 is involved in the antagonistic regulation of Type I collagen gene expression by Transforming Growth Factor-b and Interferon-g |
| 10918613 |
p300 stimulates Type I collagen synthesis in skin fibroblasts |
| 11940575 |
Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. |
| 11912212 |
Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. |
| 12379484 |
PKC delta inhibits p300/CBP-associated factor activity after phosphorylation at serine 89 |
| 12237408 |
p300 coactivator has a role in suppressing tumor cell growth |
| 11691934 |
substrate specificity |
| 12482752 |
p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function |
| 12527917 |
synergism with p68 RNA helicase |
| 12724314 |
p300 may further regulate the transcriptional activity of p53 through a novel acetylation site, Lys-305 |
| 12136661 |
p300 plays an important role in epithelial carcinogenesis by mediating transcription that negatively regulates cell proliferation.(P300-CBP coactivator) |
| 11691934 |
substrate specificity; structure activity relationship |
