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EPB41
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17715393 |
A regulated splicing event in protein 4.1R pre-mRNA-the inclusion of exon 16-encoding peptides for spectrin-actin binding-occurs in late erythroid differentiation |
| 18079699 |
In the 4.1R gene, intrasplicing ultimately determines N-terminal protein structure and function. |
| 16881872 |
4.1R60 isoforms are constitutively self-associated, whereas 4.1R80 and 4.1R135 self-association is prevented by intramolecular interactions. |
| 15564380 |
4.1R plays a key role at the centrosome, contributing to the maintenance of a radial microtubule organization |
| 16157202 |
EPB41 gene expression was unchanged in all analyzed meningiomas. This suggests that involvement of the EPB41 gene (4.1R protein) in meningioma pathogenesis should be reconsidered. |
| 17087826 |
The interaction of Plasmodium falciparum EBA-181 with the highly conserved 10 kDa domain of 4.1R provides new insight into the molecular mechanisms utilized by P. falciparum during erythrocyte entry |
| 12522012 |
synthesis of structurally distinct 4.1R protein isoforms in various cell types is regulated by a novel mechanism requiring coordination between upstream transcription initiation events and downstream alternative splicing events |
| 12807908 |
protein 4.1R has a role in recruiting hDlg to the lateral membrane in epithelial cells |
| 16060676 |
4.1R binds to the separate calponin homology CH1 and CH2 domains of beta I spectrin. |
| 12960380 |
interaction with nuclear actin during nuclear assembly in vitro | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | alpha 1 actin precursor | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | CD44 | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | CD44 antigen isoform 1 precursor | Erythrocyte membrane protein band 4.1 | - | - | Pubmed |
| HPRD | discs, large homolog 1 | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | discs, large homolog 1 | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | dopamine receptor D2 isoform long | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | dopamine receptor D2 isoform long | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | dopamine receptor D3 isoform a | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | dopamine receptor D3 isoform a | Homo sapiens protein 4.1 mRNA, complete cds. | - | - | Pubmed |
| HPRD | Erythrocyte membrane protein band 4.1 | spectrin, alpha, non-erythrocytic 1 | - | - | Pubmed |
Recent Publications on EPB41: |  |
Evolutionarily conserved coupling of transcription and alternative splicing in the EPB41 (protein 4.1R) and EPB41L3 (protein 4.1B) genes.
Recent studies have shown that transcription and alternative splicing can... | 11th August, 2006
| Life Sciences Division and Genomics Department, Lawrence Berkeley National
| Genomics. 2005 Dec;86(6):701-7. Epub 2005 Oct 20.
DOI Direct Link |
GADD45A and EPB41 as tumor suppressor genes in meningioma pathogenesis.
Deletions of 1p occur in approximately 30% of meningiomas. Based on loss... | 19th October, 2005
| Department of Molecular Pathology and Neuropathology, Chair of Oncology,
| Cancer Genet Cytogenet. 2005 Oct 1;162(1):63-7.
DOI Direct Link |
Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure.
The spectrin-based cytoskeleton assembly has emerged as a major player in... | 5th August, 2005
| Randall Division of Cell and Molecular Biophysics, King's College London,
| Mamm Genome. 2005 Mar;16(3):137-51.
DOI Direct Link |
Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms.
The EPB41 (protein 4.1) genes epitomize the resourcefulness of the... | 16th March, 2005
| Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
| Genomics. 2004 Oct;84(4):637-46.
DOI Direct Link |
Red blood cell membrane defects.
We present an overview of the currently known molecular basis of red cell... | 1st May, 2004
| Institute for Pediatrics, University of Foggia, Viale Pinto, 71100 Foggia,
| Rev Clin Exp Hematol. 2003 Mar;7(1):22-56.
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→View more research publications. |
EPB41 results (if any) from reagent suppliers | 
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EPB41 monoclonal antibody (M01)
Western Blot analysis of EPB41 expression in transfected 293T cell line by EPB41 ... Immunoperoxidase of monoclonal antibody to EPB41 ( Cat # AT1922a ) on ...
http://www.abgent.com/products/catalog_no/AT1922a_EPB41_mono...
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4.1R (C-16) Antibody sc-25969
... Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, EPB41, 2035, 1p35.3, NM_004437, NM_203342, NM_203343 · P11171 ...
http://www.scbt.com/datasheet-25969-4-1r-c-16-antibody.html...
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3C-3E
Monoclonal Anti-EPB41 antibody produced in mouse clone 3D9, purified immunoglobulin, buffered aqueous solution, 3D9 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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4.1R (h): 293T Lysate sc-114567
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, EPB41, 2035, 1p35.3, P11171 ...
http://www.scbt.com/datasheet-114567-4-1r-h-293t-lysate.html...
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Abcam antibodies and reagents product map
... DIAPH3 antibodies (1) · DOCK2 antibodies (2) · DOCK2 proteins and peptides ( 2) · Dematin antibodies (2) · Dystonin antibodies (1) · EPB41 antibodies (2) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...
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4.1 Antibody / 4.1 Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. 4.1B (E-20) Antibody, sc-25964, goat IgG, internal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-4-1.html...
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Abcam antibodies and reagents product map
ALAS2 proteins and peptides (1) · AMPD3 antibodies (1) · DYRK3 antibodies (1) · EPB41 antibodies (2) · EPO antibodies (7) · EPO proteins and peptides (5) ...
http://www.abcam.com/index.html?c=253...
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