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EPB49


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Gene DB Home
Symbol:EPB49
Name(s):erythrocyte membrane protein band 4.9 (dematin)
Type:protein-coding
Organism:Homo sapiens
Synonyms:DMT, FLJ78462, FLJ98848
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14660664 results suggest that phosphorylation of the dematin headpiece acts as a conformational switch within this headpiece domain
16697408 a crucial role for this proline residue in structural stability and folding potential of HP (sub)domains consistent with Pro-Trp stacking as a more general determinant of protein stability

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin alpha, cardiac muscleerythrocyte membrane protein band 4.9--Pubmed
HPRDcardiac muscle alpha actin 1 proproteinDematin--Pubmed
HPRDErythrocyte band 4.2 proteinerythrocyte membrane protein band 4.9--Pubmed
HPRDDematinspectrin, beta, erythrocytic--Pubmed
HPRDerythrocyte membrane protein band 4.9Spectrin, beta I--Pubmed
BINDerythrocyte membrane protein band 4.9-An unspecified isoform of DISC1 interacts with DMT.-Pubmed

Recent Publications on EPB49:

Pubmed Logo
Regulatory models of RhoA suppression by dematin, a cytoskeletal adaptor protein.
Cell motility, adhesion and actin cytoskeletal rearrangements occur upon...
2nd September, 2009
Department of Pharmacology, University of Illinois College of Medicine, Cell Adh Migr. 2009 Apr;3(2):191-4. Epub 2009 Apr 7.
Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain.
Dematin is an actin-binding protein originally identified in the...
15th August, 2009
Department of Physiology and Biophysics, Boston University School of Protein Sci. 2009 Mar;18(3):629-36.
DOI Direct Link
Phosphorylation-induced changes in backbone dynamics of the dematin headpiece C-terminal domain.
Dematin is an actin-binding protein abundant in red blood cells and other...
9th May, 2009
Department of Chemistry, University of Alaska at Anchorage, 99508, USA. J Biomol NMR. 2009 Jan;43(1):39-50. Epub 2008 Nov 22.
DOI Direct Link
Erythrocyte dematin is a candidate gene for Marie Unna hereditary hypotrichosis and related hairloss disorders.
Dematin is an actin-binding protein abundant in red blood cells and other...
11th June, 2008
Am J Hematol. 2008 May;83(5):430-2.
DOI Direct Link
Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold.
The HeadPiece (HP) domain, present in several F-actin-binding multi-domain...
11th August, 2006
NMR and Structure Analysis Unit, Department of Organic Chemistry, Faculty J Mol Biol. 2006 Jun 23;359(5):1277-92. Epub 2006 May 6.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
7601532 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

EPB49 results (if any) from reagent suppliers

Google CSE Logo
Dematin (18) Antibody sc-135881
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, EPB49, 2039, 8p21.3, Q08495 ...
http://www.scbt.com/datasheet-135881-dematin-18-antibody.htm...

Thumbshot
Dematin Antibody / Dematin Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. Dematin (G-14) Antibody, sc-26059, goat IgG, internal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-dematin.html...

Thumbshot
Dematin siRNA (h) sc-105286
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, EPB49, 2039, 8p21.3, NM_001978 ...
http://www.scbt.com/ja/datasheet-105286-dematin-sirna-h.html...

Thumbshot
Dematin (G-14) Antibody sc-26059
... Numéro d'accès d´isoforme d´ARNm, Numéro d'accès de la protéine, Numéro OMIM ™. Humain, EPB49, 2039, 8p21.3, NM_001978 · Q08495 ...
http://www.scbt.com/fr/datasheet-26059-dematin-g-14-antibody...

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