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EPO


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Gene DB Home
Symbol:EPO
Name(s):erythropoietin
Type:protein-coding
Organism:Homo sapiens
Synonyms:EP, MGC138142
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18219110 study shows breast epithelial cells are a source of Epo in breast microenvironment, suggesting presence of a paracrine/autocrine Epo function in Nipple Aspirate Fluids, triggering intracellular signaling cascade with subsequent breast cancer initiation
18160550 Erythropoietin levels in cord blood were not different between preterm infants with and without periventricular leukomalacia.
17888545 Observational study of gene-disease association. (HuGE Navigator)
18093155 Administration of rhEPO protects neurons by enhancing Bcl-2 expression, thereby inhibiting traumatic brain injury-induced neuronal apoptosis.
18201556 In vitro biological activity of egg white-hEpo was comparable to that produced by recombinant CHO cells.
17984928 Erythropoietin levels in the familial cases of restless leg syndrome were significantly lower than in the reference population.
18091448 aqueous humor EPO level is increased in eyes with primary open-angle glaucoma.
17952604 results suggest that PI3K/Akt and GSK-3beta pathway are involved in the neuroprotective effect of EPO
17577097 Erythopoietin confers immediate and sustained protection of the heart against injury from ischemia/reperfusion by a mechanism involving activation of protein kinases and ATP-dependent potassium channels.
17540710 Data show that human scalp hair follicles express erythropoietin (EPO), up-regulate EPO transcription under hypoxic conditions, and express transcripts for EPO receptors and the EPO-stimulatory transcriptional cofactor hypoxia-inducible factor-1alpha.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDerythropoietinerythropoietin receptor precursorInteraction between EPOR (PDB ID: 1EER_B) and EPO (PDB ID: 1EER_A).-Pubmed
BINDerythropoietinerythropoietin receptor precursorInteraction between EPOR (PDB ID: 1EER_C) and EPO (PDB ID: 1EER_A).-Pubmed
BINDHomo sapiens erythropoietin gene, 3'flank.retinoblastoma 1RB1 (pRB) interacts with the EPO gene 3(prime) enhancer.-Pubmed
BINDHomo sapiens erythropoietin gene, 3'flank.hypoxia-inducible factor 1, alpha subunit isoform 1HIF1A (HIF-1-alpha) interacts with the EPO gene 3(prime) enhancer.-Pubmed
BINDHomo sapiens chromosome 7-SIM2 interacts with the hypoxia-inducible enhancer of the EPO gene. This interaction was modeled on a demonstrated interaction between mouse SIM2 and the human EPO enhancer.-Pubmed
HPRDerythropoietinerythropoietin receptor precursor--Pubmed
HPRDerythropoietinerythropoietin receptor precursor--Pubmed
HPRDerythropoietinguanine nucleotide binding protein, beta polypeptide 2-like 1--Pubmed

Recent Publications on EPO:

Pubmed Logo
Phase I study of the novel, fully synthetic epothilone sagopilone (ZK-EPO) in patients with solid tumors.
BACKGROUND: Sagopilone (ZK-EPO) is a fully synthetic...
3rd November, 2009
Hammersmith Early Clinical Trials Unit, Charing Cross Hospital, Imperial Ann Oncol. 2009 Oct 30.
DOI Direct Link
Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis.
Abstract Erythropoietin (EPO) has been used to correct cancer-related...
3rd November, 2009
1 Department of Nuclear Medicine and Molecular Imaging, University Medical Cancer Biother Radiopharm. 2009 Oct;24(5):565-72.
DOI Direct Link
The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism.
Using mice, we demonstrated that when oxygen supply is lowered,...
3rd November, 2009
Institute of Veterinary Physiology, University of Zurich, Zurich, Ann N Y Acad Sci. 2009 Oct;1177:151-61.
DOI Direct Link
The Neuroprotective Effect of Erythropoietin in Docetaxel-Induced Peripheral Neuropathy Causes No Reduction of Antitumor Activity in 13762 Adenocarcinoma-Bearing Rats.
Taxanes, including docetaxel (DOCE), are severely neurotoxic, causing...
31st October, 2009
Department of Molecular Biochemistry and Pharmacology, Mario Negri Neurotox Res. 2009 Oct 30.
DOI Direct Link
Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl.
We previously reported that 4-hydroxy-3-methoxybenzaldehyde has the most...
31st October, 2009
Division of Pathophysiology and Pharmacology, College of Pharmacy, Int Immunopharmacol. 2009 Oct 27.
DOI Direct Link

View more research publications.

Press Releases on EPO:

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EmblemHealth Activates Landacorp's maxMC Medical Management Solution 5th November, 2009 SHPS

CHICO, Calif., Nov. 5 /PRNewswire/ -- Landacorp, a SHPS company, today announced the successful implementation of Landacorp's maxMC medical management software solution at EmblemHealth.

High Desert Medical Group, Dr. Richard Merkin, CEO, Featured on CNN Discussing Critical Issue of H1N1 and Pregnant Women 3rd November, 2009 Heritage Provider Network, Inc.

LANCASTER, Calif., Nov. 3 /PRNewswire/ -- High Desert Medical Group is featured on CNN discussing the critical issue of pregnant women with H1N1. CNN Correspondent Kara

Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 1st November, 2009 Schering-Plough Corporation

BOSTON, Nov. 1 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP) today reported two data presentations supporting response guided therapy with boceprevir combination therapy in

Keryx Biopharmaceuticals, Inc. Announces Upcoming Poster Presentation of Zerenex (ferric citrate) for the Treatment of Hyperphosphatemia at the Upcoming American Society of Nephrology Renal Week Meeting in San Diego 26th October, 2009 Keryx Biopharmaceuticals, Inc.

NEW YORK, Oct. 26 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) today announced that an abstract related to the clinical data of the 55-patient Phase 2 high-dose

At Last...Good News for Small Business 22nd October, 2009 Health Alliance Plan

DETROIT, Oct. 22 /PRNewswire-USNewswire/ -- Michigan's small business owners know that offering employee health coverage can help them attract and keep good employees; yet

BioNews Results for EPO

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Feasibility of intravitreal erythropoietin injections in humans
British Journal of Ophthalmology:  Oct 14 2009 11:36PM Matching: epo
EPO to Issue Patent to Phyton Biotech Covering Methods of Making Taxanes
Intellectual Property News Agency:  Oct 13 2009 9:45AM Matching: epo
The Role of Hypoxia in 2-Butoxyethanol-induced Hemangiosarcoma
Toxicological Sciences:  Oct 9 2009 8:52AM Matching: epo
Keryx Reports Results of Open Label Extension Study Examining Long-Term Use of Zerenex, an Iron-Based Phosphat
Pharmacy Choice:  Oct 5 2009 1:14PM Matching: epo
Triumfant Achieves Technology Partner Status in the McAfee Security Innovation Alliance
Freshnews.com:  Oct 6 2009 1:19PM Matching: epo
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Treating Patients With Aneurysmal SubArachnoid Hemorrhage (SAH) With Epoetin Alfa

Patents:

Patents logo
US Patent No.Title
7594135 Flash memory system startup operation
7595762 Low profile antenna
7596375 Home network name displaying methods and apparatus for multiple home networks
7596398 Multiple wavelength sensor attachment
7596592 Method and a system of remotely controlling data transfer via a data transfer network

View more patents.

EPO results (if any) from reagent suppliers

Google CSE Logo
EPO antibody (ab14016) | Abcam
Chicken polyclonal to EPO. Human erythropoietin is member of the EPO/TPO family and encodes a secreted, glycosylated cytokine hormone composed of four alpha ...
http://www.abcam.com/EPO-antibody-ab14016.html...

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Epo (XX9) Antibody sc-73963
Epo (XX9) Antibody sc-73963 Epo (XX9) Antibody sc-73963. ... rat monoclonal IgG 2a, 100µg/ml; raised against full length recombinant Epo of mouse origin ...
http://www.scbt.com/datasheet-73963-epo-xx9-antibody.html...

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EPO Receptor antibody [MM-0031-6G7] (ab56310) | Abcam
Mouse monoclonal [MM-0031-6G7] to EPO Receptor. The erythropoietin receptor ( EPOR) is a member of the cytokine receptor family. There are several isoforms
...
http://www.abcam.com/EPO-Receptor-antibody-MM-0031-6G7-ab563...

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Epo (N-19) Antibody sc-1310
See how others have used Epo (N-19): sc-1310 antibody and or Epo (N-19) antibody ... Western blot analysis of human recombinant Epo fusion protein. ...
http://www.scbt.com/datasheet-1310-epo-n-19-antibody.html...

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EPO antibodies: Developmental Biology > Organogenesis ...
EPO antibodies. ... EPO antibody. Neut, IHC-P, WB, ELISA. Rabbit polyclonal ... EPO antibody (Biotin). WB, ELISA. Chicken polyclonal. Biotin conjugated ...
http://www.abcam.com/index.html?t=8687&pt=1&c=4609&ei=&mu=ra...

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Epo (H-162) Antibody sc-7956
See how others have used Epo (H-162): sc-7956 antibody and or Epo (H-162) antibody ... Western blot analysis of Epo expression in KNRK whole cell lysate.
...
http://www.scbt.com/datasheet-7956-epo-h-162-antibody.html...

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EPO Receptor antibody (ab10653) | Abcam
Goat polyclonal to EPO Receptor. The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: ...
http://www.abcam.com/EPO-Receptor-antibody-ab10653.html...

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