Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18219110 |
study shows breast epithelial cells are a source of Epo in breast microenvironment, suggesting presence of a paracrine/autocrine Epo function in Nipple Aspirate Fluids, triggering intracellular signaling cascade with subsequent breast cancer initiation |
| 18160550 |
Erythropoietin levels in cord blood were not different between preterm infants with and without periventricular leukomalacia. |
| 17888545 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18093155 |
Administration of rhEPO protects neurons by enhancing Bcl-2 expression, thereby inhibiting traumatic brain injury-induced neuronal apoptosis. |
| 18201556 |
In vitro biological activity of egg white-hEpo was comparable to that produced by recombinant CHO cells. |
| 17984928 |
Erythropoietin levels in the familial cases of restless leg syndrome were significantly lower than in the reference population. |
| 18091448 |
aqueous humor EPO level is increased in eyes with primary open-angle glaucoma. |
| 17952604 |
results suggest that PI3K/Akt and GSK-3beta pathway are involved in the neuroprotective effect of EPO |
| 17577097 |
Erythopoietin confers immediate and sustained protection of the heart against injury from ischemia/reperfusion by a mechanism involving activation of protein kinases and ATP-dependent potassium channels. |
| 17540710 |
Data show that human scalp hair follicles express erythropoietin (EPO), up-regulate EPO transcription under hypoxic conditions, and express transcripts for EPO receptors and the EPO-stimulatory transcriptional cofactor hypoxia-inducible factor-1alpha. |
| 17893874 |
erythropoietin receptor and erythropoietin have roles in the autocrine/paracrine mechanism of growth enhancement in human ovarian cancer cells |
| 17893875 |
Epo has a role in reducing expression of apoptosis-related proteins Bcl-2 and Bcl-10 in ovarian cancer cells |
| 17467346 |
Review discusses studies on EPO circadian, monthly and even annual variations; studies in connection with short-, medium- and long-term exercise at sea-level and studies performed at moderate and high altitude [review]. |
| 18074690 |
Recovery of neurological function in a model of peripheral nerve injury is more rapid with weekly administration of darbepoetin alfa than with daily recombinant human erythropoietin treatment. |
| 17713555 |
hTERT appears to be efficiently regulated by EPO and TGFbeta in an opposite way in erythropoietic cells, arguing for a role of telomerase in red blood cell production |
| 17873970 |
EPO protects the intestine against ischemia/reperfusion injury in rats. |
| 17481772 |
Blockade of Epo inhibits retinal neovascularization in vivo, and inhibits endothelial cell proliferation response in diabetic reginopathy. |
| 17145806 |
Cervical cancers with higher Epo expression showed a significantly reduced overall survival and correlated significantly with apoptosis. |
| 17652365 |
The impact of Epo overexpression in mice and the resulting excessive erythrocytosis in the neural control of normoxic and hypoxic ventilation is reported. |
| 17615151 |
EPO contributes to regulation of hypothalamo-pituitary-adrenal (HPA) axis activation; in pathological conditions such as brain ischemia, this growth factor may control HPA axis function, preventing possible detrimental effects of HPA overactivation. |
| 16838166 |
bicycle taxi drivers with subclinical lead toxicity have decreased serum EPO |
| 17647284 |
Epo and EpoR were expressed neuroblastomas but did not modify tumor cell proliferation. |
| 17645631 |
Erythropoietin has a significant angiogenic effect in rat kidney with cyclosporine A-induced nephrotoxicity. |
| 17395782 |
Adaptive mechanisms to hematocrit levels of erythropoietin-overexpressing transgenic mice show increased plasma nitric oxide levels and erythrocyte flexibility. |
| 17636183 |
Review. Epo exhibits a "tissue-protective" effect on nonhematopoietic tissues, possibly mediated through a novel heteroreceptor, blocking apoptosis by a variety of insults. However, Epo may have a potential direct growth-promoting action on cancer cells. |
| 12476588 |
may play an important role in signal transduction via EpoR on erythroid progenitor in CRF patients. |
| 15671524 |
erythropoietin and EPOR are co-expressed in tumor cells, suggesting that erythropoietin may potentially function as an autocrine or paracrine factor in head and neck cancer |
| 17081058 |
Lysine-containing peptides comprising glycosylation sites derived from recombinant human erythropoietin were derivatized with 2-methoxy-4,5-dihydro-1H-imidazole and its deuterated analogues. |
| 11854521 |
used a transient global spinal ischemia model in rabbits to test whether exogenous EPO can cross the blood-spinal cord barrier and protect these motor neurons. |
| 14724429 |
Overexpression of EPO protects islets from destruction and does not compromise islet function. Genetic engineering with EPO may improve islet survival and engraftment in transplant setting, but regulation of gene expression will be important prerequisite. |
| 11861258 |
Carbohydrate content and structure of EPO are important determinants in their half-life in the circulation. |
| 12801298 |
hemoglobin levels are related to the rise in serum EPO that occurs during pregnancy |
| 11869305 |
renal failure patients mounted an EPO response to hypoxia but at lower EPO levels |
| 16332412 |
Therefore, rhEPO could be an effective drug for the prevention of hearing loss via a hair cell protective mechanism. |
| 15389732 |
erythropoietin has a protective role against cancer and brain injury [review] |
| 16467207 |
Binding of the transcriptionally competent Wt1(-KTS) isoform to the minimal EPO promoter was demonstrated; this promoter was activated up to 20-fold by transient cotransfection of Wt1(-KTS) in different cell lines. |
| 16627979 |
Coexpression of erythropoietin and its receptor plays a important role in tumorigenesis of sporadic clear cell renal cell carcinoma. |
| 16909043 |
EPO, at pharmacological concentrations, can activate three major signalling cascades, viz. the Jak2/STAT5, Ras/ERK and PI3K/Akt pathways in non-small cell lung carcinoma (NSCLC) cell lines |
| 12171772 |
Increased levels of circulating thrombopoietin were found in patients with clonal thrombocytosis versus patients with reactive thrombocytosis, indicating a potential differential diagnosis tool. |
| 15339684 |
The performance-enhancing effect of recombinant erythropoietin treatment is greater than the duration and diagnosis of hematologic changes associated with recombinant erythropoietin misuse. |
| 15705187 |
in vivo EPO does not affect the functionality and/or production of components of the VEGF/Flt-1 system in diabetics with normal or reduced renal function. |
| 17597020 |
Statistically analyzed distributions of the proteins reflected functional dependences among STAT3, HIF-1alpha, EPO and EPOR in cellular signal conduction. |
| 16936148 |
Erythropoietin is expressed in the human retina, and it is upregulated in diabetic patients even without retinopathy. |
| 14704034 |
EPO stimulation significantly increased the level of Akt phosphorylation, the downstream target of PI3-kinase. |
| 14990112 |
EPO levels increased incompensatively in anemia of chronic disease (ACD) children, which may be a cause of ACD. |
| 12207089 |
REVIEW: pathways by which transcription of erythropoietin is regulated by availability of molecular oxygen |
| 15467711 |
Epression of erythropoietin in prostate cancer cell lines suggesting that these cells may serve as useful experimental models for further studies of erythropoietin function for growth regulation in prostate cancer. |
| 16278379 |
Erythropoietin and erythropoietin receptor are expressed in head and neck squamous cell carcinoma |
| 12239177 |
hypoxia-inducible gene expression in human neuroblastoma cells |
| 12482504 |
a key role for NF-kappaB in EPO gene regulation in response to hypoxia |
| 12525458 |
Epo and Epo-R localized within glandular epithelial cells in both peritoneal endometriosis and eutopic endometrium. Role in pathophysiology of endometriosis. |
| 12381912 |
All regions of kidney express erythropoietin receptors. Review. |
| 12091337 |
Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB. |
| 11920206 |
Two to three weeks after initiation of hydroxyurea treatment, the sEpo values started to increase and reached levels three to 31 times higher than the baseline two to three weeks later. |
| 15210945 |
EPO+IGF-I exert cooperative actions that afford acute neuroprotection via activation of the PI3-K-Akt pathway |
| 12829027 |
protein CBP/p300 was shown to be essential for EPO- and SCF-mediated STAT5 transactivation |
| 15019812 |
Erythropoietin protein was constitutively present in seminal plasma. The seminal EPO originated from the prostate and seminal vesicle. No association between EPO levels in seminal plasma and sperm parameters was found. |
| 14583613 |
GATA-4 is critical for transcription of the Epo gene in hepatocytes and may contribute to the switch in the site of Epo gene expression from the fetal liver to the adult kidney |
| 15183662 |
Initial studies of recombinant erythropoietin as therapy for infants with neurologic injury are encouraging. Review. |
| 15257091 |
erythropoietin has a role in healing of ischemic skin wounds |
| 15988318 |
Multiple logistic regression revealed a significant association between the appearance of nucleated RBCs in the blood and erythropoietin, IL-3, IL-6, and age. |
| 16684536 |
NF-kappaB is probably the primary transcription factor by which cAMP counteracts the inhibition of Epo gene expression by IL-1. |
| 17045782 |
A "classical" homodimeric erythropoietin receptor is essental for the antiapoptotic effects of Epo on differentiated neuroblastoma SH-SY5Y cells. |
| 17372034 |
EPO prevents aberrant remodeling of the injured carotid artery. The protective effects of EPO are critically dependent on activation of eNOS. |
| 17389738 |
rhEPO treatment inhibits the progression of renal fibrosis in obstructed kidney and attenuates the TGF-beta1-induced epithelial-to-mesenchymal transition. |
| 11994541 |
While both Epo and Epo-R were detected in all samples of isolated epithelial cells analysed throughout the menstrual cycle, neither one was detected in isolated stromal cells. Epo and Epo-R protein expression in glandular epithelial cells was increased |
| 12759237 |
Results suggest that increased expression of erythropoietin may play a significant role in cervical carcinogenesis and tumor progression. |
| 12937140 |
Novel function for EPO by providing in vivo evidence for a physiological role during fibrin-induced wound healing. |
| 12975460 |
These findings suggest that recombinant human erythropoietin (EPO) attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-receptor-expressing inflammatory cells. |
| 15205261 |
erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production in vascular endothelial cells |
| 15363820 |
Increased erythropoietin may be a potential reversible mechanism to explain the association between obstructive sleep apnea and cardiovascular disease. |
| 15709164 |
erythropoietin was expressed in one half of samples by immunohistochemistry and in 100% of samples by mRNA detection in non-small cell lung carcinomas. |
| 15709172 |
Results showed that VHL disease-associated renal clear cell carcinomas and renal cysts coexpress erythropoietin and erythropoietin receptor. |
| 15718359 |
EPO may have a role in oxygenation during gestation and placental sufficiency, as seen in this study of monozygotic and dizygotic twins' cord blood analysis |
| 15795697 |
Hemoglobin and serum EPO levels were significantly higher in the chronic obstructive lung disease group than in pulmonaary fibrosis patients and controls. |
| 15777837 |
the erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| 14747752 |
Results show that recombinant human erythropoietin reduces brain injury, especially apoptotic cell death, after neonatal hypoxia-ischemia. |
| 15053948 |
Review summarizes current knowledge of the nonerythropoietic roles of Epo, its neurotrophic and neuroprotective properties, the mechanisms by which Epo produces neuroprotection and the signal transduction systems regulated by Epo in the nervous system. |
| 12734640 |
Inhibition of erythropoietin(Epo) gene expression by cadmium depends on suppression of hypoxia-inducible factor 1(HIF-1) binding activity. |
| 15590452 |
Further investigations are needed to understand the mechanism of the hepatoprotective effect of erythropoietin and the clinical importance of ischemic liver injury in the fetus. |
| 15627795 |
Angiotensin II does not alter EPO production in HepG2 cell culture under normoxic or hypoxic conditions. |
| 15769989 |
Coexpression of Erythropoietin and Erythropoietin receptor was found in all five Hippel Lindau disease-associated pheochromocytomas. |
| 15993382 |
In conclusion, erythropoietin may attenuate high glucose-induced endothelial cell apoptosis via PI-3 kinase pathway. |
| 16699298 |
findings show that three thyroid cancer cell lines expressed Epo and EpoR mRNA and that the hypoxia-mimetic cobalt induced Epo expression |
| 11906321 |
Serum erythropoietin levels (s-[epo]), haemoglobin concentration ([Hb]), haematocrit (hct), and ferritin concentration ([fer]) were measured in seven healthy male volunteers (20-23 years) exposed continuously to hypoxia (PO(2) 14 kPa) for 10 days |
| 11906322 |
Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans. |
| 12187026 |
data suggest that although chronic lymphocytic leukemia (CLL) anemia is not characterized by inadequate Epo production, in some CLL patients this factor may be correlated; in these cases, levels of TNF-alpha were higher than in other anemic cases |
| 16123502 |
Elevated in vitreous fluid of patients with proliferative diabetic retinopathy. |
| 16883594 |
The effect of 2-oxoglutarate on the production of erythropoietin and vascular endothelial growth factor (VEGF), was examined. |
| 14755373 |
Erythropoietin deficiency may be one of the endocrine abnormalities associated with autoimmune polyglandular syndrome type I. |
| 15502930 |
Prenatal high amniotic fluid erythropoietin levels can identify type 1 diabetic pregnancies at increased risk of severe perinatal complications. |
| 12419827 |
erythropoietin signalling contributes to the growth and/or survival of both transformed cells and capillary endothelial cells in female reproductive system tumours. |
| 14671634 |
after rHuEpo stimulation in the chick embryo chorioallantoic membrane assay, the generation of new blood vessels occurred more frequently following an intussusceptive microvascular growth mechanism |
| 12362243 |
triggers a signaling pathway (MAPK p42/44) in vascular endothelial cells and increases the thrombogenicity of their extracellular matrices |
| 15240563 |
the complete EPO enhancer displayed dependency on HIF-2alpha regulation, indicating that additional cis-acting elements confer HIF-2alpha specificity within this region |
| 15112358 |
Results show no significant difference in erythropoietin values between non-anemic patients with liver disease and controls. |
| 15160341 |
Increased erythropoietin expression is associated with endometrial carcinoma |
| 15347669 |
Brahma and Brahma/SWI2-related gene 1 have roles in hypoxic induction of the erythropoietin gene |
| 15856028 |
results define a novel role for EPO in mediating tumor cell invasion; increased levels of EPO/EPOR in lymph node metastases as compared to primary tumors from HNSCC patients further support the role of EPO/EPOR in HNSCC disease progression and metastasis |
| 16645141 |
Epo treatment inhibits neointimal hyperplasia after arterial injury in NO-dependent manner by acting on injured vessels and mobilizing endothelial progenitor cells to neo-endothelium. |
| 11865075 |
Erythropoietin, tumours and the von Hippel-Lindau gene: towards identification of mechanisms and dysfunction of oxygen sensing. |
| 11919332 |
Data suggest that erythropoietin may be an endogenous stimulant of blood vessel growth during neonatal gastrointestinal development. |
| 14584755 |
Only a minority of papillary thyroid carcinomas (PTC) expressed EPO, and there were no significant differences between the PTC that did or did not express EPO. |
| 15142852 |
EPO is important for development of the brain and is neuroprotective, whereas it stimulates angiogenesis in the reproductive tract and possibly in other organs--REVIEW |
| 12463751 |
Direct comparison of nonglycosylated vs. glycosylated EPO demonstrates how both carbohydrate core structure and sialic acid can dampen electrostatic contributions to receptor association rate constant with little effect on dissociation rate. |
| 15743794 |
autocrine and paracrine functions of Epo might play a role in malignant transformation of melanocytes and in the survival of melanoma cells in hypoxia |
| 15967106 |
Erythropoietin signaling has a role in promoting invasiveness of human head and neck squamous cell carcinoma |
| 16229477 |
under a variety of conditions rEPO undergoes thermal or urea-induced denaturation that may be considered as a reversible two-state process characterized by unusually high (thermal) or moderate (urea-induced) extent of the residual structure |
| 16286456 |
Epo is degraded faster than NESP at the cellular level |
| 17360900 |
Epo increases hippocampus response during picture retrieval compared with placebo independent of changes in hematocrit. |
| 15728783 |
Recombinant human erythropoietin treatment of endothelial cells causes a significant increase in asymmetric dimethylarginine (ADMA) levels in the cell culture medium. |
