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EPOR


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Symbol:EPOR
Name(s):erythropoietin receptor
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC138358
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18059484 HLA-G5 downregulates EPOR constitutive signaling of JAK2 V617F-expressing erythroleukemia cells, inhibiting cell proliferation via G1 cell cycle arrest.
17995455 The EPO-R cytosolic domain is involved in its exit.Sequence motifs that participate in endocytosis can also modulate transport along the secretory pathway.
18006699 Observational study of gene-disease association. (HuGE Navigator)
18250608 Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia.
17912463 These results suggest that the erythropoietin-independent EpoR-signaling pathway plays a potential role in cell proliferation and angiogenesis in human pterygium.
17893874 erythropoietin receptor and erythropoietin have roles in the autocrine/paracrine mechanism of growth enhancement in human ovarian cancer cells
17145806 The EpoR expression correlated significantly with apoptosis and correlated significantly with tumor size and was significantly associated with the presence of lymphovascular space involvement in Cervical cancers.
17647284 Epo and EpoR were expressed neuroblastomas but did not modify tumor cell proliferation.
17524492 Five of the antibodies recognized recombinant rat and human EPOR in HEK293 cells by Western blotting, but the same antibodies yielded different and inconsistent results when using human UT-7 cells or rat brain tissue.
15671524 erythropoietin and EPOR are co-expressed in tumor cells, suggesting that erythropoietin may potentially function as an autocrine or paracrine factor in head and neck cancer

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDKallikrein 3erythropoietin receptor precursor--Pubmed
HPRDprostate specific antigen isoform 1 preproproteinErythropoietin receptor--Pubmed
HPRDCytokine inducible SH2 containing proteinerythropoietin receptor precursor--Pubmed
HPRDCytokine inducible SH2 containing proteinerythropoietin receptor precursor--Pubmed
HPRDCRKLerythropoietin receptor precursor--Pubmed
HPRDv-crk sarcoma virus CT10 oncogene homolog-likeErythropoietin receptor--Pubmed
HPRDInterleukin 3 receptor, betaerythropoietin receptor precursor--Pubmed
HPRDcolony stimulating factor 2 receptor, beta, low-affinityErythropoietin receptor--Pubmed
BINDerythropoietinerythropoietin receptor precursorInteraction between EPOR (PDB ID: 1EER_B) and EPO (PDB ID: 1EER_A).-Pubmed
BINDerythropoietinerythropoietin receptor precursorInteraction between EPOR (PDB ID: 1EER_C) and EPO (PDB ID: 1EER_A).-Pubmed

Recent Publications on EPOR:

Pubmed Logo
The role of gene discovery, QTL analyses and gene expression in reproductive traits in the pig.
The reproductive performance of the sow is one of the key factors...
24th October, 2009
Department of Animal Science and Center for Integrated Animal Genomics, Soc Reprod Fertil Suppl. 2009;66:87-102.
Relationships of P53 and Bak with EPO and EPOR in human colorectal cancer.
BACKGROUND: EPO (erythropoietin) counteracts p53-dependent apoptosis. EPO,...
23rd October, 2009
Department of General, Medical University of Bialystok, Waszyngtona St 13, Anticancer Res. 2009 Oct;29(10):4151-6.
Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.
Transgenic expression of a gain-of-function truncated mouse erythropoietin...
20th October, 2009
Department of Pathology, University of Utah, Salt Lake City, UT, USA; Blood Cells Mol Dis. 2009 Oct 16.
DOI Direct Link
Impaired Synthesis of Erythropoietin, Glutamine Synthetase and Metallothionein in the Skin of NOD/SCID/gamma (c) (null) and Foxn1 nu/nu Mice with Misbalanced Production of MHC Class II Complex.
Most skin pathologies are characterized by unbalanced synthesis of major...
15th October, 2009
Department of Clinical Pharmacology, University Hospital of Tuebingen, Neurochem Res. 2009 Oct 14.
DOI Direct Link
Erythropoietin receptors in endometrial carcinoma as related to HIF1{alpha} and VEGF expression.
Erythropoietin receptors (EpoRs) are expressed in a large percentage of...
26th September, 2009
Department of Pathology, Democritus University of Thrace, Greece. In Vivo. 2009 Sep-Oct;23(5):699-703.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Study of the Use of a Single Dose of Erythropoietin to Treat Acute Myocardial Ischemia

Patents:

Patents logo
US Patent No.Title
7186513 Methods for monitoring multiple gene expression
7303747 Use of VEGF inhibitors for treatment of eye disorders
7306799 Use of VEGF inhibitors for treatment of eye disorders
7307142 Leptin antagonists
7309604 Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins

View more patents.

EPOR results (if any) from reagent suppliers

Google CSE Logo
EpoR antibody
Capralogics, Inc. provides polyclonal chemokine receptor antibodies.
http://www.capralogics.com/P00368.htm...

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p-EpoR (Tyr 456)-R Antibody sc-20236-R
rabbit polyclonal IgG, 200 µg/ml; recommended for detection of Tyr 456 phosphorylated EpoR of m, r and h origin by WB, IF and ELISA; blocking peptide,
...
http://www.scbt.com/datasheet-20236-p-epor-tyr-456-r-antibod...

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EPOR monoclonal antibody (M02)
EPOR (NP_000112, 31 a.a. ~ 131 a.a) partial recombinant protein with GST tag. ... Detection limit for recombinant GST tagged EPOR is approximately 0.03ng/ml
...
http://www.abgent.com/products/catalog_no/AT1932a_EPOR_monoc...

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EpoR (C-20) Antibody sc-695
See how others have used EpoR (C-20): sc-695 antibody and or EpoR (C-20) antibody ... Western blot analysis of EpoR expression in K-562 (A) and Jurkat (B
) ...
http://www.scbt.com/datasheet-695-epor-c-20-antibody.html...

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EPOR monoclonal antibody (M01)
EPOR (NP_000112, 31 a.a. ~ 131 a.a) partial recombinant protein with GST tag. ... Western Blot analysis of EPOR expression in different cell lines. ...
http://www.abgent.com/products/catalog_no/AT1931a_EPOR_monoc...

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EpoR (H-194) Antibody sc-5624
See how others have used EpoR (H-194): sc-5624 antibody and or EpoR (H-194) ... Western blot analysis of EpoR expression in K-562 whole cell lysate. ...
http://www.scbt.com/datasheet-5624-epor-h-194-antibody.html...

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EPO Receptor antibody (ab10653) | Abcam
The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (so...
http://www.abcam.com/EPO-Receptor-antibody-ab10653.html...

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