Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18059484 |
HLA-G5 downregulates EPOR constitutive signaling of JAK2 V617F-expressing erythroleukemia cells, inhibiting cell proliferation via G1 cell cycle arrest. |
| 17995455 |
The EPO-R cytosolic domain is involved in its exit.Sequence motifs that participate in endocytosis can also modulate transport along the secretory pathway. |
| 18006699 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18250608 |
Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia. |
| 17912463 |
These results suggest that the erythropoietin-independent EpoR-signaling pathway plays a potential role in cell proliferation and angiogenesis in human pterygium. |
| 17893874 |
erythropoietin receptor and erythropoietin have roles in the autocrine/paracrine mechanism of growth enhancement in human ovarian cancer cells |
| 17145806 |
The EpoR expression correlated significantly with apoptosis and correlated significantly with tumor size and was significantly associated with the presence of lymphovascular space involvement in Cervical cancers. |
| 17647284 |
Epo and EpoR were expressed neuroblastomas but did not modify tumor cell proliferation. |
| 17524492 |
Five of the antibodies recognized recombinant rat and human EPOR in HEK293 cells by Western blotting, but the same antibodies yielded different and inconsistent results when using human UT-7 cells or rat brain tissue. |
| 15671524 |
erythropoietin and EPOR are co-expressed in tumor cells, suggesting that erythropoietin may potentially function as an autocrine or paracrine factor in head and neck cancer |
| 15358619 |
activated Epo receptors appear to be quickly degraded after ubiquitination by 2 proteolytic systems that proceed successively |
| 15249201 |
These data demonstrate that EPO can promote differentiation of neuronal stem cells into astrocytes in an EPO receptor dependent manner, and this effect may be associated with the activation of ERK kinase and NF-kappaB pathway. |
| 17293480 |
The Epo receptor may be important for secretion, endothelial progenitor cell mobilization, and angiogenesis in ischemic tissue as well as Epo in peripheral vasculature of EpoR-deficient-rescued transgenic mice, compared with wild type. |
| 16627979 |
Coexpression of erythropoietin and its receptor plays a important role in tumorigenesis of sporadic clear cell renal cell carcinoma. |
| 12118093 |
functional significance of expression in breast cancer |
| 17488692 |
A novel sporadic EPOR 1453G->A (Trp439Stop) mutation was detected. All familial erythrocytosis cases, varied in phenotype, presented the EPOR 1414C->G (Tyr426Stop) mutation. |
| 17363704 |
Recognition of a vascular EpoR system which is endowed with significant pathophysiological functions opens new exploitation horizons in cardiovascular medicine. |
| 17597020 |
Statistically analyzed distributions of the proteins reflected functional dependences among STAT3, HIF-1alpha, EPO and EPOR in cellular signal conduction. |
| 16608505 |
No EPOR exon VIII mutations were found in members of 8 Greek families with primary familial and congenital polycythemia. |
| 15480420 |
the erythropoietin-receptor pathway modulates survival of cancer cells |
| 15572213 |
The Erythropoietin Receptor mutations have been shown to cause the myeloproliferative disorders disease. |
| 15878737 |
Y285 and Y344 in the cytoplasmic domain of EPOR-ME may contribute to increased Epo sensitivity that is characteristic of primary familial and congenital polycythemia phenotype. |
| 15467711 |
Epression of erythropoietin receptor in prostate cancer cell lines suggesting that these cells may serve as useful experimental models for further studies of erythropoietin receptor function for growth regulation in prostate cancer. |
| 16161153 |
data demonstrate that transformed, non-malignant and malignant prostate epithelial cells have functional EpoR |
| 16278379 |
Erythropoietin and erythropoietin receptor are expressed in head and neck squamous cell carcinoma |
| 11884148 |
Amino acid determinants of beta-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library |
| 12525458 |
Epo and Epo-R localized within glandular epithelial cells in both peritoneal endometriosis and eutopic endometrium. Epo-R expression lower in black peritoneal lesions. |
| 11999556 |
REVIEW: Role of erythropoietin receptor in myelodysplastic syndrome and leukemia. |
| 12027890 |
evidence for pY429pY431 being a new high affinity binding site for SOCS-3 on the EpoR |
| 11994541 |
While both Epo and Epo-R were detected in all samples of isolated epithelial cells analysed throughout the menstrual cycle, neither one was detected in isolated stromal cells. Epo and Epo-R protein expression in glandular epithelial cells was increased |
| 15205261 |
erythropoietin receptor and nitric oxide production are stimulated by erythropoietin and hypoxia in vascular endothelial cells |
| 15709164 |
erythropoietin receptor was expressed in almost all samples in non-small cell lung carcinomas. |
| 15709172 |
Results showed that VHL disease-associated renal clear cell carcinomas and renal cysts coexpress and erythropoietin receptor and erythropoietin. |
| 15777837 |
the erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor |
| 12021194 |
The extracellular binding site for ERP is now characterized. The site is located in the membrane proximal, extracellular part of the receptor. ERP binds to a region on the EPOR that contains the same sequence as ERP |
| 12488507 |
JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR |
| 15769989 |
Coexpression of Erythropoietin and Erythropoietin receptor was found in all five Hippel Lindau disease-associated pheochromocytomas. |
| 16084495 |
CaM binds to the membrane-proximal EpoR cytoplasmic region and plays an essential role in activation of Jak2-mediated EpoR signaling |
| 16699298 |
findings show that three thyroid cancer cell lines expressed Epo and EpoR mRNA |
| 16982687 |
Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity. |
| 15644415 |
detailed mapping of interactions of several signalling proteins with phosphorylated tyrosine-containing motifs in the cytosolic domain OF EPOR |
| 15160341 |
Increased erythropoietin receptor expression is associated with advanced-stage disease, lymphovascular invasion, lymph node metastasis of endometrial carcinoma |
| 17038666 |
erythropoietin receptor is not ubiquitinated following erythropoietin stimulation in this cancer cell line, and there is no turnover of the receptor in either unstimulated or stimulated cells |
| 14584755 |
Majority of papillary thyroid carcinomas (PTC) from children and adolescents express EPO-R, a finding associated with favorable prognostic indicators and a lower risk of recurrence. |
| 12878211 |
Expression of erythropoietin receptor splice variants in tumor cell lines. |
| 15657048 |
the TM-JM junction of EpoR forms an N-terminal helix cap required for function |
| 17110616 |
Doubt concerning the significance of previous immunohistochemical studies of EPOR expression in malignancy and emphasize the need for more specific anti-EPOR antibodies to define the true extent of EPOR expression in neoplastic tissue. |
| 17483696 |
upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic Alzheimer disease. |
